Select Publications

Book Chapters

Khoo S; McNally G; Clemens K, 2019, 'The orexin system and nicotine addiction: Preclinical insights', in Preedy VR (ed.), Neuroscience of nicotine Mechanisms and treatment, Academic Press, pp. 509 - 517, http://dx.doi.org/10.1016/B978-0-12-813035-3.00061-7

McKetin R; Clemens KJ; Kaye SS, 2013, ', Methamphetamine addiction', in Miller PM (ed.), Principles of Addiction, Academic Press

McKetin R; Kaye SS; Clemens KJ; Hermens D, 2013, 'Methamphetamine addiction', in Miller PM (ed.), Principles of addiction: comprehensive addictive behaviors and disorders, Academic Press, San Diego, CA, pp. 689 - 698, http://dx.doi.org/10.1016/B978-0-12-398336-7.00070-X

Caille S; Clemens K; Stinus L; Cador M, 2012, 'Modeling nicotine addiction in rats', in Methods in Molecular Biology, pp. 243 - 256, http://dx.doi.org/10.1007/978-1-61779-458-2_15

Journal articles

Clemens KJ; Stuart A; Ferguson SG, 2019, 'Pre-quit nicotine decreases nicotine self-administration and attenuates cue- and drug-induced reinstatement', Journal of Psychopharmacology, vol. 33, pp. 364 - 371, http://dx.doi.org/10.1177/0269881118822074

Kyme AZ; Angelis GI; Eisenhuth J; Fulton RR; Zhou V; Hart G; Popovic K; Akhtar M; Ryder WJ; Clemens KJ; Balleine BW; Parmar A; Pascali G; Perkins G; Meikle SR, 2019, 'Open-field PET: Simultaneous brain functional imaging and behavioural response measurements in freely moving small animals', NeuroImage, vol. 188, pp. 92 - 101, http://dx.doi.org/10.1016/j.neuroimage.2018.11.051

Holmes NM; Pan J; Davis A; Panayi MC; Clemens KJ, 2019, 'Rats choose high doses of nicotine in order to compensate for changes in its price and availability', Addiction Biology, vol. 24, pp. 849 - 859, http://dx.doi.org/10.1111/adb.12637

Clemens KJ; Holmes NM, 2018, 'An extended history of drug self-administration results in multiple sources of control over drug seeking behavior', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 87, pp. 48 - 55, http://dx.doi.org/10.1016/j.pnpbp.2017.11.011

Castino MR; Baker-Andresen D; Ratnu VS; Shevchenko G; Morris KV; Bredy TW; Youngson NA; Clemens KJ, 2018, 'Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats', Genes, Brain and Behavior, vol. 17, pp. 98 - 106, http://dx.doi.org/10.1111/gbb.12421

Khoo SYS; Clemens KJ; McNally GP, 2018, 'Palatable food self-administration and reinstatement are not affected by dual orexin receptor antagonism', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 87, pp. 147 - 157, http://dx.doi.org/10.1016/j.pnpbp.2017.06.028

Khoo SY; McNally GP; Clemens KJ, 2017, 'The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking', PLoS One, vol. 12, pp. e0173967 - e0173967, http://dx.doi.org/10.1371/journal.pone.0173967

Clemens KJ; Lay BPP; Holmes NM, 2017, 'Extended nicotine self-administration increases sensitivity to nicotine, motivation to seek nicotine and the reinforcing properties of nicotine-paired cues.', Addiction Biology, vol. 22, pp. 400 - 410, http://dx.doi.org/10.1111/adb.12336

Huynh C; Fam J; Ahmed SH; Clemens KJ, 2017, 'Rats quit nicotine for a sweet reward following an extensive history of nicotine use', Addiction Biology, vol. 22, pp. 142 - 151, http://dx.doi.org/10.1111/adb.12306

Sharpe MJ; Clemens KJ; Morris MJ; Westbrook RF, 2016, 'Daily Exposure to Sucrose Impairs Subsequent Learning About Food Cues: A Role for Alterations in Ghrelin Signaling and Dopamine D2 Receptors', Neuropsychopharmacology, vol. 41, pp. 1357 - 1365, http://dx.doi.org/10.1038/npp.2015.287

Macnamara CL; Holmes NM; Westbrook RF; Clemens KJ, 2016, 'Varenicline impairs extinction and enhances reinstatement across repeated cycles of nicotine self-administration in rats', Neuropharmacology, vol. 105, pp. 463 - 470, http://dx.doi.org/10.1016/j.neuropharm.2016.02.023

