Select Publications

Journal articles

Menounos S; Hansbro PM; Diwan AD; Das A, 2021, 'Pathophysiological Correlation between Cigarette Smoking and Amyotrophic Lateral Sclerosis', NeuroSci, vol. 2, pp. 120 - 134, http://dx.doi.org/10.3390/neurosci2020008

Koremans FW; Chen X; Das A; Diwan AD, 2021, 'Changes in back pain scores after bariatric surgery in obese patients: A systematic review and meta-analysis', Journal of Clinical Medicine, vol. 10, http://dx.doi.org/10.3390/jcm10071443

Tu J; Castillo JV; Das A; Diwan AD, 2021, 'Degenerative cervical myelopathy: Insights into its pathobiology and molecular mechanisms', Journal of Clinical Medicine, vol. 10, pp. 1 - 28, http://dx.doi.org/10.3390/jcm10061214

Zhao K; An R; Xiang Q; Li G; Wang K; Song Y; Liao Z; Li S; Hua W; Feng X; Wu X; Zhang Y; Das A; Yang C, 2021, 'Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration', Cell Proliferation, vol. 54, http://dx.doi.org/10.1111/cpr.12941

Shariev A; Menounos S; Laos AJ; Laxman P; Lai D; Hua S; Zinger A; McRae CR; Casbolt LS; Combes V; Smith G; Hung TT; Dixon KM; Thordarson P; Mason RS; Das A, 2021, 'Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic', Redox Biology, vol. 38, http://dx.doi.org/10.1016/j.redox.2020.101790

Yin H; Wang K; Das A; Li G; Song Y; Luo R; Cheung JPY; Zhang T; Li S; Yang C, 2021, 'The REDD1/TXNIP Complex Accelerates Oxidative Stress-Induced Apoptosis of Nucleus Pulposus Cells through the Mitochondrial Pathway', Oxidative Medicine and Cellular Longevity, vol. 2021, pp. 7397516, http://dx.doi.org/10.1155/2021/7397516

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2019, 'Erratum: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))', Cell, vol. 176, pp. 944 - 945, http://dx.doi.org/10.1016/j.cell.2019.01.026

Youngson NA; Mezbah Uddin G; Das A; Martinez C; Connaughton HS; Whiting S; Yu J; Sinclair DA; John Aitken R; Morris MJ, 2019, 'Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice', Reproduction, vol. 158, pp. 169 - 179, http://dx.doi.org/10.1530/REP-18-0574

Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, vol. 9, http://dx.doi.org/10.1038/s41467-018-05613-7

Longchamp A; Mirabella T; Arduini A; MacArthur MR; Das A; Treviño-Villarreal JH; Hine C; Ben-Sahra I; Knudsen NH; Brace LE; Reynolds J; Mejia P; Tao M; Sharma G; Wang R; Corpataux JM; Haefliger JA; Ahn KH; Lee CH; Manning BD; Sinclair DA; Chen CS; Ozaki CK; Mitchell JR, 2018, 'Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production', Cell, vol. 173, pp. 117 - 129.e14, http://dx.doi.org/10.1016/j.cell.2018.03.001

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, vol. 173, pp. 74 - 89.e20, http://dx.doi.org/10.1016/j.cell.2018.02.008

Bonkowski MS; Das A; Schultz M; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair D, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING', Innovation in aging, vol. 2, pp. 388 - 388, http://dx.doi.org/10.1093/geroni/igy023.1446

Bonkowski MS; Das A; Schultz MB; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair DA, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING', Innovation in aging, vol. 2, pp. 799 - 799, http://dx.doi.org/10.1093/geroni/igy023.2966

Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep40159

Das A; Sinclair D; Bonkowski M; Johnston I; Wu L, 2017, 'Extension of physical endurance and protection against physical, chemical and radiological trauma by NAD + precursors', Journal of Science and Medicine in Sport, vol. 20, pp. S165 - S166, http://dx.doi.org/10.1016/j.jsams.2017.09.564

Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, vol. 15, pp. 706 - 715, http://dx.doi.org/10.1111/acel.12481

Libert S; Pointer K; Bell EL; Das A; Cohen DE; Asara JM; Kapur K; Bergmann S; Preisig M; Otowa T; Kendler KS; Chen X; Hettema JM; Van Den Oord EJ; Rubio JP; Guarente L, 2011, 'SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive', Cell, vol. 147, pp. 1459 - 1472, http://dx.doi.org/10.1016/j.cell.2011.10.054

