Dr Guozhen Liu, an ARC Future Fellow, has taken a role as a Senior Lecturer at the Graduate School of Biomedical Engineering, UNSW in 2018. Before that, Dr Liu worked as an Associate Professor at Macquarie University. Gaining her PhD degree in Chemistry in 2006 under the supervision of Prof Justin Gooding at UNSW, Dr Liu is recognised for her innovative cross-disciplinary research in the area of nanoscale analysis, nanotechnology, biosensors,...view more
Dr Guozhen Liu, an ARC Future Fellow, has taken a role as a Senior Lecturer at the Graduate School of Biomedical Engineering, UNSW in 2018. Before that, Dr Liu worked as an Associate Professor at Macquarie University. Gaining her PhD degree in Chemistry in 2006 under the supervision of Prof Justin Gooding at UNSW, Dr Liu is recognised for her innovative cross-disciplinary research in the area of nanoscale analysis, nanotechnology, biosensors, and biomedical devices. Dr Liu conducted her postdoctoral research at CSIRO (2006-2008) and UNSW (2008-2010), respectively before she accepted a faculty position as Associate Professor at the Central China Normal University, China (2010-2015). In 2015 Dr Liu moved back to Sydney and worked as Research Fellow at ARC Centre of Excellence for Nanoscale BioPhtotnics (CNBP) before she was awarded the ARC Future Fellowship in 2016.
Dr Liu’s research career has alternated between industrial and academic research. Besides building effective collaborations within academia, Dr Liu has maintained close engagement with the industry sector in the conduction of translational research. Dr Liu’s industrial experience includes four years spent as R&D Manager for AgaMatrix Inc. (2010-2015), working for the US based company in China. This position saw her developing medical devices including glucose test strips and glucose meters. The sensing technologies described in her patents have attracted the attention and investment of industry end-users, such as Medtronic and Regeneus Ltd. These technologies have been, or are in the process of being commercialised, with one already available as a market product. Dr Liu has attracted more than $2M in national and international research funding since 2015.
Dr Liu is leading her own research team on Precision Diagnostics and Therapeutics covering the area of nanoscale analysis, stimuli-responsive nanoparticles, advanced sensing technologies and biomedical devices, with a focus on developing multifunctional theranostic tools and devices for life science, especially neuroscience. Liu’s group is also a part of the CNBP (www.cnbp.org.au). As a result, much of her research has a focus on applied research by “Creating Windows to the Body” where she modifies the bio-nano interfaces for diagnostic medical devices, bioimaging and biomaterials as well as more fundamental research on real-time in vivo sensing and cellular response systems. Besides the biomedical research, the group is also interested in the development of assays and portable devices for food safety and early diagnosis of plant diseases. Current research projects within Liu’s team include:
- Electrochemical and optical sensors for detection of key analytes in cellular environments, such as microRNA, cytokines, exosomes, microvesicles, and ROS/RNS
- Stimuli-responsive nanoparticles towards intelligent personialised nanomedcine
- Engineering of surfaces with switching molecules for real time in vivo sensing
- Pathogen and toxin detection in foods and agriculture
- Single cell analysis
- Biomedical devices
- Member of IEEE
- Member of Engineering in Medicine and Biology Society
- Chartered member of Royal Australian Chemical Institute (RACI)
- Member of American Chemical Society
- Member of Chinese Chemical Society
- Member of International Society of Aptamers (INSOAP)
- Kaixin Zhang (MQ PhD candidate, 2015-)
- Fuyuan Zhang (MQ PhD candidate, 2016-)
- Submedha Prabhu (MQ PhD candidate, 2017-)
- Fei Deng (PhD candidate, 2017-）
- Jagjit Kaur (PhD candidate, 2018-)
- Yi Li (PhD candidate, 2018-)
- Laicong Qiao (PhD candidate, 2018-)
Research Funding and Awards
- Macquarie University Research Infrastructure Block Grant for 3D-printer for biomedical applications, 2017, Australia
- ARC Future Fellowship, 2017-2021, Australia
- Academic Excellence Award for transdisciplinary research publications in 2017.
