By Associate Professor Kirsty Walters

Journal articles

Aflatounian A; Paris VR; Richani D; Edwards MC; Cochran BJ; Ledger WL; Gilchrist RB; Bertoldo MJ; Wu LE; Walters KA, 2022, 'Declining muscle NAD⁺ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation', Molecular Metabolism, vol. 65, pp. 101583, http://dx.doi.org/10.1016/j.molmet.2022.101583

Walters KA; Moreno-Asso A; Stepto NK; Pankhurst MW; Paris VR; Rodgers RJ, 2022, 'Key signalling pathways underlying the aetiology of polycystic ovary syndrome', Journal of Endocrinology, vol. 255, pp. R1 - R26, http://dx.doi.org/10.1530/JOE-22-0059

Xiong T; Paris VR; Edwards MC; Hu Y; Cochran BJ; Rye KA; Ledger WL; Padmanabhan V; Handelsman DJ; Gilchrist RB; Walters KA, 2022, 'Androgen signaling in adipose tissue, but less likely skeletal muscle, mediates development of metabolic traits in a PCOS mouse model', American Journal of Physiology - Endocrinology and Metabolism, vol. 323, pp. E145 - E158, http://dx.doi.org/10.1152/ajpendo.00418.2021

Coyle CS; Prescott M; Handelsman DJ; Walters KA; Campbell RE, 2022, 'Chronic androgen excess in female mice does not impact luteinizing hormone pulse frequency or putative GABAergic inputs to GnRH neurons', Journal of Neuroendocrinology, vol. 34, pp. e13110, http://dx.doi.org/10.1111/jne.13110

Rodriguez Paris V; Wong XYD; Solon-Biet SM; Edwards MC; Aflatounian A; Gilchrist RB; Simpson SJ; Handelsman DJ; Kaakoush NO; Walters KA, 2022, 'The interplay between PCOS pathology and diet on gut microbiota in a mouse model', Gut Microbes, vol. 14, http://dx.doi.org/10.1080/19490976.2022.2085961

XIONG T; PARIS VRODRIGUEZ; EDWARDS MC; COCHRAN BJ; RYE K-A; LEDGER WL; PADMANABHAN V; HANDELSMAN DJ; GILCHRIST RB; WALTERS KA, 2022, 'Androgen Actions in Adipose Tissue, But Not Skeletal Muscle, are Involved in the Development of Metabolic PCOS Features in a Mouse Model', Fertility & Reproduction, vol. 04, pp. 169 - 169, http://dx.doi.org/10.1142/s2661318222740814

RODRIGUEZ PARIS V; ALEXOPOULOS SJ; HU Y; SHAH DP; AFLATOUNIAN A; EDWARDS MC; BERTOLDO MJ; GILCHRIST RB; HOEHN KL; WALTERS KA, 2022, 'Mitochondrial Uncoupler BAM15 Ameliorates Associated Metabolic PCOS Traits in a Hyperandrogenic PCOS Mouse Model', Fertility & Reproduction, vol. 04, pp. 208 - 208, http://dx.doi.org/10.1142/s2661318222741194

MARINOVA MB; HO W-HJ; BERTOLDO MJ; LOVRIC V; SELESNIEMI K; WALSH WR; SINCLAIR DA; WALTERS K; GILCHRIST RB; WU LE, 2022, 'NMN Supplementation Rescues Fertility and Bone Strength in Chemotherapy-Treated Mice', Fertility & Reproduction, vol. 04, pp. 149 - 149, http://dx.doi.org/10.1142/s2661318222740619

SUCQUART IE; NAGARKAR R; EDWARDS MC; PARIS VRODRIGUEZ; AFLATOUNIAN A; BERTOLDO MJ; CAMPBELL RE; BEGG DP; HANDELSMAN DJ; PADMANABHAN V; ANDERSON RA; GILCHRIST RB; WALTERS KA, 2022, 'Pharmacological Antagonism of the Kisspeptin-Neurokinin System Improved Adverse Metabolic Traits in a PCOS Mouse Model', Fertility & Reproduction, vol. 04, pp. 160 - 160, http://dx.doi.org/10.1142/s2661318222740723

