Associate Professor Guozhen Liu

A/Prof Guozhen Liu is an ARC Future Fellow and Associate Professor at Graduate School of Biomedical Engineering, UNSW. Gaining her PhD degree in Chemistry in 2006 under the supervision of Prof Justin Gooding at UNSW, Liu is recognised for her innovative cross-disciplinary research in the area of biosensors, point-of-care diagnostics, and biomedical devices. She conducted her postdoctoral research at CSIRO (2006-2008) and UNSW (2008-2010), respectively before she accepted a faculty position as Associate Professor at the Central China Normal University, China (2010-2015). In 2015 Liu moved back to Sydney and worked as a Senior Research Fellow at ARC Centre of Excellence for Nanoscale BioPhtotnics (CNBP), Macquarie University before she was awarded the prestigious ARC Future Fellowship in 2016.

Liu’s research career has alternated between industrial and academic research. Besides building effective collaborations within academia, she has maintained close engagement with the industry sector in the conduction of translational research. Liu’s industrial experience includes four years spent as R&D Manager for AgaMatrix Inc. (2010-2015), working for the US based company in China. This position saw her developing medical devices including glucose test strips and glucose meters. The sensing technologies described in her patents have attracted the attention and investment of industry end-users, such as AstraZeneca, BioLegend, Regeneus Ltd and AgaMatrix Inc. These technologies have been, or are in the process of being commercialised. Liu has attracted more than $5M in national and international research funding since 2016.

Professional Interests:

vice-chair in IEEE Sensors Council NSW chapter

Member of IEEE
Member of Australian Diabetes Society
Member of Engineering in Medicine and Biology Society
Chartered member of Royal Australian Chemical Institute (RACI)
Member of American Chemical Society
Member of Chinese Chemical Society
Member of Internatioanl Electrochemistry Society
Member of International Society of Aptamers (INSOAP)

Visit A/Prof Guozhen Liu's research web pages:

https://guozhenliu.weebly.com

https://research.unsw.edu.au/people/associate-professor-guozhen-liu

My Grants

Georgina Sweet Award for Women in Quantitative Biomedical Science 2020 , $25,000, Guozhen Liu
AstraZeneca Conference Sponsorship Fund, 2020, $14,000, Guozhen Liu
UNSW Digital Grid Futures Institute Seed Fund, 2020, $30,000, Guozhen Liu
UNSW IRS 2020 Network Lab application fund, 2020-2021, $192,511, Nigel Lovell, et al, Guozhen Liu
UNSW-CAS Collaborative Research Bridging Grant, 2019, $50,000, Guozhen Liu
UNSW Conference Seed Fund, 2019, $10,000, Guozhen Liu
Australian Research Council Linkage Project (LP180100801), 2019-2022, $475,000, Guozhen Liu, Nigel Lovell. Kourosh Kalantar-Zadeh, Margaret Morris, David Penn
UNSW Biomedical Engineering Seed Fund, 2019-2022, $450,000, Guozhen Liu, Margaret Morris, Jerry Greenfield, Maria Craig, Peter Vranes
Cooperative Research Centres Project (CRC-P) Grant with Nutromics, 2019-2021, $2.15M, Guozhen Liu (Lead CI at UNSW)
MedImmune Industry Funding, 2018-2019, $591,000, Guozhen Liu
Australian Research Council Future Fellowship (FT160100039), 2017-2021, $652,000, Guozhen Liu
ANSTO PhD Project Funding, 2018-2019, $7,500, Guozhen Liu (for PhD student Jagjit Kaur)
ANSTO PhD Project Funding, 2017-2018, $7,500, Guozhen Liu (for PhD student Fuyuan Zhang)
Macquarie University Research Infrastructure Block Grant for 3D-printer for biomedical applications, 2017, $100,000
Australian Research Council Linkage Project, 2016-2019, $342,000, Ewa Goldys, Guozhen Liu, Graham Vesey
Macquarie University Research Development Grant, 2015-2016, $50,000, Guozhen Liu, Ewa Goldys, Ayad Anwar
Macquarie University Research Infrastructure Block Grant, 2015, $100,000
Regeneus Inc. Industry Funding, 2015, $75,000, Guozhen Liu, Ewa Goldys
National Natural Science Foundation of China General Project Funding, 2016-2019, Guozhen Liu
Central China Normal University Infrastructure Funding, 2014, China
Ministry of Education Self-determined Research Funding, 2013-2016, China
Wuhan Rongtan Tech, Industry Funding, 2011-2012, China
National Natural Science Foundation of China Early Career Research Funding, 2010-2012, China
Central China Normal University New Staff Funding, 2010, China
International Postgraduate Scholarship (IPRS) 2003, awarded by Australian government

My Qualifications

PhD in Chemistry, School of Chemistry, University of New South Wales, Australia (2003 –2006) under the supervising of Prof Justin Gooding
Master in Analytical Chemistry, College of Material Science and Chemical Engineering, China University of Geosciences, China (1997-2000)
Bachelor in Chemical Education, Department of Chemistry, Hubei Normal University, China (1993-1997)

