Select Publications

Journal articles

Kokkinos J; Sharbeen G; Haghighi KS; Ignacio RMC; Kopecky C; Gonzales-Aloy E; Youkhana J; Timpson P; Pereira BA; Ritchie S; Pandzic E; Boyer C; Davis TP; Butler LM; Goldstein D; McCarroll JA; Phillips PA, 2021, 'Ex vivo culture of intact human patient derived pancreatic tumour tissue', Scientific Reports, vol. 11, pp. 1944, http://dx.doi.org/10.1038/s41598-021-81299-0

Cong VT; Wang W; Tilley RD; Sharbeen G; Phillips PA; Gaus K; Gooding JJ, 2021, 'Can the Shape of Nanoparticles Enable the Targeting to Cancer Cells over Healthy Cells?', Advanced Functional Materials, vol. 31, http://dx.doi.org/10.1002/adfm.202007880

Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, vol. 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496

Nemec S; Lam J; Zhong J; Heu C; Timpson P; Li Q; Youkhana J; Sharbeen G; Phillips PA; Kilian KA, 2021, 'Interfacial Curvature in Confined Coculture Directs Stromal Cell Activity with Spatial Corralling of Pancreatic Cancer Cells', Advanced Biology, vol. 5, pp. e2000525, http://dx.doi.org/10.1002/adbi.202000525

Kokkinos J; Jensen A; Sharbeen G; McCarroll JA; Goldstein D; Haghighi KS; Phillips PA, 2021, 'Does the microenvironment hold the hidden key for functional precision medicine in pancreatic cancer?', Cancers, vol. 13, pp. 2427 - 2427, http://dx.doi.org/10.3390/cancers13102427

Nemec S; Lam J; Zhong J; Heu C; Timpson P; Li Q; Youkhana J; Sharbeen G; Phillips PA; Kilian KA, 2021, 'Cancer‐Associated Fibroblasts: Interfacial Curvature in Confined Coculture Directs Stromal Cell Activity with Spatial Corralling of Pancreatic Cancer Cells (Adv. Biology 6/2021)', Advanced Biology, vol. 5, pp. 2170064 - 2170064, http://dx.doi.org/10.1002/adbi.202170064

Kokkinos J; Ignacio RM; Haghighi K; Kopecky C; Sharbeen G; Gonzales-Aloy E; Youkhana J; Butler L; Goldstein D; McCarroll J; Phillips P, 2021, 'Patient-derived pancreatic tumours in a dish: implications for real-time precision medicine', HPB, vol. 23, pp. S235 - S235, http://dx.doi.org/10.1016/j.hpb.2020.11.590

Barrera LN; Evans A; Lane B; Brumskill S; Oldfield FE; Campbell F; Andrews T; Lu Z; Perez-Mancera PA; Liloglou T; Ashworth M; Jalali M; Dawson R; Nunes Q; Phillips PA; Timms JF; Halloran C; Greenhalf W; Neoptolemos JP; Costello E, 2020, 'Fibroblasts from distinct pancreatic pathologies exhibit disease-specific properties', Cancer Research, vol. 80, pp. 2861 - 2873, http://dx.doi.org/10.1158/0008-5472.CAN-19-3534

Kokkinos J; Ignacio RMC; Sharbeen G; Boyer C; Gonzales-Aloy E; Goldstein D; McCarroll JA; Phillips PA, 2020, 'Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs', Biomaterials, vol. 240, pp. 119742, http://dx.doi.org/10.1016/j.biomaterials.2019.119742

Tjandra KC; McCarthy N; Yang L; Laos AJ; Sharbeen G; Phillips PA; Forgham H; Sagnella SM; Whan RM; Kavallaris M; Thordarson P; McCarroll JA, 2020, 'Identification of Novel Medulloblastoma Cell-Targeting Peptides for Use in Selective Chemotherapy Drug Delivery', Journal of Medicinal Chemistry, vol. 63, pp. 2181 - 2193, http://dx.doi.org/10.1021/acs.jmedchem.9b00851

Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, vol. 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6

Barrera LN; Evans A; Lane B; Brumskill S; Oldfield F; Campbell F; Andrews T; Lu Z; Perez-Mancera PA; Liloglou T; Jalali M; Dawson R; Nunes Q; Phillips P; Timms JF; Menon U; Halloran C; Greenhalf W; Neoptolemos JP; Costello E, 2019, 'PDAC-associated fibroblasts are less responsive to an anti-fibrotic stimulus and more responsive to a positive regulator of fibroblast activation than normal activated fibroblasts', Pancreatology, vol. 19, pp. S158 - S158, http://dx.doi.org/10.1016/j.pan.2019.05.423

