Select Publications

Book Chapters

Fletcher JI; Haber M; Henderson MJ; Norris MD, 2012, 'Targeting Multidrug Resistance in Neuroblastoma', in Hayat MA (ed.), NEUROBLASTOMA, edn. Pediatric Cancer-Diagnosis Therapy and Prognosis, SPRINGER, pp. 115 - 123, http://dx.doi.org/10.1007/978-94-007-2418-1_11

Journal articles

Somers K; Kosciolek A; Bongers A; El-Ayoubi A; Karsa M; Mayoh C; Wadham C; Middlemiss S; Neznanov N; Kees UR; Lock RB; Gudkov A; Sutton R; Gurova K; Haber M; Norris MD; Henderson MJ, 2019, 'Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia', International Journal of Cancer, http://dx.doi.org/10.1002/ijc.32582

Somers K; Wen VW; Middlemiss SMC; Osborne B; Forgham H; Jung MS; Karsa M; Clifton M; Bongers A; Gao J; Mayoh C; Raoufi-Rad N; Kusnadi EP; Hannan KM; Scott DA; Kwek A; Liu B; Flemming C; Chudakova DA; Pandher R; Failes TW; Lim J; Angeli A; Osterman AL; Imamura T; Kees UR; Supuran CT; Pearson RB; Hannan RD; Davis TP; McCarroll J; Kavallaris M; Turner N; Gudkov AV; Haber M; Norris MD; Henderson MJ, 2019, 'A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction', Oncogene, vol. 38, pp. 3824 - 3842, http://dx.doi.org/10.1038/s41388-018-0666-5

Jung M; Russell A; Kennedy C; Gifford A, 2018, 'Clinical Importance of Myc Family Oncogene Aberrations in Epithelial Ovarian Cancer', JNCI: Cancer Spectrum, vol. 2, http://dx.doi.org/10.1093/jncics/pky047

Murray J; Valli E; Yu DMT; Truong AM; Gifford AJ; Eden GL; Gamble LD; Hanssen KM; Flemming CL; Tan A; Tivnan A; Allan S; Saletta F; Cheung L; Ruhle M; Schuetz JD; Henderson MJ; Byrne JA; Norris MD; Haber M; Fletcher JI, 2017, 'Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo', European Journal of Cancer, vol. 83, pp. 132 - 141, http://dx.doi.org/10.1016/j.ejca.2017.06.024

Jung MS; Russell AJ; Liu B; George J; Liu PY; Liu T; DeFazio A; Bowtell DDL; Oberthuer A; London WB; Fletcher JI; Haber M; Norris MD; Henderson MJ, 2017, 'A Myc activity signature predicts poor clinical outcomes in Myc-associated cancers', Cancer Research, vol. 77, pp. 971 - 981, http://dx.doi.org/10.1158/0008-5472.CAN-15-2906

Somers K; Chudakova DA; Middlemiss SMC; Wen VW; Clifton M; Kwek A; Liu B; Mayoh C; Bongers A; Karsa M; Pan S; Cruikshank S; Scandlyn M; Hoang W; Imamura T; Kees UR; Gudkov AV; Chernova OB; Haber M; Norris MD; Henderson MJ, 2016, 'CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements', Oncotarget, vol. 7, pp. 46067 - 46087, http://dx.doi.org/10.18632/oncotarget.10022

Fletcher JI; Williams RT; Henderson MJ; Norris MD; Haber M, 2016, 'ABC transporters as mediators of drug resistance and contributors to cancer cell biology', Drug Resistance Updates, vol. 26, pp. 1 - 9, http://dx.doi.org/10.1016/j.drup.2016.03.001

Pasalic L; Williams R; Siupa A; Campbell H; Henderson MJ; Chen VMY, 2016, 'Enumeration of extracellular vesicles by a new improved flow cytometric method is comparable to fluorescence mode nanoparticle tracking analysis', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 12, pp. 977 - 986, http://dx.doi.org/10.1016/j.nano.2015.12.370

