Select Publications

Journal articles

Walters KA; Rodriguez Paris V; Aflatounian A; Handelsman DJ, 2019, 'Androgens and ovarian function: translation from basic discovery research to clinical impact.', J Endocrinol, http://dx.doi.org/10.1530/JOE-19-0096

Stepto NK; Moreno-Asso A; McIlvenna LC; Walters KA; Rodgers RJ, 2019, 'Molecular Mechanisms of Insulin Resistance in Polycystic Ovary Syndrome. Unraveling the Conundrum in Skeletal Muscle?', J Clin Endocrinol Metab, http://dx.doi.org/10.1210/jc.2019-00167

Burchall GF; Pouniotis DS; Teede HJ; Ranasinha S; Walters KA; Piva TJ, 2019, 'Expression of the plasminogen system in the physiological mouse ovary and in the pathological polycystic ovary syndrome (PCOS) state', Reproductive Biology and Endocrinology, vol. 17, http://dx.doi.org/10.1186/s12958-019-0472-0

Bertoldo MJ; Caldwell AS L; Riepsamen AH; Lin D; Gonzalez MB; Robker RL; Ledger WL; Gilchrist RB; Handelsman DJ; Walters KA, 2019, 'A hyperandrogenic environment causes intrinsic defects that are detrimental to follicular dynamics in a PCOS mouse model', Endocrinology, vol. 160, pp. 699 - 715, http://dx.doi.org/10.1210/en.2018-00966

Walters KA; Eid S; Edwards MC; Thuis-Watson R; Desai R; Bowman M; Marren AJ; Handelsman DJ, 2019, 'Steroid profiles by liquid chromatography-mass spectrometry of matched serum and single dominant ovarian follicular fluid from women undergoing IVF', Reproductive BioMedicine Online, vol. 38, pp. 30 - 37, http://dx.doi.org/10.1016/j.rbmo.2018.10.006

Tarulli GA; Laven-Law G; Shehata M; Walters KA; Denis IM; Rahman MM; Handelsman DJ; Dean NR; Tilley WD; Hickey TE, 2019, 'Androgen Receptor Signalling Promotes a Luminal Phenotype in Mammary Epithelial Cells', Journal of Mammary Gland Biology and Neoplasia, vol. 24, pp. 99 - 108, http://dx.doi.org/10.1007/s10911-018-9406-2

Bertoldo MJ; Uddin GM; Youngson NA; Agapiou D; Walters KA; Sinclair DA; Morris MJ; Gilchrist RB, 2018, 'Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide.', Hum Reprod Open, vol. 2018, pp. hoy010, http://dx.doi.org/10.1093/hropen/hoy010

Upton DH; Walters KA; McTavish KJ; Holt J; Handelsman DJ; Allan CM, 2018, 'Reproductive failure in mice expressing transgenic follicle-stimulating hormone is not caused by loss of oocyte quality', Biology of Reproduction, vol. 98, pp. 491 - 500, http://dx.doi.org/10.1093/biolre/ioy015

Walters KA; Gilchrist RB; Ledger WL; Teede HJ; Handelsman DJ; Campbell RE, 2018, 'New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins', Trends in Endocrinology and Metabolism, vol. 29, pp. 841 - 852, http://dx.doi.org/10.1016/j.tem.2018.08.005

Walters KA; Edwards MC; Tesic D; Caldwell AS L; Jimenez M; Smith JT; Handelsman DJ, 2018, 'The Role of Central Androgen Receptor Actions in Regulating the Hypothalamic-Pituitary-Ovarian Axis', Neuroendocrinology, vol. 106, pp. 389 - 400, http://dx.doi.org/10.1159/000487762

Walters KA; Bertoldo MJ; Handelsman DJ, 2018, 'Evidence from animal models on the pathogenesis of PCOS', Best Practice and Research: Clinical Endocrinology and Metabolism, vol. 32, pp. 271 - 281, http://dx.doi.org/10.1016/j.beem.2018.03.008

Bertoldo MJ; Walters KA; Ledger WL; Gilchrist RB; Mermillod P; Locatelli Y, 2018, 'In-vitro regulation of primordial follicle activation: challenges for fertility preservation strategies', Reproductive BioMedicine Online, vol. 36, pp. 491 - 499, http://dx.doi.org/10.1016/j.rbmo.2018.01.014

Walters KA; Handelsman DJ, 2018, 'Role of androgens in the ovary', Molecular and Cellular Endocrinology, vol. 465, pp. 36 - 47, http://dx.doi.org/10.1016/j.mce.2017.06.026

Camlin NJ; Jarnicki AG; Vanders RL; Walters KA; Hansbro PM; McLaughlin EA; Holt JE, 2017, 'Grandmaternal smoke exposure reduces female fertility in a murine model, with great-grandmaternal smoke exposure unlikely to have an effect', Human Reproduction, vol. 32, pp. 1270 - 1281, http://dx.doi.org/10.1093/humrep/dex073

