By Dr Laura Jane Sharpe

Journal articles

Fenton NM; Qian L; Paine EG; Sharpe LJ; Brown AJ, 2024, 'A paREDOX in the control of cholesterol biosynthesis: Does the NADPH sensor and E3 ubiquitin ligase MARCHF6 protect mammalian cells during oxidative stress by controlling sterol biosynthesis?', BioEssays, 46, http://dx.doi.org/10.1002/bies.202400073

Fenton NM; Qian L; Scott NA; Paine EG; Sharpe LJ; Brown AJ, 2024, 'SC5D is the sixth enzyme in cholesterol biosynthesis targeted by the E3 ubiquitin ligase MARCHF6', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1869, http://dx.doi.org/10.1016/j.bbalip.2024.159482

Qian L; Scott NA; Capell-Hattam IM; Draper EA; Fenton NM; Luu W; Sharpe LJ; Brown AJ, 2023, 'Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6', Journal of Lipid Research, 64, http://dx.doi.org/10.1016/j.jlr.2023.100362

Fenton NM; Nguyen TB; Sharpe LJ; Brown AJ, 2023, 'Refining sugar's involvement in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868, http://dx.doi.org/10.1016/j.bbalip.2022.159266

Qian L; Sharpe LJ; Gokool A; Voineagu I; Brown AJ, 2023, 'Controlling an E3 ligase and its substrate: A function for MARCHF6 circRNA', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868, http://dx.doi.org/10.1016/j.bbalip.2022.159237

Capell-Hattam IM; Fenton NM; Coates HW; Sharpe LJ; Brown AJ, 2022, 'The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally', Journal of Lipid Research, 63, http://dx.doi.org/10.1016/j.jlr.2022.100295

Yang A; Alrosan AZ; Sharpe LJ; Brown AJ; Callaghan R; Gelissen IC, 2022, 'Corrigendum to “Regulation of ABCG4 transporter expression by sterols and LXR ligands” [PMID: 33141061, DOI: 10.1016/j.bbagen.2020.129769] (BBA - General Subjects (2021) 1865(1), (S0304416520302804), (10.1016/j.bbagen.2020.129769))', Biochimica et Biophysica Acta - General Subjects, 1866, http://dx.doi.org/10.1016/j.bbagen.2022.130169

Brown AJ; Sharpe LJ; Rogers MJ, 2021, 'Oxysterols: From physiological tuners to pharmacological opportunities', British Journal of Pharmacology, 178, pp. 3089 - 3103, http://dx.doi.org/10.1111/bph.15073

Yang A; Alrosan AZ; Sharpe LJ; Brown AJ; Callaghan R; Gelissen IC, 2021, 'Regulation of ABCG4 transporter expression by sterols and LXR ligands', Biochimica et Biophysica Acta - General Subjects, 1865, http://dx.doi.org/10.1016/j.bbagen.2020.129769

Scott NA; Sharpe LJ; Brown AJ, 2021, 'The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1866, http://dx.doi.org/10.1016/j.bbalip.2020.158837

Sharpe LJ; Coates HW; Brown AJ, 2020, 'Post-translational control of the long and winding road to cholesterol', Journal of Biological Chemistry, 295, pp. 17549 - 17559, http://dx.doi.org/10.1074/jbc.REV120.010723

Sharpe LJ; Coates HW; Brown AJ, 2020, 'Post-translational control of the long and winding road to cholesterol.', J Biol Chem, 295, pp. 17549 - 17559, http://dx.doi.org/10.1074/jbc.REV120.010723

Capell-Hattam IM; Sharpe LJ; Qian L; Hart-Smith G; Prabhu AV; Brown AJ, 2020, 'Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally', Journal of Biological Chemistry, 295, pp. 2850 - 2865, http://dx.doi.org/10.1074/jbc.RA119.011323

Scott NA; Sharpe LJ; Capell-Hattam IM; Gullo SJ; Luu W; Brown AJ, 2020, 'The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6', Biochemical Journal, 477, pp. 541 - 555, http://dx.doi.org/10.1042/BCJ20190647

Brown A; Sharpe L, 2019, 'Oxysterols', Encyclopedia of Molecular Pharmacology, 3rd Edition, pp. 1 - 6, http://dx.doi.org/10.1007/978-3-030-21573-6_10016-1

Sharpe LJ; Howe V; Scott NA; Luu W; Phan L; Berk JM; Hochstrasser M; Brown AJ, 2019, 'Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation', Journal of Biological Chemistry, 294, pp. 2436 - 2448, http://dx.doi.org/10.1074/jbc.RA118.005069

Aleidi SM; Yang A; Sharpe LJ; Rao G; Cochran BJ; Rye KA; Kockx M; Brown AJ; Gelissen IC, 2018, 'The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863, pp. 359 - 368, http://dx.doi.org/10.1016/j.bbalip.2017.12.011

