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Journal articles

Thoms JAI; Truong P; Subramanian S; Knezevic K; Harvey G; Huang Y; Seneviratne JA; Carter DR; Joshi S; Skhinas J; Chacon D; Shah A; de Jong I; Beck D; Göttgens B; Larsson J; Wong JWH; Zanini F; Pimanda JE, 2021, 'Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells', Blood, vol. 138, pp. 1441 - 1455, http://dx.doi.org/10.1182/blood.2020009707

Thoms JAI; Pimanda JE; Heidenreich O, 2021, 'To switch or not to switch: PU.1 expression is the question', Blood, vol. 138, pp. 1289 - 1291, http://dx.doi.org/10.1182/blood.2021012112

Yang J; Gao C; Liu M; Liu Y-C; Kwon J; Qi J; Tian X; Stein A; Liu YV; Kong NR; Wu Y; Yin S; Xi J; Chen Z; Kumari K; Wong H; Luo H; Silberstein LE; Thoms JAI; Unnikrishnan A; Pimanda JE; Tenen DG; Chai L, 2021, 'Targeting an inducible SALL4-mediated cancer vulnerability with sequential therapy.', Cancer Res, http://dx.doi.org/10.1158/0008-5472.CAN-21-0030

Chandrakanthan V; Rorimpandey P; Zanini F; Chacon D; Kang YC; Knezevic K; Huang Y; Qiao Q; Oliver R; Unnikrishnan A; Carter D; Lee B; Brownlee C; Power C; Mendez-Ferrer S; Enikolopov G; Walsh W; Göttgens B; Taoudi S; Beck D; Pimanda J, 2021, 'Mesoderm-Derived PDGFRA+ Cells Regulate the Emergence of Hematopoietic Stem Cells in the Dorsal Aorta', , http://dx.doi.org/10.1101/2021.08.08.455592

Tavassoli H; Rorimpandey P; Kang YC; Carnell M; Brownlee C; Pimanda JE; Chan PPY; Chandrakanthan V, 2021, 'Label-Free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics', Small, vol. 17, pp. e2006176, http://dx.doi.org/10.1002/smll.202006176

Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Srivastava P; Potas JR; Hung T; Power C; Hardy P; Ma DD; Kilian KA; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE, 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, vol. 7, pp. eabd1929 - eabd1929, http://dx.doi.org/10.1126/sciadv.abd1929

Tavassoli H; Rorimpandey P; Kang YC; Carnell M; Brownlee C; Pimanda JE; Chan PPY; Chandrakanthan V, 2021, 'Heart on A Chip: Label‐Free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics (Small 8/2021)', Small, vol. 17, pp. 2170034 - 2170034, http://dx.doi.org/10.1002/smll.202170034

Saini SK; Ørskov AD; Bjerregaard AM; Unnikrishnan A; Holmberg-Thydén S; Borch A; Jensen KV; Anande G; Bentzen AK; Marquard AM; Tamhane T; Treppendahl MB; Gang AO; Dufva IH; Szallasi Z; Ternette N; Pedersen AG; Eklund AC; Pimanda J; Grønbæk K; Hadrup SR, 2020, 'Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers', Nature Communications, vol. 11, http://dx.doi.org/10.1038/s41467-020-19464-8

Tavassoli H; Rorimpandey P; Kang YC; Carnell M; Brownlee C; Pimanda J; Chan PPY; Chandrakanthan V, 2020, 'Label-free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics', , http://dx.doi.org/10.1101/2020.08.31.243592

Carmichael CL; Wang J; Nguyen T; Kolawole O; Benyoucef A; de Mazière C; Milne AR; Samuel S; Gillinder K; Hediyeh-Zadeh S; Vo ANQ; Huang Y; Knezevic K; McInnes WRL; Shields BJ; Mitchell H; Ritchie ME; Lammens T; Lintermans B; van Vlierberghe P; Wong NC; Haigh K; Thoms JAI; Toulmin E; Curtis DJ; Oxley EP; Dickins RA; Beck D; Perkins A; McCormack MP; Davis MJ; Berx G; Zuber J; Pimanda JE; Kile BT; Goossens S; Haigh JJ, 2020, 'The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1', Blood, vol. 136, pp. 957 - 973, http://dx.doi.org/10.1182/blood.2019002548