Pinho AV; Van Bulck M; Chantrill L; Arshi M; Sklyarova T; Herrmann D; Vennin C; Gallego-Ortega D; Mawson A; Giry-Laterriere M; Magenau A; Leuckx G; Baeyens L; Gill AJ; Phillips P; Timpson P; Biankin AV; Wu J; Rooman I, 2018, 'ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling', Nature Communications, vol. 9, pp. 5083, http://dx.doi.org/10.1038/s41467-018-07497-z

Barrera L; Evans A; Lane B; Brumskill S; Oldfield F; Campbell F; Andrews T; Perez-Mancera P; Liloglou T; Phillips P; Halloran C; Greenhalf W; Neoptolemos JP; Costello E, 2018, 'Disease associated fibroblasts from various pancreatic disorders exhibit subtype specific genetic profile', Pancreatology, vol. 18, pp. S94 - S94, http://dx.doi.org/10.1016/j.pan.2018.05.254

Akerman A; Sharbeen G; Holst J; Youkhana J; McCarroll J; Goldstein D; Erkan M; Phillips P, 2018, 'Targeting a solute carrier to metabolically reprogram tumour-promoting stromal cells in pancreatic cancer', Pancreatology, vol. 18, pp. S156 - S156, http://dx.doi.org/10.1016/j.pan.2018.05.419

Yeo D; Phillips P; Baldwin GS; He H; Nikfarjam M, 2017, 'Inhibition of group 1 p21-activated kinases suppresses pancreatic stellate cell activation and increases survival of mice with pancreatic cancer', International Journal of Cancer, vol. 140, pp. 2101 - 2111, http://dx.doi.org/10.1002/ijc.30615

Sharbeen G; Youkhana J; Mawson A; McCarroll J; Nunez A; Biankin A; Johns A; Goldstein D; Phillips P, 2017, 'MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity', Oncotarget, vol. 8, pp. 9216 - 9229, http://dx.doi.org/10.18632/oncotarget.13985

Rooman I; Pinho A; Phillips P; Biankin A; Wu J, 2017, 'Altered Slit-Robo signalling activates TGF-beta signalling and stroma remodelling in the pancreas.', Pancreatology, vol. 17, pp. S6 - S7, http://dx.doi.org/10.1016/j.pan.2017.05.020

Akerman A; Vennin C; Sharbeen G; Warren SC; Timpson P; Phillips PA, 2016, 'Novel therapeutics and preclinical imaging for pancreatic cancer - View from the lab', Cancer Forum, vol. 40, pp. 16 - 22

Sharbeen G; McCarroll J; Liu J; Youkhana J; Limbri LF; Biankin AV; Johns A; Kavallaris M; Goldstein D; Phillips PA, 2016, 'Delineating the Role of βIV-Tubulins in Pancreatic Cancer: βIVb-Tubulin Inhibition Sensitizes Pancreatic Cancer Cells to Vinca Alkaloids', Neoplasia (United States), vol. 18, pp. 753 - 764, http://dx.doi.org/10.1016/j.neo.2016.10.011

McCarroll JA; Teo J; Boyer C; Youkhana J; Sagnella S; Duong H; Sharbeen G; Goldstein D; Davis T; Kavallaris M; Phillips P; Liu J, 2016, 'A rationally optimized nanoparticle system for the delivery of RNA interference therapeutics into pancreatic tumors in vivo.', Biomacromolecules, vol. 17, pp. 2337 - 2351, http://dx.doi.org/10.1021/acs.biomac.6b00185

Barrera L; Lane B; Brumskill S; Oldfield F; Lamond R; Wilkinson L; Bermejo-Rodriguez C; Aughton K; Sanna R; Nunes Q; Perez-Mancera P; Campbell F; Andrews T; Phillips P; Halloran C; Sutton R; Greenhalf W; Neoptolemos J; Costello E, 2016, 'Identification of novel signalling pathways dysregulated in pancreatic cancer-associated fibroblasts', Pancreatology, vol. 16, pp. S31 - S31, http://dx.doi.org/10.1016/j.pan.2016.05.106

Sharbeen G; Youkhana J; McCarroll J; Akerman A; Goldstein D; Phillips P, 2016, 'MutY-Homolog modulates pancreatic cancer cell survival and chemoresistance', Pancreatology, vol. 16, pp. S5 - S5, http://dx.doi.org/10.1016/j.pan.2016.05.024

Yeo D; He H; Phillips P; Baldwin G; Nikfarjam M, 2016, 'Targeting PAK1 in pancreatic stellate cells increases pancreatic cancer survival', Pancreatology, vol. 16, pp. S26 - S27, http://dx.doi.org/10.1016/j.pan.2016.05.092