Castino MR; Cornish JL; Clemens KJ, 2015, 'Inhibition of histone deacetylases facilitates extinction and attenuates reinstatement of nicotine self-administration in rats', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0124796

Clemens KJ; Castino MR; Cornish JL; Goodchild AK; Holmes NM, 2014, 'Behavioral and Neural Substrates of Habit Formation in Rats Intravenously Self-Administering Nicotine', Neuropsychopharmacology, vol. 39, pp. 2584 - 2593, http://dx.doi.org/10.1038/npp.2014.111

Clemens KJ; Castino MR; Cornish JL; Goodchild AK; Holmes NM, 2014, 'Behavioral and Neural Substrates of Habit Formation in Rats Intravenously Self-Administering Nicotine', Neuropsychopharmacology, http://dx.doi.org/10.1038/npp.2014.111

Castino M; Cornish J; Goodchild A; Clemens K, 2013, 'THE ROLE OF HISTONE ACETYLATION IN THE ACQUISITION, EXTINCTION AND REINSTATEMENT OF NICOTINE SELF-ADMINISTRATION IN RATS', BEHAVIOURAL PHARMACOLOGY, vol. 24, pp. E50 - E50, http://dx.doi.org/10.1097/01.fbp.0000434849.25290.97

Motbey CP; Clemens KJ; Apetz N; Winstock AR; Ramsey J; Li KM; Wyatt N; Callaghan PD; Bowen MT; Cornish JL; McGregor IS, 2013, 'High levels of intravenous mephedrone (4-methylmethcathinone) self-administration in rats: Neural consequences and comparison with methamphetamine', Journal of Psychopharmacology, vol. 27, pp. 823 - 836, http://dx.doi.org/10.1177/0269881113490325

Pardey MC; Kumar NN; Goodchild AK; Clemens KJ; Homewood J; Cornish JL, 2012, 'Long-term effects of chronic oral ritalin administration on cognitive and neural development in adolescent Wistar Kyoto rats', Brain Sciences, vol. 2, pp. 375 - 404, http://dx.doi.org/10.3390/brainsci2030375

Holmes N; Clemens KJ, 2011, 'Multiple interpretations of cocaine-seeking behaviour after prolonged self-administration training.', Journal of Neuroscience, vol. 31, pp. 3935 - 3936, http://dx.doi.org/10.1523/JNEUROSCI.6354-10.2011

Clemens KJ; Caillé S; Cador M, 2010, 'The effects of response operandum and prior food training on intravenous Nicotine self-administration in rats', Psychopharmacology, vol. 211, pp. 43 - 54, http://dx.doi.org/10.1007/s00213-010-1866-z

Vendruscolo LF; Gueye AB; Vendruscolo JCM; Clemens KJ; Mormède P; Darnaudéry M; Cador M, 2010, 'Reduced alcohol drinking in adult rats exposed to sucrose during adolescence', Neuropharmacology, vol. 59, pp. 388 - 394, http://dx.doi.org/10.1016/j.neuropharm.2010.05.015

Clemens KJ; Caillé S; Stinus L; Cador M, 2009, 'The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats', International Journal of Neuropsychopharmacology, vol. 12, pp. 1355 - 1366, http://dx.doi.org/10.1017/S1461145709000273

Hamlin AS; Mcnally GP; Choi EA; Clemens KJ, 2009, 'Paraventricular thalamus mediates context-induced reinstatement (renewal) of extinguished reward seeking', European Journal of Neuroscience, vol. 29, pp. 802 - 812, http://dx.doi.org/10.1111/j.1460-9568.2009.06623.x

Cornish JL; Clemens KJ; Thompson MR; Callaghan PD; Dawson B; McGregor IS, 2008, 'High ambient temperature increases intravenous methamphetamine self-administration on fixed and progressive ratio schedules in rats', Journal of Psychopharmacology, vol. 22, pp. 100 - 110, http://dx.doi.org/10.1177/0269881107082286

Clemens KJ; Vendruscolo LF, 2008, 'Anxious to drink: Gabapentin normalizes GABAergic transmission in the central amygdala and reduces symptoms of ethanol dependence', Journal of Neuroscience, vol. 28, pp. 9087 - 9089, http://dx.doi.org/10.1523/JNEUROSCI.2928-08.2008

Hamlin AS; Clemens KJ; Mcnally GP, 2008, 'Renewal of extinguished cocaine-seeking', Neuroscience, vol. 151, pp. 659 - 670, http://dx.doi.org/10.1016/j.neuroscience.2007.11.018

