Select Publications

Book Chapters

Osborne B; Brandon AE; Smith GC; Turner N, 2019, 'Chapter 16 Impact of Lifestyle and Clinical Interventions on Mitochondrial Function in Obesity and Type 2 Diabetes', in Mitochondria in Obesity and Type 2 Diabetes, pp. 367 - 397,

Osborne B; Brandon AE; Smith GC; Turner N, 2019, 'Impact of lifestyle and clinical interventions on mitochondrial function in obesity and type 2 diabetes', in Morio B; Penicaud L; Rigoulet M (ed.), Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases, ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, pp. 367 - 397,

Osborne B; Brandon A; Smith GC; Turner N, 2019, 'Impact of Lifestyle and Clinical Interventions on Mitochondrial Function in Obesity and Type 2 Diabetes', in Morio B; Pénicaud L; Rigoulet M (ed.), Mitochondria in Obesity and Type 2 Diabetes, Elsevier, pp. 367 - 397,

Journal articles

Lee K; Vakili S; Burden HJ; Adams S; Smith GC; Kulatea B; Wright-McNaughton M; Sword D; Watene-O'Sullivan C; Atiola RD; Paul RG; Plank LD; Kallingappa P; King F; Wilcox P; Merriman TR; Krebs JD; Hall RM; Murphy R; Merry TL; Shepherd PR, 2022, 'The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition', MOLECULAR METABOLISM, vol. 59,

Metcalfe LK; Shepherd PR; Smith GC; Turner N, 2022, 'Limited Metabolic Effect of the CREBRFR457Q Obesity Variant in Mice', Cells, vol. 11,

Walter S; Ho J; Alvarado R; Smith G; Croucher DR; Liang S; Grayson JW; Mangussi-Gomes J; Van Es SL; Earls P; Rimmer J; Campbell R; Kalish L; Sacks R; Harvey RJ, 2022, 'Mepolizumab decreases tissue eosinophils while increasing type-2 cytokines in eosinophilic chronic rhinosinusitis', Clinical and Experimental Allergy,

Uebel K; Iqbal MP; Carland J; Smith G; Islam MS; Shulruf B; Nathan S, 2021, 'Factors Determining Medical Students’ Experience in an Independent Research Year During the Medical Program', Medical Science Educator, vol. 31, pp. 1471 - 1478,

Shariev A; Menounos S; Laos AJ; Laxman P; Lai D; Hua S; Zinger A; McRae CR; Casbolt LS; Combes V; Smith G; Hung TT; Dixon KM; Thordarson P; Mason RS; Das A, 2021, 'Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic', Redox Biology, vol. 38,

Metcalfe LK; Krishnan M; Turner N; Yaghootkar H; Merry TL; Dewes O; Hindmarsh JH; De Zoysa J; Dalbeth N; Stamp LK; Merriman TR; Smith G; Shepherd P; Murphy R, 2020, 'The Māori and Pacific specific CREBRF variant and adult height', International Journal of Obesity, vol. 44, pp. 748 - 752,

Prodhan UK; Pundir S; Chiang VSC; Milan AM; Barnett MPG; Smith GC; Markworth JF; Knowles SO; Cameron-smith D, 2020, 'Comparable postprandial amino acid and gastrointestinal hormone responses to beef steak cooked using different methods: A randomised crossover trial', Nutrients, vol. 12,

Abdel Shaheed C; Carland JE; Graham GG; Stocker SL; Smith G; Hicks M; Williams KM; Furlong T; Macdonald P; Greenfield JR; Smith FC; Chowdhury G; Day RO, 2019, 'Is the use of metformin in patients undergoing dialysis hazardous for life? A systematic review of the safety of metformin in patients undergoing dialysis', British Journal of Clinical Pharmacology, vol. 85, pp. 2772 - 2783,

Metcalfe LK; Smith GC; Turner N, 2019, 'Defining lipid mediators of insulin resistance: controversies and challenges', JOURNAL OF MOLECULAR ENDOCRINOLOGY, vol. 62, pp. R65 - R82,

Metcalfe LK; Shepherd PR; Smith GC; Turner N, 2019, 'Metabolic characterisation of knock-in mice harbouring the ‘obesity variant’ of CREBRF', Obesity Research & Clinical Practice, vol. 13, pp. 288 - 288,

Larsen PS; Donges CE; Guelfi KJ; Smith GC; Adams DR; Duffield R, 2017, 'Effects of aerobic, strength or combined exercise on perceived appetite and appetite-related hormones in inactive middle-aged men', International Journal of Sport Nutrition and Exercise Metabolism, vol. 27, pp. 389 - 398,

Smith GC, 2017, 'FOX01 Is the Headline Akt Regulating Hepatic Glucose Metabolism', Endocrinology, vol. 158, pp. 2436 - 2438,

Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, vol. 7,

Rewcastle GW; Kolekar S; Buchanan CM; Gamage SA; Giddens AC; Tsang KY; Kendall JD; Singh R; Lee WJ; Smith GC; Han W; Matthews DJ; Denny WA; Shepherd PR; Jamieson SMF, 2017, 'Biological characterization of SN32976, a selective inhibitor of PI3κ and mTOR with preferential activity to PI3κα, in comparison to established pan PI3κ inhibitors', Oncotarget, vol. 8, pp. 47725 - 47740,

Smith GC, 2016, 'Acute Changes in Non-esterified Fatty Acids in Patients with Type 2 Diabetes Receiving Bariatric Surgery', Obesity Surgery, vol. 27, pp. 649 - 656,

Thomas F; Smith GC; Lu J; Babor R; Booth M; Beban G; Chase JG; Murphy R, 2016, 'Differential Acute Impacts of Sleeve Gastrectomy, Roux-en-Y Gastric Bypass Surgery and Matched Caloric Restriction Diet on Insulin Secretion, Insulin Effectiveness and Non-Esterified Fatty Acid Levels Among Patients with Type 2 Diabetes', Obesity Surgery, vol. 26, pp. 1924 - 1931,

Chowdhury MKH; Wu LE; Coleman JLJ; Smith NJ; Morris MJ; Shepherd PR; Smith GC, 2016, 'Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling', Biochemical Journal, vol. 473, pp. 1247 - 1255,

Dent JR; Chowdhury MKH; Tchijov S; Dulson D; Smith G, 2016, 'Interleukin-6 is a negative regulator of hepatic glucose production in the isolated rat liver', Archives of Physiology and Biochemistry, vol. 122, pp. 103 - 109,

Mayfield K; Siskind D; Winckel K; Russell AW; Kisely S; Smith G; Hollingworth S, 2016, 'Glucagon-like peptide-1 agonists combating clozapine-associated obesity and diabetes', Journal of Psychopharmacology, vol. 30, pp. 227 - 236,

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, vol. 471, pp. 243 - 253,

Murphy R; Smith G; Isaac I; Hutchinson D; Semple RK, 2015, 'Novel mutation in insulin receptor gene identified after muscle biopsy in a Niuean woman with severe insulin resistance', Diabetic Medicine, vol. 32, pp. e24 - e28,

Nuora A; Chiang VSC; Milan AM; Tarvainen M; Pundir S; Quek SY; Smith GC; Markworth JF; Ahotupa M; Cameron-Smith D; Linderborg KM, 2015, 'The impact of beef steak thermal processing on lipid oxidation and postprandial inflammation related responses', Food Chemistry, vol. 184, pp. 57 - 64,

Chowdhury MKH; Montgomery MK; Morris MJ; Cognard E; Shepherd PR; Smith GC, 2015, 'Glucagon phosphorylates serine 552 of β-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver', Archives of Physiology and Biochemistry, vol. 121, pp. 88 - 96,

Albert BB; Derraik JGB; Brennan CM; Biggs JB; Smith GC; Garg ML; Cameron-Smith D; Hofman PL; Cutfield WS, 2014, 'Higher omega-3 index is associated with increased insulin sensitivity and more favourable metabolic profile in middle-aged overweight men', Scientific Reports, vol. 4,

Smith GC; McEwen H; Steinberg JD; Shepherd PR, 2014, 'The activation of the Akt/PKB signalling pathway in the brains of clozapine-exposed rats is linked to hyperinsulinemia and not a direct drug effect', Psychopharmacology,

Jüllig M; Yip S; Xu A; Smith G; Middleditch M; Booth M; Babor R; Beban G; Murphy R, 2014, 'Lower Fetuin-A, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes', PLoS ONE, vol. 9,

Donges CE; Duffield R; Smith GC; Short MJ; Edge JA, 2014, 'Cytokine mRNA expression responses to resistance, aerobic, and concurrent exercise in sedentary middle-aged men', Applied Physiology, Nutrition and Metabolism, vol. 39, pp. 130 - 137,

Smith GC; Zhang ZY; Mulvey T; Petersen N; Lach S; Xiu P; Phillips A; Han W; Wang MW; Shepherd PR, 2014, 'Clozapine directly increases insulin and glucagon secretion from islets: Implications for impairment of glucose tolerance', Schizophrenia Research, vol. 157, pp. 128 - 133,

Smith GC; Ong WK; Costa JL; Watson M; Cornish J; Grey A; Gamble GD; Dickinson M; Leung S; Rewcastle GW; Han W; Shepherd PR, 2013, 'Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength', FEBS Journal, vol. 280, pp. 5337 - 5349,

Donges CE; Duffield R; Guelfi KJ; Smith GC; Adams DR; Edge JA, 2013, 'Comparative effects of single-mode vs. duration-matched concurrent exercise training on body composition, low-grade inflammation, and glucose regulation in sedentary, overweight, middle-aged men', Applied Physiology, Nutrition and Metabolism, vol. 38, pp. 779 - 788,

Smith G, 2013, 'How do antipsychotic drugs cause diabetes and obesity?', Obesity Research & Clinical Practice, vol. 7, pp. e41 - e41,