My Awards

Georgina Sweet Award for Women in Quantitative Biomedical Science 2020, Australia
The second prize of Innovation and Entrepreneurship Competition for Overseas High-level Talents 2018, China, Australia and South Africa
The Rising Star Award, Australian Association of Chinese Biomedical Scientists, 2018, Australia
Academic Excellence Award for transdisciplinary research publications in 2017, Australia
ARC Future Fellowship, 2016, Australia
Shortlisted by Georgina Sweet Award for Women in Quantitative Biomedical Science 2016, Australia
Travel grant and Childcare grant for Emerging Therapeutics Summit 2016, Melbourne, awarded by International Innovative Research Network
Best Poster Award, CNBP Annual Retreat 2015, Lake Macquarie, Australia
International Postgraduate Scholarship (IPRS) 2003, awarded by Australian government

My Research Activities

Dr Liu is leading a research team on Integrated Devices and Intelligent Diagnostics (ID², https://guozhenliu.weebly.com/) covering the area of point-of-care testing, nanoscale analysis, stimuli-responsive nanoparticles, advanced sensing technologies and biomedical devices. Liu’s group targets to “Creating tools to quantify our health” where she modifies the bio-nano interfaces for diagnostic medical devices, bioimaging and biomaterials as well as more fundamental research on real-time in vivo sensing and adaptive cellular response systems. Besides the biomedical research, the group is also interested in the development of assays and portable devices for food safety.

Current research projects:

Smart sensing platforms for detection of key analytes in the body such as insulin, glucose, cytokines, microRNA, nucleic acids, exosomes, and ROS/RNS
CRISPR/Cas based biosensing technologies
Stimuli-responsive nanoparticles towards intelligent personialised nanomedicine
3D microfluidic paper based point-of-care devices
Pathogen and toxin detection in foods and agriculture
Single cell analysis
Wearable and implantable in vivo devices

Refereed Journal Articles (Names underlined were students or postdocs under Liu's supervision; *corresponding author; Google citations: https://scholar.google.com.au/citations?user=xms_zr0AAAAJ&hl=en)