French JD; Johnatty SE; Lu Y; Beesley J; Gao B; Kalimutho M; Henderson MJ; Russell AJ; Kar S; Chen X; Hillman KM; Kaufmann S; Sivakumaran H; O'Reilly M; Wang C; Korbie DJ; Lambrechts D; Despierre E; Van Nieuwenhuysen E; Lambrechts S; Vergote I; Karlan B; Lester J; Orsulic S; Walsh C; Fasching PA; Beckmann MW; Ekici AB; Hein A; Matsuo K; Hosono S; Pisterer J; Hillemanns P; Nakanishi T; Yatabe Y; Goodman MT; Lurie G; Matsuno RK; Thompson PJ; Pejovic T; Bean Y; Heitz F; Harter P; Du Bois A; Schwaab I; Hogdall E; Kjaer SK; Jensen A; Hogdall C; Lundvall L; Engelholm SA; Brown B; Flanagan JM; Metcalf MD; Siddiqui N; Sellers T; Fridley B; Cunningham J; Schildkraut JM; Iversen E; Weber RP; Brennan D; Berchuck A; Pharoah P; Harnett P; Norris MD; Haber M; Goode EL; Lee JS; Khanna KK; Meyer KB; Chenevix-Trench G; DeFazio A; Edwards SL; MacGregor S, 2016, 'Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer', Oncotarget, vol. 7, pp. 6353 - 6368, http://dx.doi.org/10.18632/oncotarget.7047

Richmond J; Carol H; Evans K; High L; Mendomo A; Robbins A; Meyer C; Venn NC; Marschalek R; Henderson M; Sutton R; Kurmasheva RT; Kees UR; Houghton PJ; Smith MA; Lock RB, 2015, 'Effective targeting of the P53-MDM2 axis in preclinical models of infant MLL-rearranged acute lymphoblastic leukemia', Clinical Cancer Research, vol. 21, pp. 1395 - 1405, http://dx.doi.org/10.1158/1078-0432.CCR-14-2300

Hedditch EL; Gao B; Russell AJ; Lu Y; Emmanuel C; Beesley J; Johnatty SE; Chen X; Harnett P; George J; Williams RT; Flemming C; Lambrechts D; Despierre E; Lambrechts S; Vergote I; Karlan B; Lester J; Orsulic S; Walsh C; Fasching P; Beckmann MW; Ekici AB; Hein A; Matsuo K; Hosono S; Nakanishi T; Yatabe Y; Pejovic T; Bean Y; Heitz F; Harter P; Du Bois A; Schwaab I; Hogdall E; Kjaer SK; Jensen A; Hogdall C; Lundvall L; Engelholm SA; Brown B; Flanagan J; Metcalf MD; Siddiqui N; Sellers T; Fridley B; Cunningham J; Schildkraut J; Iversen E; Weber RP; Berchuck A; Goode E; Bowtell DD; Chenevix-Trench G; Defazio A; Norris MD; Macgregor S; Haber M; Henderson MJ, 2014, 'ABCA transporter gene expression and poor outcome in epithelial ovarian cancer', Journal of the National Cancer Institute, vol. 106, http://dx.doi.org/10.1093/jnci/dju149

Cheung L; Flemming CL; Watt F; Masada N; Yu DM T; Huynh T; Conseil G; Tivnan A; Polinsky A; Gudkov AV; Munoz MA; Vishvanath A; Cooper DM F; Henderson MJ; Cole SP C; Fletcher JI; Haber M; Norris MD, 2014, 'High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)', Biochemical Pharmacology, vol. 91, pp. 97 - 108, http://dx.doi.org/10.1016/j.bcp.2014.05.023

Cheung L; Flemming CL; Watt F; Masada N; Yu DMT; Huynh T; Conseil G; Tivnan A; Polinsky A; Gudkov AV; Munoz MA; Vishvanath A; Cooper DMF; Henderson MJ; Cole SPC; Fletcher JI; Haber M; Norris MD, 2014, 'High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)', Biochemical Pharmacology, vol. 91, pp. 97 - 108, http://dx.doi.org/10.1016/j.bcp.2014.05.023