Rodgers RJ; Abbott JA; Walters KA; Ledger WL, 2021, 'Translational Physiology of Anti-Müllerian Hormone: Clinical Applications in Female Fertility Preservation and Cancer Treatment', Frontiers in Endocrinology, vol. 12, pp. 689532, http://dx.doi.org/10.3389/fendo.2021.689532

Rodriguez Paris V; Walters KA, 2021, 'Humanin: A Potential Treatment for PCOS?', Endocrinology (United States), vol. 162, http://dx.doi.org/10.1210/endocr/bqab085

Paris VR; Edwards MC; Aflatounian A; Bertoldo MJ; Ledger WL; Handelsman DJ; Gilchrist RB; Walters KA, 2021, 'Pathogenesis of reproductive and metabolic PCOSTraits in a mouse model', Journal of the Endocrine Society, vol. 5, pp. bvab060, http://dx.doi.org/10.1210/jendso/bvab060

Coyle C; Ruddenklau A; Prescott M; Walters KA; Campbell RE, 2021, 'Chronic Excess of Non-Aromatizable Androgens From Puberty Does Not Drive a Neuroendocrine Phenotype Observed in Other Preclinical Rodent Models of PCOS', Journal of the Endocrine Society, vol. 5, pp. A533 - A534, http://dx.doi.org/10.1210/jendso/bvab048.1086

Paris VR; Alexopoulos SJ; Hu Y; Shah DP; Aflatounian A; Edwards MC; Bertoldo M; Kyle HL; Walters KA, 2021, 'Metabolic PCOS Features Are Ameliorated by Mitochondrial Uncoupler BAM15 in a PCOS Mouse Model', Journal of the Endocrine Society, vol. 5, pp. A769 - A770, http://dx.doi.org/10.1210/jendso/bvab048.1565

Sucquart IE; Nagarkar R; Edwards MC; Rodriguez Paris V; Aflatounian A; Bertoldo MJ; Campbell RE; Gilchrist RB; Begg DP; Handelsman DJ; Padmanabhan V; Anderson RA; Walters KA, 2021, 'Neurokinin 3 Receptor Antagonism Ameliorates Key Metabolic Features in a Hyperandrogenic PCOS Mouse Model', Endocrinology (United States), vol. 162, http://dx.doi.org/10.1210/endocr/bqab020

Bertoldo MJ; Paris VR; Gook DA; Edwards MC; Wu K; Liang CJJ; Marinova MB; Wu LE; Walters KA; Gilchrist RB, 2021, 'Impact of nicotinamide mononucleotide on transplanted mouse ovarian tissue', Reproduction, vol. 161, pp. 215 - 226, http://dx.doi.org/10.1530/REP-20-0539

Rodriguez Paris V; Solon-Biet SM; Senior AM; Edwards MC; Desai R; Tedla N; Cox MJ; Ledger WL; Gilchrist RB; Simpson SJ; Handelsman DJ; Walters KA, 2020, 'Defining the impact of dietary macronutrient balance on PCOS traits', Nature Communications, vol. 11, pp. 5262, http://dx.doi.org/10.1038/s41467-020-19003-5

David JH; Kirsty AW; Lam PL, 2020, 'Simplified method to measure mouse fertility', Endocrinology (United States), vol. 161, pp. 1 - 6, http://dx.doi.org/10.1210/ENDOCR/BQAA114

Aflatounian A; Edwards MC; Paris VR; Bertoldo MJ; Desai R; Gilchrist RB; Ledger WL; Handelsman DJ; Walters KA, 2020, 'Androgen signaling pathways driving reproductive and metabolic phenotypes in a PCOS mouse model', Journal of Endocrinology, vol. 245, pp. 381 - 395, http://dx.doi.org/10.1530/JOE-19-0530