Glass JJ; Phillips PA; Gunning PW; Stehn JR, 2015, 'Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells', BMC Cancer, vol. 15, http://dx.doi.org/10.1186/s12885-015-1741-8

Sharbeen G; McCarroll J; Goldstein D; Phillips PA, 2015, 'Exploiting Base Excision Repair to Improve Therapeutic Approaches for Pancreatic Cancer', Frontiers in Nutrition, vol. 2, pp. 10, http://dx.doi.org/10.3389/fnut.2015.00010

Vuong QV; Hirun S; Chuen TLK; Goldsmith CD; Murchie S; Bowyer MC; Phillips PA; Scarlett CJ, 2015, 'Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts', International Journal of Food Science and Technology, vol. 50, pp. 169 - 177, http://dx.doi.org/10.1111/ijfs.12618

Vuong QV; Hirun S; Chuen TLK; Goldsmith CD; Munro B; Bowyer MC; Chalmers AC; Sakoff JA; Phillips PA; Scarlett CJ, 2015, 'Physicochemical, antioxidant and anti-cancer activity of a Eucalyptus robusta (Sm.) leaf aqueous extract', Industrial Crops and Products, vol. 64, pp. 167 - 174, http://dx.doi.org/10.1016/j.indcrop.2014.10.061

McCarroll JA; Dwarte T; Baigude H; Dang J; Yang L; Erlich RB; Kimpton K; Teo J; Sagnella SM; Akerfeldt MC; Liu J; Phillips PA; Rana TM; Kavallaris M, 2015, 'Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer', Oncotarget, vol. 6, pp. 12020 - 12034, http://dx.doi.org/10.18632/oncotarget.2664

McCarroll JA; Sharbeen G; Liu J; Youkhana J; Goldstein D; McCarthy N; Limbri LF; Dischl D; Ceyhan GO; Erkan M; Johns AL; Biankin AV; Kavallaris M; Phillips PA, 2015, 'βIII-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer', Oncotarget, vol. 6, pp. 2235 - 2249, http://dx.doi.org/10.18632/oncotarget.2946

Barrera L; Lane B; Brumskill S; Oldfield F; Nunes Q; Campbell F; Andrews T; Phillips P; Halloran C; Greenhalf W; Neoptolemos J; Costello E, 2015, 'Simultaneous integration of microRNA and mRNA expression in the analysis of quiescent and activated human fibroblasts in the diseased pancreas', Pancreatology, vol. 15, pp. S19 - S20, http://dx.doi.org/10.1016/j.pan.2015.05.103

Luo AS; Lim A; Jung HJ; Phillips PA; Grimm MC, 2014, 'Retinoic acid is required for the generation of protective appendiceal regulatory T cells', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 29, pp. 20 - 20, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343863000041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Vuong QV; Hirun S; Phillips PA; Chuen TLK; Bowyer MC; Goldsmith CD; Scarlett CJ, 2014, 'Fruit-derived phenolic compounds and pancreatic cancer: Perspectives from Australian native fruits', Journal of Ethnopharmacology, vol. 152, pp. 227 - 242, http://dx.doi.org/10.1016/j.jep.2013.12.023

Vuong QV; Hirun S; Chuen TLK; Goldsmith CD; Bowyer MC; Chalmers AC; Phillips PA; Scarlett CJ, 2014, 'Physicochemical composition, antioxidant and anti-proliferative capacity of a lilly pilly (Syzygium paniculatum) extract', Journal of Herbal Medicine, vol. 4, pp. 134 - 140, http://dx.doi.org/10.1016/j.hermed.2014.04.003

McCarroll JA; Naim S; Sharbeen G; Russia N; Lee J; Kavallaris M; Goldstein D; Phillips PA, 2014, 'Role of pancreatic stellate cells in chemoresistance in pancreatic cancer', Frontiers in Physiology, vol. 5 APR, http://dx.doi.org/10.3389/fphys.2014.00141

McCarroll J; Teo J; Boyer C; Goldstein D; Kavallaris M; Phillips PA, 2014, 'Potential applications of nanotechnology for the diagnosis and treatment of pancreatic cancer', Frontiers in Physiology, vol. 5, pp. 1 - 10, http://dx.doi.org/10.3389/fphys.2014.00002

Byrne FL; Yang L; Phillips PA; Hansford LM; Fletcher JI; Ormandy CJ; McCarroll JA; Kavallaris M, 2014, 'RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model', Oncogene, vol. 33, pp. 882 - 890, http://dx.doi.org/10.1038/onc.2013.11

