Select Publications

Book Chapters

Estrella RP; Whitelock JM; Roubin RH; Packer NH; Karlsson NG, 2009, 'Small-scale enzymatic digestion of glycoproteins and proteoglycans for analysis of oligosaccharides by LC-MS and FACE gel electrophoresis', in Methods in Molecular Biology, pp. 171 - 192,

Whitelock J; Melrose J, 2006, 'Adhesion of cells to biomaterials', in Metin Akay (ed.), Wiley Encyclopedia of Biomedical Engineering, edn. 1, John Wiley & Sons, USA, pp. 16 - 23

Melrose J; Whitelock J, 2006, 'Extracellular Matrix', in Metin Akay (ed.), Wiley Encyclopedia of Biomedical Engineering, edn. 1, John Wiley & Sons, USA, pp. 1556 - 1577

Journal articles

Farrugia BL; Mizumoto S; Lord MS; O’Grady RL; Kuchel RP; Yamada S; Whitelock JM, 2019, 'Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms', Journal of Biological Chemistry, vol. 294, pp. 11458 - 11472,

Gunatillake T; Chui A; Fitzpatrick E; Ignjatovic V; Monagle P; Whitelock J; Zanten D; Eijsink J; Borg A; Stevenson J; Brennecke SP; Erwich JJHM; Said JM; Murthi P, 2019, 'Decreased placental glypican expression is associated with human fetal growth restriction', Placenta, vol. 76, pp. 6 - 9,

Farrugia B; Mi Y; Kim HN; Whitelock J; Baker S; Wiesmann W; Li Z; Maitz P; Lord M, 2018, 'Chitosan‐Based Heparan Sulfate Mimetics Promote Epidermal Formation in a Human Organotypic Skin Model', Advanced Functional Materials, vol. 28,

Tang F; Lord M; Stallcup W; Whitelock J, 2018, 'Cell surface chondroitin sulfate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulfate proteoglycan, perlecan, and is involved in cell adhesion', The Journal of Biochemistry, vol. 163, pp. 399 - 412,

Hayes A; Sugahara K; Farrugia B; Whitelock JM; Caterson B; Melrose J, 2018, 'Biodiversity of CS–proteoglycan sulphation motifs: Chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis', Biochemical Journal, vol. 475, pp. 587 - 620,

Farrugia BL; Lord MS; Whitelock JM; Melrose J, 2018, 'Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair', Biomaterials Science, vol. 6, pp. 947 - 957,

Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2018, 'The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies', Journal of Histochemistry and Cytochemistry, vol. 66, pp. 321 - 336,

Vassie JA; Whitelock JM; Lord MS, 2018, 'Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells', Molecular Pharmaceutics, vol. 15, pp. 994 - 1004,

Lord MS; Tang F; Rnjak-Kovacina J; Smith JGW; Melrose J; Whitelock JM, 2018, 'The multifaceted roles of perlecan in fibrosis', Matrix Biology, vol. 68-69, pp. 150 - 166,

Lord M; Rnjak-Kovacina J; Tang F; Whitelock J, 2018, 'Glycosaminoglycan and Proteoglycan-Based Biomaterials: Current Trends and Future Perspectives', Advanced Healthcare Materials, vol. 7, pp. 1701042 - 1701042,

Chui AKL; Gunatillake TN; Ignjatovic V; Monagle PT; Murthi P; Brennecke SP; Whitelock JM; Said JM, 2017, 'Antiangiogenic effects of decorin restored by unfractionated, low molecular weight, and nonanticoagulant heparins.', Blood Adv, vol. 1, pp. 1243 - 1253,

Rnjak-Kovacina J; Tang F; Lin X; Whitelock JM; Lord MS, 2017, 'Recombinant Domain V of Human Perlecan Is a Bioactive Vascular Proteoglycan', Biotechnology Journal, vol. 12,

