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Journal articles
2024, 'SC5D is the sixth enzyme in cholesterol biosynthesis targeted by the E3 ubiquitin ligase MARCHF6.', Biochim Biophys Acta Mol Cell Biol Lipids, 1869, pp. 159482, http://dx.doi.org/10.1016/j.bbalip.2024.159482
,2023, 'Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6', Journal of Lipid Research, 64, http://dx.doi.org/10.1016/j.jlr.2023.100362
,2023, 'Refining sugar's involvement in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868, http://dx.doi.org/10.1016/j.bbalip.2022.159266
,2023, 'Controlling an E3 ligase and its substrate: A function for MARCHF6 circRNA', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868, http://dx.doi.org/10.1016/j.bbalip.2022.159237
,2022, 'The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally', Journal of Lipid Research, 63, http://dx.doi.org/10.1016/j.jlr.2022.100295
,2022, 'Corrigendum to “Regulation of ABCG4 transporter expression by sterols and LXR ligands” [PMID: 33141061, DOI: 10.1016/j.bbagen.2020.129769] (BBA - General Subjects (2021) 1865(1), (S0304416520302804), (10.1016/j.bbagen.2020.129769))', Biochimica et Biophysica Acta - General Subjects, 1866, http://dx.doi.org/10.1016/j.bbagen.2022.130169
,2021, 'Oxysterols: From physiological tuners to pharmacological opportunities', British Journal of Pharmacology, 178, pp. 3089 - 3103, http://dx.doi.org/10.1111/bph.15073
,2021, 'Regulation of ABCG4 transporter expression by sterols and LXR ligands', Biochimica et Biophysica Acta - General Subjects, 1865, http://dx.doi.org/10.1016/j.bbagen.2020.129769
,2021, 'The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1866, http://dx.doi.org/10.1016/j.bbalip.2020.158837
,2020, 'Post-translational control of the long and winding road to cholesterol', Journal of Biological Chemistry, 295, pp. 17549 - 17559, http://dx.doi.org/10.1074/jbc.REV120.010723
,2020, 'Post-translational control of the long and winding road to cholesterol.', J Biol Chem, 295, pp. 17549 - 17559, http://dx.doi.org/10.1074/jbc.REV120.010723
,2020, 'Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally', Journal of Biological Chemistry, 295, pp. 2850 - 2865, http://dx.doi.org/10.1074/jbc.RA119.011323
,2020, 'The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6', Biochemical Journal, 477, pp. 541 - 555, http://dx.doi.org/10.1042/BCJ20190647
,2019, 'Oxysterols', Encyclopedia of Molecular Pharmacology, 3rd Edition, pp. 1 - 6, http://dx.doi.org/10.1007/978-3-030-21573-6_10016-1
,2019, 'Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation', Journal of Biological Chemistry, 294, pp. 2436 - 2448, http://dx.doi.org/10.1074/jbc.RA118.005069
,2018, 'The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863, pp. 359 - 368, http://dx.doi.org/10.1016/j.bbalip.2017.12.011
,2017, 'New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862, pp. 647 - 657, http://dx.doi.org/10.1016/j.bbalip.2017.03.009
,2017, 'Identifying sterol response elements within promoters of genes', , 1583, pp. 185 - 191, http://dx.doi.org/10.1007/978-1-4939-6875-6_13
,2017, 'Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis', Journal of Steroid Biochemistry and Molecular Biology, 165, pp. 363 - 368, http://dx.doi.org/10.1016/j.jsbmb.2016.08.003
,2016, 'DHCR7: A vital enzyme switch between cholesterol and vitamin D production', Progress in Lipid Research, 64, pp. 138 - 151, http://dx.doi.org/10.1016/j.plipres.2016.09.003
,2016, 'Cholesterol homeostasis: How do cells sense sterol excess?', Chemistry and Physics of Lipids, 199, pp. 170 - 178, http://dx.doi.org/10.1016/j.chemphyslip.2016.02.011
,2016, 'Oxysterols: Old Tale, New Twists', Annual Review of Pharmacology and Toxicology, 56, pp. 447 - 467, http://dx.doi.org/10.1146/annurev-pharmtox-010715-103233
,2016, 'A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes', Molecular and Cellular Biology, 36, pp. 285 - 294, http://dx.doi.org/10.1128/MCB.00890-15
,2016, 'A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes', Atherosclerosis, 252, pp. e250 - e250, http://dx.doi.org/10.1016/j.atherosclerosis.2016.07.057
,2016, 'Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis', Journal of Biological Chemistry, http://dx.doi.org/10.1074/jbc.M115.699546
,2015, 'Navigating the shallows and rapids of cholesterol synthesis downstream of HMGCR', Journal of Nutritional Science and Vitaminology, 61, pp. S154 - S156, http://dx.doi.org/10.3177/jnsv.61.S154