Rodgers RJ; Reid GD; Koch J; Deans R; Ledger WL; Friedlander M; Gilchrist RB; Walters KA; Abbott JA, 2017, 'The safety and efficacy of controlled ovarian hyperstimulation for fertility preservation in women with early breast cancer: A systematic review', Human Reproduction, vol. 32, pp. 1033 - 1045, http://dx.doi.org/10.1093/humrep/dex027

Caldwell AS L; Edwards MC; Desai R; Jimenez M; Gilchrist RB; Handelsman DJ; Walters KA, 2017, 'Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, pp. E3334 - E3343, http://dx.doi.org/10.1073/pnas.1616467114

Walters KA; Edwards MC; Jimenez M; Handelsman DJ; Allan CM, 2017, 'Subfertility in androgen-insensitive female mice is rescued by transgenic FSH', Reproduction, Fertility and Development, vol. 29, pp. 1426 - 1426, http://dx.doi.org/10.1071/rd16022

Solon-Biet SM; Cogger VC; Pulpitel T; Heblinski M; Wahl D; McMahon AC; Warren A; Durrant-Whyte J; Walters KA; Krycer JR; Ponton F; Gokarn R; Wali JA; Ruohonen K; Conigrave AD; James DE; Raubenheimer D; Morrison CD; Le Couteur DG; Simpson SJ, 2016, 'Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework', Cell Metabolism, vol. 24, pp. 555 - 565, http://dx.doi.org/10.1016/j.cmet.2016.09.001

Walters KA; Simanainen U; Gibson DA, 2016, 'Androgen action in female reproductive physiology', Current Opinion in Endocrinology, Diabetes and Obesity, vol. 23, pp. 291 - 296, http://dx.doi.org/10.1097/MED.0000000000000246

Walters KA, 2016, 'Androgens in polycystic ovary syndrome: Lessons from experimental models', Current Opinion in Endocrinology, Diabetes and Obesity, vol. 23, pp. 257 - 263, http://dx.doi.org/10.1097/MED.0000000000000245

Walters KA; Handelsman DJ, 2016, 'Androgen receptor splice variants and polycystic ovary syndrome: Cause or effect?', Asian Journal of Andrology, vol. 18, pp. 442 - 443, http://dx.doi.org/10.4103/1008-682X.161600

Upton DH; Walters KA; Allavena RE; Jimenez M; Desai R; Handelsman DJ; Allan CM, 2016, 'Global or Granulosa Cell-Specific Pten Mutations in Combination with Elevated FSH Levels Fail to Cause Ovarian Tumours in Mice', Hormones and Cancer, vol. 7, pp. 316 - 326, http://dx.doi.org/10.1007/s12672-016-0272-3

Wang X; Gook DA; Walters KA; Anazodo A; Ledger WL; Gilchrist RB, 2016, 'Improving fertility preservation for girls and women by coupling oocyte in vitro maturation with existing strategies', Women's Health, vol. 12, pp. 275 - 278, http://dx.doi.org/10.2217/whe-2016-0019

Handelsman DJ; Jimenez M; Singh GK S; Spaliviero J; Desai R; Walters KA, 2015, 'Measurement of testosterone by immunoassays and mass spectrometry in mouse serum, testicular, and ovarian extracts', Endocrinology, vol. 156, pp. 400 - 405, http://dx.doi.org/10.1210/en.2014-1664

Caldwell AS L; Eid S; Kay CR; Jimenez M; McMahon AC; Desai R; Allan CM; Smith JT; Handelsman DJ; Walters KA, 2015, 'Haplosufficient genomic androgen receptor signaling is adequate to protect female mice from induction of polycystic ovary syndrome features by prenatal hyperandrogenization', Endocrinology, vol. 156, pp. 1441 - 1452, http://dx.doi.org/10.1210/en.2014-1887

Walters KA, 2015, 'Role of androgens in normal and pathological ovarian function', Reproduction, vol. 149, pp. R193 - R218, http://dx.doi.org/10.1530/REP-14-0517

Upton DH; Fuller ES; Colvin EK; Walters KA; Jimenez M; Desai R; Handelsman DJ; Howell VM; Allan CM, 2015, 'Granulosa Cell-Specific Brca1 Loss Alone or Combined with Trp53 Haploinsufficiency and Transgenic FSH Expression Fails to Induce Ovarian Tumors', Hormones and Cancer, vol. 6, pp. 142 - 152, http://dx.doi.org/10.1007/s12672-015-0222-5

Solon-Biet SM; Walters KA; Simanainen UK; McMahon AC; Ruohonen K; Ballard JW O; Raubenheimer D; Handelsman DJ; Couteur DG L; Simpson SJ, 2015, 'Macronutrient balance, reproductive function, and lifespan in aging mice', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, pp. 3481 - 3486, http://dx.doi.org/10.1073/pnas.1422041112