- ARC Linkage Project, 2016-2019, Australia
- Macquarie University Research Development Grant, 2015-2016, Australia
- Macquarie University Research Infrastructure Block Grant, 2015, Australia
- Regeneus Inc. Industry Funding, 2015, Australia
- National Natural Science Foundation of China General Project Funding, 2016-2019, China
- Travel grant and Childcare grant for Emerging Therapeutics Summit 2016, Melbourne, awarded by International Innovative Research Network
- Shortlisted by Georgina Sweet Award for Women in Quantitative Biomedical Science 2016, Australia
- Best Poster Award, CNBP Annual Retreat 2015, Lake Macquarie, Australia
- Central China Normal University Infrastructure Funding, 2014, China
- Ministry of Education Self-determined Research Funding, 2013-2016, China
- Wuhan Rongtan Tech, Industry Funding, 2011-2012, China
- National Natural Science Foundation of China Early Career Research Funding, 2010-2012, China
- Central China Normal University New Staff Funding, 2010, China
- International Postgraduate Scholarship (IPRS) 2003, awarded by Australian government
- Cell selection method, G. Liu, E.M. Goldys, A. Anwer, Australian provisional patent No.: 2015904816
- Biological detection system, G. Liu, E.M. Goldys, Australian provisional patent No.: PCT/AU2016/000401
- Electrochemical affinity sensor, J.J. Gooding, G. Liu, Patent No.: US 20140174949 A1
- Electrochemical competition sensor, J.J. Gooding, G. Liu, Patent No.: US 20140174950 A1
- A method for in situ covalent attachment of gold nanoparticles to surfaces, G. Liu, W. Guo, Chinese Patent No.: CN103276434 A (Granted at China)
- Chelating amphiphiles, M.J. Maghaddam, C.J. Drummond, G. Liu, Patent No.: WO2010139003 A1
- Electrochemical Sensor, J.J. Gooding, G. Liu, Patent No.: US 8110079 B2 (Granted at US)
Refereed Journal Articles (Names underlined were students under Liu's supervision; *corresponding author; Google citations: https://scholar.google.com.au/citations?user=xms_zr0AAAAJ&hl=en)
- C.M. Cao, F.Y. Zhang, E. M. Goldys, F. Gao, G. Liu*, Advances in Structure-Switching Aptasensing Towards Real-time Detection of Cytokines, Trends Anal. Chem., 2018, in press [Review paper]
- K. Ma, F.L., Zhang, N. Sayyadi, W. J. Chen, A. Anwer, A. Care, B. Xu, W. J. Tian, E. M. Goldys, G. Liu*, "Turn-on' fluorescent aptasensor based on AIEgen labelling for the localisation of IFN-y in live cells, ACS Sens., 2018, 3(2), 320-326
- K.X. Zhang, G. Liu*, E.M. Goldys, Robust immunosensing system based on biotin-streptavidin coupling for spatially localized femtogram mL-1 level detection of interleukin-6, Biosens. Bioelectron., 2018, 102, 80-86
- M. Qi, J.W. Huang, H. Wei, C.M. Cao, S.L. Feng, Q. Guo, E.M. Goldys, R. Li, G. Liu*, Graphene oxide thin film with dual function integrated into a nano-sandwich device for in vivo monitoring of interleukin-6, ACS Appl. Mater. Interfaces, 2017, 9(48), 41659-41668
- S.L. Feng, G. Liu, L. Jiang, Y. Zhu, E.M. Goldys, D.W. Inglis, A microfluidic needle for sampling and delivery of chemical signals by segmented flows, Appl. Phys. Lett, 2017, 111, 183702.
- S.L. Feng, A.M. Skelley, A.G. Anwer, G. Liu, D.W. Inglis, Maximizing Particle Concentration in Deterministic Lateral Displacement Arrays, Biomicrofluidics, 2017, 11, 024121.
- G. Liu*, K. Zhang, K. Ma, A. Care, M.R. Hutchinson, E. M. Goldys, Graphene quantum dots based "switch-on" nanosensors for intracellular cytokine monitoring, Nanoscale, 2017, 9, 4934-4943.