,2015, 'The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters', Journal of Biological Chemistry, 290, pp. 24604 - 24613, http://dx.doi.org/10.1074/jbc.M115.675579
,2015, 'Cholesterol sensing by the ABCG1 lipid transporter: Requirement of a CRAC motif in the final transmembrane domain', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1851, pp. 956 - 964, http://dx.doi.org/10.1016/j.bbalip.2015.02.016
,2015, 'The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally', Journal of Lipid Research, 56, pp. 888 - 897, http://dx.doi.org/10.1194/jlr.M056986
,2015, 'Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1', Oncotarget, 6, pp. 7438 - 7453, http://dx.doi.org/10.18632/oncotarget.3476
,2014, 'Desmosterol in brain is elevated because DHCR24 Needs REST for robust expression but REST is poorly expressed', Developmental Neuroscience, 36, pp. 132 - 142, http://dx.doi.org/10.1159/000362363
,2014, 'DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: Implications for the activities of this multi-functional enzyme', Bioscience Reports, 34, pp. 107 - 117, http://dx.doi.org/10.1042/BSR20130127
,2014, 'Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesi[s]', Journal of Lipid Research, 55, pp. 410 - 420, http://dx.doi.org/10.1194/jlr.M043257
,2014, 'The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme a reductase and the cholesterol synthesis pathway', Molecular and Cellular Biology, 34, pp. 1262 - 1270, http://dx.doi.org/10.1128/MCB.01140-13
,2014, 'The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1841, pp. 1431 - 1439, http://dx.doi.org/10.1016/j.bbalip.2014.07.006
,2014, 'The UPS and downs of cholesterol homeostasis', Trends in Biochemical Sciences, 39, pp. 527 - 535, http://dx.doi.org/10.1016/j.tibs.2014.08.008
,2014, 'A Lipidomic Perspective on Intermediates in Cholesterol Synthesis as Indicators of Disease Status', Journal of Genetics and Genomics, 41, pp. 275 - 282, http://dx.doi.org/10.1016/j.jgg.2014.03.001
,2014, 'One E3 ligase targets two key control points in cholesterol synthesis (605.5)', The FASEB Journal, 28, http://dx.doi.org/10.1096/fasebj.28.1_supplement.605.5
,2013, 'Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis', Progress in Lipid Research, 52, pp. 666 - 680, http://dx.doi.org/10.1016/j.plipres.2013.09.002
,2013, 'Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)', Journal of Biological Chemistry, 288, pp. 18707 - 18715, http://dx.doi.org/10.1074/jbc.R113.479808
,2013, 'Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression', Atherosclerosis, 228, pp. 362 - 369, http://dx.doi.org/10.1016/j.atherosclerosis.2013.03.016
,2013, 'The role of signalling in cellular cholesterol homeostasis', IUBMB Life, 65, pp. 675 - 684, http://dx.doi.org/10.1002/iub.1182
,2012, 'CBT REDUCES RATINGS OF BREATHING DIFFICULTY IN RESPONSE TO EXTERNAL RESISTIVE LOADS IN PEOPLE WITH COPD', RESPIROLOGY, 17, pp. 32 - 32, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000301120800116&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2012, 'Akt acutely activates the cholesterogenic transcription factor SREBP-2.', Biochimica et Biophysica ACTA - Molecular Cell Research, 1823, pp. 458 - 464, http://dx.doi.org/10.1016/j.bbamcr.2011.09.017
,2012, 'Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: Studies of apolipoprotein E and VSVGt', Biochemical Journal, 447, pp. 51 - 60, http://dx.doi.org/10.1042/BJ20111891
,2012, 'Is seladin-1 really a selective Alzheimer's disease indicator?', Journal of Alzheimer's Disease, 30, pp. 35 - 39, http://dx.doi.org/10.3233/JAD-2012-111955
,2012, 'Protein kinase A modulates the activity of a major human isoform of ABCG1', Journal of Lipid Research, 53, pp. 2133 - 2140, http://dx.doi.org/10.1194/jlr.M028795
,2012, 'Species variation in ABCG1 isoform expression: Implications for the use of animal models in elucidating ABCG1 function', Atherosclerosis, 226, pp. 408 - 411, http://dx.doi.org/10.1016/j.atherosclerosis.2012.12.009
,2012, 'Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: Cooperative induction of key enzymes in lipid synthesis by sterol regulatory element binding proteins.', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, 1821, pp. 1350 - 1360, http://dx.doi.org/10.1016/j.bbalip.2012.07.006
,2011, 'Akt phosphorylates Sec24: New clues into the regulation of ER-to-Golgi trafficking', Traffic (Malden), 12, pp. 19 - 27, http://dx.doi.org/10.1111/j.1600-0854.2010.01133.x
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