Caldwell AS L; Middleton LJ; Jimenez M; Desai R; McMahon AC; Allan CM; Handelsman DJ; Walters KA, 2014, 'Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models', Endocrinology, vol. 155, pp. 3146 - 3159, http://dx.doi.org/10.1210/en.2014-1196

Gao YR; Walters KA; Desai R; Zhou H; Handelsman DJ; Simanainen U, 2014, 'Androgen receptor inactivation resulted in acceleration in pubertal mammary gland growth, upregulation of ERα expression, and Wnt/β-catenin signaling in female mice', Endocrinology, vol. 155, pp. 4951 - 4963, http://dx.doi.org/10.1210/en.2014-1226

Cheng XB; Jimenez M; Desai R; Middleton LJ; Joseph SR; Ning G; Allan CM; Smith JT; Handelsman DJ; Walters KA, 2013, 'Characterizing the neuroendocrine and ovarian defects of androgen receptor-knockout female mice', American Journal of Physiology - Endocrinology and Metabolism, vol. 305, http://dx.doi.org/10.1152/ajpendo.00263.2013

Walters KA; Allan CM; Handelsman DJ, 2012, 'Rodent models for human polycystic ovary syndrome', Biology of Reproduction, vol. 86, http://dx.doi.org/10.1095/biolreprod.111.097808

Simanainen U; Gao YR; Walters KA; Watson G; Desai R; Jimenez M; Handelsman DJ, 2012, 'Androgen resistance in female mice increases susceptibility to DMBA-induced mammary tumors', Hormones and Cancer, vol. 3, pp. 113 - 124, http://dx.doi.org/10.1007/s12672-012-0107-9

Walters KA; Middleton LJ; Joseph SR; Hazra R; Jimenez M; Simanainen U; Allan CM; Handelsman DJ, 2012, 'Targeted loss of androgen receptor signaling in murine granulosa cells of preantral and antral follicles causes female subfertility', Biology of Reproduction, vol. 87, http://dx.doi.org/10.1095/biolreprod.112.102012

McNamara KM; Harwood DT; Simanainen U; Walters KA; Jimenez M; Handelsman DJ, 2010, 'Measurement of sex steroids in murine blood and reproductive tissues by liquid chromatography-tandem mass spectrometry', Journal of Steroid Biochemistry and Molecular Biology, vol. 121, pp. 611 - 618, http://dx.doi.org/10.1016/j.jsbmb.2010.02.001

Walters KA; Simanainen U; Handelsman DJ, 2010, 'Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models', Human Reproduction Update, vol. 16, pp. 543 - 558, http://dx.doi.org/10.1093/humupd/dmq003

Walters KA; McTavish KJ; Seneviratne MG; Jimenez M; McMahon AC; Allan CM; Salamonsen LA; Handelsman DJ, 2009, 'Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function', Endocrinology, vol. 150, pp. 3274 - 3282, http://dx.doi.org/10.1210/en.2008-1750

Walters KA; Allan CM; Handelsman DJ, 2008, 'Androgen actions and the ovary', Biology of Reproduction, vol. 78, pp. 380 - 389, http://dx.doi.org/10.1095/biolreprod.107.064089

McTavish KJ; Jimenez M; Walters KA; Spaliviero J; Groome NP; Themmen AP; Visser JA; Handelsman DJ; Allan CM, 2007, 'Rising follicle-stimulating hormone levels with age accelerate female reproductive failure', Endocrinology, vol. 148, pp. 4432 - 4439, http://dx.doi.org/10.1210/en.2007-0046

Walters KA; Allan CM; Jimenez M; Lim PR; Davey RA; Zajac JD; Illingworth P; Handelsman DJ, 2007, 'Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fer', Endocrinology, vol. 148, pp. 3674 - 3684, http://dx.doi.org/10.1210/en.2007-0248

Walters KA; Armstrong DG; Telfer EE, 2007, 'Bovine mural granulosa cells, and not the oocyte, are the major source of proteases capable of IGFBP-2 degradation', Animal Reproduction Science, vol. 98, pp. 365 - 370, http://dx.doi.org/10.1016/j.anireprosci.2006.04.047

Walters KA; Binnie JP; Campbell BK; Armstrong DG; Telfer EE, 2006, 'The effects of IGF-I on bovine follicle development and IGFBP-2 expression are dose and stage dependent', Reproduction, vol. 131, pp. 515 - 523, http://dx.doi.org/10.1530/rep.1.00682

Thomas FH; Walters KA; Telfer EE, 2003, 'How to make a good oocyte: An update on in-vitro models to study follicle regulation', Human Reproduction Update, vol. 9, pp. 541 - 555, http://dx.doi.org/10.1093/humupd/dmg042


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