2020

M. R. Benzigar, Ripon Bhattacharjee, M. Baharfar G. Liu*, Current methods for diagnosis of human coronaviruses: pros and cons, Anal. Bioanal. Chem, 2020, https://doi.org/10.1007/s00216-020-03046-0
S. Clement, J. M. Campbell, W. Deng, A. Guller, S. Nisar, G. Liu, B. C. Wilson, E. M. Goldys, Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer, Adv. Sci, 2020, 2003584, 1-34https://doi.org/10.1002/advs.202003584,
M. R. Benzigar, V. D.B.C Dasireddy, X. Guan, T. Wu, G. Liu*, Advances on emerging materials for flexible supercapacitors: current trends and beyond, Adv. Funct. Mater., 2020, 2002993, 1-41, https://doi.org/10.1002/adfm.202002993. (IF: 16.836)
S. N. Prabhu, G. Chinthaka P., A. S. Davidson, G. Liu, Molecularly Imprinted Polymer‐based detection of creatinine towards smart sensing, Medical Devices & Sensors, 2020, in press, https://doi.org/10.1002/mds3.10133
M. Baharfar, M. Rahbar, M. Tajiki, G. Liu*, Engineering Strategies for Enhancing the Performance of Electrochemical Paper-Based Analytical Devices, Biosens. Bioelectron., 2020, 167, 112506, https://doi.org/10.1016/j.bios.2020.112506 (IF-10.25)
M. Yang, X. Wu, H. Li, G. Cui, Z. Bai, L. Wang, M. Kraft, G. Liu, L. Wen, A Novel Rare Cell Sorting Microfluidic Chip Based on Magnetic Nanoparticle Labels, J. Micromech. Microeng., 2020, in press, https://iopscience.iop.org/article/10.1088/1361-6439/abbb7b/meta
M. Frank, M. Baratta, K. Zhang, I. Fallon, M. Pearson, G. Liu, M. Hutchinson, L. Watkins, E. Goldys, S. Maier, Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1b protein in dorsal hippocampus
Journal: Brain Behavior and Immunity, Brain, Behavior, and Immunity, 2020, 30,2002993, https://doi.org/10.1016/j.bbi.2020.07.042, (IF: 6.633)
Z. Bai, Y. Liu, R. Kong, T. Nie, Y. Sun, H. Li, T. Sun, C. Pandey, Y. Wang, H. Zhang, Q. Song, G. Liu, M. Kraft, W. Zhao, X. Wu, L. Wen, Near-field Terahertz Sensing of Hela cells and Pseudomonas Based on Monolithic Integrated Metamaterials with Spintronic Terahertz Emitter, ACS Appl. Mater. Interfaces, 2020, 12, 32, 35895–35902, https://doi.org/10.1021/acsami.0c08543 (IF: 8.758)
L. Qiao, M. Benzigar, A. Subramony, N. Lovell, G. Liu*, Advances in Sweat Wearables: Sample Extraction, Real-Time Biosensing, and Flexible Platforms, ACS Appl. Mater. Interfaces, 2020, 12, 30, 34337–34361, https://doi.org/10.1021/acsami.0c07614 (IF: 8.758)
J. Zhou, L. Yin, Y. Dong, L. Peng, G. Liu, S. Man, L. Ma*, Cas13a Based Bacterial Detection Platform: Sensing Pathogen Staphylococcus aureus in Food Samples, Anal. Chim. Acta, 2020, 1127, 225-233, https://doi.org/10.1016/j.aca.2020.06.041 (IF: 5.977)
Y. Dai*, Y. Wu*, G. Liu, J. J. Gooding, CRISPR Mediated Biosensing Toward Understanding Cellular Biology and Point-of-Care Diagnosis, Angew. Chem. Int. Ed., 2020, 132, 20938-20950, https://doi.org/10.1002/ange.202005398, (IF: 12.959)
A. Arman, F. Deng, E. M. Goldys, G. Liu*, M. R. Hutchinson*, In vivo intrathecal IL-1β quantification in rats: monitoring the molecular signals of neuropathic pain, Brain, Behavior, and Immunity, 2020, 88, 442-450, https://doi.org/10.1016/j.bbi.2020.04.009, (IF: 6.633)
L. Peng, J. Zhou, G. Liu, L. Yin, S. Ren, S. Li*, L. Ma*, CRISPR-Cas12a based aptasensor for sensitive and selective ATP detection, Sens. Actuators B: Chem, 2020, 128164, 1-5, https://doi.org/10.1016/j.snb.2020.128164 (IF: 7.100)
S. Ni, Z. Shen, P. Zhang, G. Liu*, Enhanced performance of an electrochemical aptasensor for real-time detection of vascular endothelial growth factor (VEGF) by nanofabrication and ratiometric measurement, Anal. Chim. Acta, 2020, 1121, 74-82, https://doi.org/10.1016/j.aca.2020.05.003, (IF: 5.977)
S. Rani, S. Bandyopadhyay-Ghosh*, S. B. Ghosh, G. Liu, Advances in Sensing Technologies for Monitoring of Bone Health, Biosensors, 2020, 10, 42, https://doi.org/10.3390/bios10040042, (IF: 3.240)
Z. Shen, J. Huang, H. Wei, H. Niu, B. Li, R. Li, G. Liu*, Validation of an in vivo electrochemical immunosensing platform for simultaneous detection of multiple cytokines in Parkinson’s Disease mice model, Bioelectrochemistry, 2020, 134, 107532, https://doi.org/10.1016/j.bioelechem.2020.107532, (IF: 4.722)
Z. Luo, T. Lv, K. Zhu, Y. Li, L. Wang, J. J. Gooding, G. Liu*, B. Liu*, Paper-based Ratiometric Fluorescence Analytical Devices towards Point-of-Care Testing of Human Serum Albumin, Angew. Chem. Int. Ed., 2020, 59, 1-7, https://doi.org/10.1002/anie.201915046, (IF: 12.959)
A. Hassanzadeh-Barforoushi*, M. Ebrahimiwarkiani, D. Gallego-Ortega, G. Liu, T. Barber, Capillary-assisted microfluidic biosensing platform captures single cell secretion dynamics in nanoliter compartments, Biosens. Bioelectron., 2020, 112113, https://doi.org/10.1016/j.bios.2020.112113, (IF: 10.257)
F. Deng, A. Arman, E. M. Goldys, M. R. Hutchinson*, G. Liu*, A method for in vivo quantification of cytokine IL-1ß in the rat intrathecal space, ACS Applied Bio Materials, 2020, 3 (1), 539-546, https://doi.org/10.1021/acsabm.9b00958, (IF=N?A, new journal)