Walters KA, 2020, 'Polycystic ovary syndrome: Is it androgen or estrogen receptor?', Current Opinion in Endocrine and Metabolic Research, vol. 12, pp. 1 - 7, http://dx.doi.org/10.1016/j.coemr.2020.01.003

Paris VR; Kaakoush NO; Solon-Biet SM; Edwards MC; Ledger WL; Gilchrist RB; Simpson SJ; Handelsman DJ; Walters KA, 2020, 'MON-022 Dissecting the Interplay Between Diet and PCOS Pathology on Gut Microbiota in a PCOS Mouse Model', Journal of the Endocrine Society, vol. 4, http://dx.doi.org/10.1210/jendso/bvaa046.568

Cox MJ; Edwards MC; Aflatounian A; Paris VR; Ledger WL; Gilchrist RB; Handelsman DJ; Walters KA, 2020, 'SAT-018 Androgen Actions in Adipose Tissue and the Brain Are Key Mediators in the Development of Polycystic Ovary Syndrome', Journal of the Endocrine Society, vol. 4, http://dx.doi.org/10.1210/jendso/bvaa046.088

Stener-Victorin E; Padmanabhan V; Walters KA; Campbell RE; Benrick A; Giacobini P; Dumesic DA; Abbott DH, 2020, 'Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome', Endocrine Reviews, vol. 41, http://dx.doi.org/10.1210/endrev/bnaa010

Bertoldo MJ; Listijono DR; Ho WHJ; Riepsamen AH; Goss DM; Richani D; Jin XL; Mahbub S; Campbell JM; Habibalahi A; Loh WGN; Youngson NA; Maniam J; Wong ASA; Selesniemi K; Bustamante S; Li C; Zhao Y; Marinova MB; Kim LJ; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O'Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2020, 'NAD⁺ Repletion Rescues Female Fertility during Reproductive Aging', Cell Reports, vol. 30, pp. 1670 - 1681.e7, http://dx.doi.org/10.1016/j.celrep.2020.01.058

Cox MJ; Edwards MC; Paris VR; Aflatounian A; Ledger WL; Gilchrist RB; Padmanabhan V; Handelsman DJ; Walters KA, 2020, 'Androgen Action in Adipose Tissue and the Brain are Key Mediators in the Development of PCOS Traits in a Mouse Model', Endocrinology (United States), vol. 161, pp. 1 - 15, http://dx.doi.org/10.1210/ENDOCR/BQAA061

Stepto NK; Moreno-Asso A; McIlvenna LC; Walters KA; Rodgers RJ, 2019, 'Molecular Mechanisms of Insulin Resistance in Polycystic Ovary Syndrome: Unraveling the Conundrum in Skeletal Muscle?', Journal of Clinical Endocrinology and Metabolism, vol. 104, pp. 5372 - 5381, http://dx.doi.org/10.1210/jc.2019-00167

Walters KA; Paris VR; Aflatounian A; Handelsman DJ, 2019, 'Androgens and ovarian function: Translation from basic discovery research to clinical impact', Journal of Endocrinology, vol. 242, pp. R23 - R50, http://dx.doi.org/10.1530/JOE-19-0096

Rodriguez Paris V; Solon-Biet S; Edwards M; Cox M; Ledger W; Gilchrist R; Simpson S; Handelsman D; Walters K, 2019, 'MON-231 Dietary Interventions Can Ameliorate Polycystic Ovary Syndrome (PCOS) Traits in a PCOS Mouse Model', Journal of the Endocrine Society, vol. 3, http://dx.doi.org/10.1210/js.2019-mon-231

