My Expertise
- Aging and age-related diseases
- NAD+ metabolism and H2S signaling
- Angiogenesis and endothelial homeostasis
- Tissue Regeneration, wound healing, muscle regeneration after injury
- Exercise physiology
Field of Research (FoR)
SEO tags
Biography
Research Focus
Ageing, Musculoskeletal Health, Spine Degeneration, Sirtuins
Why we get frail and how to reverse it
Old mice are new again: anti-ageing pill restores vitality
My Grants
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CRO MetroBiotech International: Testing the efficacy of NAD precursors in wound healing using mouse models (2018 - present)
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UNSW RIS_LSCI_MWAC (Associate Investigator): Laser Speckle Imaging...view more
Research Focus
Ageing, Musculoskeletal Health, Spine Degeneration, Sirtuins
Why we get frail and how to reverse it
Old mice are new again: anti-ageing pill restores vitality
My Grants
-
CRO MetroBiotech International: Testing the efficacy of NAD precursors in wound healing using mouse models (2018 - present)
-
UNSW RIS_LSCI_MWAC (Associate Investigator): Laser Speckle Imaging Equipment Grant (2017)
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NHMRC APP1093643 (Associate Investigator): New drugs to prevent premature ageing and side effects of chemotherapy (2015 - 2018)
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Paul F. Glenn Postdoctoral Fellowship, Massachusetts Institute of Technology: Molecular dynamics of Sirtuin enzymes (2010 - 2014)
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National Institute of Health Quantitative Chemical Biology Fellowship, Stanford University: Polyketide biosynthesis (2005 - 2008)
My Qualifications
Education
- PhD, Stanford University, USA (2010)
- MSc, IIT Kanpur, India (2004)
- BSc, University of Kalyani, India (2002)
My Research Activities
Patents
- Methods for enhancing vascular density (Application No. PCT/AU2017/051435
My Research Supervision
Supervision keywords
Areas of supervision
Currently recruiting Honours, ILP, Masters, PhD students. If interested email me at abhirupdas@unsw.edu.au
Project 1: Effects of smoking on spine degeneration
How does smoke from cigarette, bushfire and even air pollution cause spine degeneration (back pain, neck pain, spinal cord injury) and how does it affect our healthspan? We are using animal models and patient data to understand the trend, mechanism and find possible cure.
Project 2: Growth differentiation factor 6 (GDF6) protein and tissue regeneration
The goal of this project is to develop a novel therapeutic strategy that uses biomaterial scaffolds, stem cells and GDF6 protein to promote tissue regeneration. The applications will be numerous - to grow muscle after injury and to regenerate intervertebral discs in patients with back pain.
Project 3: Microbiome and spine health
We are investigating how the microbes in and on our body (microbiome) affect the health of our spine and specially in patients undergoing spinal surgeries.
Currently supervising
PhDs
ILPs
My Engagement
Media
Why we get frail and how to reverse it
Article by Liam Mannix in Sydney Morning Herald: Old mice are new again
Channel 9 news: Two naturally-occurring molecules found to reverse signs of ageing in mice
Listen to Prof. David Sinclair talking about my latest work on vascular ageing at WBUR Boston
Harvard Medical School, News and Research: Rewinding the clock
Harvard Medicine Magazine: Time’s toll reversed by bolstering blood vessels
UNSW Newsroom: Discovery offers hope for improving physical performance as we age
MIT News: Study suggests method for boosting growth of blood vessels and muscle
Scientists Reverse Vascular Aging
Sydney Morning Herald: Fountain of Youth
Sydney Morning Herald: Never Say Die
Old Dog, New Tricks-Role of Hydrogen Sulfide and NAD+ in Angiogenesis and Health
My Teaching
- Animal Care and Ethics Course (14/129A), UNSW Sydney (2015 - present)
- Invited Lecture (PHAR3251): Targeting PI3-kinase(s) in cancer, UNSW Sydney (2015)
- Session 1 Practical (PHAR3251): PI3K Inhibition and Cancer Cell Growth, University of New South Wales, Australia (2015)
- Session 2 Practical (PHAR3251): PI3 Inhibition and Cancer Cell Metastasis, University of New South Wales, Australia (2015)
- Massachusetts Institute of Technology Teaching Certificate (2014)
- Advanced Undergraduate Seminar Course (7.341): Unraveling the Molecular Mechanisms of Aging and Age-related Diseases, Massachusetts Institute of Technology, USA (2013)
- General Chemistry (CHEM 31A/B), Stanford University, USA (2004)
Location
Research and Education Centre
St. George Hospital Campus
Kogarah, NSW 2217
Map reference (Google map)
ORCID as entered in ROS
https://orcid.org/0000-0003-1866-457X