2019

F. Deng, Y. Li, Md J. Hossain, M. D. Kendig, R. Arnold, E. M. Goldys, M. J. Morris, G. Liu*, Analyst, 2019, 144, 5682 - 5690 [Highlighted on the journal Front Cover]
G. Liu*, C. Bursill, S. P. Cartland, A. G. Anwer, L. M. Parker, K. Zhang, S. Feng, M. He, D. W. Inglis, M. M. Kavurma, M.R. Hutchinson, E. M Goldys*, A nanoparticle-based affinity sensor that identifier and select highly cytokine-secreting cells, iScience, 2019, 20, 137-147
G. Liu*, C. Cao, H. Wei, S. Feng, S. Ni, On-Chip Structure-Switching Aptamer Modified Magnetic Nanobeads for Continuous Monitoring of Interferon-gamma Ex Vivo, Microsystems & Nanoengineering, 2019, accepted, [IF=5.1]
B. V. Dang, A. Hassanzadeh-Barforoushi, M. S. Syed, D. Yang, S.-J. Kim, R. Taylor, G.-J. Liu, G. Liu*, Tracie Barber*. Microfluidic actuation via 3D-printed molds towards multiplex biosensing of cell apoptosis, ACS Sensors, 2019, accepted [IF=6.9]
Y. Li, L. Liu, G. Liu*, CRISPR/Cas multiplexed biosensing: a challenge or an insurmountable obstacle? Trend in Biotechnology, 2019, I:https://doi.org/10.1016/j.tibtech.2019.04.012 [IF=13.6]
Y. Alhamoud, D, Yang, S. S. F. Kenston, G. Liu, L. Liu, H. Zhou, F. Ahmed, J. Zhao, Advanced in biosensors for the detection of ochratoxin A: Bioreceptors, nanomaterials, and their applications, Biosens. Bioelectron., 2019, 141, 11418 [IF=9.5]
T. Jiang, L. Zhou, H. Liu, P. Zhang, G. Liu, P. Gong, C. Li, W. Tan, J. Chen, L. Cai, A Monitorable Mitochondria-targeting DNAtrain for Image-guided Synergistic Cancer Therapy, Anal. Chem. 2019, 91, 6996-7000, DOI: 10.1021/acs.analchem.9b01777 [IF=6.3]
K. Wen, X. Xu, J. Chen, L. Lv, L. Wu, Y. Hu, X. Wu, A. Peng, G. Liu, H. Huang, Triplet Tellurophene-based Semiconducting Polymer Nanoparticles for Near-Infrared-mediated Cancer Theranostics, ACS Appl. Mater. Interfaces, 2019, 11, 19, 17884-17893, https://pubs.acs.org/doi/10.1021/acsami.9b05196 [IF=8.1]
F. Deng, E.M. Goldys, G. Liu*, Molecularly imprinted polymer-based reusable biosensing device on stainless steel for spatially localized detection of cytokine IL-1β, Sensors and Actuators B: Chemical, 2019, 292, 277-283, https://doi.org/10.1016/j.snb.2019.04.142 [IF=5.7]
L. Liu, D. Yang, G. Liu*. Signal amplification strategies for paper-based analytical devices, Biosens. Bioelectron., 2019, 136, 60-75. http://authors.elsevier.com/sd/article/S0956566319303355 [IF=8.2]
F. Zhang, F. Deng, G-J Liu, R. Middleton, D. Inglis, A. Anwer, S. Wang, G. Liu*, IFN-γ-induced signal-on fluorescence aptasensors: from hybridization chain reaction amplification to 3D optical fiber sensing interface towards a deployable device for cytokine sensing, Molecular Systems Design & Engineering, 2019, in press https://pubs.rsc.org/en/Content/ArticleLanding/2019/ME/C9ME00047J#!divAbstract
Y. Li, S. Li, J. Wang, G. Liu*, CRISPR/Cas systems towards next generation biosensing, Trends in Biotechnology, 2019, 37 (7), 730-743, DOI: https://doi.org/10.1016/j.tibtech.2018.12.005 [Review paper]
K. Ma, G-J. Liu, L. Yan, S. Wen, B. XU, W. Tian, E. Goldys, G. Liu*, AIEgen based PLGA magnetic nanoparticles to localize cytokine VEGF for early diagnosis and photothermal therapy, Nanomedicine, 2019, in press, https://www.futuremedicine.com/doi/full/10.2217/nnm-2018-0467
F. Zhang, L. Liu, S. Ni, J. Deng, G.J. Liu, R. Middleton, D. Inglis, S. Wang, G. Liu*, Turn-on fluorescence aptasensor on magnetic nanobeads for aflatoxin M1 detection based on an Exonuclease III assisted signal amplification strategy, Nanomaterials, 2019, 9(104), 1-13
W. Wu, M. Jia, Z. Wang, W Zhang, Q. Zhang, G. Liu, Z. Zhang, P. Li, Simultaneous voltammetric determination of cadmium(II), lead(II), mercury(II), zinc(II), and copper(II) using a glassy carbon el ectrode modified with magnetite (Fe3O4) nanoparticles and fluorinated multiwalled carbon nanotubes, Microchimica Acta, 2019, 186:97, https://doi.org/10.1007/s00604-018-3216-5
J. Kaur, C. Jiang, G. Liu*, Different strategies for detection of HbA1c emphasizing on HbA1c biosensors and point-of-care analyzers, Biosens. Bioelectron., 2019, 123, 85-100 [Review paper] https://doi.org/10.1016/j.bios.2018.06.018

