Select Publications

Journal articles

Farrugia BL; Mizumoto S; Lord MS; O'Grady RL; Kuchel RP; Yamada S; Whitelock JM, 2019, 'Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms.', J Biol Chem, http://dx.doi.org/10.1074/jbc.RA119.008647

Gunatillake T; Chui A; Fitzpatrick E; Ignjatovic V; Monagle P; Whitelock J; Zanten D; Eijsink J; Borg A; Stevenson J; Brennecke SP; Erwich JJ H M; Said JM; Murthi P, 2019, 'Decreased placental glypican expression is associated with human fetal growth restriction', Placenta, vol. 76, pp. 6 - 9, http://dx.doi.org/10.1016/j.placenta.2018.12.007

Farrugia BL; Mi Y; Kim HN; Whitelock JM; Baker SM; Wiesmann WP; Li Z; Maitz P; Lord MS, 2018, 'Chitosan-Based Heparan Sulfate Mimetics Promote Epidermal Formation in a Human Organotypic Skin Model', Advanced Functional Materials, vol. 28, http://dx.doi.org/10.1002/adfm.201802818

Tang F; Lord MS; Stallcup WB; Whitelock JM, 2018, 'Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion', Journal of Biochemistry, vol. 163, pp. 399 - 412, http://dx.doi.org/10.1093/jb/mvy008

Hayes A; Sugahara K; Farrugia B; Whitelock JM; Caterson B; Melrose J, 2018, 'Biodiversity of CS–proteoglycan sulphation motifs: Chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis', Biochemical Journal, vol. 475, pp. 587 - 620, http://dx.doi.org/10.1042/BCJ20170820

Farrugia BL; Lord MS; Whitelock JM; Melrose J, 2018, 'Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair', Biomaterials Science, vol. 6, pp. 947 - 957, http://dx.doi.org/10.1039/c7bm01158j

Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2018, 'The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies', Journal of Histochemistry and Cytochemistry, vol. 66, pp. 321 - 336, http://dx.doi.org/10.1369/0022155417740881

Vassie JA; Whitelock JM; Lord MS, 2018, 'Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells', Molecular Pharmaceutics, vol. 15, pp. 994 - 1004, http://dx.doi.org/10.1021/acs.molpharmaceut.7b00920

Lord MS; Tang F; Rnjak-Kovacina J; Smith JG W; Melrose J; Whitelock JM, 2018, 'The multifaceted roles of perlecan in fibrosis', Matrix Biology, vol. 68-69, pp. 150 - 166, http://dx.doi.org/10.1016/j.matbio.2018.02.013

Rnjak-Kovacina J; Tang F; Whitelock JM; Lord MS, 2018, 'Glycosaminoglycan and Proteoglycan-Based Biomaterials: Current Trends and Future Perspectives', Advanced Healthcare Materials, vol. 7, http://dx.doi.org/10.1002/adhm.201701042

Chui AK L; Gunatillake TN; Ignjatovic V; Monagle PT; Murthi P; Brennecke SP; Whitelock JM; Said JM, 2017, 'Antiangiogenic effects of decorin restored by unfractionated, low molecular weight, and nonanticoagulant heparins.', Blood Adv, vol. 1, pp. 1243 - 1253, http://dx.doi.org/10.1182/bloodadvances.2017004333

Rnjak-Kovacina J; Tang F; Lin X; Whitelock JM; Lord MS, 2017, 'Recombinant Domain V of Human Perlecan Is a Bioactive Vascular Proteoglycan', Biotechnology Journal, vol. 12, http://dx.doi.org/10.1002/biot.201700196

Krilis M; Qi M; Madigan MC; Wong JW H; Abdelatti M; Guymer RH; Whitelock J; McCluskey P; Zhang P; Qi J; Hunyor AP; Krilis SA; Giannakopoulos B, 2017, 'Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration', Oncotarget, vol. 8, pp. 49016 - 49032, http://dx.doi.org/10.18632/oncotarget.14940

Kim HN; Whitelock JM; Lord MS, 2017, 'Structure-activity relationships of bioengineered heparin/heparan sulfates produced in different bioreactors', Molecules, vol. 22, http://dx.doi.org/10.3390/molecules22050806

Chui A; Gunatillake T; Brennecke SP; Ignjatovic V; Monagle PT; Whitelock JM; Van Zanten DE; Eijsink J; Wang Y; Deane J; Borg AJ; Stevenson J; Erwich JJ; Said JM; Murthi P, 2017, 'Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 37, pp. 1168 - 1179, http://dx.doi.org/10.1161/ATVBAHA.117.309422

Lord MS; Jung MS; Whitelock JM, 2017, 'Optimization of bioengineered heparin/heparan sulfate production for therapeutic applications', Bioengineered, pp. 1 - 4, http://dx.doi.org/10.1080/21655979.2017.1301328