Jolly CJ; Pimanda JE, 2020, 'Titans awake: HMAs for virus-driven ATL', Blood, vol. 136, pp. 777 - 779, http://dx.doi.org/10.1182/blood.2020006488

Tavassoli H; Kang YC; Rorimpandey P; Pimanda J; Chandrakanthan V; Chan PPY, 2020, 'Capturing Neonatal Cardiomyocyte – Endothelial interactions on-a-Chip', , http://dx.doi.org/10.1101/2020.08.10.243600

Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2020, 'RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia', Clinical Cancer Research, vol. 26, pp. 3597 - 3607, http://dx.doi.org/10.1158/1078-0432.CCR-20-0184

Richards LA; Kumari A; Knezevic K; Thoms JAI; von Jonquieres G; Napier CE; Ali Z; O'Brien R; Marks-Bluth J; Maritz MF; Pickett HA; Morris J; Pimanda JE; MacKenzie KL, 2020, 'DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts', Haematologica, vol. 105, pp. 1517 - 1526, http://dx.doi.org/10.3324/haematol.2018.215699

Khanna A; Thoms JAI; Stringer BW; Chung SA; Ensbey KS; Jue TR; Jahan Z; Subramanian S; Anande G; Shen H; Unnikrishnan A; McDonald KL; Day BW; Pimanda JE, 2020, 'Constitutive CHK1 Expression Drives a pSTAT3-CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth', Molecular cancer research : MCR, vol. 18, pp. 709 - 722, http://dx.doi.org/10.1158/1541-7786.MCR-19-0934

Anande G; Deshpande N; Mareschal S; Batcha A; Hampton H; Herold T; Lehmann S; Wilkins M; Wong JWH; Unnikrishnan A; Pimanda J, 2020, 'RNA splicing alterations induce a cellular stress response associated with poor prognosis in AML', , http://dx.doi.org/10.1101/2020.01.10.895714

Lee Q; Padula MP; Pinello N; Williams SH; O’Rourke MB; Fumagalli MJ; Orkin JD; Song R; Shaban B; Brenner O; Pimanda JE; Weninger W; de Souza WM; Melin AD; Wong JJL; Crim MJ; Monette S; Roediger B; Jolly CJ, 2020, 'Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys', PLoS Pathogens, vol. 16, pp. e1008262, http://dx.doi.org/10.1371/journal.ppat.1008262

Krivtsov AV; Evans K; Gadrey JY; Eschle BK; Hatton C; Uckelmann HJ; Ross KN; Perner F; Olsen SN; Pritchard T; McDermott L; Jones CD; Jing D; Braytee A; Chacon D; Earley E; McKeever BM; Claremon D; Gifford AJ; Lee HJ; Teicher BA; Pimanda JE; Beck D; Perry JA; Smith MA; McGeehan GM; Lock RB; Armstrong SA, 2019, 'A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia', Cancer Cell, vol. 36, pp. 660 - 673.e11, http://dx.doi.org/10.1016/j.ccell.2019.11.001

Thoms JAI; Beck D; Pimanda JE, 2019, 'Transcriptional networks in acute myeloid leukemia', Genes Chromosomes and Cancer, vol. 58, pp. 859 - 874, http://dx.doi.org/10.1002/gcc.22794

Chacon D; Braytee A; Huang Y; Thoms J; Subramanian S; Sauerland MC; Bohlander SK; Braess J; Woermann BJ; Berdel WE; Hiddemann W; Gabrys B; Metzeler KH; Herold T; Pimanda J; Beck D, 2019, 'Prospective Identification of Acute Myeloid Leukemia Patients Who Benefit from Gene-Expression Based Risk Stratification', BLOOD, vol. 134, http://dx.doi.org/10.1182/blood-2019-129519

