Researcher

Dr Manoj Krishan Saxena

Field of Research (FoR)

Biography

Research Interests:
My primary research interest is in therapeutic thermal regulation for acute brain injury in critically ill patients:
There is uncertainty about the optimal temperature range for critically ill patients with acute brain injury (ABI) due to traumatic brain injury (TBI), cardiac arrest and ischaemic/haemorrhagic stroke syndromes (ISS).

There is emerging evidence that hyperthermia and hypothermia is associated with adverse...view more

Research Interests:
My primary research interest is in therapeutic thermal regulation for acute brain injury in critically ill patients:
There is uncertainty about the optimal temperature range for critically ill patients with acute brain injury (ABI) due to traumatic brain injury (TBI), cardiac arrest and ischaemic/haemorrhagic stroke syndromes (ISS).

There is emerging evidence that hyperthermia and hypothermia is associated with adverse outcomes in patients with ABI.
Targeted temperature management (TTM) is increasingly being advocated for ABI, particularly after cardiac arrest and ISS, but there is uncertainty about the optimal range, duration and methods of TTM and whether this strategy results in improved patient-centred outcomes.
Survivors of ABI are left with high levels of disability and burden of disease that is borne by the patient, family and community. Any modest change in quality of survival will have a substantive impact on all affected by ABI.

In order to develop protocols of high internal validity to conduct  a high-quality RCT, a substantive amount of preparatory work is required to define the hypothesis, determine clinical equipoise and to test the feasibility of the interventions in pilot trials.

Additionally, our department has established research programs in fluid resuscitation, the endocrine response to critical illness (Professor John Myburgh) and therapeutic thermal regulation for severe infections; we are also establishing a multi-modal neuro-monitoring research program (Dr Andrew Cheng), which includes cerebral micro dialysis and the measurement of brain temperature and tissue oxygenation in critically ill patients with brain injuries.

Broad Research Areas:
Clinical Research, Injury, Neurotrauma, Evidence Based Medicine

Qualifications:
MBBChir, BSc, MRCP(UK), FRACP, FCICM

Society Memberships & Professional Activities:
Examiner for UNSW., Examiner for College of Intensive Care Medicine., Fellow of the Royal Australasian College of Physicians., Fellow of the College of Intensive Care Medicine.

Specific Research Keywords:
Neural Injury and Diseases, Intensive Care, International Health

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Contact

+61 2 9657 0381