2018

H. Wei, S.N. Ni, C.M. Cao, G. F. Yang, G. Liu*，Graphene oxides signal reporters based multifunctional immunosensing platform for amperometric profiling of multiple cytokines in serum, ACS Sens., 2018, 3(8), 1553-1561
C. Cao. R. Jin, H. Wei, et al, G. Liu*, Graphene Oxide Based Recyclable In vivo Device for Amperometric Monitoring of Interferon-γ in Inflammatory Mice, ACS Appl. Mater. Interfaces, 2018, 10(39), 33078-33087
J. Li, et al, G. Liu, et al, Perspective: Biomedical sensing and imaging with optical fibers—Innovation through convergence of science disciplines, APL Photonics, 2018, 3, 100902
K. Zhang, M.V. Baratta, G. Liu*, M.G. Frank, N.R. Leslie, L.R. Watkins, S.F. Maier, M.R. Hutchinson, E.M. Goldys, A novel platform for in vivo detection of cytokine release within discrete brain regions, Brain Behav. Immu., 2018, S0889-159(18), 30130-30132. https://doi.org/101016/j.bbi.2018.04.011
F. Zhang, B. Liu, G. Liu, W. Sheng, Y. Zhang, Q. Liu, S. Wang, Novel magnetic nanobeads-based fluoroimmunoassays for zearalenone detection in cereals using protein G as the recognition linker, Sens. Actuators B Chem., 2018, 270, 149-157. https://doi.org/10.1016/j.snb.2018.04.131
C.M. Cao, F. Zhang, E. M. Goldys, F. Gao, G. Liu*, Advances in structure-switching aptasensing towards real-time detection of cytokines, TrAC Trends Anal. Chem., 2018, 102, 379-396 [Review paper]
F. Zhang, B. Liu, G. Liu, Y. Zhang, J. Wang, S. Wang, Substrycture-activity relationship studies on antibody recogntion for phenylurea compounds using immunoassay and computational chemistry, Sci. Rep., 2018, 8(3131), 1-8. https://doi.org/10.1016/j.trac.2018.03.002
K. Ma, F., Zhang, N. Sayyadi, W. J. Chen, A. Anwer, A. Care, B. Xu, W. J. Tian, E. M. Goldys,G. Liu*, Turn-on fluorescent aptasensor based on AIEgen labelling for the localisation of IFN-y in live cells, ACS Sens., 2018, 3(2), 320-326. https://pubs.acs.org/doi/10.1021/acssensors.7b00720
K.X. Zhang, G. Liu*, E.M. Goldys, Robust immunosensing system based on biotin-streptavidin coupling for spatially localized femtogram mL^-1 level detection of interleukin-6, Biosens. Bioelectron., 2018, 102, 80-86. https://doi.org/10.1016/j.bios.2017.11.023

2017

M. Qi, J.W. Huang, H. Wei, C.M. Cao, S.L. Feng, Q. Guo, E.M. Goldys, R. Li, G. Liu*,Graphene oxide thin film with dual function integrated into a nano-sandwich device for in vivo monitoring of interleukin-6, ACS Appl. Mater. Interfaces, 2017, 9(48), 41659-41668. https://pubs.acs.org/doi/pdf/10.1021/acsami.7b10753
S.L. Feng, G. Liu, L. Jiang, Y. Zhu, E.M. Goldys, D.W. Inglis, A microfluidic needle for sampling and delivery of chemical signals by segmented flows, Appl. Phys. Lett, 2017, 111, 183702.
S.L. Feng, A.M. Skelley, A.G. Anwer, G. Liu, D.W. Inglis, Maximizing Particle Concentration in Deterministic Lateral Displacement Arrays, Biomicrofluidics, 2017, 11, 024121.
G. Liu*, K. Zhang, K. Ma, A. Care, M.R. Hutchinson, E. M. Goldys, Graphene quantum dots based "switch-on" nanosensors for intracellular cytokine monitoring, Nanoscale, 2017, 9, 4934-4943.
C.M. Cao, Y. Zhang, C. Jiang, M. Qi, G. Liu*, Advances on Aryldiazonium Salt Chemistry Based Interfacial Fabrication for Sensing Applications, ACS Appl. Mater. Interfaces, 2017, 9(6), 5031-5049. [Review paper]
A. Rehman, A. Anwer, M, Gosnell, S. Mahbub, G. Liu, E.M. Goldys, Fluorescence quenching of free and bound NADH in Hela cells determined by hyperspectral imaging nad unmixing of cell autofluorescence, Biomed. Opt. Express, 2017, 8(3), 1488-1498
G. Liu*, K.X. Zhang, A. Nadort, M.R. Huctchinson, E.M. Goldys, Sensitive cytokine assay based on optical fiber allowing localised and spatially resolved detection of interleukin-6, ACS Sens., 2017, 2(2), 218-226.
C. Jiang, S.M. Silva, S. Fan, Y. Wu, M.T. Alam, G. Liu, J.J. Gooding, Aryldiazonium elelctrochemistry derived mixed organic layers: from surface chemistry to its applications, J. Electroanal. Chem, 2017, 785, 265-278. [Review paper]
Y. Lu, Y. Xia, G. Liu, M. Pan, M. Li, N. A. Lee, S. Wang, A Review of Methods for Detecting Melamine in Food Samples, Crit. Rev. Anal. Chem., 2017, 47(1), 51-66.[Review paper]

2016

X. Gong, G. Liu, Y. Li, Y. Yu, W.Y. Teoh, Functionalized-graphene composites: Fabrication and applications in sustainable energy and environment, Chem. Mater., 2016, 28(22), 8082-8118.[Review paper]
M. Qi, Y. Zhang, C.M. Cao, M. Zhang, S. Liu, G. Liu*, Decoration of RGO nanosheets with aryldiazonium salt and gold nanoparticles towards a label-free amperimetric immunosensor for detecting TNF-a in live cells, Anal. Chem., 2016, 88(19), 9614-9621.
M. Qi, Y. Zhang, C.M. Cao, Y. Lu, G. Liu*, Increased sensitivity of extracellular glucose monitoring based on AuNP decorated GO nanocomposites, RSC Adv., 2016, 6, 39180-39187.
Y. Lu, M. Li, M. Ding, G. Liu, Y. Zhang, S.Wang, Detection of biosphenol-A with electrochemical immunosensor: The comparison of the competition and displacement format assay, J. Electroanal. Chem., 2016, 779, 34-38.
G. Liu*, M. Qi, M. Hutchinson, G. Yang, E.M. Goldys, Recent Advances in Cytokine Detection by Immunosensing, Biosens. Bioelectron., 2016, 79, 810-821. [Review paper]
G. Liu*, M. Qi, Y. Zhang, C.M. Cao, E.M. Goldys, Nanocomposites of Gold Nanoparticles and Graphene Oxide Towards an Stable Label-Free Electrochemical Immunosensor for Detection of Cardiac Marker TroponinI, Anal. Chim. Acta, 2016, 909, 1-8. [Front cover feature article]
D. Song, C. Guo, J. Zhao, H. Suo, X. Zhao, G. Liu, Host Sensitized Near-infrared Emission in Nd3+ -Yb3+ Co-doped Na2GdMg2V3O12 Phosphor, Ceram. Int., 2016, 42(11):12988-12994
W. Z. W. Ismail, G. Liu, K. Zhang, E.M. Goldys, J.M. Dawes, Dopamine Sensing and Measurement using Threshold and Spectral Measurements in Random Lasers,Opt. Express, 2016, 24(2), A85-A91.