Chiu SK; Orive SL; Moon MJ; Saw J; Ellis S; Kile BT; Huang Y; Chacon D; Pimanda JE; Beck D; Hamilton JR; Tremblay CS; Curtis DJ, 2019, 'Shared roles for Scl and Lyl1 in murine platelet production and function', Blood, vol. 134, pp. 826 - 835, http://dx.doi.org/10.1182/blood.2019896175

Poulos RC; Perera D; Packham D; Shah A; Janitz C; Pimanda JE; Hawkins N; Ward RL; Hesson LB; Wong JWH, 2019, 'Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing', JNCI CANCER SPECTRUM, vol. 3, http://dx.doi.org/10.1093/jncics/pkz012

Kumar P; Beck D; Galeev R; Thoms JAI; Talkhoncheh MS; de Jong I; Unnikrishnan A; Baudet A; Subramaniam A; Pimanda JE; Larsson J, 2019, 'HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells', Blood Advances, vol. 3, pp. 681 - 691, http://dx.doi.org/10.1182/bloodadvances.2018023986

Carmichael C; Wang J; Nguyen T; De Maziere C; Milne A; Goossens S; Davis M; Zadeh S; Vo A; McCormack M; Shields B; Haigh K; Huang Y; Thoms J; Knezevic K; Ritchie M; Berx G; Pimanda J; Kile B; Haigh J, 2019, '2008 - ALTERED EXPRESSION OF EPITHELIAL TO MESENCHYMAL TRANSITION MODULATORS IN ACUTE MYELOID LEUKAEMIA - A MODEL OF LSD1 CORRUPTION', Experimental Hematology, vol. 76, pp. S44 - S44, http://dx.doi.org/10.1016/j.exphem.2019.06.282

Jacquelin S; Straube J; Cooper L; Vu T; Song A; Bywater M; Baxter E; Heidecker M; Wackrow B; Porter A; Ling V; Green J; Austin R; Kazakoff S; Waddell N; Hesson LB; Pimanda JE; Stegelmann F; Bullinger L; Döhner K; Rampal RK; Heckl D; Hill GR; Lane SW, 2018, 'Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation', Blood, vol. 132, pp. 2707 - 2721, http://dx.doi.org/10.1182/blood-2018-04-846220

Jing D; Huang Y; Liu X; Sia KCS; Zhang JC; Tai X; Wang M; Toscan CE; McCalmont H; Evans K; Mayoh C; Poulos RC; Span M; Mi J; Zhang C; Wong JWH; Beck D; Pimanda JE; Lock RB, 2018, 'Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia', Cancer Cell, vol. 34, pp. 906 - 921.e8, http://dx.doi.org/10.1016/j.ccell.2018.11.002

Chiu SK; Saw J; Huang Y; Sonderegger SE; Wong NC; Powell DR; Beck D; Pimanda JE; Tremblay CS; Curtis DJ, 2018, 'A novel role for Lyl1 in primitive erythropoiesis', Development (Cambridge), vol. 145, http://dx.doi.org/10.1242/dev.162990

Liu Q; Thoms JAI; Nunez AC; Huang Y; Knezevic K; Packham D; Poulos RC; Williams R; Beck D; Hawkins NJ; Ward RL; Wong JWH; Hesson LB; Sloane MA; Pimanda JE, 2018, 'Disruption of a 35 KB enhancer impairs CTCF binding and MLH1 expression in colorectal cells', Clinical Cancer Research, vol. 24, pp. 4602 - 4611, http://dx.doi.org/10.1158/1078-0432.CCR-17-3678

Smeets MF; Tan SY; Xu JJ; Anande G; Unnikrishnan A; Chalk AM; Taylor SR; Pimanda JE; Wall M; Purton LE; Walkley CR, 2018, 'Srsf2P95H initiates myeloid bias and myelodysplastic/ myeloproliferative syndrome from hemopoietic stem cells', Blood, vol. 132, pp. 608 - 621, http://dx.doi.org/10.1182/blood-2018-04-845602

Ali A; Penneroux J; Dal Bello R; Massé A; Quentin S; Unnikrishnan A; Hernandez L; Raffoux E; Ben Abdelali R; Renneville A; Preudhomme C; Pimanda J; Dombret H; Soulier J; Fenaux P; Clappier E; Adès L; Puissant A; Itzykson R, 2018, 'Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia', Leukemia, vol. 32, pp. 1856 - 1860, http://dx.doi.org/10.1038/s41375-018-0076-2