- C.M. Cao, Y. Zhang, C. Jiang, M. Qi, G. Liu*, Advances on Aryldiazonium Salt Chemistry Based Interfacial Fabrication for Sensing Applications, ACS Appl. Mater. Interfaces, 2017, 9(6), 5031-5049. [Review paper]
- A. Rehman, A. Anwer, M, Gosnell, S. Mahbub, G. Liu, E.M. Goldys, Fluorescence quenching of free and bound NADH in Hela cells determined by hyperspectral imaging nad unmixing of cell autofluorescence, Biomed. Opt. Express, 2017, 8(3), 1488-1498
- G. Liu*, K.X. Zhang, A. Nadort, M.R. Huctchinson, E.M. Goldys, Sensitive cytokine assay based on optical fiber allowing localised and spatially resolved detection of interleukin-6, ACS Sens., 2017, 2(2), 218-226.
- C. Jiang, S.M. Silva, S. Fan, Y. Wu, M.T. Alam, G. Liu, J.J. Gooding, Aryldiazonium elelctrochemistry derived mixed organic layers: from surface chemistry to its applications, J. Electroanal. Chem, 2017, 785, 265-278. [Review paper]
- Y. Lu, Y. Xia, G. Liu, M. Pan, M. Li, N. A. Lee, S. Wang, A Review of Methods for Detecting Melamine in Food Samples, Crit. Rev. Anal. Chem., 2017, 47(1), 51-66.[Review paper]
- X. Gong, G. Liu, Y. Li, Y. Yu, W.Y. Teoh, Functionalized-graphene composites: Fabrication and applications in sustainable energy and environment, Chem. Mater., 2016, 28(22), 8082-8118. [Review paper]
- M. Qi, Y. Zhang, C.M. Cao, M. Zhang, S. Liu, G. Liu*, Decoration of RGO nanosheets with aryldiazonium salt and gold nanoparticles towards a label-free amperimetric immunosensor for detecting TNF-a in live cells, Anal. Chem., 2016, 88(19), 9614-9621.
- M. Qi, Y. Zhang, C.M. Cao, Y. Lu, G. Liu*, Increased sensitivity of extracellular glucose monitoring based on AuNP decorated GO nanocomposites, RSC Adv., 2016, 6, 39180-39187.
- Y. Lu, M. Li, M. Ding, G. Liu, Y. Zhang, S.Wang, Detection of biosphenol-A with electrochemical immunosensor: The comparison of the competition and displacement format assay, J. Electroanal. Chem., 2016, 779, 34-38.
- G. Liu*, M. Qi, M. Hutchinson, G. Yang, E.M. Goldys, Recent Advances in Cytokine Detection by Immunosensing, Biosens. Bioelectron., 2016, 79, 810-821. [Review paper]
- G. Liu*, M. Qi, Y. Zhang, C.M. Cao, E.M. Goldys, Nanocomposites of Gold Nanoparticles and Graphene Oxide Towards an Stable Label-Free Electrochemical Immunosensor for Detection of Cardiac Marker TroponinI, Anal. Chim. Acta, 2016, 909, 1-8. [Front cover feature article]
- D. Song, C. Guo, J. Zhao, H. Suo, X. Zhao, G. Liu, Host Sensitized Near-infrared Emission in Nd3+ -Yb3+ Co-doped Na2GdMg2V3O12 Phosphor, Ceram. Int., 2016, 42(11):12988-12994
- W. Z. W. Ismail, G. Liu, K. Zhang, E.M. Goldys, J.M. Dawes, Dopamine Sensing and Measurement using Threshold and Spectral Measurements in Random Lasers,Opt. Express, 2016, 24(2), A85-A91.
- G. Liu*, Y. Zhang, M. Qi, F. Chen, Covalent Anchoring of Multifunctionized Gold Nanoparticles on Electrodes towards an Electrochemical Sensor for Detection of Cadmium Ions, Anal. Methods, 2015, 7, 5619-5626.