Yip S; Murphy R; Signal M; Chase JG; Smith G; Beban G; Booth M; Babor R, 2013, 'Lower Glycemic Fluctuations Early After Bariatric Surgery Partially Explained by Caloric Restriction', Obesity Surgery, pp. 1 - 9,

de Bock M; Derraik JGB; Brennan CM; Biggs JB; Smith GC; Cameron-Smith D; Wall CR; Cutfield WS, 2012, 'Psyllium supplementation in adolescents improves fat distribution & lipid profile: A randomized, participant-blinded, placebo-controlled, crossover trial', PLoS ONE, vol. 7,

Donges CE; Burd NA; Duffield R; Smith GC; West DWD; Short MJ; Mackenzie R; Plank LD; Shepherd PR; Phillips SM; Edge JA, 2012, 'Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men', Journal of Applied Physiology, vol. 112, pp. 1992 - 2001,

Smith GC; Ong WK; Rewcastle GW; Kendall JD; Han W; Shepherd PR, 2012, 'Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo', Biochemical Journal, vol. 442, pp. 161 - 169,

de Bock M; Derraik J; Brennan C; Biggs J; Smith G; Cameron-Smith D; Wall C; Cutfield W, 2012, 'Psyllium supplementation improves parameters of the metabolic syndrome: A randomized, participant-blinded, placebo controlled, crossover trial', Obesity Research & Clinical Practice, vol. 6, pp. 54 - 54,

Smith GC; Konycheva G; Dziadek MA; Ravelich SR; Patel S; Reddy S; Breier BH; Vickers MH; Owens JA; Ferguson LR, 2011, 'Pre-and postnatal methyl deficiency in the rat differentially alters glucose homeostasis', Journal of Nutrigenetics and Nutrigenomics, vol. 4, pp. 175 - 191,

Smith GC; Vickers MH; Shepherd PR, 2011, 'Olanzapine effects on body composition, food preference, glucose metabolism and insulin sensitivity in the rat', Archives of Physiology and Biochemistry, vol. 117, pp. 241 - 249,

Costa JL; Smith G; Watson M; Lin JM; Callon K; Gamble G; Cheng A; Vickers MH; Shepherd PR; Cornish J; Grey A, 2011, 'The atypical anti-psychotic clozapine decreases bone mass in rats in vivo', Schizophrenia Research, vol. 126, pp. 291 - 297,

Smith GC; Vickers MH; Cognard E; Shepherd PR, 2009, 'Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: Implications for glucose metabolism and food choice behaviour', Schizophrenia Research, vol. 115, pp. 30 - 40,

Smith GC; Chaussade C; Vickers M; Jensen J; Shepherd PR, 2008, 'Atypical antipsychotic drugs induce derangements in glucose homeostasis by acutely increasing glucagon secretion and hepatic glucose output in the rat', Diabetologia, vol. 51, pp. 2309 - 2317,

Smith GC; Chaussade C; Vickers M; Shepherd PR, 2008, 'Second generation antipsychotic medications induce type 2 diabete like syndrome by increasing hepatic glucose output and subsequently insulin secretion: Implications for mechanism of drug action', European Psychiatry, vol. 23, pp. S169 - S169,

Kim L-J; Chalmers TJ; Smith GC; Das A; Poon EWK; Wang J; Tucker SP; Sinclair DA; Quek L-E; Wu LE, 'Nicotinamide mononucleotide (NMN) deamidation by the gut microbiome and evidence for indirect upregulation of the NAD+metabolome', ,

Conference Papers

Smith GP; Mack M, 2014, 'Practical Considerations for Interpreting Flood Hazard', in Hydrology and Water Resources Symposium 2014, Engineers Australia, Perth, pp. 293 - 301, presented at 35th Hydrology and Water Resources Symposium, Perth, 24 February 2014 - 27 February 2014,;dn=389233953218405;res=IELENG

Riley M; Smith GP; Wasko CD, 2012, 'Review of flood hazard prediction on urban floodplains', in Hydrology and Water Resources Symposium 2012, Sydney, NSW, pp. 628 - 636, presented at Hydrology and Water Resources Symposium 2012, Sydney, NSW, 19 November 2012 - 22 November 2012

Jamieson SM; Smith GC; Kolekar S; Lee W-J; Singh R; Buchanan C; Denny WA; Han W; Kendall JD; Rewcastle GW; Shepherd PR, 2011, 'Abstract B162: Inhibition of the p110αisoform of PI 3-kinase prevents PIK3CA H1047R mutant tumor growth but is associated with impaired glucose metabolism.', in mTOR / PI3-Kinase, American Association for Cancer Research, pp. B162 - B162, presented at Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA,

Rahman P; Sharma A; Smith G, 2011, 'Estimating design floods for gauged urban catchments under climate change conditions case study: Cooks river, Sydney', in 34th IAHR Congress 2011 - Balance and Uncertainty: Water in a Changing World, Incorporating the 33rd Hydrology and Water Resources Symposium and the 10th Conference on Hydraulics in Water Engineering, pp. 356 - 363

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