Select Publications

Book Chapters

Yik JJ; Crossley M; Quinlan KGR, 2018, 'Genome editing of erythroid cell culture model systems', in Erythropoiesis methods and protocols, Springer, pp. 245 - 257,

Journal articles

Knights AJ; Vohralik EJ; Houweling PJ; Stout ES; Norton LJ; Alexopoulos SJ; Yik JJ; Mat Jusoh H; Olzomer EM; Bell-Anderson KS; North KN; Hoehn KL; Crossley M; Quinlan KGR, 2020, 'Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)', Nature Communications, vol. 11, pp. 2922,

Yang L; Chen Z; Stout ES; Delerue F; Ittner LM; Wilkins MR; Quinlan KGR; Crossley M, 2020, 'Methylation of a CGATA element inhibits binding and regulation by GATA-1', Nature Communications, vol. 11, pp. 2560,

Vohralik EJ; Psaila AM; Knights AJ; Quinlan KGR, 2020, 'EoTHINophils: Eosinophils as key players in adipose tissue homeostasis', Clinical and Experimental Pharmacology and Physiology, vol. 47, pp. 1495 - 1505,

Knights AJ; Yang L; Shah M; Norton LJ; Green GS; Stout ES; Vohralik EJ; Crossley M; Quinlan KGR, 2020, 'Krüppel-like factor 3 (klf3) suppresses nf-b-driven inflammation in mice', Journal of Biological Chemistry, vol. 295, pp. 608 - 6091,

Byrne FL; Olzomer EM; Marriott GR; Quek LE; Katen A; Su J; Nelson ME; Hart-Smith G; Larance M; Sebesfi VF; Cuff J; Martyn GE; Childress E; Alexopoulos SJ; Poon IK; Faux MC; Burgess AW; Reid G; McCarroll JA; Santos WL; Quinlan KG; Turner N; Fazakerley DJ; Kumar N; Hoehn KL, 2020, 'Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress', Redox Biology, vol. 28, pp. 101374 - 101374,

Shah M; Funnell APW; Quinlan KGR; Crossley M, 2019, 'Hit and Run Transcriptional Repressors Are Difficult to Catch in the Act', BioEssays, vol. 41, pp. e1900041,

Martyn GE; Wienert B; Kurita R; Nakamura Y; Quinlan KGR; Crossley M, 2019, 'A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site', Blood, vol. 133, pp. 852 - 856,

Caruana BT; Byrne FL; Knights AJ; Quinlan KGR; Hoehn KL, 2019, 'Characterization of glucose transporter 6 in lipopolysaccharide-induced bone marrow-derived macrophage function', Journal of Immunology, vol. 202, pp. 1826 - 1832,

Artuz CM; Knights AJ; Funnell APW; Gonda TJ; Ravid K; Pearson RCM; Quinlan KGR; Crossley M, 2018, 'Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules', Biotechnology Reports, vol. 20,

Wienert B; Martyn GE; Funnell APW; Quinlan KGR; Crossley M, 2018, 'Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies', Trends in Genetics, vol. 34, pp. 927 - 940,

Knights AJ; Vohralik EJ; Hoehn KL; Crossley M; Quinlan KGR, 2018, 'Defining Eosinophil Function in Adiposity and Weight Loss', BioEssays, vol. 40,

Martyn GE; Wienert B; Yang L; Shah M; Norton LJ; Burdach J; Kurita R; Nakamura Y; Pearson RCM; Funnell APW; Quinlan KGR; Crossley M, 2018, 'Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding', Nature Genetics, vol. 50, pp. 498 - 503,

Summers MA; Rupasinghe T; Vasiljevski ER; Evesson FJ; Mikulec K; Peacock L; Quinlan KGR; Cooper ST; Roessner U; Stevenson DA; Little DG; Schindeler A, 2018, 'Dietary intervention rescues myopathy associated with neurofibromatosis type 1', Human Molecular Genetics, vol. 27, pp. 577 - 588,

Norton LJ; Hallal S; Stout ES; Funnell APW; Pearson RCM; Crossley M; Quinlan KGR, 2017, 'Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch', Scientific Reports, vol. 7,