Lord MS; Cheng B; Farrugia BL; McCarthy S; Whitelock JM, 2017, 'Platelet factor 4 binds to vascular proteoglycans and controls both growth factor activities and platelet activation', Journal of Biological Chemistry, vol. 292, pp. 4054 - 4063, http://dx.doi.org/10.1074/jbc.M116.760660

Lord MS; Ellis AL; Farrugia BL; Whitelock JM; Grenett H; Li C; O'Grady RL; DeCarlo AA, 2017, 'Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing', Journal of Controlled Release, vol. 250, pp. 48 - 61, http://dx.doi.org/10.1016/j.jconrel.2017.02.009

Vassie JA; Whitelock JM; Lord MS, 2017, 'Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells', Acta Biomaterialia, vol. 50, pp. 127 - 141, http://dx.doi.org/10.1016/j.actbio.2016.12.010

Dos Santos M; Michopoulou A; André-Frei V; Boulesteix S; Guicher C; Dayan G; Whitelock J; Damour O; Rousselle P, 2016, 'Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin', Aging, vol. 8, pp. 751 - 768, http://dx.doi.org/10.18632/AGING.100928

Lord MS; Cheng B; Tang F; Lyons JG; Rnjak-Kovacina J; Whitelock JM, 2016, 'Bioengineered human heparin with anticoagulant activity', Metabolic Engineering, vol. 38, pp. 105 - 114, http://dx.doi.org/10.1016/j.ymben.2016.07.006

Rnjak-Kovacina J; Tang F; Whitelock JM; Lord MS, 2016, 'Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications', Colloids and Surfaces B: Biointerfaces, vol. 148, pp. 130 - 138, http://dx.doi.org/10.1016/j.colsurfb.2016.08.039

Hayes AJ; Shu CC; Lord MS; Little CB; Whitelock JM; Melrose J, 2016, 'Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc', European Cells and Materials, vol. 32, pp. 40 - 57, http://dx.doi.org/10.22203/eCM.v032a03

Farrugia BL; Chandrasekar K; Johnson L; Whitelock JM; Marks DC; Irving DO; Lord MS, 2016, 'Perspectives on the use of biomaterials to store platelets for transfusion', Biointerphases, vol. 11, http://dx.doi.org/10.1116/1.4952450

Lord MS; Farrugia BL; Yan CM Y; Vassie JA; Whitelock JM, 2016, 'Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts', Journal of Biomedical Materials Research - Part A, vol. 104, pp. 1736 - 1746, http://dx.doi.org/10.1002/jbm.a.35704

Shu CC; Jackson MT; Smith MM; Smith SM; Penm S; Lord MS; Whitelock JM; Little CB; Melrose J, 2016, 'Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis', Arthritis and Rheumatology, vol. 68, pp. 868 - 879, http://dx.doi.org/10.1002/art.39529

Farrugia BL; Whitelock JM; O’Grady R; Caterson B; Lord MS, 2016, 'Mast Cells Produce a Unique Chondroitin Sulfate Epitope', Journal of Histochemistry and Cytochemistry, vol. 64, pp. 85 - 98, http://dx.doi.org/10.1369/0022155415620649

Melrose J; Shu C; Whitelock JM; Lord MS, 2016, 'The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation', Matrix Biology, vol. 52-54, pp. 363 - 383, http://dx.doi.org/10.1016/j.matbio.2016.01.008

Vassie JA; Whitelock JM; Lord MS, 2015, 'Glycosaminoglycan functionalized nanoparticles exploit glycosaminoglycan functions', Methods in Molecular Biology, vol. 1229, pp. 557 - 565, http://dx.doi.org/10.1007/978-1-4939-1714-3_44

Shawky MS; Ricciardelli C; Lord M; Whitelock J; Ferro V; Britt K; Thompson EW, 2015, 'Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk', Journal of Mammary Gland Biology and Neoplasia, http://dx.doi.org/10.1007/s10911-015-9346-z

Farrugia BL; Lord MS; Melrose J; Whitelock JM, 2015, 'Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?', Molecules, vol. 20, pp. 4254 - 4276, http://dx.doi.org/10.3390/molecules20034254

Gunatillake T; Chui A; Lord M; Whitelock J; Murthi P; Ignatovic V; Monagle P; Brennecke S; Said J, 2015, '[289-POS]: Placental heparan sulphate glycosaminoglycans in pre-eclampsia.', Pregnancy Hypertens, vol. 5, pp. 144, http://dx.doi.org/10.1016/j.preghy.2014.10.295

Lord MS; Farrugia BL; Rnjak-Kovacina J; Whitelock JM, 2015, 'Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix', Expert Review of Molecular Diagnostics, vol. 15, pp. 77 - 95, http://dx.doi.org/10.1586/14737159.2015.979158

Lord MS; Whitelock JM; Simmons A; Williams RL; Milthorpe BK, 2014, 'Fibrinogen adsorption and platelet adhesion to silica surfaces with stochastic nanotopography', Biointerphases, vol. 9, pp. 041002, http://dx.doi.org/10.1116/1.4900993