Gao B; Russell A; Beesley J; Chen XQ; Healey S; Henderson M; Wong M; Emmanuel C; Galletta L; Johnatty SE; Bowtell D; Haber M; Norris M; Harnett P; Chenevix-Trench G; Balleine RL; Defazio A; Gertig D; Green A; Webb P; Hung J; Moore S; Traficante N; Fereday S; Harrap K; Sadkowsky T; Pandeya N; Stuart-Harris R; Kirsten F; Rutovitz J; Clingan P; Glasgow A; Proietto A; Braye S; Otton G; Shannon J; Bonaventura T; Stewart J; Begbie S; Friedlander M; Bell D; Baron-Hay S; Ferrier A; Gard G; Nevell D; Pavlakis N; Valmadre S; Young B; Camaris C; Crouch R; Edwards L; Hacker N; Marsden D; Robertson G; Beale P; Beith J; Carter J; Dalrymple C; Hamilton A; Houghton R; Russell P; Links M; Grygiel J; Hill J; Brand A; Byth K; Jaworski R; Sharma R; Achen A; Wain G; Ward B; Papadimos D; Crandon A; Cummings M; Horwood K; Obermair A; Perrin L; Wyld D; Nicklin J; Davy M; Oehler MK; Hall C; Dodd T; Healy T; Pittman K; Henderson D; Miller J; Pierdes J; Blomfield P; Challis D; McIntosh R; Parker A; Brown B; Rome R; Allen D; Grant P; Hyde S; Laurie R; Robbie M; Healy D, 2014, 'Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer', Scientific Reports, vol. 4, http://dx.doi.org/10.1038/srep04669

Johnatty SE; Beesley J; Gao B; Chen X; Lu Y; Law MH; Henderson MJ; Russell AJ; Hedditch EL; Emmanuel C; Fereday S; Webb PM; Goode EL; Vierkant RA; Fridley BL; Cunningham JM; Fasching PA; Beckmann MW; Ekici AB; Hogdall E; Kjaer SK; Jensen A; Hogdall C; Brown R; Paul J; Lambrechts S; Despierre E; Vergote I; Lester J; Karlan BY; Heitz F; Du Bois A; Harter P; Schwaab I; Bean Y; Pejovic T; Levine DA; Goodman MT; Camey ME; Thompson PJ; Lurie G; Shildkraut J; Berchuck A; Terry KL; Cramer DW; Norris MD; Haber M; MacGregor S; DeFazio A; Chenevix-Trench G, 2013, 'ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and the Cancer Genome Atlas', Gynecologic Oncology, vol. 131, pp. 8 - 14, http://dx.doi.org/10.1016/j.ygyno.2013.07.107

Huynh T; Norris MD; Haber M; Henderson MJ, 2012, 'ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastoma', FRONTIERS IN ONCOLOGY, vol. 2, http://dx.doi.org/10.3389/fonc.2012.00178

McDonald WJ; Sangster SM; Moffat LD; Henderson M; Too CKL, 2010, 'alpha 4 Phosphoprotein Interacts With EDD E3 Ubiquitin Ligase and Poly(A)-Binding Protein', Journal of Cellular Biochemistry, vol. 110, pp. 1123 - 1129, http://dx.doi.org/10.1002/jcb.22624

Hu G; Wang XL; Saunders D; Henderson M; Russell AJ; Herring BP; Zhou J, 2010, 'Modulation of myocardin function by the ubiquitin E3 ligase UBR5', The Journal of Biological Chemistry, vol. 285, pp. 11800 - 11809, http://dx.doi.org/10.1074/jbc.M109.079384

Porro A; Haber M; Diolaiti D; Iraci N; Henderson M; Gherardi S; Valli E; Munoz M; Xue C; Flemming C; Schwab M; Wong JH; Marshall GM; Della valle G; Norris MD; Perini G, 2010, 'Direct and Coordinate Regulation of ATP-binding Cassette Transporter Genes by Myc Factors Generates Specific Transcription Signatures That Significantly Affect the Chemoresistance Phenotype of Cancer Cells', The Journal of Biological Chemistry, vol. 285, pp. 19532 - 19543, http://dx.doi.org/10.1074/jbc.M109.078584