Hamey JJ; Wienert B; Quinlan KGR; Wilkins MR, 2017, 'METTL21B Is a Novel Human lysine methyltransferase of translation elongation factor 1A: Discovery by CRISPR/Cas9 Knockout', Molecular and Cellular Proteomics, vol. 16, pp. 2229 - 2242,

Wienert B; Martyn GE; Kurita R; Nakamura Y; Quinlan KGR; Crossley M, 2017, 'KLF1 drives the expression of fetal hemoglobin in British HPFH', Blood, vol. 130, pp. 803 - 807,

Baldwin JN; McKay MJ; Simic M; Hiller CE; Moloney N; Nightngale EJ; Burns J; 1000 Norms Project Consortium ; Huebscher M, 2017, 'Self-reported knee pain and disability among healthy individuals: reference data and factors associated with the Knee injury and Osteoarthritis Outcome Score (KOOS) and KOOS-Child', Osteoarthritis and Cartilage, vol. 25, pp. 1282 - 1290,

Houweling PJ; Berman YD; Turner N; Quinlan KGR; Seto JT; Yang N; Lek M; MacArthur DG; Cooney G; North KN, 2017, 'Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans', International Journal of Obesity, vol. 41, pp. 1154 - 1157,

Martyn GE; Quinlan KGR; Crossley M, 2017, 'The regulation of human globin promoters by CCAAT box elements and the recruitment of NF-Y', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1860, pp. 525 - 536,

Norton LJ; Funnell APW; Burdach J; Wienert B; Kurita R; Nakamura Y; Philipsen S; Pearson RCM; Quinlan KGR; Crossley M, 2017, 'KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells', Blood Advances, vol. 1, pp. 685 - 692,

McKay MJ; Baldwin JN; Ferreira P; Simic M; Vanicek N; Burns J; Nightingale E; Pourkazemi F; Sman A; Hiller C; Mousavi S; Nicholson L; Rose K; Chard A; Mackey M; Moloney N; Raymond J; Yan AF; Hübscher M; Refshauge K; Wegener C; Lee F; North K; Quinlan K, 2017, 'Reference values for developing responsive functional outcome measures across the lifespan', Neurology, vol. 88, pp. 1512 - 1519,

McKay MJ; Baldwin JN; Ferreira P; Simic M; Vanicek N; Burns J; Nightingale E; Pourkazemi F; Sman A; Hiller C; Mousavi S; Nicholson L; Rose K; Chard A; Mackey M; Moloney N; Raymond J; Yan AF; Hübscher M; Refshauge K; Wegener C; Lee F; North K; Quinlan K, 2017, 'Normative reference values for strength and flexibility of 1,000 children and adults', Neurology, vol. 88, pp. 36 - 43,

Baldwin JN; McKay MJ; Hiller CE; Nightingale EJ; Moloney N; Burns J; Baldwin J; Chard A; Ferreira P; Yan AF; Hawke F; Lee (née Zheng) F; Mackey M; Mousavi S; Nicholson L; Pourkazemi F; Raymond J; Rose K; Simic M; Sman A; Wegener C; Refshauge KM; Hübscher M; Vanicek N; Quinlan K; North K, 2017, 'Correlates of Perceived Ankle Instability in Healthy Individuals Aged 8 to 101 Years', Archives of Physical Medicine and Rehabilitation, vol. 98, pp. 72 - 79,

Knights AJ; Yik JJ; Jusoh HM; Norton LJ; Funnell APW; Pearson RCM; Bell-Anderson KS; Crossley M; Quinlan KGR, 2016, 'Krüppel-like factor 3 (KLF3/BKLF) is required for widespread repression of the inflammatory modulator galectin-3 (Lgals3)', Journal of Biological Chemistry, vol. 291, pp. 16048 - 16058,

Lee FXZ; Houweling PJ; North KN; Quinlan KGR, 2016, 'How does α-actinin-3 deficiency alter muscle function? Mechanistic insights into ACTN3, the 'gene for speed'', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1863, pp. 686 - 693,