2015

G. Liu*, Y. Zhang, M. Qi, F. Chen, Covalent Anchoring of Multifunctionized Gold Nanoparticles on Electrodes towards an Electrochemical Sensor for Detection of Cadmium Ions, Anal. Methods, 2015, 7, 5619-5626.
Y. Zhang, M. Qi, G. Liu*, C-C Bonding of Graphene Oxide on 4-Aminophenyl Modified Gold Electrodes towards Simultaneous Detection of Heavy Metal Ions, Electroanalysis, 2015, 27 (5), 1110-1118.
G. Liu*, Y. Zhang, W. Guo, Covalent Functionalization of Gold Nanoparticles as Electronic Bridges and Signal Amplifiers Towards an Electrochemical Immunosensor for Botulinum Neurotoxin Type A, Biosens. Bioelectron., 2014, 61, 547-553.

2014

X. Gong, Y. Bi, Y. Zhao, G. Liu, W.Y. Teoh, Graphene Oxide-based Electrochemical Sensor: a Platform for Ultrasensitive Detection of Heavy Metal Ions, RSC Advances, 2014, 4 (47), 24653-24657.
F. Chen, G. Liu, Y. Shi, P. Xi, J. Cheng, J. Hong, R. Shen, X. Yao, D. Bai, Z. Zeng, A Coumarin-derived Fluorescent Chemosensor for Selectively Detecting Cu²⁺: Synthesis, DFT Calculations and Cell Imaging Applications, Talanta, 2014, 124(15), 139-145.
G. Liu*, W. Guo, Y. Zhang, Covalent Fabrication of Methyl Parathion Hydrolase on Gold Nanoparticles Modified Carbon Substrates for Designing a Methyl Parathion Biosensor,Biosens. Bioelectron., 2014,53 (15), 440-446.
G. Liu*, W. Guo, D. Song, A Multianalyte Electrochemical Immunosensor Based on Patterned Carbon Nanotubes Modified Substrates for Detection of Pesticides,Biosens. Bioelectron., 2014, 52 (15), 360-366.
A. Li, J. Liu, G. Liu, J. Zhang, S. Feng, Design and Synthesis of Fluorescent Core-shell Nanoparticles with Tunable LCST Behavior and Metal-enhanced Fluorescence,J. Polym. Sci. Part A: Polym. Chem., 2014, 52(1), 87-95.
C. Fairman, M. Chockalingam, G. Liu, A.H. Soeriyadi, J.J. Gooding. Light-Induced Organic Monolayer Modification of Iodinated Carbon Electrodes, Langmuir,2014, 30, 332−339.

2013

W. Guo, F. Jiang, J. Chu, D. Song, G. Liu*, A Sensitive Hydrogen Peroxide Biosensor Based on Aryldiazonium salts and SWNTs Modified Gold Electrodes, J. Electroanal. Chem., 2013, 703, 63-69.
U.E. Wawrzyniak, P. Ciosek, M. Zaborowski, G. Liu, J.J. Gooding. Gly-Gly-His Immobilized On Monolayer Modified Back-Side Contact Miniaturized Sensors for Complexation of Copper Ions,Electroanalysis, 2013, 25(8), 1-11.
F. Chen, P. Xi, C. Ma, C. Shao, J. Wang, S. Wang, G. Liu, Z. Zeng. In Situ Preparation, Characterization, Magnetic and Catalytic Studies of Surfactant Free RGO/FexCo100−xnanocomposites, Dalton Trans., 2013, 42, 7936-7942.
G. Liu*, D. Song, F. Chen. Towards the Fabrication of a Label-free Amperometric Immunosensor Using SWNTs for Direct Detection of Paraoxon, Talanta, 2013, 104, 103-108.
G. Liu, S.G. Iyengar, J.J. Gooding. An Amperometric Immunosensor Based on a Gold Nanoparticle-Diazonium Salt Modified Sensing Interface for the Detection of HbA1c in Human Blood, Electroanalysis, 2013, 25(4), 881-887.