Unnikrishnan A; Vo ANQ; Pickford R; Raftery MJ; Nunez AC; Verma A; Hesson LB; Pimanda JE, 2018, 'AZA-MS: A novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo', Leukemia, vol. 32, pp. 900 - 910, http://dx.doi.org/10.1038/leu.2017.340

Beck D; Thoms JAI; Palu C; Herold T; Shah A; Olivier J; Boelen L; Huang Y; Chacon D; Brown A; Babic M; Hahn C; Perugini M; Zhou X; Huntly BJ; Schwarzer A; Klusmann JH; Berdel WE; Wörmann B; Büchner T; Hiddemann W; Bohlander SK; To LB; Scott HS; Lewis ID; D'Andrea RJ; Wong JWH; Pimanda JE, 2018, 'A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients', Leukemia, vol. 32, pp. 263 - 272, http://dx.doi.org/10.1038/leu.2017.210

Pimanda J, 2018, 'Generating Multipotent Stem Cells From Primary Human Adipocytes for Tissue Repair', Experimental Hematology, vol. 64, pp. S94 - S94, http://dx.doi.org/10.1016/j.exphem.2018.06.121

Pimanda J, 2018, 'Mesoderm-Derived PDGFRA+ Cells Regulate Emergence of Hematopoietic Stem Cells in the Dorsal Aorta', Experimental Hematology, vol. 64, pp. S45 - S45, http://dx.doi.org/10.1016/j.exphem.2018.06.051

Schwarzer A; Emmrich S; Schmidt F; Beck D; Ng M; Reimer C; Adams FF; Grasedieck S; Witte D; Käbler S; Wong JWH; Shah A; Huang Y; Jammal R; Maroz A; Jongen-Lavrencic M; Schambach A; Kuchenbauer F; Pimanda JE; Reinhardt D; Heckl D; Klusmann JH, 2017, 'The non-coding RNA landscape of human hematopoiesis and leukemia', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00212-4

Liu K; Beck D; Thoms JAI; Liu L; Zhao W; Pimanda JE; Zhou X, 2017, 'Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method', Bioinformatics, vol. 33, pp. 2622 - 2630, http://dx.doi.org/10.1093/bioinformatics/btx280

Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, vol. 20, pp. 572 - 585, http://dx.doi.org/10.1016/j.celrep.2017.06.067

Chandrakanthan V; Qiao Q; Chan Kang Y; Knezevic K; Oliver R; Loo C; Anande G; Lee B; Walsh W; Power C; Wong J; Pimanda J, 2017, 'Declined presentation characterisation of stromal cell populations in the foetal liver and their contributions to embryonic haematopoietic and vascular development', Experimental Hematology, vol. 53, pp. S118 - S118, http://dx.doi.org/10.1016/j.exphem.2017.06.295

Jacquelin S; Straube J; Song A; Cooper L; Vu T; Heidecker M; Pimanda J; Hesson L; Hill G; Cloonan N; Heckl D; Lane S, 2017, 'In vivo CRISPR editing of DNMT3A in JAK2V617F hematopoietic stem cells induces myelofibrosis', Experimental Hematology, vol. 53, pp. S95 - S95, http://dx.doi.org/10.1016/j.exphem.2017.06.224

Chiu SK; Saw J; Huang Y; Beck D; Powell D; Pimanda J; Tremblay C; Curtis D, 2017, 'Maintenance of primitive haematopoiesis is shared by SCL and LYL1', Experimental Hematology, vol. 53, pp. S115 - S115, http://dx.doi.org/10.1016/j.exphem.2017.06.288

Poulos RC; Thoms JAI; Guan YF; Unnikrishnan A; Pimanda JE; Wong JWH, 2016, 'Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif', Cell Reports, vol. 17, pp. 2865 - 2872, http://dx.doi.org/10.1016/j.celrep.2016.11.055

