By Professor Andrew John Brown

Journal articles

Wong J; Quinn CM; Gelissen I; Jessup W; Brown AJ, 2008, 'The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation', Atherosclerosis, 196, pp. 180 - 189, http://dx.doi.org/10.1016/j.atherosclerosis.2007.03.030

Brown AJ, 2008, 'Viral hepatitis and fatty liver disease: how an unwelcome guest makes pate of the host', Biochemical Journal, 416, pp. e15 - e17

Brown AJ, 2007, 'Cholesterol, statins and cancer', Clinical and Experimental Pharmacology and Physiology, 34, pp. 135 - 141

Brown AJ, 2007, 'Low-carb diets, fasting and euphoria: Is there a link between ketosis and y-hydroxybutyrate (GHB)?', Journal of Medical Hypotheses, 68, pp. 268 - 271

Yan DB; Mayranpaa M; Wong J; Perttila J; Lehto M; Jauhiainen M; Kovanen P; Ehnholm C; Brown AJ; Olkkonen V, 2007, 'OSBP-related protein 8 (ORP8) regulates ABCA1 expression and cholesterol efflux to apolipoprotein A-I', Chemistry and Physics of Lipids, 149, pp. S73 - S73

Wong J; Quinn CM; Guillemin GJ; Brown AJ, 2007, 'Primary human astrocytes product 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis', Journal of Neurochemistry, 103, pp. 1764 - 1773

Wong J; Quinn CM; Brown AJ, 2007, 'Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol', Lipids in Health and Disease, 6

Jessup W; Gelissen I; Kritharides L; Quinn CM; Kockx M; Brown AJ; Rye K; Harris M; Packianathan M; Cartland SP, 2006, 'ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I', Arteriosclerosis, Thrombosis and Vascular Biology, 26, pp. 534 - 540

Gelissen I; Rye K-A; Quinn C; Brown A; Kockx M; Cartland S; Kritharides L; Jessup W, 2006, 'Concerted action of ABCA1 and ABCG1 in cell cholesterol export', Vascular Pharmacology, 45, pp. e23 - e23, http://dx.doi.org/10.1016/j.vph.2006.08.107

Du XR; Kristiana I; Wong J; Brown AJ, 2006, 'Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: A link between a key cell proliferative pathway and membrane synthesis', Molecular Biology of the Cell, 17, pp. 2735 - 2745

Jessup W; Brown AJ; van Reyk DM; Mattsson Hult en L; Dean RT, 2006, 'Oxysterols in biological systems: sources, metabolism and pathophysiological relevance', Redox Report, 11, pp. 255 - 262

Wong J; Quinn CM; Brown AJ, 2006, 'SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR', Biochemical Journal, 400, pp. 485 - 491

Quinn CM; Jessup W; Wong J; Kritharides L; Brown AJ, 2005, 'Expression and regulation of sterol 27-hydroxylase (CYP27A1) in humanmacrophages: a role for RXR and PPAR gamma ligands', Biochemical Journal, 385, pp. 823 - 830

Brown AJ; Wong J; Quinn CM, 2005, 'Human macrophages can synthesise de novo an oxysterol ligand for the liver X receptor: Effects of statins and consequences for cholesterol efflux', Atherosclerosis Supplements, 6, pp. 96 - 96

Jessup W; Brown AJ, 2005, 'Novel routes for metabolism of 7-Ketocholesterol', Rejuvenation Research, 8, pp. 9 - 12

Du XR; Pham Y; Brown AJ, 2004, 'Effects of 25-hydroxycholesterol on cholesterol esterification andsterol regulatory element-binding protein processing are dissociable -Implications for cholesterol movement to the regulatory pool in theendoplasmic reticulum', The Journal of Biological Chemistry, 279, pp. 47010 - 47016

Brown AJ, 2004, 'Of cholesterol-free mice and men', Current Opinion in Lipidology, 15, pp. 373 - 375

Wong J; Quinn CM; Brown AJ, 2004, 'Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux', Arteriosclerosis, Thrombosis and Vascular Biology, 24, pp. 2365 - 2371, http://www.sciencedirect.com/science/article/B6WVB-4DYM7R6-1F1/2/3c81550ef6b4b3f41c3b52d70fee5c03