Krilis M; Qi M; Madigan MC; Wong JWH; Abdelatti M; Guymer RH; Whitelock J; McCluskey P; Zhang P; Qi J; Hunyor AP; Krilis SA; Giannakopoulos B, 2017, 'Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration', Oncotarget, vol. 8, pp. 49016 - 49032,

Kim HN; Whitelock JM; Lord MS, 2017, 'Structure-activity relationships of bioengineered heparin/heparan sulfates produced in different bioreactors', Molecules, vol. 22,

Chui A; Gunatillake T; Brennecke SP; Ignjatovic V; Monagle PT; Whitelock JM; Van Zanten DE; Eijsink J; Wang Y; Deane J; Borg AJ; Stevenson J; Erwich JJ; Said JM; Murthi P, 2017, 'Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 37, pp. 1168 - 1179,

Lord MS; Jung MS; Whitelock JM, 2017, 'Optimization of bioengineered heparin/heparan sulfate production for therapeutic applications', Bioengineered, pp. 1 - 4,

Lord MS; Cheng B; Farrugia BL; McCarthy S; Whitelock JM, 2017, 'Platelet factor 4 binds to vascular proteoglycans and controls both growth factor activities and platelet activation', Journal of Biological Chemistry, vol. 292, pp. 4054 - 4063,

Lord MS; Ellis AL; Farrugia BL; Whitelock JM; Grenett H; Li C; O'Grady RL; DeCarlo AA, 2017, 'Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing', Journal of Controlled Release, vol. 250, pp. 48 - 61,

Vassie JA; Whitelock JM; Lord MS, 2017, 'Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells', Acta Biomaterialia, vol. 50, pp. 127 - 141,

Dos Santos M; Michopoulou A; André-Frei V; Boulesteix S; Guicher C; Dayan G; Whitelock J; Damour O; Rousselle P, 2016, 'Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin', Aging, vol. 8, pp. 751 - 768,

Lord MS; Cheng B; Tang F; Lyons JG; Rnjak-Kovacina J; Whitelock JM, 2016, 'Bioengineered human heparin with anticoagulant activity', Metabolic Engineering, vol. 38, pp. 105 - 114,

Rnjak-Kovacina J; Tang F; Whitelock JM; Lord MS, 2016, 'Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications', Colloids and Surfaces B: Biointerfaces, vol. 148, pp. 130 - 138,

Hayes AJ; Shu CC; Lord MS; Little CB; Whitelock JM; Melrose J, 2016, 'Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc', European Cells and Materials, vol. 32, pp. 40 - 57,

Farrugia BL; Chandrasekar K; Johnson L; Whitelock JM; Marks D; Irving D; Lord M, 2016, 'Perspectives on the use of biomaterials to store platelets for transfusion', Biointerphases: an open access journal for the biomaterials interface community, vol. 11, pp. 029701 - 029701,

Lord MS; Farrugia BL; Yan CMY; Vassie JA; Whitelock JM, 2016, 'Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts', Journal of Biomedical Materials Research - Part A, vol. 104, pp. 1736 - 1746,

Shu CC; Jackson MT; Smith MM; Smith SM; Penm S; Lord MS; Whitelock JM; Little CB; Melrose J, 2016, 'Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis', Arthritis and Rheumatology, vol. 68, pp. 868 - 879,

Farrugia BL; Whitelock JM; O'Grady R; Caterson B; Lord MS, 2016, 'Mast Cells Produce a Unique Chondroitin Sulfate Epitope', Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, vol. 64, pp. 85 - 98,

Melrose J; Shu C; Whitelock JM; Lord MS, 2016, 'The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation', Matrix Biology, vol. 52-54, pp. 363 - 383,

Vassie JA; Whitelock JM; Lord MS, 2015, 'Glycosaminoglycan functionalized nanoparticles exploit glycosaminoglycan functions', Methods in Molecular Biology, vol. 1229, pp. 557 - 565,

Shawky MS; Ricciardelli C; Lord M; Whitelock J; Ferro V; Britt K; Thompson EW, 2015, 'Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk', Journal of Mammary Gland Biology and Neoplasia, vol. 20, pp. 121 - 131,

Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2015, 'Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?', Molecules, vol. 20, pp. 4254 - 4276,

Gunatillake T; Chui A; Lord M; Whitelock J; Murthi P; Ignatovic V; Monagle P; Brennecke S; Said J, 2015, '[289-POS]: Placental heparan sulphate glycosaminoglycans in pre-eclampsia.', Pregnancy Hypertens, vol. 5, pp. 144,

Lord MS; Farrugia BL; Rnjak-Kovacina J; Whitelock JM, 2015, 'Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix', Expert Review of Molecular Diagnostics, vol. 15, pp. 77 - 95,

Lord MS; Whitelock JM; Simmons A; Williams RL; Milthorpe BK, 2014, 'Fibrinogen adsorption and platelet adhesion to silica surfaces with stochastic nanotopography', Biointerphases, vol. 9, pp. 041002,

Lord MS; Whitelock JM, 2014, 'Bioengineered heparin: Is there a future for this form of the successful therapeutic?', Bioengineered, vol. 5, pp. 222 - 226,

Baljinnyam E; Umemura M; Chuang C; De Lorenzo MS; Iwatsubo M; Chen S; Goydos JS; Ishikawa Y; Whitelock JM; Iwatsubo K, 2014, 'Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling', Pigment Cell and Melanoma Research, vol. 27, pp. 611 - 620,

Chui A; Murthi P; Gunatillake T; Brennecke SP; Ignjatovic V; Monagle PT; Whitelock JM; Said JM, 2014, 'Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?', Placenta, vol. 35, pp. 596 - 605,

Lord MS; Tsoi BM; Farrugia BL; Simon Ting SR; Baker S; Wiesmann WP; Whitelock JM, 2014, 'Synthesis and characterization of water soluble biomimetic chitosans for bone and cartilage tissue regeneration', Journal of Materials Chemistry B, vol. 20, pp. 6517 - 6526,

Chuang CY; Degendorfer G; Hammer A; Whitelock JM; Malle E; Davies MJ, 2014, 'Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells', Biochemical Journal, vol. 459, pp. 313 - 322,

Lord MS; Chuang CY; Melrose J; Davies MJ; Iozzo RV; Whitelock JM, 2014, 'The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling', Matrix Biology, vol. 35, pp. 112 - 122,

Lord MS; Jung MS; Cheng B; Whitelock JM, 2014, 'Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1', Matrix Biology, vol. 35, pp. 123 - 131,

Farrugia BL; Whitelock JM; Jung M; O'Grady RL; McGrath B; McCarthy SJ; Lord MS, 2014, 'The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan', Biomaterials, vol. 35, pp. 1462 - 1477,

Chuang CY; Degendorfer G; Hammer A; Malle E; Kawasaki H; Yamakura F; Whitelock JM; Davies MJ, 2013, 'Peroxynitrite-mediated damage in the artery wall and its consequences', FREE RADICAL BIOLOGY AND MEDICINE, vol. 65, pp. S6 - S6,

Tang F; Lord M; Whitelock J, 2012, 'The roles of melanoma-associated protein (CSPG4) and perlecan (HSPG2) in cancer, potential targets for drug therapy', GLYCOBIOLOGY, vol. 22, pp. 1605 - 1605,

Lord MS; Estrella RP; Chuang CY; Youssef P; Karlsson NG; Flannery CR; Whitelock J, 2012, 'Not all lubricin isoforms are substituted with a glycosaminoglycan chain', Connective Tissue Research, vol. 53, pp. 132 - 141,

Jin C; Ekwall AKH; Bylund JE; Bjorkman L; Estrella RP; Whitelock J; Eisler T; Bokarewa MI; Karlsson NG, 2012, 'Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity', The Journal of Biological Chemistry, vol. 287, pp. 35922 - 35933,

Cheng JY; Whitelock J; Poole-Warren LA, 2012, 'Syndecan-4 is associated with betá-cells in the pancreas and the MIN6 beta-cell line', Histochemistry and Cell Biology, vol. 138, pp. 933 - 944,

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