2012

G. Liu*, S. Wang, J. Liu, D. Song. An Electrochemical Immunosensor Based on Chemical Assembly of Vertically Aligned Carbon Nanotubes on Carbon Substrates for Direct Detection of Pesticide Endosulfan in Environmental Water, Anal. Chem., 2012, 84(9), 3921-3928.
X. Luo, J. Liu, G. Liu, R. Wang, Z. Liu. Manipulation of the Bioactivity of Glucose Oxidase via RAFT Controlled Surface Modification, J. Polym. Sci. Part A: Polym. Chem., 2012, 50(14), 2786-2793.
G. Liu, S.M. Khor, S.G. Iyengar, J.J. Gooding. Development of an Electrochemical Immunosensor for the Detection of HbA1c in Serum, Analyst, 2012, 137, 829-832.
G. Liu, S.G. Iyengar, J.J. Gooding. An Electrochemical Impedance Immunosensor Based on Gold Nanoparticle-Modified Electrodes for the Detection of HbA1c in Human Blood,Electroanalysis, 2012, 24(7), 1509-1516.

2011

G. Liu. Modification of Aryldiazonium Salts on Electrodes towards Designing Stable and Versatile Sensing Interfaces, Aus. J. Chem., 2011, 64, 658.
G. Liu, J. Liu, T.P. Davis, J.J. Gooding. Electrochemical Impedance Immunosensor Based on Gold Nanoparticles and Aryldiazonium Salts Functionalized Gold Interface for the Detection of Antibody, Biosens. Bioelectron., 2011, 26(8), 3660-3665.
G. Liu, E. Luais, J.J. Gooding. The Fabrication of Stable Gold nanoparticle Modified Interfaces for Electrochemistry, Langmuir, 2011, 27(7), 4173-4186.
G. Liu, N.M.K. Tse, M.R. Hill, D.F. Kennedy, C.J. Drummond, Disordered Mesoporous Gadolinosilicate Nanoparticles Prepared Using Gadolinium Based Ionic Liquid Emulsions: Potential as Magnetic Resonance Imaging Contrast Agent, Aus. J. Chem., 2011, 64, 617-624.
S.M. Khor, G. Liu, J.R. Peterson, S.G. Iyengar, J.J. Gooding. An Electrochemical Immunobiosensor for Direct Detection of Veterinary Drug Residues in Undiluted Complex Matrices, Electroanalysis, 2011, 23(8), 1797-1804.
S.M. Khor, G. Liu, S.G. Iyengar, J.J. Gooding. The Importance of Interfacial Design for the Sensitivity of a Label-Free Electrochemical Immuno-Biosensor for Small Organic Molecules.Biosens. Bioelectron., 2011, 26(5), 2038-2044.
X. Chen, M. Chockalingam, G. Liu, E. Luais, A.L. Gui, J.J. Gooding, A Molecule with Dual Functionality 4-Aminophenylmethylphosphonic Acid: A Comparison Between Layers Formed on Indium Tin Oxide by In Situ Generation of an Aryl Diazonium Salt or by Self-Assembly of the Phosphonic Acid, Electroanalysis, 2011, 23(11), 2633-2642.
C. Hua, W. H. Zhang, S.R. M.D. Almeida, S. Ciampi, D. Gloria, G. Liu, J.B. Harper, J.J. Gooding, A Novel Route to Copper(II) detection Using ‘Click’ Chemistry-induced Aggregation of Gold Nanoparticles, Analyst, 2011, 137, 82-86. [Front cover feature article]

2010

A.L. Gui, G. Liu, M. Chockalingam, G.L. Saux, J.B. Harper, J.J. Gooding. A Comparative Study of Modifying Gold and Carbon Electrode with 4-nitrophenyl Diazonium Salt. Electroanalysis, 2010, 22(16), 1824-1830.
A.L. Gui, G. Liu, M. Chockalingam, G.L. Saux, J.B. Harper, J.J. Gooding. A Comparative Study of Modifying Gold and Carbon Electrode with 4-sulfophenyl Diazonium Salt. Electroanalysis, 2010, 22(12), 1283-1289.
G. Liu, M. Chockalingham, S.M. Khor, A.L. Gui, J.J. Gooding. A Comparative Study of the Modification Gold and Glassy Carbon Surfaces with Mixed Layers of In situ Generated Aryl Diazonium Compounds. Electroanalysis, 2010, 22(9), 918-926

2009

G. Liu, C.E. Conn, L. Waddington, S.T. Mudie, C.J. Drummond. Colloidal Amphiphiles Self-Assembly Particles Comprised of Gadolinium Oleate and Myverol: Evaluation as Contrast Agents for Magnetic Resonance Imaging. Langmuir, 2009, 26(4), 2383-2391.
G. Liu, C.E. Conn, C.J. Drummond. Lanthanide Metal Oleates: Chelation, Self-Assembly and Exemplification of ordered Nanostructured Colloidal Contrast Agents for Medical Imaging. J. Phys. Chem. B, 2009, 113(49), 15949-15959.
G. Liu, J.J. Gooding. Towards the Fabrication of Label-free Amperometric Immunosensors Using SWNTs. Electrochem. Commun., 2009, 11: 1982-1985.

