Select Publications

Journal articles

Chen J; Campbell AP; Wakelin LPG; Finch AM, 2022, 'Characterisation of bis(4-aminoquinoline)s as α1A adrenoceptor allosteric modulators', European Journal of Pharmacology, vol. 916, pp. 174659, http://dx.doi.org/10.1016/j.ejphar.2021.174659

Smith NJ; Grant JN; Moon JI; So SS; Finch AM, 2021, 'Critically evaluating sweet taste receptor expression and signaling through a molecular pharmacology lens', FEBS Journal, vol. 288, pp. 2660 - 2672, http://dx.doi.org/10.1111/febs.15768

Ngo T; Wilkins BP; So SS; Keov P; Chahal KK; Finch AM; Coleman JLJ; Kufareva I; Smith NJ, 2021, 'Orphan receptor GPR37L1 remains unliganded', Nature Chemical Biology, vol. 17, pp. 383 - 386, http://dx.doi.org/10.1038/s41589-021-00748-z

Ngo T; Wilkins B; So S; Keov P; Chahal K; Finch A; Coleman JLJ; Kufareva I; Smith N, 2020, 'Orphan G protein-coupled receptor, GPR37L1: pharmacological toolbox empty once again', , http://dx.doi.org/10.1101/2020.09.11.290486

Lizarme-Salas Y; Ariawan AD; Ratnayake R; Luesch H; Finch A; Hunter L, 2020, 'Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity', , http://dx.doi.org/10.3762/bxiv.2020.93.v1

Lizarme-Salas Y; Ariawan AD; Ratnayake R; Luesch H; Finch A; Hunter L, 2020, 'Vicinal difluorination as a C=C surrogate: An analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity', Beilstein Journal of Organic Chemistry, vol. 16, pp. 2663 - 2670, http://dx.doi.org/10.3762/BJOC.16.216

Healey RD; Wojciechowski JP; Monserrat-Martinez A; Tan SL; Marquis CP; Sierecki E; Gambin Y; Finch AM; Thordarson P, 2018, 'Design, Synthesis, and Evaluation of N- and C-Terminal Protein Bioconjugates as G Protein-Coupled Receptor Agonists', Bioconjugate Chemistry, vol. 29, pp. 403 - 409, http://dx.doi.org/10.1021/acs.bioconjchem.7b00716

Urmi KF; Finch AM; Griffith R, 2017, 'Template selection and refinement considerations for modelling aminergic GPCR-ligand complexes', Journal of Molecular Graphics and Modelling, vol. 76, pp. 488 - 503, http://dx.doi.org/10.1016/j.jmgm.2017.07.030

Campbell AP; Wakelin LPG; Denny WA; Finch AM, 2017, 'Homobivalent conjugation increases the allosteric effect of 9-aminoacridine at the α1-adrenergic receptors', Molecular Pharmacology, vol. 91, pp. 135 - 144, http://dx.doi.org/10.1124/mol.116.105874

Chen J; Campbell AP; Urmi KF; Wakelin LPG; Denny WA; Griffith R; Finch AM, 2014, 'Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines', Bioorganic and Medicinal Chemistry, vol. 22, pp. 5910 - 5916, http://dx.doi.org/10.1016/j.bmc.2014.09.017

Campbell AP; MacDougall IJA; Griffith R; Finch AM, 2014, 'An aspartate in the second extracellular loop of the α1B adrenoceptor regulates agonist binding', European Journal of Pharmacology, vol. 733, pp. 90 - 96, http://dx.doi.org/10.1016/j.ejphar.2014.03.034

Kim MY; Finch AM; Lumbers ER; Boyce AC; Gibson KJ; Eiby YA; Lingwood BE, 2014, 'Expression of adrenoceptor subtypes in preterm piglet heart is different to term heart', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0092167

Ngo T; Nicholas TJ; Chen J; Finch AM; Griffith R, 2013, '5-HT1A receptor pharmacophores to screen for off-target activity of á1-adrenoceptor antagonists', Journal of Computer - Aided Molecular Design, vol. 27, pp. 305 - 319, http://dx.doi.org/10.1007/s10822-013-9647-5

Chen J; Murad AK; Wakelin L; Denny WA; Griffith R; Finch AM, 2013, 'a1-Adrenoceptor and serotonin 5-HT1A receptor affinity of homobivalent 4-aminoquinoline compounds: An investigation of the effect of linker length', Biochemical Pharmacology, vol. 85, pp. 1534 - 1541, http://dx.doi.org/10.1016/j.bcp.2013.03.010

Stoddart ES; Senadheera SN; MacDougall I; Griffith R; Finch AM, 2011, 'A novel structural framework for á1a/d-adrenoceptor selective antagonists identified using subtype selective pharmacophores', PLoS One, vol. 6, pp. e19695, http://dx.doi.org/10.1371/journal.pone.0019695