Howe V; Sharpe LJ; Prabhu AV; Brown AJ, 2017, 'New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862, pp. 647 - 657, http://dx.doi.org/10.1016/j.bbalip.2017.03.009

Sharpe LJ; Brown AJ, 2017, 'Identifying sterol response elements within promoters of genes', , 1583, pp. 185 - 191, http://dx.doi.org/10.1007/978-1-4939-6875-6_13

Prabhu AV; Luu W; Sharpe LJ; Brown AJ, 2017, 'Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis', Journal of Steroid Biochemistry and Molecular Biology, 165, pp. 363 - 368, http://dx.doi.org/10.1016/j.jsbmb.2016.08.003

Prabhu AV; Luu W; Li D; Sharpe LJ; Brown AJ, 2016, 'DHCR7: A vital enzyme switch between cholesterol and vitamin D production', Progress in Lipid Research, 64, pp. 138 - 151, http://dx.doi.org/10.1016/j.plipres.2016.09.003

Howe V; Sharpe LJ; Alexopoulos SJ; Kunze SV; Chua NK; Li D; Brown AJ, 2016, 'Cholesterol homeostasis: How do cells sense sterol excess?', Chemistry and Physics of Lipids, 199, pp. 170 - 178, http://dx.doi.org/10.1016/j.chemphyslip.2016.02.011

Luu W; Sharpe LJ; Capell-Hattam I; Gelissen IC; Brown AJ, 2016, 'Oxysterols: Old Tale, New Twists', Annual Review of Pharmacology and Toxicology, 56, pp. 447 - 467, http://dx.doi.org/10.1146/annurev-pharmtox-010715-103233

Loregger A; Cook ECL; Nelson JK; Moeton M; Sharpe LJ; Engberg S; Karimova M; Lambert G; Brown AJ; Zelcer N, 2016, 'A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes', Molecular and Cellular Biology, 36, pp. 285 - 294, http://dx.doi.org/10.1128/MCB.00890-15

Loregger A; Cook E; Nelson J; Moeton M; Sharpe L; Engberg S; Karimova M; Lambert G; Zelcer N, 2016, 'A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes', Atherosclerosis, 252, pp. e250 - e250, http://dx.doi.org/10.1016/j.atherosclerosis.2016.07.057

Prabhu AV; Luu W; Sharpe LJ; Brown AJ, 2016, 'Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis', Journal of Biological Chemistry, http://dx.doi.org/10.1074/jbc.M115.699546

Sharpe LJ; Howe V; Prabhu AV; Luu W; Brown AJ, 2015, 'Navigating the shallows and rapids of cholesterol synthesis downstream of HMGCR', Journal of Nutritional Science and Vitaminology, 61, pp. S154 - S156, http://dx.doi.org/10.3177/jnsv.61.S154

Aleidi SM; Howe V; Sharpe LJ; Yang A; Rao G; Brown AJ; Gelissen IC, 2015, 'The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters', Journal of Biological Chemistry, 290, pp. 24604 - 24613, http://dx.doi.org/10.1074/jbc.M115.675579

Sharpe LJ; Rao G; Jones PM; Glancey E; Aleidi SM; George AM; Brown AJ; Gelissen IC, 2015, 'Cholesterol sensing by the ABCG1 lipid transporter: Requirement of a CRAC motif in the final transmembrane domain', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1851, pp. 956 - 964, http://dx.doi.org/10.1016/j.bbalip.2015.02.016

Luu W; Hart-Smith G; Sharpe LJ; Brown AJ, 2015, 'The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally', Journal of Lipid Research, 56, pp. 888 - 897, http://dx.doi.org/10.1194/jlr.M056986

Moon H; Ruelcke JE; Choi E; Sharpe LJ; Nassar ZD; Bielefeldt-Ohmann H; Parat MO; Shah A; Francois M; Inder KL; Brown AJ; Russell PJ; Parton RG; Hill MM, 2015, 'Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1', Oncotarget, 6, pp. 7438 - 7453, http://dx.doi.org/10.18632/oncotarget.3476

Tint GS; Pan L; Shang Q; Sharpe LJ; Brown AJ; Li M; Yu H, 2014, 'Desmosterol in brain is elevated because DHCR24 Needs REST for robust expression but REST is poorly expressed', Developmental Neuroscience, 36, pp. 132 - 142, http://dx.doi.org/10.1159/000362363

Zerenturk EJ; Sharpe LJ; Brown AJ, 2014, 'DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: Implications for the activities of this multi-functional enzyme', Bioscience Reports, 34, pp. 107 - 117, http://dx.doi.org/10.1042/BSR20130127