Aflatounian A; Edwards M; Gilchrist R; Bertoldo M; Ledger W; Handelsman D; Walters K, 2019, 'OR08-2 Androgen Receptor- Vs Estrogen Receptor-Mediated Actions in the Development of Distinct Clinical Polycystic Ovary Syndrome (PCOS) Phenotypes', Journal of the Endocrine Society, vol. 3, http://dx.doi.org/10.1210/js.2019-or08-2

Burchall GF; Pouniotis DS; Teede HJ; Ranasinha S; Walters KA; Piva TJ, 2019, 'Expression of the plasminogen system in the physiological mouse ovary and in the pathological polycystic ovary syndrome (PCOS) state', Reproductive Biology and Endocrinology, vol. 17, pp. 33, http://dx.doi.org/10.1186/s12958-019-0472-0

Tarulli GA; Laven-Law G; Shehata M; Walters KA; Denis IM; Rahman MM; Handelsman DJ; Dean NR; Tilley WD; Hickey TE, 2019, 'Androgen Receptor Signalling Promotes a Luminal Phenotype in Mammary Epithelial Cells', Journal of Mammary Gland Biology and Neoplasia, vol. 24, pp. 99 - 108, http://dx.doi.org/10.1007/s10911-018-9406-2

Bertoldo MJ; Caldwell ASL; Riepsamen AH; Lin D; Gonzalez MB; Robker RL; Ledger WL; Gilchrist RB; Handelsman DJ; Walters KA, 2019, 'A hyperandrogenic environment causes intrinsic defects that are detrimental to follicular dynamics in a PCOS mouse model', Endocrinology, vol. 160, pp. 699 - 715, http://dx.doi.org/10.1210/en.2018-00966

Walters KA; Eid S; Edwards MC; Thuis-Watson R; Desai R; Bowman M; Marren AJ; Handelsman DJ, 2019, 'Steroid profiles by liquid chromatography-mass spectrometry of matched serum and single dominant ovarian follicular fluid from women undergoing IVF', Reproductive BioMedicine Online, vol. 38, pp. 30 - 37, http://dx.doi.org/10.1016/j.rbmo.2018.10.006

Walters KA; Gilchrist RB; Ledger WL; Teede HJ; Handelsman DJ; Campbell RE, 2018, 'New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins', Trends in Endocrinology and Metabolism, vol. 29, pp. 841 - 852, http://dx.doi.org/10.1016/j.tem.2018.08.005

Walters KA; Bertoldo MJ; Handelsman DJ, 2018, 'Evidence from animal models on the pathogenesis of PCOS', Best Practice and Research: Clinical Endocrinology and Metabolism, vol. 32, pp. 271 - 281, http://dx.doi.org/10.1016/j.beem.2018.03.008

Bertoldo MJ; Walters KA; Ledger WL; Gilchrist RB; Mermillod P; Locatelli Y, 2018, 'In-vitro regulation of primordial follicle activation: challenges for fertility preservation strategies', Reproductive BioMedicine Online, vol. 36, pp. 491 - 499, http://dx.doi.org/10.1016/j.rbmo.2018.01.014

Walters KA; Edwards MC; Tesic D; Caldwell ASL; Jimenez M; Smith JT; Handelsman DJ, 2018, 'The Role of Central Androgen Receptor Actions in Regulating the Hypothalamic-Pituitary-Ovarian Axis', Neuroendocrinology, vol. 106, pp. 389 - 400, http://dx.doi.org/10.1159/000487762

Walters KA; Handelsman DJ, 2018, 'Role of androgens in the ovary', Molecular and Cellular Endocrinology, vol. 465, pp. 36 - 47, http://dx.doi.org/10.1016/j.mce.2017.06.026

Upton DH; Walters KA; McTavish KJ; Holt J; Handelsman DJ; Allan CM, 2018, 'Reproductive failure in mice expressing transgenic follicle-stimulating hormone is not caused by loss of oocyte quality', Biology of Reproduction, vol. 98, pp. 491 - 500, http://dx.doi.org/10.1093/biolre/ioy015