Javidpour P; Das A; Khosla C; Tsai SC, 2011, 'Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (Hed KR): Molecular basis of stereo- and regiospecificities', Biochemistry, vol. 50, pp. 7426 - 7439, http://dx.doi.org/10.1021/bi2006866

Szu PH; Govindarajan S; Meehan MJ; Das A; Nguyen DD; Dorrestein PC; Minshull J; Khosla C, 2011, 'Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase', Chemistry and Biology, vol. 18, pp. 1021 - 1031, http://dx.doi.org/10.1016/j.chembiol.2011.07.015

Das A; Szu PH; Fitzgerald JT; Khosla C, 2010, 'Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis', Journal of the American Chemical Society, vol. 132, pp. 8831 - 8833, http://dx.doi.org/10.1021/ja102517q

Tahanian E; Lord-Dufour S; Das A; Khosla C; Roy R; Annabi B, 2010, 'Inhibition of tubulogenesis and of carcinogen-mediated signaling in brain endothelial cells highlight the antiangiogenic properties of a mumbaistatin analog', Chemical Biology and Drug Design, vol. 75, pp. 481 - 488, http://dx.doi.org/10.1111/j.1747-0285.2010.00961.x

Das A; Khosla C, 2009, 'In Vivo and In Vitro Analysis of the Hedamycin Polyketide Synthase', Chemistry and Biology, vol. 16, pp. 1197 - 1207, http://dx.doi.org/10.1016/j.chembiol.2009.11.005

Das A; Khosla C, 2009, 'ChemInform Abstract: Biosynthesis of Aromatic Polyketides in Bacteria', ChemInform, vol. 40, http://dx.doi.org/10.1002/chin.200932273

Das A; Khosla C, 2009, 'Biosynthesis of Aromatic Polyketides in Bacteria', Accounts of Chemical Research, vol. 42, pp. 631 - 639, http://dx.doi.org/10.1021/ar8002249

Lord-Dufour S; Copland IB; Levros LC; Post M; Das A; Khosla C; Galipeau J; Rassart E; Annabi B, 2009, 'Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1α: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells', Stem Cells, vol. 27, pp. 489 - 497, http://dx.doi.org/10.1634/stemcells.2008-0855

Lee TS; Das A; Khosla C, 2007, 'Structure-activity relationships of semisynthetic mumbaistatin analogs', Bioorganic and Medicinal Chemistry, vol. 15, pp. 5207 - 5218, http://dx.doi.org/10.1016/j.bmc.2007.05.019

Koremans FW; Chen X; Das A; Diwan AD, 'Changes in back pain scores after bariatric surgery in obese patients: A systematic review and meta-analysis', , http://dx.doi.org/10.1101/2020.08.25.20182022

Kim L-J; Chalmers TJ; Smith GC; Das A; Poon EWK; Wang J; Tucker SP; Sinclair DA; Quek L-E; Wu LE, 'Nicotinamide mononucleotide (NMN) deamidation by the gut microbiome and evidence for indirect upregulation of the NAD+metabolome', , http://dx.doi.org/10.1101/2020.09.10.289561

Conference Abstracts

Murphy T; Wu L; Sandow S; Das A; Naim H, 2020, 'Effect of Dietary Nicotinamide Mononucleotide (NMN) on Function and Mechanics of Skeletal Muscle Arteries from Aged Mice', in FASEB JOURNAL, WILEY, San Diego, CA, Vol. 34, presented at Annual Meeting on Experimental Biology, San Diego, CA, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.04752

Preprints

Kim L-J; Chalmers T; Smith G; Li C; Das A; Poon WKE; Wang J; Tucker S; Sinclair D; Quek L-E; Wu L, Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome, http://dx.doi.org/10.21203/rs.3.rs-87047/v1

Shariev A; Laos AJ; Lai D; Hua S; Zinger A; McRae CR; Casbolt LS; Combes V; Hung T-T; Dixon KM; Thordarson P; Mason RS; Das A, Skin protective effects of RM191A, a novel superoxide dismutase mimetic, http://dx.doi.org/10.1101/2020.05.10.086694


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