Luu W; Zerenturk EJ; Kristiana I; Bucknal MP; Sharpe LJ; Brown AJ, 2014, 'Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesi[s]', Journal of Lipid Research, 55, pp. 410 - 420, http://dx.doi.org/10.1194/jlr.M043257

Zelcer N; Sharpe LJ; Loregger A; Kristiana I; Cook ECL; Phan L; Stevenson J; Brown AJ, 2014, 'The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme a reductase and the cholesterol synthesis pathway', Molecular and Cellular Biology, 34, pp. 1262 - 1270, http://dx.doi.org/10.1128/MCB.01140-13

Prabhu AV; Sharpe LJ; Brown AJ, 2014, 'The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1841, pp. 1431 - 1439, http://dx.doi.org/10.1016/j.bbalip.2014.07.006

Sharpe LJ; Cook ECL; Zelcer N; Brown AJ, 2014, 'The UPS and downs of cholesterol homeostasis', Trends in Biochemical Sciences, 39, pp. 527 - 535, http://dx.doi.org/10.1016/j.tibs.2014.08.008

Sharpe LJ; Burns V; Brown AJ, 2014, 'A Lipidomic Perspective on Intermediates in Cholesterol Synthesis as Indicators of Disease Status', Journal of Genetics and Genomics, 41, pp. 275 - 282, http://dx.doi.org/10.1016/j.jgg.2014.03.001

Brown A; Sharpe L; Loregger A; Cook E; Phan L; Stevenson J; Zelcer N, 2014, 'One E3 ligase targets two key control points in cholesterol synthesis (605.5)', The FASEB Journal, 28, http://dx.doi.org/10.1096/fasebj.28.1_supplement.605.5

Zerenturk EJ; Sharpe LJ; Ikonen E; Brown AJ, 2013, 'Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis', Progress in Lipid Research, 52, pp. 666 - 680, http://dx.doi.org/10.1016/j.plipres.2013.09.002

Sharpe LJ; Brown AJ, 2013, 'Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)', Journal of Biological Chemistry, 288, pp. 18707 - 18715, http://dx.doi.org/10.1074/jbc.R113.479808

Luu W; Sharpe LJ; Brown AJ, 2013, 'Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression', Atherosclerosis, 228, pp. 362 - 369, http://dx.doi.org/10.1016/j.atherosclerosis.2013.03.016

Luu W; Sharpe LJ; Gelissen IC; Brown AJ, 2013, 'The role of signalling in cellular cholesterol homeostasis', IUBMB Life, 65, pp. 675 - 684, http://dx.doi.org/10.1002/iub.1182

Dimitri A; Livermore N; Sharpe L; Gandevia SC; Mckenzie DK; Butler JE, 2012, 'CBT REDUCES RATINGS OF BREATHING DIFFICULTY IN RESPONSE TO EXTERNAL RESISTIVE LOADS IN PEOPLE WITH COPD', RESPIROLOGY, 17, pp. 32 - 32, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000301120800116&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Luu W; Sharpe LJ; Stevenson J; Brown AJ, 2012, 'Akt acutely activates the cholesterogenic transcription factor SREBP-2.', Biochimica et Biophysica ACTA - Molecular Cell Research, 1823, pp. 458 - 464, http://dx.doi.org/10.1016/j.bbamcr.2011.09.017

Kockx M; Dinnes DL; Huang K; Sharpe LJ; Jessup W; Brown AJ; Kritharides L, 2012, 'Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: Studies of apolipoprotein E and VSVGt', Biochemical Journal, 447, pp. 51 - 60, http://dx.doi.org/10.1042/BJ20111891

Sharpe LJ; Wong J; Garner B; Halliday GM; Brown AJ, 2012, 'Is seladin-1 really a selective Alzheimer's disease indicator?', Journal of Alzheimer's Disease, 30, pp. 35 - 39, http://dx.doi.org/10.3233/JAD-2012-111955

Gelissen IC; Sharpe LJ; Sandoval C; Rao G; Kockx M; Kritharides L; Jessup WK; Brown AJP, 2012, 'Protein kinase A modulates the activity of a major human isoform of ABCG1', Journal of Lipid Research, 53, pp. 2133 - 2140, http://dx.doi.org/10.1194/jlr.M028795

Burns V; Sharpe LJ; Gelissen IC; Brown AJ, 2012, 'Species variation in ABCG1 isoform expression: Implications for the use of animal models in elucidating ABCG1 function', Atherosclerosis, 226, pp. 408 - 411, http://dx.doi.org/10.1016/j.atherosclerosis.2012.12.009

Zerenturk EJ; Sharpe LJ; Brown AJ, 2012, 'Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: Cooperative induction of key enzymes in lipid synthesis by sterol regulatory element binding proteins.', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, 1821, pp. 1350 - 1360, http://dx.doi.org/10.1016/j.bbalip.2012.07.006

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