Clemens KJ; Cornish JL; Hunt GE; McGregor IS, 2007, 'Repeated weekly exposure to MDMA, methamphetamine or their combination: Long-term behavioural and neurochemical effects in rats', Drug and Alcohol Dependence, vol. 86, pp. 183 - 190, http://dx.doi.org/10.1016/j.drugalcdep.2006.06.004

Clemens KJ; McGregor IS; Hunt GE; Cornish JL, 2007, 'MDMA, methamphetamine and their combination: Possible lessons for party drug users from recent preclinical research', Drug and Alcohol Review, vol. 26, pp. 9 - 15, http://dx.doi.org/10.1080/09595230601036945

Clemens KJ; Cornish JL; Hunt GE; McGregor IS, 2006, 'Intravenous methamphetamine self-administration in rats: Effects of intravenous or intraperitoneal MDMA co-administration', Pharmacology Biochemistry and Behavior, vol. 85, pp. 454 - 463, http://dx.doi.org/10.1016/j.pbb.2006.09.015

McGregor I; Clemens K; Cornish J; Thompson M; Li K; Hunt G, 2005, 'MDMA, methamphetamine and their combination: Comparison of long-term behavioural and neural effects in rats', BEHAVIOURAL PHARMACOLOGY, vol. 16, pp. S11 - S11, http://dx.doi.org/10.1097/00008877-200509001-00033

Cornish JL; Lontos JM; Clemens KJ; McGregor IS, 2005, 'Cocaine and heroin ('speedball') self-administration: The involvement of nucleus accumbens dopamine and μ-opiate, but not δ-opiate receptors', Psychopharmacology, vol. 180, pp. 21 - 32, http://dx.doi.org/10.1007/s00213-004-2135-9

Clemens KJ; Cornish JL; Li KM; Hunt GE; McGregor IS, 2005, 'MDMA ('Ecstasy') and methamphetamine combined: Order of administration influences hyperthermic and long-term adverse effects in female rats', Neuropharmacology, vol. 49, pp. 195 - 207, http://dx.doi.org/10.1016/j.neuropharm.2005.03.002

Thompson MR; Li KN; Clemens KJ; Gurtman CG; Hunt GE; Cornish JL; McGregor IS, 2004, 'Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats', Neuropsychopharmacology, vol. 29, pp. 694 - 704, http://dx.doi.org/10.1038/sj.npp.1300347

Clemens KJ; Van Nieuwenhuyzen PS; Li KM; Cornish JL; Hunt GE; McGregor IS, 2004, 'MDMA ("ecstacy"), methamphetamine and their combination: Long-term changes in social interaction and neurochemistry in the rat', Psychopharmacology, vol. 173, pp. 318 - 325, http://dx.doi.org/10.1007/s00213-004-1786-x

McGregor IS; Clemens KJ; Van Der Plasse G; Li KM; Hunt GE; Chen F; Lawrence AJ, 2003, 'Increased anxiety 3 months after brief exposure to MDMA ('Ecstasy') in rats: Association with altered 5-HT transporter and receptor density', Neuropsychopharmacology, vol. 28, pp. 1472 - 1484, http://dx.doi.org/10.1038/sj.npp.1300185

McGregor IS; Gurtman CG; Morley KC; Clemens KJ; Blokland A; Li KM; Cornish JL; Hunt GE, 2003, 'Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: Drug-induced hyperthermia does not predict long-term outcomes', Psychopharmacology, vol. 168, pp. 465 - 474, http://dx.doi.org/10.1007/s00213-003-1452-8

Working Papers

Youngson N; Castino M; Stuart A; Kershaw K; Holmes N; Waters P; Morris K; Clemens K, 2019, A natural antisense to brain-derived neurotrophic factor impairs extinction of drug seeking, http://dx.doi.org10.1101/851949

Conference Abstracts

Khoo SY; McNally GP; Clemens KJ, 2015, 'effect of the dual orexin receptor antagonist TCS1102 on intravenous nicotine self-administration and reinstatement in the rat', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, Vol. 134, pp. 215 - 215, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300525&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Castino M; Youngson N; Baker-Andresen D; Ratnu V; Bredy T; Clemens K, 2015, 'Transcriptional and epigenetic factors underlying the extinction of nicotine-seeking behaviour in the rat', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, Vol. 134, pp. 349 - 349, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300896&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Clemens K; Lay B; Holmes N, 2015, 'The effect of the partial receptor agonist varenicline on responding maintained by nicotine-associated cues', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, Vol. 134, pp. 349 - 350, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300899&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a


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