Fletcher JI; Haber M; Henderson M; Norris MD, 2010, 'ABC transporters in cancer: more than just drug efflux pumps', Nature Reviews Cancer, vol. 10, pp. 147 - 156, http://dx.doi.org/10.1038/nrc2789

Henderson M; Choi S; Beesley A; Baker DL; Wright DC; Papa R; Murch A; Campbell L; Lock RB; Norris MD; Haber M; Kees UR, 2008, 'A xenograft model of infant leukaemia reveals a complex MLL translocation', British Journal of Haematology, vol. 140, pp. 716 - 719, http://dx.doi.org/10.1111/j.1365-2141.2007.06966.x

O Brien P; Davies M; Scurry JP; Smith A; Barton CA; Henderson M; Saunders DN; Gloss B; Patterson K; Clancy JL; Heinzelmann-Schwarz V; Scolyer R; Zeng Y; Williams E; Scurr LL; Defazio A; Quinn DI; Watts CK; Hacker NF; Henshall SM; Sutherland RL, 2008, 'The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro', British Journal of Cancer, vol. 98, pp. 1085 - 1093, http://dx.doi.org/10.1038/sj.bjc.6604281

Henderson M; Choi S; Beesley A; Sutton R; Venn NC; Marshall GM; Kees UR; Haber M; Norris MD, 2008, 'Mechanism of relapse in pediatric acute lymphoblastic leukemia', Cell Cycle, vol. 7, pp. 1315 - 1320, http://dx.doi.org/10.4161/cc.7.10.5885

Munoz MA; Henderson M; Haber M; Norris MD, 2007, 'Role of the MRP1/ABCC1 multidrug transporter protein in cancer', IUBMB Life, vol. 59, pp. 752 - 757, http://dx.doi.org/10.1080/15216540701736285

Ohshima R; Ohta T; Wu W; Koike A; Iwatani T; Henderson M; Watts CK; Otsubo T, 2007, 'Putative tumor suppressor EDD interacts with and up-regulates APC', Genes To Cells, vol. 12, pp. 1339 - 1345, http://dx.doi.org/10.1111/j.1365-2443.2007.01138.x

Munoz MA; Saunders DA; Henderson M; Clancy JL; Russell AJ; Lehrbach GM; Musgrove EA; Watts CK; Sutherland RL, 2007, 'The E3 Ubiquitin Ligase EDD Regulates S-Phase and G(2)/M DNA Damage Checkpoints', Cell Cycle, vol. 6 (24), pp. 3070 - 3077, http://dx.doi.org/10.4161/cc.6.24.5021

Choi S; Henderson M; Kwan EN; Sutton R; Giles J; Venn NC; Marshall GM; Haber M; Norris MD; Giles J, 2007, 'Relapse in children with acute lymphoblastic leukaemia involving selection of a pre-existing drug resistant subclone', Blood, vol. 110, pp. 632 - 639, http://dx.doi.org/10.1182/blood-2007-01-067785

Henderson M; Munoz MA; Saunders DN; Clancy JL; Russell AJ; Williams B; Pappin D; Khanna KK; Jackson SP; Sutherland RL; Watts CK, 2006, 'EDD mediates DNA damage-induced activation of CHK2', The Journal of Biological Chemistry, vol. 281, pp. 39990 - 40000, http://dx.doi.org/10.1074/jbc.M602818200

Saunders DN; Hird S; Withington SL; Dunwoodie SL; Henderson M; Biben C; Sutherland RL; Ormandy CJ; Watts CK, 2004, 'Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion', Molecular and Cellular Biology, vol. 24, pp. 7225 - 7234, http://dx.doi.org/10.1128/MCB.24.16.7225-7234.2004

Eblen ST; Kumar N; Shah K; Henderson M; Watts CK; Shokat KM; Weber MF, 2003, 'Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs', The Journal of Biological Chemistry, vol. 278, pp. 14926 - 14935, http://dx.doi.org/10.1074/jbc.M300485200