Unnikrishnan A; Guan YF; Huang Y; Beck D; Thoms JAI; Peirs S; Knezevic K; Ma S; De Walle IV; De Jong IDE; Ali Z; Zhong L; Raftery MJ; Taghon T; Larsson J; MacKenzie KL; Van Vlierberghe P; Wong JWH; Pimanda JE, 2016, 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network', Nucleic Acids Research, vol. 44, pp. 10644 - 10661, http://dx.doi.org/10.1093/nar/gkw804

Hesson LB; Ng B; Zarzour P; Srivastava S; Kwok CT; Packham D; Nunez AC; Beck D; Ryan R; Dower A; Ford CE; Pimanda JE; Sloane MA; Hawkins NJ; Bourke MJ; Wong JWH; Ward RL, 2016, 'Integrated genetic, epigenetic, and transcriptional profiling identifies molecular pathways in the development of laterally spreading tumors', Molecular Cancer Research, vol. 14, pp. 1217 - 1228, http://dx.doi.org/10.1158/1541-7786.MCR-16-0175

Nasrallah R; Fast EM; Solaimani P; Knezevic K; Eliades A; Patel R; Thambyrajah R; Unnikrishnan A; Thoms J; Beck D; Vink CS; Smith A; Wong J; Shepherd M; Kent D; Roychoudhuri R; Paul F; Klippert J; Hammes A; Willnow T; Göttgens B; Dzierzak E; Zon LI; Lacaud G; Kouskoff V; Pimanda JE, 2016, 'Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes', Blood, vol. 128, pp. 1928 - 1939, http://dx.doi.org/10.1182/blood-2016-02-697870

Richmond J; Robbins A; Evans K; Beck D; Kurmasheva RT; Billups CA; Carol H; Heatley S; Sutton R; Marshall GM; White D; Pimanda J; Houghton PJ; Smith MA; Lock RB, 2016, 'Acute sensitivity of Ph-like acute lymphoblastic leukemia to the SMAC-mimetic birinapant', Cancer Research, vol. 76, pp. 4579 - 4591, http://dx.doi.org/10.1158/0008-5472.CAN-16-0523

Botezatu L; Michel LC; Makishima H; Schroeder T; Germing U; Haas R; Van der Reijden B; Marneth AE; Bergevoet SM; Jansen JH; Przychodzen B; Wlodarski M; Niemeyer C; Platzbecker U; Ehninger G; Unnikrishnan A; Beck D; Pimanda J; Hellström-Lindberg E; Malcovati L; Boultwood J; Pellagatti A; Papaemmanuil E; Le Coutre P; Kaeda J; Opalka B; Möröy T; Dührsen U; Maciejewski J; Khandanpour C, 2016, 'GFI136N as a therapeutic and prognostic marker for myelodysplastic syndrome', Experimental Hematology, vol. 44, pp. 590 - 595.e1, http://dx.doi.org/10.1016/j.exphem.2016.04.001

Huang Y; Thoms JAI; Tursky ML; Knezevic K; Beck D; Chandrakanthan V; Suryani S; Olivier J; Boulton A; Glaros EN; Thomas SR; Lock RB; MacKenzie KL; Bushweller JH; Wong JWH; Pimanda JE, 2016, 'MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation', Leukemia, vol. 30, pp. 1552 - 1561, http://dx.doi.org/10.1038/leu.2016.55

Perera D; Poulos RC; Shah A; Beck D; Pimanda JE; Wong JWH, 2016, 'Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes', Nature, vol. 532, pp. 259 - 263, http://dx.doi.org/10.1038/nature17437

Khanna A; Pimanda JE, 2016, 'Clinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers', International Journal of Cancer, vol. 138, pp. 525 - 532, http://dx.doi.org/10.1002/ijc.29431

Shields BJ; Jackson JT; Metcalf D; Shi W; Huang Q; Garnham AL; Glaser SP; Beck D; Pimanda JE; Bogue CW; Smyth GK; Alexander WS; McCormack MP, 2016, 'Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a', Genes and Development, vol. 30, pp. 78 - 91, http://dx.doi.org/10.1101/gad.268425.115


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