Jessup W; Quinn CM; Brown AJ; Kritharides L, 2003, 'Expression and regulation of sterol 27-hydroxylase (CYP27A1) in humanmacrophages', Atherosclerosis Supplements, 4, pp. 219 - 219

Lyons MA; Maeda N; Brown AJ, 2002, 'Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1581, pp. 119 - 126, http://dx.doi.org/10.1016/S1388-1981(02)00156-7

Brown AJ; Sun L; Feramisco JD; Brown MS; Goldstein JL, 2002, 'Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism', Molecular Cell, 10, pp. 237 - 245, http://dx.doi.org/10.1016/S1097-2765(02)00591-9

Upston JM; Niu X; Brown AJ; Mashima R; Wang H; Senthilmohan R; Kettle AJ; Dean RT; Stocker R, 2002, 'Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis', American Journal of Pathology, 160, pp. 701 - 710, http://dx.doi.org/10.1016/S0002-9440(10)64890-0

Gatto LM; Lyons MA; Brown AJ; Samman S, 2002, 'Trans fatty acids affect lipoprotein metabolism in rats', Journal of Nutrition, 132, pp. 1242 - 1248, http://dx.doi.org/10.1093/jn/132.6.1242

Brown AJ, 2002, 'Atherosclerosis: cell biology and lipoproteins: cholesterol absorption inhibitors: gateway therapy for hypercholesterolaemia', Current Opinions in Lipidology, 13, pp. 701 - 703

Brown AJ, 2001, 'Atherosclerosis: Cell biology and lipoproteins', Current Opinion in Lipidology, 12, pp. 671 - 673, http://dx.doi.org/10.1097/00041433-200112000-00012

Upston JM; Witting PK; Brown AJ; Stocker R; Keaney JF, 2001, 'Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits', Free Radical Biology and Medicine, 31, pp. 1245 - 1253, http://dx.doi.org/10.1016/S0891-5849(01)00721-3

Lyons MA; Maeda N; Brown AJ, 2001, '7-ketocholesterol metabolism is dependent upon sterol 27-hydroxylase in human hepatic cells but not in sterol 27-hydroxylase knockout mice.', HEPATOLOGY, 34, pp. 471A - 471A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171224701188&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gatto LM; Lyons MA; Brown AJ; Samman S, 2001, 'Trans fatty acids and cholesterol metabolism: Mechanistic studies in rats and rabbits fed semipurified diets', International Journal of Food Sciences and Nutrition, 52, pp. 435 - 441, http://dx.doi.org/10.1080/09637480120078320

Burnett JR; Moses EA; Croft KD; Brown AJ; Grainger K; Vasikaran SD; Leitersdorf E; Watts GF, 2001, 'Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis', Clinica Chimica Acta, 306, pp. 63 - 69, http://dx.doi.org/10.1016/S0009-8981(01)00391-6

Hamilton JA; Jessup W; Brown AJ; Whitty G, 2001, 'Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL', Biochemical Journal, 355, pp. 207 - 214, http://dx.doi.org/10.1042/bj3550207

HAMILTON JA; JESSUP W; BROWN AJ; WHITTY G, 2001, 'Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL', Biochemical Journal, 355, pp. 207 - 214, http://dx.doi.org/10.1042/bj3550207

Lyons MA; Brown AJ, 2001, '7-Ketocholesterol delivered to mice in chylomicron remnant-like particles is rapidly metabolised, excreted and does not accumulate in aorta', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1530, pp. 209 - 218, http://dx.doi.org/10.1016/S1388-1981(01)00083-X

Thomas SR; Leichtweis SB; Pettersson K; Croft KD; Mori TA; Brown AJ; Stocker R, 2001, 'Dietary cosupplementation with vitamin E and coenzyme Q10 inhibits atherosclerosis in apolipoprotein E gene knockout mice', Arteriosclerosis, Thrombosis, and Vascular Biology, 21, pp. 585 - 593, http://dx.doi.org/10.1161/01.ATV.21.4.585

Lyons MA; Brown AJ, 2001, 'Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells', Lipids, 36, pp. 701 - 711, http://dx.doi.org/10.1007/s11745-001-0775-8