Barrera L; Oldfield F; Nunes Q; Campbell F; Lane B; Andrews T; Phillips P; Greenhalf W; Neoptolemos J; Costello E, 2013, 'Isolation of Quiescent and Activated Human Pancreatic Stellate Cells for MicroRNA Profiling', PANCREAS, vol. 42, pp. 1339 - 1339, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330468400040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Vuong QV; Hirun S; Chuen TLK; Goldsmith CD; Bowyer MC; Scarlett CJ; Chalmers AC; Phillips PA, 2013, 'Physicochemical composition, antioxidant and anti-proliferative capacity of a lilly pilly (Syzygium paniculatum) extract', Journal of Herbal Medicine, http://dx.doi.org/10.1016/j.hermed.2014.04.003

Luo AS; Jung HJ; Phillips PA; Grimm MC, 2013, 'The mechanisms of regulatory T cell expansion following appendicitis induction', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 28, pp. 11 - 11, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324106900019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Vuong QV; Hirun S; Roach PD; Bowyer MC; Phillips PA; Scarlett CJ, 2013, 'Effect of extraction conditions on total phenolic compounds and antioxidant activities of Carica papaya leaf aqueous extracts', Journal of Herbal Medicine, vol. 3, pp. 104 - 111, http://dx.doi.org/10.1016/j.hermed.2013.04.004

Sheahan AV; Phillips PA; Khachigian LM, 2013, 'Therapeutic perspectives on pancreatic cancer', Current Cancer Drug Targets, vol. 13, pp. 400 - 410, http://dx.doi.org/10.2174/1568009611313040004

Teo J; Erlich RB; Sagnella S; Dwarte T; Davis TP; Kavallaris M; McCarroll J; Boyer C; Duong HTT; Phillips P; Sharbeen G; Goldstein D, 2013, 'Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers', Molecular Pharmaceutics, vol. 10, pp. 2435 - 2444, http://dx.doi.org/10.1021/mp400049e

Sheahan AV; Phillips PA; Khachigian LM, 2013, 'Therapeutic Perspectives on Pancreatic Cancer', Current Cancer Drug Targets, vol. 888, pp. 1 - 6, http://dx.doi.org/10.2174/15680096113138880007

Barrera L; Oldfield F; Nunes Q; Campbell F; Lane B; Andrews T; Phillips P; Greenhalf W; Neoptolemos J; Costello E, 2013, 'Isolation of pancreatic stellate cells for future analysis of microRNA', Pancreatology, vol. 13, pp. S58 - S58, http://dx.doi.org/10.1016/j.pan.2013.04.205

Erkan M; Adler G; Apte MV; Bachem MG; Buchholz M; Detlefsen S; Esposito I; Friess H; Gress TM; Habisch HJ; Hwang RN; Jaster R; Kleeff JH; Kloppel G; Kordes C; Logsdon CD; Masamune A; Michalski CW; Oh J; Pinzani M; Reiser-erkan C; Tsukamoto H; Wilson JS, 2012, 'StellaTUM: current consensus and discussion on pancreatic stellate cell research', Gut, vol. 61, pp. 172 - 178, http://dx.doi.org/10.1136/gutjnl-2011-301220

Barreto SG; Jardine D; Phillips P; Bhatia M; Saccone GTP, 2011, 'Reply', Pancreas, vol. 40, pp. 1144 - 1145, http://dx.doi.org/10.1097/MPA.0b013e31822b88b2

Arun SJ; Xu Z; Fiala-Beer E; Phillips P; Goldstein D; Biankin A; Pirola R; Wilson JS; Apte MV, 2011, 'Hepatocyte growth factor: a potential therapeutic target in pancreatic cancer', CANCER RESEARCH, vol. 71, http://dx.doi.org/10.1158/1538-7445.AM2011-LB-395

Vonlaufen A; Phillips PA; Xu ; Zhang X; Yang L; Pirola R; Wilson JS; Apte MV, 2011, 'Withdrawal of alcohol promotes regression while continued alcohol intake promotes persistence of LPS-induced pancreatic injury in alcohol-fed rats', Gut, vol. 60, pp. 238 - 246, http://dx.doi.org/10.1136/gut.2010.211250

Yang L; Phillips PA; Xu Z; Youkhana J; Vonlaufen A; Pirola R; Wilson J; Apte MV, 2010, 'Collagen-I Increases the Expression of Transgelin and Lumican (Regulators of Cell Migration) by Activated Pancreatic Stellate Cells', PANCREAS, vol. 39, pp. 1358 - 1359, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000282946600262&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1


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