Researcher

Dr Shweta Gautam

Keywords

Fields of Research (FoR)

Gastroenterology and Hepatology, Cancer Genetics

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Biography

I am a molecular biologist with a PhD in Biochemistry and Molecular Genetics from The University of New South Wales (Sydney). I hold a master's degree in Biotechnology and bachelor's degree in Chemistry from India.   

Currently, I work as a Postdoc with the Gastrointestinal Viral Oncology Group, South West Clinical School, Ingham Institute, Liverpool. The group investigates the association of human papillomavirus and related biomarkers in...view more

I am a molecular biologist with a PhD in Biochemistry and Molecular Genetics from The University of New South Wales (Sydney). I hold a master's degree in Biotechnology and bachelor's degree in Chemistry from India.   

Currently, I work as a Postdoc with the Gastrointestinal Viral Oncology Group, South West Clinical School, Ingham Institute, Liverpool. The group investigates the association of human papillomavirus and related biomarkers in oesophageal adenocarcinoma. I am especially interested in studying the signatures within the human papillomavirus associated and viral negative oesophageal adenocarcinoma using  mutiomics approach.   

My PhD work investigated the sequence preference of anti-cancer drug bleomycin and gamma radiation on telomeric rich plasmid DNA sequences. Briefly, bleomycin is an anti-tumour agent that is clinically used to treat several types of cancers. Bleomycin cleaves DNA at specific DNA sequences and genome-wide DNA sequencing specificity data indicated that the sequence 5'-RTGT*AY (where T* is the site of bleomycin cleavage, R is G/A and Y is T/C) is preferentially cleaved by bleomycin in human cells. By systematic variation of single nucleotides in the 5'-RTGT*AY sequence, this study was able to investigate the effect of nucleotide changes on bleomycin cleavage efficiency. I also examined the DNA sequence specificity of gamma radiation- induced DNA damage in purified DNA sequences. Furthermore, a comparison between the radiation-induced damage plasmid DNA and genome-wide human DNA data was studied.

I have over five years of postgraduate research experience from the Post Graduate Institute of Medical Education and Research (PGIMER), India. I reviewed the role of Isoniazid (an anti-tuberculosis drug) on Potts’ spine patients while working in the Department of Nuclear Medicine. I also worked in the Department of Histopathology and evaluated the mRNA expression levels in medulloblastoma and primitive neuroectodermal tumours. 

 


My Grants

APAGE Research Programme Award-2020- Human Papillomavirus in Barrett Dysplasia and Adenocarcinoma - An Asian Barrett Consortium Epidemiology Study in the Asia-Pacific (The ABC-HPV Study)

Narellan Rotary Men's Health Award-2020- Signatures within the human papillomavirus (HPV) associated and viral negative oesophageal adenocarcinoma- a multiomic approach.


My Qualifications

PhD in Biochemistry and Molecular Genetics

M.Sc. in Biotechnology

 


My Awards

Australian Postgraduate Award (2013-2017)


My Research Activities

HPV and Oesophageal Adenocarcinoma

Genomics, proteomics and Microbiome of Oesophageal Adenocarcinoma

Bleomycin and radiation effect on DNA sequences


My Research Supervision


Areas of supervision

Investigating the role of Human papillomavirus in the progression and survival of upper gastrointestinal cancers.


Currently supervising

 Supervising 2 HDR candidates (Doctor of Philosophy) as a secondary supervisor.

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Contact

+61-2-8738 9193

Publications

by Dr Shweta Gautam