- Y. Zhang, M. Qi, G. Liu*, C-C Bonding of Graphene Oxide on 4-Aminophenyl Modified Gold Electrodes towards Simultaneous Detection of Heavy Metal Ions,Electroanalysis, 2015, 27 (5), 1110-1118.
- G. Liu*, Y. Zhang, W. Guo, Covalent Functionalization of Gold Nanoparticles as Electronic Bridges and Signal Amplifiers Towards an Electrochemical Immunosensor for Botulinum Neurotoxin Type A, Biosens. Bioelectron., 2014, 61, 547-553.
- X. Gong, Y. Bi, Y. Zhao, G. Liu, W.Y. Teoh, Graphene Oxide-based Electrochemical Sensor: a Platform for Ultrasensitive Detection of Heavy Metal Ions, RSC Advances, 2014, 4 (47), 24653-24657.
- F. Chen, G. Liu, Y. Shi, P. Xi, J. Cheng, J. Hong, R. Shen, X. Yao, D. Bai, Z. Zeng, A Coumarin-derived Fluorescent Chemosensor for Selectively Detecting Cu2+: Synthesis, DFT Calculations and Cell Imaging Applications, Talanta, 2014, 124(15), 139-145.
- G. Liu*, W. Guo, Y. Zhang, Covalent Fabrication of Methyl Parathion Hydrolase on Gold Nanoparticles Modified Carbon Substrates for Designing a Methyl Parathion Biosensor, Biosens. Bioelectron., 2014,53 (15), 440-446.
- G. Liu*, W. Guo, D. Song, A Multianalyte Electrochemical Immunosensor Based on Patterned Carbon Nanotubes Modified Substrates for Detection of Pesticides,Biosens. Bioelectron., 2014, 52 (15), 360-366.
- A. Li, J. Liu, G. Liu, J. Zhang, S. Feng, Design and Synthesis of Fluorescent Core-shell Nanoparticles with Tunable LCST Behavior and Metal-enhanced Fluorescence,J. Polym. Sci. Part A: Polym. Chem., 2014, 52(1), 87-95.
- C. Fairman, M. Chockalingam, G. Liu, A.H. Soeriyadi, J.J. Gooding. Light-Induced Organic Monolayer Modification of Iodinated Carbon Electrodes, Langmuir,2014, 30, 332−339.
- W. Guo, F. Jiang, J. Chu, D. Song, G. Liu*, A Sensitive Hydrogen Peroxide Biosensor Based on Aryldiazonium salts and SWNTs Modified Gold Electrodes, J. Electroanal. Chem., 2013, 703, 63-69.
- U.E. Wawrzyniak, P. Ciosek, M. Zaborowski, G. Liu, J.J. Gooding. Gly-Gly-His Immobilized On Monolayer Modified Back-Side Contact Miniaturized Sensors for Complexation of Copper Ions, Electroanalysis, 2013, 25(8), 1-11.
- F. Chen, P. Xi, C. Ma, C. Shao, J. Wang, S. Wang, G. Liu, Z. Zeng. In Situ Preparation, Characterization, Magnetic and Catalytic Studies of Surfactant Free RGO/FexCo100−xnanocomposites, Dalton Trans., 2013, 42, 7936-7942.
- G. Liu*, D. Song, F. Chen. Towards the Fabrication of a Label-free Amperometric Immunosensor Using SWNTs for Direct Detection of Paraoxon, Talanta, 2013, 104, 103-108.
- G. Liu, S.G. Iyengar, J.J. Gooding. An Amperometric Immunosensor Based on a Gold Nanoparticle-Diazonium Salt Modified Sensing Interface for the Detection of HbA1c in Human Blood, Electroanalysis, 2013, 25(4), 881-887.
- G. Liu, S. Wang, J. Liu, D. Song. An Electrochemical Immunosensor Based on Chemical Assembly of Vertically Aligned Carbon Nanotubes on Carbon Substrates for Direct Detection of Pesticide Endosulfan in Environmental Water, Anal. Chem., 2012, 84(9), 3921-3928.
- X. Luo, J. Liu, G. Liu, R. Wang, Z. Liu. Manipulation of the Bioactivity of Glucose Oxidase via RAFT Controlled Surface Modification, J. Polym. Sci. Part A: Polym. Chem., 2012, 50(14), 2786-2793.