Lord MS; Whitelock JM, 2014, 'Bioengineered heparin: Is there a future for this form of the successful therapeutic?', Bioengineered, vol. 5, pp. 222 - 226, http://dx.doi.org/10.4161/bioe.29388

Baljinnyam E; Umemura M; Chuang C; De Lorenzo MS; Iwatsubo M; Chen S; Goydos JS; Ishikawa Y; Whitelock JM; Iwatsubo K, 2014, 'Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling', Pigment Cell and Melanoma Research, vol. 27, pp. 611 - 620, http://dx.doi.org/10.1111/pcmr.12250

Chui A; Murthi P; Gunatillake T; Brennecke SP; Ignjatovic V; Monagle PT; Whitelock JM; Said JM, 2014, 'Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?', Placenta, vol. 35, pp. 596 - 605, http://dx.doi.org/10.1016/j.placenta.2014.05.009

Lord MS; Tsoi BM; Farrugia BL; Simon Ting SR; Baker S; Wiesmann WP; Whitelock JM, 2014, 'Synthesis and characterization of water soluble biomimetic chitosans for bone and cartilage tissue regeneration', Journal of Materials Chemistry B, vol. 20, pp. 6517 - 6526, http://dx.doi.org/10.1039/c4tb00531g

Chuang CY; Degendorfer G; Hammer A; Whitelock JM; Malle E; Davies MJ, 2014, 'Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells', Biochemical Journal, vol. 459, pp. 313 - 322, http://dx.doi.org/10.1042/BJ20131471

Lord MS; Whitelock JM; Chuang CY; Davies MJ; Melrose J; Iozzo RV, 2014, 'The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling', Matrix Biology, http://dx.doi.org/10.1016/j.matbio.2014.01.016

Lord MS; Jung M; Cheng B; Whitelock JM, 2014, 'Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1', Matrix Biology, http://dx.doi.org/10.1016/j.matbio.2013.12.005

Farrugia BL; Whitelock JM; Jung MS; McGrath B; O'Grady RL; McCarthy SJ; Lord MS, 2014, 'The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan', Biomaterials, vol. 35, pp. 1462 - 1477, http://dx.doi.org/10.1016/j.biomaterials.2013.10.068

Chuang CY; Degendorfer G; Hammer A; Malle E; Kawasaki H; Yamakura F; Whitelock JM; Davies MJ, 2013, 'Peroxynitrite-mediated damage in the artery wall and its consequences', FREE RADICAL BIOLOGY AND MEDICINE, vol. 65, pp. S6 - S6, http://dx.doi.org/10.1016/j.freeradbiomed.2013.08.117

Tang F; Lord M; Whitelock J, 2012, 'The roles of melanoma-associated protein (CSPG4) and perlecan (HSPG2) in cancer, potential targets for drug therapy', GLYCOBIOLOGY, vol. 22, pp. 1605 - 1605, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310368700259&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Lord MS; Estrella RP; Chuang CY; Youssef P; Karlsson NG; Flannery CR; Whitelock JM, 2012, 'Not all lubricin isoforms are substituted with a glycosaminoglycan chain', Connective Tissue Research, vol. 53, pp. 132 - 141, http://dx.doi.org/10.3109/03008207.2011.614364

Jin C; Ekwall AK H; Bylund J; Björkman L; Estrella RP; Whitelock JM; Eisler T; Bokarewa M; Karlsson NG, 2012, 'Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity', Journal of Biological Chemistry, vol. 287, pp. 35922 - 35933, http://dx.doi.org/10.1074/jbc.M112.363119

Cheng JY C; Whitelock J; Poole-Warren L, 2012, 'Syndecan-4 is associated with betα-cells in the pancreas and the MIN6 beta-cell line', Histochemistry and Cell Biology, vol. 138, pp. 933 - 944, http://dx.doi.org/10.1007/s00418-012-1004-6

Cheng JY C; Raghunath M; Whitelock J; Poole-Warren L, 2011, 'Matrix components and scaffolds for sustained islet function', Tissue Engineering - Part B: Reviews, vol. 17, pp. 235 - 247, http://dx.doi.org/10.1089/ten.teb.2011.0004

Kennett EC; Chuang CY; Degendorfer G; Whitelock JM; Davies MJ, 2011, 'Mechanisms and consequences of oxidative damage to extracellular matrix', Biochemical Society Transactions, vol. 39, pp. 1279 - 1287, http://dx.doi.org/10.1042/BST0391279

Whitelock J; Melrose J, 2011, 'Heparan sulfate proteoglycans in healthy and diseased systems', Wiley Interdisciplinary Reviews: Systems Biology and Medicine, vol. 3, pp. 739 - 751, http://dx.doi.org/10.1002/wsbm.149


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