Antipatis C; Finch A; Ashworth C, 2008, 'Effect of controlled alterations in maternal dietary retinol on foetal and neonatal retinol status and pregnancy outcome in pigs', Livestock Science, vol. 118, pp. 247 - 254, http://dx.doi.org/10.1016/j.livsci.2008.01.026

Laird AS; Finch A; Waite PM; Carrive P, 2008, 'Peripheral changes above and below injury level lead to prolonged vascular responses following high spinal cord injury', American Journal of Physiology - Heart and Circulatory Physiology, vol. 294, pp. H785 - H792, http://dx.doi.org/10.1152/ajpheart.01002.2007

Riek RP; Finch A; Begg G; Graham RM, 2008, 'Wide turn diversity in protein transmembrane helices implications for G-protein-coupled receptor and other polytopic membrane protein structure and function', Molecular Pharmacology, vol. 73, pp. 1092 - 1104, http://dx.doi.org/10.1124/mol.107.043042

Mcneil CJ; Nwagwu MO; Finch A; Page KP; Thain A; Mcardle HJ; Ashworth C, 2007, 'Glucocorticoid exposure and tissue gene expression of 11â HSD-1, 11 â HSD-2, and glucocorticoid receptor in a porcine model of differential fetal growth', Reproduction, vol. 133, pp. 653 - 661, http://dx.doi.org/10.1530/rep.1.01198

Finch AM; Graham RM, 2006, 'The α1D-adrenergic receptor: Cinderella or ugly stepsister', Molecular Pharmacology, vol. 69, pp. 1 - 4, http://dx.doi.org/10.1124/mol.105.020230

Du XR; Gao X; Kiriazis H; Moore X; Ming Z; Su Y; Wang K; Finch A; Dart A; Graham RM, 2006, 'Cardiac overexpression of the alpha(1A)-adrenergic receptor limits post-infarct ventricular remodeling and dysfunction, and improves survival', Journal of Molecular and Cellular Cardiology, vol. 41, pp. 735 - 735, http://dx.doi.org/10.1016/j.yjmcc.2006.06.022

Finch A; Graham RM, 2006, 'The alpha(1D)-adrenergic receptor: Cinderella or ugly stepsister', Molecular Pharmacology, vol. 69, pp. 1 - 4, http://dx.doi.org/10.1124/mol.105.020230

Du X; Gao X; Kiriazis H; Moore X; Ming Z; Su Y; Finch A; Hannan R; Dart A; Graham RM, 2006, 'Transgenic alpha(1A)-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival', Cardiovascular Research, vol. 71, pp. 735 - 743, http://dx.doi.org/10.1016/j.cardiores.2006.06.015

Mcneil CJ; Finch A; Page KP; Clarke SD; Ashworth C; Mcardle HJ, 2005, 'The effect of fetal pig size and stage of gestation on tissue fatty acid metabolism and profile', Reproduction, vol. 129, pp. 757 - 763, http://dx.doi.org/10.1530/rep.1.00451

Du X; Fang L; Gao X; Kiriazis H; Feng X; Hotchkin E; Finch AM; Chaulet H; Graham RM, 2004, 'Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction', Journal of Molecular and Cellular Cardiology, vol. 37, pp. 979 - 987, http://dx.doi.org/10.1016/j.yjmcc.2004.07.010

Finch A; Yang LG; Nwagwu MO; Page KP; Mcardle HJ; Ashworth C, 2004, 'Placental transport of leucine in a porcine model of low birth weight', Reproduction, vol. 128, pp. 229 - 235, http://dx.doi.org/10.1530/rep.1.00193

McGinty SJ; Finch AM; Griffith R; Graham RM; Bremner JB, 2004, 'Synthesis and biological evaluation of bicyclic and tricyclic substituted nortropan derivatives: discovery of a novel selective Ą1D-adrenergic receptor ligand', Bioorganic and Medicinal Chemistry, vol. 12, pp. 5639 - 5650, http://dx.doi.org/10.1016/j.bmc.2004.07.063

Page KP; Ashworth C; Mcardle HJ; Finch A; Nwagwu MO, 2003, 'Sodium transport across the chorioallantoic membrane of porcine placenta involves the epithelial sodium channel (ENaC)', The Journal of Physiology, vol. 547, pp. 849 - 857, http://dx.doi.org/10.1113/jphysiol.2002.031153

Finch AM; Antipatis C; Pickard AR; Ashworth CJ, 2002, 'Patterns of fetal growth within Large White x Landrace and Chinese Meishan gilt litters at three stages of gestation', Reproduction, Fertility and Development, vol. 14, pp. 419 - 425, http://dx.doi.org/10.1071/RD01131