2008

G. Liu, M.N. Paddon-Row, J.J. Gooding. Protein Modulation of Electrochemical Signals: Application to Immunobiosensing. Chem. Commun., 2008, 3870-3872.
C. Fairman, S.S.C. Yu, G. Liu, A.J. Downard, B.D. Hibbert, J.J. Gooding. Exploration of Variables in the Fabrication of Pyrolysed Photoresist. J. Solid State Electrochem., 2008, 12(10): 1357-1365.

2007

G. Liu, M.N. Paddon-Row, J.J. Gooding. Molecular Wire Modified Glassy Carbon Electrode for Achieving Direct Electron Transfer to Native Glucose Oxidase.Electrochem. Commun., 2007, 9(9): 2218-2223.
G. Liu, T. Böcking, J.J. Gooding. Diazonium salts: Stable Monolayers on Gold Electrodes for Sensing Applications. J. Electroanal. Chem., 2007, 600(2):335-344.

2006

G. Liu, J.J. Gooding. An Electrochemical Interface Comprising Molecular Wires and Poly(ethylene glycol) Spacer Units Self-Assembled on Carbon Electrodes for Studies of Protein Electrochemistry. Langmuir, 2006, 22(17):7421-7430.
G. Liu, Q.T. Nguyen, E. Chow, T. Bocking, D.B. Hibbert, J.J. Gooding. Study of Factors Affecting the Performance of Voltammetric Copper Sensors based on Gly-Gly-His Modified Glassy Carbon and Gold Electrodes. Electroanalysis, 2006 18(12): 1141-1151.

2005

G. Liu, J. Liu, T. Böcking, P.K. Eggers, .J.J. Gooding. The Modification of Glassy Carbon and Gold Electrodes with Aryl Diazonium Salt: The Impact of the Electrode Materials on the Rate of Heterogeneous Electron Transfer. Chem. Phys., 2005, 319: 136-146.

Scholarly Book Chapters

J.J. Gooding, G. Liu, A.L. Gui. Book chapter 9: The Use of Aryl Diazonium Salts in the Fabrication of Biosensors and Chemical Sensors, in book Aryl Diazonium Salts: New Coupling Agents and Surface Science 2012, Wiley publisher, p.197-218

Research in Media Coverage:

https://newsroom.unsw.edu.au/news/general/unsw-academic-wins-prestigious-biomedical-research-award

https://parkinsonsnewstoday.com/2020/04/22/device-measures-pro-inflammatory-cytokines-parkinsons-patients/

https://www.theweek.in/news/health/2019/08/12/australian-health-start-ups-eye-indian-market.html

https://www.engineering.unsw.edu.au/news/cell-surface-sensors-could-advance-precision-medicine

https://www.scimex.org/newsfeed/cell-surface-sensors-could-advance-precision-medicine

https://www.theweek.in/news/health/2019/08/12/australian-health-start-ups-eye-indian-market.html

https://www.engineering.unsw.edu.au/news/cytokine-research-opens-window-onto-live-brain-processes

https://www.mq.edu.au/research-impact/2016/11/11/developing-novel-nano-tools-to-better-understand-the-brain/#.WP5bPNKGMtI

http://www.arc.gov.au/nanoscale-sensor-spot-disease

https://www.photonics.com/Article.aspx?AID=61870

https://phys.org/news/2017-03-nanoscale-sensor-disease.html

http://www.researchcareer.com.au/news/cytokine-sensor-to-see-sub-cellular

http://getstem.com.au/nanoscale-sensor-spot-disease/

https://www.eedesignit.com/diseases-to-be-detected-with-nanoscale-sensor/

https://www.mdtmag.com/news/2017/03/nanoscale-sensor-spot-disease

http://www.mq.edu.au/newsroom/2015/11/24/new-agreement-to-open-the-door-to-next-generation-cell-therapies/

http://www.proactiveinvestors.com.au/companies/news/65781/regeneus-secures-commercial-rights-for-breakthrough-stem-cell-technology-65781.html

My Research Supervision

Areas of supervision

Advanced Sensing technologies and biosensors
CRISPR/Cas biosensors
Nanotechnologies towards surface chemistry and stimuli-responsive nanoparticles
Point-of-Care diagnostics
Microfluidic paper based analytical devices
Wearable sweat biosensing devices

Teaching

BIOM9650: Biosensors and Transducers
BIOM9420: Clinical Laboratory Science
BIOM9311: Mass Transfer in Medicine

We are looking for highly motivated postgraduate students pursuing PhD, Master or Honours degree to join the research team. We also welcome the postdoctoral researchers and visiting scholars to explore the opportunities. Please email Dr Guozhen Liu (guozhen.liu@unsw.edu.au) with your CV.

Postgraduate Scholarship Opportunities

Domestic Research Scholarship: https://research.unsw.edu.au/domestic-research-scholarships
International Research Scholarship: https://research.unsw.edu.au/international-research-scholarships
International Joint Scholarship: https://research.unsw.edu.au/unsw-home-country-joint-scholarships
UNSW-China Scholarship Council (CSC) Joint Scholarship program. For more details, visit https://research.unsw.edu.au/unsw-home-country-joint-scholarships. To apply CSC, visit http://www.csc.edu.cn/chuguo.
For excellent candidates, the top-up scholarship (7k pa) will be provided.