- G. Liu, S.M. Khor, S.G. Iyengar, J.J. Gooding. Development of an Electrochemical Immunosensor for the Detection of HbA1c in Serum, Analyst, 2012, 137, 829-832.
- G. Liu, S.G. Iyengar, J.J. Gooding. An Electrochemical Impedance Immunosensor Based on Gold Nanoparticle-Modified Electrodes for the Detection of HbA1c in Human Blood, Electroanalysis, 2012, 24(7), 1509-1516.
- G. Liu. Modification of Aryldiazonium Salts on Electrodes towards Designing Stable and Versatile Sensing Interfaces, Aus. J. Chem., 2011, 64, 658.
- G. Liu, J. Liu, T.P. Davis, J.J. Gooding. Electrochemical Impedance Immunosensor Based on Gold Nanoparticles and Aryldiazonium Salts Functionalized Gold Interface for the Detection of Antibody, Biosens. Bioelectron., 2011, 26(8), 3660-3665.
- G. Liu, E. Luais, J.J. Gooding. The Fabrication of Stable Gold nanoparticle Modified Interfaces for Electrochemistry, Langmuir, 2011, 27(7), 4173-4186.
- G. Liu, N.M.K. Tse, M.R. Hill, D.F. Kennedy, C.J. Drummond, Disordered Mesoporous Gadolinosilicate Nanoparticles Prepared Using Gadolinium Based Ionic Liquid Emulsions: Potential as Magnetic Resonance Imaging Contrast Agent, Aus. J. Chem., 2011, 64, 617-624.
- S.M. Khor, G. Liu, J.R. Peterson, S.G. Iyengar, J.J. Gooding. An Electrochemical Immunobiosensor for Direct Detection of Veterinary Drug Residues in Undiluted Complex Matrices, Electroanalysis, 2011, 23(8), 1797-1804.
- S.M. Khor, G. Liu, S.G. Iyengar, J.J. Gooding. The Importance of Interfacial Design for the Sensitivity of a Label-Free Electrochemical Immuno-Biosensor for Small Organic Molecules. Biosens. Bioelectron., 2011, 26(5), 2038-2044.
- X. Chen, M. Chockalingam, G. Liu, E. Luais, A.L. Gui, J.J. Gooding, A Molecule with Dual Functionality 4-Aminophenylmethylphosphonic Acid: A Comparison Between Layers Formed on Indium Tin Oxide by In Situ Generation of an Aryl Diazonium Salt or by Self-Assembly of the Phosphonic Acid, Electroanalysis, 2011, 23(11), 2633-2642.
- C. Hua, W. H. Zhang, S.R. M.D. Almeida, S. Ciampi, D. Gloria, G. Liu, J.B. Harper, J.J. Gooding, A Novel Route to Copper(II) detection Using ‘Click’ Chemistry-induced Aggregation of Gold Nanoparticles, Analyst, 2011, 137, 82-86. [Front cover feature article]
- A.L. Gui, G. Liu, M. Chockalingam, G.L. Saux, J.B. Harper, J.J. Gooding. A Comparative Study of Modifying Gold and Carbon Electrode with 4-nitrophenyl Diazonium Salt. Electroanalysis, 2010, 22(16), 1824-1830.
- A.L. Gui, G. Liu, M. Chockalingam, G.L. Saux, J.B. Harper, J.J. Gooding. A Comparative Study of Modifying Gold and Carbon Electrode with 4-sulfophenyl Diazonium Salt. Electroanalysis, 2010, 22(12), 1283-1289.
- G. Liu, M. Chockalingham, S.M. Khor, A.L. Gui, J.J. Gooding. A Comparative Study of the Modification Gold and Glassy Carbon Surfaces with Mixed Layers of In situ Generated Aryl Diazonium Compounds. Electroanalysis, 2010, 22(9), 918-926
- G. Liu, C.E. Conn, L. Waddington, S.T. Mudie, C.J. Drummond. Colloidal Amphiphiles Self-Assembly Particles Comprised of Gadolinium Oleate and Myverol: Evaluation as Contrast Agents for Magnetic Resonance Imaging. Langmuir, 2009, 26(4), 2383-2391.