Sleer LS; Brown AJ; Stanley K, 2001, 'Interaction of caveolin with 7-ketocholesterol', Atherosclerosis, 159, pp. 49 - 55

Brown AJ, 2000, 'Atherosclerosis: Cell biology and lipoproteins', Current Opinion in Lipidology, 11, pp. 667 - 669, http://dx.doi.org/10.1097/00041433-200012000-00016

Brown AJ; Watts GF; Burnett JR; Dean RT; Jessup W, 2000, 'Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture', Journal of Biological Chemistry, 275, pp. 27627 - 27633, http://dx.doi.org/10.1074/jbc.M004060200

Brown AJ; Mander EL; Gelissen IC; Kritharides L; Dean RT; Jessup W, 2000, 'Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells: Accumulation of oxidized esters in lysosomes', Journal of Lipid Research, 41, pp. 226 - 236

Brown AJ; Mander EL; Gelissen IC; Kritharides L; Dean RT; Jessup W, 2000, 'Accumulation of oxidised esters in lysosomes of macrophage foam cells', Atherosclerosis, 151, pp. 291 - 291, http://dx.doi.org/10.1016/s0021-9150(00)81321-0

Gaus K; Dass CR; Gelissen IC; Kritharides L; Brown AJ; Dean RT; Jessup W, 2000, 'Mechanisms of 7-ketocholesterol-mediated inhibition of cholesterol efflux from human foam cell macrophages', Atherosclerosis, 151, pp. 185 - 185, http://dx.doi.org/10.1016/s0021-9150(00)80842-4

Lyons MA; Brown AJ, 2000, 'Metabolism of 7-ketocholesterol by sterol 27-hydroxylase in human hepatic cells', Atherosclerosis, 151, pp. 291 - 291, http://dx.doi.org/10.1016/s0021-9150(00)81320-9

Rees DM; Kritharides L; Jessup W; Dean RT; Brown AJ, 2000, 'Paradoxical effects of oxysterols on cholesterol efflux and APO E release from foam cell macrophages', Heart, Lung and Circulation, 9, pp. A116 - A116, http://dx.doi.org/10.1046/j.1443-9506.2000.07066.x

Brown AJ; Dean RT; Jessup W, 2000, 'Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture', Atherosclerosis, 151, pp. 291 - 291, http://dx.doi.org/10.1016/s0021-9150(00)81322-2

Lyons MA; Samman S; Gatto L; Brown AJ, 1999, 'Rapid hepatic metabolism of 7-ketocholesterol in vivo: Implications for dietary oxysterols', Journal of Lipid Research, 40, pp. 1846 - 1857

Gelissen IC; Rye KA; Brown AJ; Dean RT; Jessup W, 1999, 'Oxysterol efflux from macrophage foam cells: The essential role of acceptor phospholipid', Journal of Lipid Research, 40, pp. 1636 - 1646

Brown AJ; Cartland S; Kraemer FB; Dean RT; Jessup W, 1999, 'Oxysterol-regulation of cholesterol esterification and hydrolysis in macrophages', FASEB JOURNAL, 13, pp. A1378 - A1378, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033400334&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lyons MA; Samman S; Gatto L; Brown AJ, 1999, 'Rapid hepatic metabolism of 7-Ketocholesterol in vivo: Implications for dietary oxysterols', FASEB JOURNAL, 13, pp. A1378 - A1378, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033400332&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lyons MA; Brown AJ, 1999, '7-Ketocholesterol', International Journal of Biochemistry and Cell Biology, 31, pp. 369 - 375, http://dx.doi.org/10.1016/S1357-2725(98)00123-X

Brown AJ; Jessup W, 1999, 'Oxysterols and atherosclerosis', Atherosclerosis, 142, pp. 1 - 28, http://dx.doi.org/10.1016/S0021-9150(98)00196-8

Alwan CL; Brown AJ; Cooper VA; Samman S, 1999, 'The role of ascorbic acid in the mosaic of coronary heart disease: Lipid metabolism and antioxidant functions', Journal of Clinical Biochemistry and Nutrition, 26, pp. 85 - 98, http://dx.doi.org/10.3164/jcbn.26.85

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