McKay MJ; Baldwin JN; Ferreira P; Simic M; Vanicek N; Hiller CE; Nightingale EJ; Moloney NA; Quinlan KG; Pourkazemi F; Sman AD; Nicholson LL; Mousavi SJ; Rose K; Raymond J; Mackey MG; Chard A; Hübscher M; Wegener C; Fong Yan A; Refshauge KM; Burns J, 2016, '1000 Norms Project: Protocol of a cross-sectional study cataloging human variation', Physiotherapy (United Kingdom), vol. 102, pp. 50 - 56,

Hogarth MW; Garton FC; Houweling PJ; Tukiainen T; Lek M; Macarthur DG; Seto JT; Quinlan KGR; Yang N; Head SI; North KN, 2016, 'Analysis of the ACTN3 heterozygous genotype suggests that α-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashion', Human Molecular Genetics, vol. 25, pp. 866 - 877,

Lim WF; Burdach J; Funnell APW; Pearson RCM; Quinlan KGR; Crossley M, 2015, 'Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain', Nucleic Acids Research, vol. 44, pp. 3118 - 3130,

Quinlan KG; Summers MA; Payne JM; Little DG; North KN; Schindeler A, 2015, 'Skeletal muscle and motor deficits in Neurofibromatosis Type 1', J Musculoskelet Neuronal Interact, vol. 15, pp. 161 - 170

Wienert B; Funnell APW; Norton LJ; Pearson RCM; Wilkinson-White LE; Lester K; Vadolas J; Porteus MH; Matthews JM; Quinlan KGR; Crossley M, 2015, 'Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin', Nature Communications, vol. 6, pp. 7085,

Dewi V; Kwok A; Lee S; Lee MM; Tan YM; Nicholas HR; Isono KI; Wienert B; Mak KS; Knights AJ; Quinlan KGR; Cordwell SJ; Funnell APW; Pearson RCM; Crossley M, 2015, 'Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity', Journal of Biological Chemistry, vol. 290, pp. 8591 - 8605,

Head SI; Chan S; Houweling PJ; Quinlan KGR; Murphy R; Wagner S; Friedrich O; North KN, 2015, 'Altered Ca2+ kinetics associated with α-actinin-3 deficiency may explain positive selection for ACTN3 null allele in human evolution', PLoS genetics, vol. 11, pp. e1004862,

Yuen M; Sandaradura SA; Dowling JJ; Kostyukova AS; Moroz N; Quinlan KG; Lehtokari VL; Ravenscroft G; Todd EJ; Ceyhan-Birsoy O; Gokhin DS; Maluenda J; Lek M; Nolent F; Pappas CT; Novak SM; D'Amico A; Malfatti E; Thomas BP; Gabriel SB; Gupta N; Daly MJ; Ilkovski B; Houweling PJ; Davidson AE; Swanson LC; Brownstein CA; Gupta VA; Medne L; Shannon P; Martin N; Bick DP; Flisberg A; Holmberg E; Van Den Bergh P; Lapunzina P; Waddell LB; Sloboda DD; Bertini E; Chitayat D; Telfer WR; Laquerrière A; Gregorio CC; Ottenheijm CAC; Bönnemann CG; Pelin K; Beggs AH; Hayashi YK; Romero NB; Laing NG; Nishino I; Wallgren-Pettersson C; Melki J; Fowler VM; MacArthur DG; North KN; Clarke NF, 2014, 'Leiomodin-dysfunction results in thin filament disorganization and nemaline myopathy', Journal of Clinical Investigation, vol. 124, pp. 4693 - 4708,

Clifton MK; Westman BJ; Thong SY; O'Connell MR; Webster MW; Shepherd NE; Quinlan KG; Crossley M; Blobel GA; Mackay JP, 2014, 'The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins', PLoS ONE, vol. 9,

Funnell APW; Vernimmen D; Lim WF; Mak KS; Wienert B; Martyn GE; Artuz CM; Burdach J; Quinlan KGR; Higgs DR; Whitelaw E; Pearson RCM; Crossley M, 2014, 'Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells', BMC Molecular Biology, vol. 15,

Garton FC; Seto JT; Quinlan KGR; Yang N; Houweling PJ; North KN, 2014, 'α-Actinin-3 deficiency alters muscle adaptation in response to denervation and immobilization', Human molecular genetics, vol. 23, pp. 1879 - 1893,

