Researcher

Professor Jeff Holst

Keywords

Fields of Research (FoR)

Cancer cell biology, Cancer therapy (excl. chemotherapy and radiation therapy), Medical biochemistry - amino acids and metabolites, Medical biochemistry and metabolomics

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Biography

I am a fundamental and translational cancer researcher developing new ways to profile and target metabolic pathways in melanoma, glioblastoma, breast and prostate cancer. My research has focussed primarily on the role of uptake and metabolism of amino acids by cancer cells and how these integrate and cooperate with glucose metabolism to drive cell growth. My lab has developed a range of novel methods for exploring these metabolic processes in...view more

I am a fundamental and translational cancer researcher developing new ways to profile and target metabolic pathways in melanoma, glioblastoma, breast and prostate cancer. My research has focussed primarily on the role of uptake and metabolism of amino acids by cancer cells and how these integrate and cooperate with glucose metabolism to drive cell growth. My lab has developed a range of novel methods for exploring these metabolic processes in cancer, including 3D explant models for analysis of metabolism (metabolomics) and therapeutic development.

I am Director of Engagement and Industry Partnerships in the School of Medical Sciences at UNSW, and co-Director of the Adult Cancer Program together with A/Prof Caroline Ford. In addition, I am part of the Strategic Advisory Committee of the UNSW Cancer Theme.


My Grants

Charlie Teo Foundation Pilot Grant, Developing a metabolic roadmap to discover novel therapeutic avenues to starve glioblastoma. Jan 2021-Dec 2021 (CIA)

Tour de Cure Senior Research Grant, A new therapy targeting “gluttonous” prostate cancer cells Jan 2020-Dec 2020 (CIA)

Cancer Council NSW Project Grant, Targeting glutamine addiction of triple-negative breast cancer (TNBC). Jan 2018-Dec 2020 (CIA)

Cancer Council NSW Project Grant, Nutrient stress-mediated adaptive responses as novel targets in BRAF mutant melanoma. July 2017-Dec 2020 (CIA)

NHMRC/MRFF Lifting Clinical Trials and Registries Capacity Grant, Immunotherapy Targeting of Cytomegalovirus antigens in Glioblastoma: INTERROGATE-GBM. June 2018-June 2022 (CIC)

NHMRC Project Grant APP1144108 Metabolically Reprogramming the Stroma to Starve Pancreatic Tumours. Jan 2018-Dec 2020 (CID)

Avner Pancreatic Cancer Foundation, Starvation of pancreatic tumours by metabolically reprogramming both tumour and stromal cells. January 2019-December 2020 (CIC)


My Qualifications

BSc (Hons), PhD


My Research Activities

The Translational Cancer Metabolism Laboratory is focussed on understanding the role of amino acid uptake and metabolism in melanoma, breast and prostate cancer. The lab examines the basic biology regulating amino acid transporter expression and function, the downstream metabolic pathways, as well as developing new therapeutics to target the transporters and metabolic processes.

Key Publications:

Quek LE, van Geldermalsen M, Guan YF, Wahi K, Mayoh C, Balaban S, Pang A, Wang Q, Cowley MJ, Brown KK, Turner N, Hoy AJ, Holst J. Glutamine addiction promotes glucose oxidation in triple-negative breast cancer. Oncogene, 41(34):4066-78, 2022.

Wang Q, Guan YF, Hancock SE, Wahi K, van Geldermalsen M, Zhang BK, Pang A, Nagarajah R, Mak B, Freidman N, Horvath LG, Turner N, Holst J. Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth. The Journal of Pathology, 254(2):135-146, 2021.

Zhang BK, Moran AM, Bailey CG, Rasko JEJ, Holst J*, Wang Q*. EGF-activated PI3K/Akt signaling coordinates leucine uptake by regulating LAT3 expression in prostate cancer. Cell Communication and Signaling, 17(1):83, 2019. *=Co-Senior Author

van Geldermalsen M, Quek LE, Turner N, Freidman N, Pang A, Guan YF, Krycer JR, Ryan R, Wang Q, Holst J. Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways. BMC Cancer, 18(1):689, 2018.

Marshall AD, van Geldermalsen M, Otte NJ, Lum T, Vellozzi M, Thoeng A, Pang A, Nagarajah R, Zhang B, Wang Q, Anderson L, Rasko JEJ, Holst J. ASCT2 Regulates Glutamine Uptake and Cell Growth in Endometrial Carcinoma. Oncogenesis, 6(7):e367, 2017.

van Geldermalsen M, Wang Q, Nagarajah R, Marshall A, Thoeng A, Gao D, Ritchie W, Feng Y, Bailey CG, Deng N, Harvey K, Beith JM, Selinger C, O’Toole S, Rasko JEJ, Holst J. ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer. Oncogene, 35(24):3201-8, 2016.

Wang Q, Hardie R-A, Hoy AJ, van Geldermalsen M, Gao D, Fazli L, Sadowski MC, Balaban S, Schreuder M, Nagarajah R, Wong JJ-L, Metierre C, Pinello N, Otte, NJ, Lehman ML, Gleave M, Nelson CC, Bailey CG, Ritchie W, Rasko JEJ, Holst J. Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. The Journal of Pathology 236(3):278-89, 2015. 

Wang Q, Beaumont KA, Otte NJ, Font J, Bailey CG, van Geldermalsen M, Sharp DM, Tiffen JC, Ryan RM, Jormakka M, Haass NK, Rasko JEJ, Holst J. Targeting glutamine transport to suppress melanoma cell growth. International Journal of Cancer 135(5):1060-71, 2014.

Wang Q, Tiffen J, Bailey CG, Lehman ML, Ritchie W, Fazli L, Metierre C, Feng Y, Li E, Gleave M, Buchanan G, Nelson CC, Rasko JEJ and Holst J. Targeting amino acid transport in metastatic castration-resistant prostate cancer: Effects on cell cycle, cell growth and tumor development. Journal of the National Cancer Institute. 105(19):1463-73, 2013.

Wong JJ-L, Ritchie W, Ebner OA, Selbach M, Wong JWH, Huang Y, Gao D, Pinello N, Gonzalez M, Baidya K, Thoeng A, Khoo T-L, Bailey CG, Holst J* and Rasko JEJ*Orchestrated intron retention regulates normal granulocyte differentiation. Cell. 154(3) 583-595, 2013.

Wang Q, Bailey CG, Ng C, Tiffen J, Thoeng A, Minhas V, Lehman ML, Hendy SC, Buchanan G, Nelson CC, Rasko JEJ and Holst J. Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport in prostate cancer progression. Cancer Research 71(24):7525-36, 2011


My Research Supervision


Supervision keywords


Areas of supervision

PhD

Honours

Med Honours


Currently supervising

Michelle Devadason (PhD student)

Ella Grey (Honours student)

Carley Purcell (PhD student with Chaffer Lab)

Sofia Mason (PhD student with Chaffer Lab)


My Engagement

I am flexible work champion for the Faculty of Medicine and Health Equity, Diversity and Inclusion Committee (MEDIC).


My Teaching

I currently teach in Pharmacology, including lectures, tutorials and practicals on cancer therapeutics for PHAR3251 and PHAR3111.

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Location

Level 2 | Lowy Cancer Research Centre C25
UNSW SYDNEY NSW 2052 AUSTRALIA

Contact

+61-2-9065 8953