Clancy JL; Henderson M; Russell AJ; Anderson D; Bova RJ; Campbell IG; Choong DH; Macdonald GAM; Mann GJ; Nolan T; Brady G; Olopade OI; Woollatt E; Davies MJ; Segara D; Hacker NF; Henshall SM; Sutherland RL; Watts CK, 2003, 'Edd, the human orthologue of the hyperplastic discs tumour supressor gene, is amplified and overexpressed in cancer', Oncogene, vol. 22, pp. 5070 - 5081, http://dx.doi.org/10.1038/sj.onc.1206775

Beh KJ; Hulme DJ; Callaghan MJ; Leish Z; Lenane I; Windon RG; Maddox JF, 2002, 'A genome scan for quantitative trait loci affecting resistance to Trichostrongylus colubriformis in sheep', Animal Genetics, vol. 33, pp. 97 - 106, http://dx.doi.org/10.1046/j.1365-2052.2002.00829.x

Henderson MJ; Russell AJ; Hird S; Muñoz M; Clancy JL; Lehrbach GM; Calanni ST; Jans DA; Sutherland RL; Watts CKW, 2002, 'EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response', Journal of Biological Chemistry, vol. 277, pp. 26468 - 26478, http://dx.doi.org/10.1074/jbc.M203527200

Beh KJ; Callaghan MJ; Leish Z; Hulme DJ; Lenane I; Maddox JF, 2001, 'A genome scan for QTL affecting fleece and wool traits in Merino sheep', Wool Technology and Sheep Breeding, vol. 49, pp. 88 - 97

Callaghan M; Russel AJ; Woollatt E; Sutherland GR; Sutherland RL; Watts CK, 1998, 'Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs', Oncogene, vol. 17, pp. 3479 - 3491, http://dx.doi.org/10.1038/sj.onc.1202249

Hamilton JA; Callaghan MJ; Sutherland RL; Watts CKW, 1997, 'Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase', Molecular Endocrinology, vol. 11, pp. 490 - 502, http://dx.doi.org/10.1210/mend.11.4.9909

Callaghan MJ; Beh KJ, 1996, 'A tandemly repetitive DNA sequence is present at diverse locations in the genome of Ostertagia circumcincta', Gene, vol. 174, pp. 273 - 279, http://dx.doi.org/10.1016/0378-1119(96)00093-5

Callaghan MJ; Beh KJ, 1994, 'A Middle-Repetitive DNA Sequence Element in the Sheep Parasitic Nematode, Trichostrongylus Colubriformis', Parasitology, vol. 109, pp. 345 - 350, http://dx.doi.org/10.1017/S0031182000078379

Callaghan MJ; Beh KJ, 1994, 'Characterization of a tandemly repetitive DNA sequence from Haemonchus contortus', International Journal for Parasitology, vol. 24, pp. 137 - 141, http://dx.doi.org/10.1016/0020-7519(94)90068-X

Sleasman JW; Henderson M; Barrett DJ, 1991, 'Con A-induced suppressor cell function depends on the activation of the CD4+CD45RA inducer T cell subpopulation', Cellular Immunology, vol. 133, pp. 367 - 378, http://dx.doi.org/10.1016/0008-8749(91)90111-N

Champion A; Gooley AA; Callaghan M; Carrin MI; Bernstein RL; Smith Williams EKL, 1991, 'Immunodominant carbohydrate determinants in the multicellular stages of Dictyostelium discoideum', Journal of General Microbiology, vol. 137, pp. 2431 - 2438, http://dx.doi.org/10.1099/00221287-137-10-2431

Conference Papers

Somers K; Middlemiss S; Biktasova A; Karsa M; Cheung L; Kosciolek A; Evans K; Mayoh C; Kees UR; Korotchkina L; Chernova OB; Lock RB; Gudkov AV; Haber M; Norris MD; Henderson MJ, 2017, 'Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Washington, DC, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC, 01 April 2017 - 05 April 2017, http://dx.doi.org/10.1158/1538-7445.AM2017-1175


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