Sullivan K; El-hoss J; Quinlan KGR; Deo N; Garton F; Seto JTC; Gdalevitch M; Turner N; Cooney GJ; Kolanczyk M; North KN; Little DG; Schindeler A, 2014, 'NF1 is a critical regulator of muscle development and metabolism', Human Molecular Genetics, vol. 23, pp. 1250 - 1259,

Thomas KC; Zheng XF; Suarez FG; Raftery JM; Quinlan KGR; Yang N; North KN; Houweling PJ, 2014, 'Evidence based selection of commonly used RT-qPCR reference genes for the analysis of mouse skeletal muscle', PLoS ONE, vol. 9,

Seto JT; Quinlan KGR; Lek M; Zheng XF; Garton F; Macarthur DG; Hogarth MW; Houweling PJ; Gregorevic P; Turner N; Cooney GJ; Yang N; North KN, 2013, 'ACTN3 genotype infuences muscle performance through the regulation of calcineurin signaling', Journal of Clinical Investigation, vol. 123, pp. 4255 - 4263,

Yang S; Schneider D; Mcdonald M; Setoh JWS; Houweling PJ; Lek M; Hograth P; Morse A; Raftery J; Balasuriya H; MacArthur D; Eisman JA; Berman Y; Quinlan K; Center JR; Nguyen TV; Prince R; Wilson S; Zhu S; Little S; North A, 2011, '&-Actinin-3 deficiency is associated with reducted bone mass in human and mouse', Bone, vol. 49, pp. 790 - 798,

Seto JT; Lek M; Quinlan KG; Houweling PJ; Zheng XF; Garton F; MacArthur DG; Raftery JM; Garvey SM; Hauser MA; Yang N; Head SI; North K, 2011, 'Deficiency of alpha-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling', Human Molecular Genetics, vol. 20, pp. 2914 - 2927,

Seto JT; Chan SM; Turner N; MacArthur D; Raftery J; Berman Y; Quinlan KG; Cooney GJ; Head SI; Yang N; North K, 2011, 'The effect of alpha-actinin-3 deficiency on muscle aging', Experimental Gerontology, vol. 46, pp. 292 - 302,

Nunez N; Clifton MM; Funnell AP; Artuz CM; Hallal S; Quinlan KG; Font J; Vandevenne M; Setiyaputra S; Pearson RC; Mackay JP; Crossley M, 2011, 'The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain', The Journal of Biological Chemistry, vol. 286, pp. 38190 - 38201,

Lek M; Quinlan KGR; North KN, 2010, 'The evolution of skeletal muscle performance: Gene duplication and divergence of human sarcomeric α-actinins', BioEssays, vol. 32, pp. 17 - 25,

Quinlan K; Seto JT; Turner N; Vandebrouck A; Floetenmeyer M; MacArthur D; Raftery J; Lek M; Yang N; Parton RG; Cooney GJ; North K, 2010, 'Alpha-actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle', Human Molecular Genetics, vol. 19, pp. 1335 - 1346,

MacArthur DG; Seto JT; Chan S; Quinlan KG; Raftery JM; Turner N; Nicholson MD; Kee AJ; Hardeman EC; Gunning PW; Cooney GJ; Head SI; Yang N; North KN, 2008, 'An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance', Human Molecular Genetics, vol. 17, pp. 1076 - 1086,

Quinlan KG; Verger A; Yaswen P; Crossley M, 2007, 'Amplification of zinc finger gene 217 (ZNF217) and cancer: When good fingers go bad', Biochimica et Biophysica ACTA - Reviews on Cancer, vol. 1775, pp. 333 - 340,

MacArthur DG; Seto JT; Raftery JM; Quinlan KG; Huttley GA; Hook JW; Lemckert FA; Kee AJ; Edwards MR; Berman Y; Hardeman EC; Gunning PW; Easteal S; Yang N; North KN, 2007, 'Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans', Nature Genetics, vol. 39, pp. 1261 - 1265,

Stankovic-valentin N; Verger A; Deltour-valerdi S; Quinlan KG; Crossley M; Leprince D, 2006, 'A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP', FEBS Journal, vol. 273, pp. 2879 - 2890,

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