Bertoldo MJ; Uddin GM; Youngson NA; Agapiou D; Walters KA; Sinclair DA; Morris MJ; Gilchrist RB, 2018, 'Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide.', Hum Reprod Open, vol. 2018, pp. hoy010 - hoy010, http://dx.doi.org/10.1093/hropen/hoy010

Camlin NJ; Jarnicki AG; Vanders RL; Walters KA; Hansbro PM; McLaughlin EA; Holt JE, 2017, 'Grandmaternal smoke exposure reduces female fertility in a murine model, with great-grandmaternal smoke exposure unlikely to have an effect', Human Reproduction, vol. 32, pp. 1270 - 1281, http://dx.doi.org/10.1093/humrep/dex073

Rodgers RJ; Reid GD; Koch J; Deans R; Ledger WL; Friedlander M; Gilchrist RB; Walters KA; Abbott JA, 2017, 'The safety and efficacy of controlled ovarian hyperstimulation for fertility preservation in women with early breast cancer: A systematic review', Human Reproduction, vol. 32, pp. 1033 - 1045, http://dx.doi.org/10.1093/humrep/dex027

Caldwell ASL; Edwards MC; Desai R; Jimenez M; Gilchrist RB; Handelsman DJ; Walters KA, 2017, 'Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, pp. E3334 - E3343, http://dx.doi.org/10.1073/pnas.1616467114

Walters KA; Edwards MC; Jimenez M; Handelsman DJ; Allan CM, 2017, 'Subfertility in androgen-insensitive female mice is rescued by transgenic FSH', Reproduction, Fertility and Development, vol. 29, pp. 1426 - 1434, http://dx.doi.org/10.1071/RD16022

Upton DH; Walters KA; Allavena RE; Jimenez M; Desai R; Handelsman DJ; Allan CM, 2016, 'Global or Granulosa Cell-Specific Pten Mutations in Combination with Elevated FSH Levels Fail to Cause Ovarian Tumours in Mice', Hormones and Cancer, vol. 7, pp. 316 - 326, http://dx.doi.org/10.1007/s12672-016-0272-3

Shankara-Narayana N; Zawada S; Walters KA; Desai R; Marren A; Handelsman DJ, 2016, 'Accuracy of a Direct Progesterone Immunoassay', JOURNAL OF APPLIED LABORATORY MEDICINE, vol. 1, pp. 294 - 299, http://dx.doi.org/10.1373/jalm.2016.020123

Solon-Biet SM; Cogger VC; Pulpitel T; Heblinski M; Wahl D; McMahon AC; Warren A; Durrant-Whyte J; Walters KA; Krycer JR; Ponton F; Gokarn R; Wali JA; Ruohonen K; Conigrave AD; James DE; Raubenheimer D; Morrison CD; Le Couteur DG; Simpson SJ, 2016, 'Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework', Cell Metabolism, vol. 24, pp. 555 - 565, http://dx.doi.org/10.1016/j.cmet.2016.09.001

Walters KA; Simanainen U; Gibson DA, 2016, 'Androgen action in female reproductive physiology', Current Opinion in Endocrinology, Diabetes and Obesity, vol. 23, pp. 291 - 296, http://dx.doi.org/10.1097/MED.0000000000000246

Walters KA, 2016, 'Androgens in polycystic ovary syndrome: Lessons from experimental models', Current Opinion in Endocrinology, Diabetes and Obesity, vol. 23, pp. 257 - 263, http://dx.doi.org/10.1097/MED.0000000000000245

Wang X; Gook DA; Walters KA; Anazodo A; Ledger WL; Gilchrist RB, 2016, 'Improving fertility preservation for girls and women by coupling oocyte in vitro maturation with existing strategies', Women's Health, vol. 12, pp. 275 - 278, http://dx.doi.org/10.2217/whe-2016-0019

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