Researcher

Dr Tri Giang Phan

Biography

Tri studied graduated from medicine at the University of Sydney in 1994 and completed a double fellowship in Internal Medicine and Pathology in 2002 under the guidance Dr Stephen Adelstein and Dr Roger Garsia in the Department of Clinical Immunology at the Royal Prince Alfred Hospital, Sydney. For his PhD he developed a B cell receptor knock-in mouse model to study in vivo B cell responses to foreign and self-antigen under the supervision of...view more

Tri studied graduated from medicine at the University of Sydney in 1994 and completed a double fellowship in Internal Medicine and Pathology in 2002 under the guidance Dr Stephen Adelstein and Dr Roger Garsia in the Department of Clinical Immunology at the Royal Prince Alfred Hospital, Sydney. For his PhD he developed a B cell receptor knock-in mouse model to study in vivo B cell responses to foreign and self-antigen under the supervision of Prof Antony Basten and Prof Robert Brink at the Centenary Institute, Sydney.

His interest in defining the in vivo contexts of B cell responses and resolving germinal centre selection events in space and time lead to post-doctoral studies with Prof Jason Cyster at the Howard Hughes Medical Institute, University of California, San Francisco where he used intravital two-photon microscopy to investigate the initiation of B cell responses in the lymph node. Tri established an intravital two-photon microscope facility at the Garvan Institute in 2010. His lab combines in vivo optical marking, single cell transcriptomics and CRISPR/Cas9 technologies to track the origin and fate of cells critical to immune responses in infection, autoimmunity and cancer.


My Grants

NHMRC

 


My Qualifications

MBBS, FRACP, FRCPA, PhD


My Awards

2014 - ANSTO Eureka Prize for Innovative Use of Technology
2011 - NHMRC Career Development Fellowship
2006 - NHMRC C.J. Martin Post-doctoral Research Fellowship
2006 - American Australian Association Sir Keith Murdoch Fellowship
2005 - University of Sydney Early Career Development Award
2005 - Australasian Society of Immunology New Investigator Award
1999 - D.S. Nelson Prize (Royal College of Pathologists of Australasia)
1998 - Eddie Hirst Memorial Prize (Royal College of Pathologists of Australasia)
1994 - University Medal, Faculty of Medicine, University of Sydney


My Research Activities

B cell biology

Germinal centres

Memory B cells

Plasma cells

Vaccine induced-immunity

Multiple myeloma

Cancer


My Research Supervision


Areas of supervision

ILP, Honours projects, PhD projects

 

Project title: Tracking B cell fate decisions in time and space

Discipline: Immunology

Project level: PhD/Hons

Supervisor / supervisory team: Conjoint Associate Professor Tri Phan

Project commencement: January 2019

Summary: B cells make antibodies that protect us from infection. However, B cells can also make antibodies that attack us and cause autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. By using state-of-the-art intravital two-photon microscopy and single cell sequencing technologies, this project aim to track the fate of B cells as they make the cell fate decision to become an antibody secreting plasma cell in the setting of vaccination and autoimmunity. By understanding how this process is regulated in space and time we hope to develop new strategies to make better vaccines and treat autoimmune diseases.


Currently supervising

Ms Imogen Moran

Ms Mayan Amiezer


My Teaching

Adult Health 1 Year 3 Course Tutor

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Location

Garvan Institute
384 Victoria St
Darlinghurst NSW 2010

Contact

92958414
92958404