By Dr Simon Brayford

Book Chapters

Brayford S; Schevzov G; Vos J; Gunning P, 2015, 'The role of the actin cytoskeleton in cancer and its potential use as a therapeutic target', in The Cytoskeleton in Health and Disease, pp. 373 - 391, http://dx.doi.org/10.1007/978-1-4939-2904-7_16

Journal articles

Brayford S; Duly A; Teo WS; Dwarte T; Gonzales-Aloy E; Ma Z; McVeigh L; Failes TW; Arndt GM; McCarroll JA; Kavallaris M, 2023, 'βIII-tubulin suppression enhances the activity of Amuvatinib to inhibit cell proliferation in c-Met positive non-small cell lung cancer cells', Cancer Medicine, 12, pp. 4455 - 4471, http://dx.doi.org/10.1002/cam4.5128

Parker AL; Teo WS; Brayford S; Moorthi UK; Arumugam S; Ferguson C; Parton RG; McCarroll JA; Kavallaris M, 2022, 'βIII-Tubulin Structural Domains Regulate Mitochondrial Network Architecture in an Isotype-Specific Manner', Cells, 11, http://dx.doi.org/10.3390/cells11050776

Cagigas ML; Bryce NS; Ariotti N; Brayford S; Gunning PW; Hardeman EC, 2022, 'Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation', Nature Materials, 21, pp. 120 - 128, http://dx.doi.org/10.1038/s41563-021-01087-z

Law AL; Jalal S; Pallett T; Mosis F; Guni A; Brayford S; Yolland L; Marcotti S; Levitt JA; Poland SP; Rowe-Sampson M; Jandke A; Köchl R; Pula G; Ameer-Beg SM; Stramer BM; Krause M, 2021, 'Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-25916-6

Brayford S; Kenny FN; Hiratsuka T; Serna-Morales E; Yolland L; Luchici A; Stramer BM, 2019, 'Heterotypic contact inhibition of locomotion can drive cell sorting between epithelial and mesenchymal cell populations', Journal of Cell Science, 132, pp. jcs223974, http://dx.doi.org/10.1242/jcs.223974

Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028

Conference Papers

Brayford S; Teo WS; Parker A; McVeigh L; McCarroll JA; Kavallaris M, 2020, 'Abstract 1442: Identifying the molecular basis by which βIII-tubulin promotes tumor cell survival and drug resistance in non-small cell lung cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. 1442 - 1442, http://dx.doi.org/10.1158/1538-7445.am2020-1442

Conference Presentations

Brayford S, 2018, 'EphB2 acts via ERK signalling to promote active cell repulsion and cell sorting', presented at The Dynamic Cell III, Manchester Conference Centre, Manchester, UK, 19 March 2018 - 21 March 2018, https://www.eventsforce.net/biochemsoc/frontend/reg/absViewDocumentFE.csp?popup=1&documentID=298&eventID=17

Brayford S; Schevzov G; Hardeman EC; Bear JE; Gunning PW, 2014, 'Tropomyosin 5a/b actin filaments collaborate with arp2/3 actin filaments to regulate cell motility.', presented at ASCB/IFCB Meeting, PA, Philadelphia, 06 December 2014 - 10 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094100083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints

Law A-L; Jalal S; Pallett T; Mosis F; Guni A; Brayford S; Yolland L; Marcotti S; Levitt JA; Poland SP; Rowe-Sampson M; Jandke A; Köchl R; Pula G; Ameer-Beg SM; Stramer BM; Krause M, 2020, Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration, , http://dx.doi.org/10.1101/2020.05.11.083030

Brayford S; Serna-Morales E; Luchici A; Hiratsuka T; Stramer BM, 2018, EphB2 and ERK signaling are required for heterotypic contact inhibition of locomotion to drive cell sorting, , http://dx.doi.org/10.1101/373696

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