- G. Liu, C.E. Conn, C.J. Drummond. Lanthanide Metal Oleates: Chelation, Self-Assembly and Exemplification of ordered Nanostructured Colloidal Contrast Agents for Medical Imaging. J. Phys. Chem. B, 2009, 113(49), 15949-15959.
- G. Liu, J.J. Gooding. Towards the Fabrication of Label-free Amperometric Immunosensors Using SWNTs. Electrochem. Commun., 2009, 11: 1982-1985.
- G. Liu, M.N. Paddon-Row, J.J. Gooding. Protein Modulation of Electrochemical Signals: Application to Immunobiosensing. Chem. Commun., 2008, 3870-3872.
- C. Fairman, S.S.C. Yu, G. Liu, A.J. Downard, B.D. Hibbert, J.J. Gooding. Exploration of Variables in the Fabrication of Pyrolysed Photoresist. J. Solid State Electrochem., 2008, 12(10): 1357-1365.
- G. Liu, M.N. Paddon-Row, J.J. Gooding. Molecular Wire Modified Glassy Carbon Electrode for Achieving Direct Electron Transfer to Native Glucose Oxidase.Electrochem. Commun., 2007, 9(9): 2218-2223.
- G. Liu, T. Böcking, J.J. Gooding. Diazonium salts: Stable Monolayers on Gold Electrodes for Sensing Applications. J. Electroanal. Chem., 2007, 600(2):335-344.
- G. Liu, J.J. Gooding. An Electrochemical Interface Comprising Molecular Wires and Poly(ethylene glycol) Spacer Units Self-Assembled on Carbon Electrodes for Studies of Protein Electrochemistry. Langmuir, 2006, 22(17):7421-7430.
- G. Liu, Q.T. Nguyen, E. Chow, T. Bocking, D.B. Hibbert, J.J. Gooding. Study of Factors Affecting the Performance of Voltammetric Copper Sensors based on Gly-Gly-His Modified Glassy Carbon and Gold Electrodes. Electroanalysis, 2006 18(12): 1141-1151.
- G. Liu, J. Liu, T. Böcking, P.K. Eggers, .J.J. Gooding. The Modification of Glassy Carbon and Gold Electrodes with Aryl Diazonium Salt: The Impact of the Electrode Materials on the Rate of Heterogeneous Electron Transfer. Chem. Phys., 2005, 319: 136-146.
Scholarly Book Chapters
- J.J. Gooding, G. Liu, A.L. Gui. Book chapter 9: The Use of Aryl Diazonium Salts in the Fabrication of Biosensors and Chemical Sensors, in book Aryl Diazonium Salts: New Coupling Agents and Surface Science 2012, Wiley publisher, p.197-218
Research in Media Coverage:
We are looking for highly motivated postgraduate students pursuing PhD, Master or Honours degree to join the research team. We also welcome the postdoctoral researchers and visiting scholars to explore the opportunities. Once joining our team, the candidates will be colloborating with the research groups of Prof Ewa Goldys (Biophotonics), Prof Nigel Lovell (Biomedical electronics), and Prof Mark Hutchinson (Neuroscience). If you are interested in joining us, please email Dr Guozhen Liu (firstname.lastname@example.org) with your CV.
Postgraduate Scholarship Opportunities
- Domestic Research Scholarship: https://research.unsw.edu.au/domestic-research-scholarships
- International Research Scholarship: https://research.unsw.edu.au/international-research-scholarships
- International Joint Scholarship: https://research.unsw.edu.au/unsw-home-country-joint-scholarships
- UNSW-China Scholarship Council (CSC) Joint Scholarship program. For more details, visit https://research.unsw.edu.au/unsw-home-country-joint-scholarships. To apply CSC, visit http://www.csc.edu.cn/chuguo.
- For excellent candidates, the top-up scholarship (7k pa) will be provided.
Postdoctoral Fellowship Opportunities