Ashworth CJ; Finch AM; Page KR; Nwagwu MO; McArdle HJ, 2001, 'Causes and consequences of fetal growth retardation in pigs.', Reproduction (Cambridge, England) Supplement, vol. 58, pp. 233 - 246

Rocke JA; Sinclair AG; Edwards SA; Cordoba R; Pkiyach S; Penny PC; Finch AM; Horgan GW, 2001, 'The effect of feeding salmon oil to sows throughout pregnancy on pre-weaning mortality of piglets', Animal Science, vol. 73, pp. 489 - 500, http://dx.doi.org/10.1017/s135772980005846x

Finch AM; Wong AK; Paczkowski NJ; Wadi SK; Craik DJ; Fairlie DP; Taylor SM, 1999, 'Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a', Journal of Medicinal Chemistry, vol. 42, pp. 1965 - 1974, http://dx.doi.org/10.1021/jm9806594

Short A; Wong AK; Finch AM; Haaima G; Shiels IA; Fairlie DP; Taylor SM, 1999, 'Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat', British Journal of Pharmacology, vol. 126, pp. 551 - 554, http://dx.doi.org/10.1038/sj.bjp.0702338

Paczkowski NJ; Finch AM; Whitmore JB; Short AJ; Wong AK; Monk PN; Cain SA; Fairlie DP; Taylor SM, 1999, 'Pharmacological characterization of antagonists of the C5a receptor', British Journal of Pharmacology, vol. 128, pp. 1461 - 1466, http://dx.doi.org/10.1038/sj.bjp.0702938

Vogen SM; Finch AM; Wadi SK; Thatcher J; Monk PN; Taylor SM; Sanderson SD, 1999, 'The influence of Lys68 in decapeptide agonists of C5a on C5a receptor binding, activation and selectivity', Journal of Peptide Research, vol. 53, pp. 8 - 17, http://dx.doi.org/10.1111/j.1399-3011.1999.tb01612.x

Wong AK; Finch AM; Pierens GK; Craik DJ; Taylor SM; Fairlie DP, 1998, 'Small molecular probes for G-protein-coupled C5a receptors: Conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a', Journal of Medicinal Chemistry, vol. 41, pp. 3417 - 3425, http://dx.doi.org/10.1021/jm9800651

Finch AM; Vogen SM; Sherman SA; Kirnarsky L; Taylor SM; Sanderson SD, 1997, 'Biologically active conformer of the effector region of human C5a and modulatory effects of N-terminal receptor binding determinants on activity', Journal of Medicinal Chemistry, vol. 40, pp. 877 - 884, http://dx.doi.org/10.1021/jm960727r

Tempero RM; Hollingsworth MA; Burdick MD; Finch AM; Taylor SM; Vogen SM; Morgan EL; Sanderson SD, 1997, 'Molecular Adjuvant Effects of a Conformationally Biased Agonist of Human C5a Anaphylatoxin', Journal of Immunology, vol. 158, pp. 1377 - 1382

Kawatsu R; Sanderson SD; Blanco I; Kendall N; Finch AM; Taylor SM; Colcher D, 1996, 'Conformationally biased analogs of human C5a mediate changes in vascular permeability', Journal of Pharmacology and Experimental Therapeutics, vol. 278, pp. 432 - 440

Sanderson SD; Kimarsky L; Sherman SA; Vogen SM; Prakash O; Finch AM; Taylor SM; Ember JA, 1995, 'Decapeptide Agonists of Human C5a: The Relationship between Conformation and Neutrophil Response', Journal of Medicinal Chemistry, vol. 38, pp. 3669 - 3675, http://dx.doi.org/10.1021/jm00018a028

Finch AM; Heron AE; Tolhurst SL; Florin TH; Sanderson SD; Taylor SM, 1995, 'The effect of C5a and U46619 on the isolated, perfused human placental lobule: Development of a method for the online estimation of tissue fluid accumulation', Journal of Pharmacological and Toxicological Methods, vol. 34, pp. 133 - 141, http://dx.doi.org/10.1016/1056-8719(95)00046-3

Taylor SM; Finch AM; Heron AE; Brown LC; Florin THJ, 1994, 'Reversibility of tachyphylaxis to C5a in guinea pig tissues, perfused human placental lobule, and umbilical artery', Inflammation, vol. 18, pp. 645 - 657, http://dx.doi.org/10.1007/BF01535262

Sanderson SD; Kimarsky L; Sherman SA; Ember JA; Finch AM; Taylor SM, 1994, 'Decapeptide Agonists of Human C5a: The Relationship between Conformation and Spasmogenic and Platelet Aggregatory Activities', Journal of Medicinal Chemistry, vol. 37, pp. 3171 - 3180, http://dx.doi.org/10.1021/jm00045a023


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