Select Publications

Book Chapters

Ittner LM; Lee WS; Stefanoska K; Asih PR; Ke YD, 2018, 'Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models', in NeurodegeneratIve Diseases: Clinical Aspects, Molecular Genetics and Biomarkers, pp. 187 - 219, http://dx.doi.org/10.1007/978-3-319-72938-1_10

harasta AE; ittner LM, 2017, 'Alzheimer’s Disease: Insights from genetic mouse models and current advances in human IPSC-derived neurons', in Beart P; Robinson M; Rattray M ; Maragakis NJ (ed.), Neurodegenerative Diseases Pathology, Mechanisms, and Potential Therapeutic Targets, Springer, pp. 3 - 20, https://link.springer.com/chapter/10.1007/978-3-319-57193-5_1

Journal articles

Katzeff JS; Bright F; Lo K; Kril JJ; Connolly A; Crossett B; Ittner LM; Kassiou M; Loy CT; Hodges JR; Piguet O; Kiernan MC; Halliday GM; Kim WS, 2020, 'Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-70687-7

van der Hoven J; van Hummel A; Przybyla M; Asih PR; Gajwani M; Feiten AF; Ke YD; Ittner A; van Eersel J; Ittner LM, 2020, 'Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-70845-x

Yang L; Chen Z; Stout ES; Delerue F; Ittner LM; Wilkins MR; Quinlan KGR; Crossley M, 2020, 'Methylation of a CGATA element inhibits binding and regulation by GATA-1', Nature Communications, vol. 11, pp. 2560, http://dx.doi.org/10.1038/s41467-020-16388-1

Sokias R; Werry EL; Alison Cheng HW; Lloyd JH; Sohler G; Danon JJ; Montgomery AP; Du JJ; Gao Q; Hibbs DE; Ittner LM; Reekie TA; Kassiou M, 2020, 'Tricyclic heterocycles display diverse sensitivity to the A147T TSPO polymorphism', European Journal of Medicinal Chemistry, vol. 207, http://dx.doi.org/10.1016/j.ejmech.2020.112725

Watt G; Chesworth R; Przybyla M; Ittner A; Garner B; Ittner LM; Karl T, 2020, 'Chronic cannabidiol (CBD) treatment did not exhibit beneficial effects in 4-month-old male TAU58/2 transgenic mice', Pharmacology Biochemistry and Behavior, vol. 196, pp. 172970, http://dx.doi.org/10.1016/j.pbb.2020.172970

Ittner A; Asih PR; Tan ARP; Prikas E; Bertz J; Stefanoska K; Lin Y; Volkerling AM; Ke YD; Delerue F; Ittner LM, 2020, 'Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ', Acta Neuropathologica, vol. 140, pp. 279 - 294, http://dx.doi.org/10.1007/s00401-020-02191-1

Chan G; van Hummel A; van der Hoven J; Ittner LM; Ke YD, 2020, 'Neurodegeneration and Motor Deficits in the Absence of Astrogliosis upon Transgenic Mutant TDP-43 Expression in Mature Mice', American Journal of Pathology, vol. 190, pp. 1713 - 1722, http://dx.doi.org/10.1016/j.ajpath.2020.04.009

Przybyla M; Van Eersel J; Van Hummel A; Van Der Hoven J; Sabale M; Harasta A; Müller J; Gajwani M; Prikas E; Mueller T; Stevens CH; Power J; Housley GD; Karl T; Kassiou M; Ke YD; Ittner A; Ittner LM, 2020, 'Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature', Brain, vol. 143, pp. 1889 - 1904, http://dx.doi.org/10.1093/brain/awaa133

Ariawan AD; Sun B; Wojciechowski JP; Lin I; Du EY; Goodchild SC; Cranfield CG; Ittner LM; Thordarson P; Martin AD, 2020, 'Effect of polar amino acid incorporation on Fmoc-diphenylalanine-based tetrapeptides', Soft Matter, vol. 16, pp. 4800 - 4805, http://dx.doi.org/10.1039/d0sm00320d

Sun B; Ariawan AD; Warren H; Goodchild SC; In Het Panhuis M; Ittner LM; Martin AD, 2020, 'Programmable enzymatic oxidation of tyrosine-lysine tetrapeptides', Journal of Materials Chemistry B, vol. 8, pp. 3104 - 3112, http://dx.doi.org/10.1039/d0tb00250j

Watt G; Przybyla M; Zak V; van Eersel J; Ittner A; Ittner LM; Karl T, 2020, 'Novel Behavioural Characteristics of Male Human P301S Mutant Tau Transgenic Mice – A Model for Tauopathy', Neuroscience, vol. 431, pp. 166 - 175, http://dx.doi.org/10.1016/j.neuroscience.2020.01.047

Vo SV; Banister SD; Freelander I; Werry EL; Reekie TA; Ittner LM; Kassiou M, 2020, 'Reversing binding sensitivity to A147T translocator protein', RSC Medicinal Chemistry, vol. 11, pp. 511 - 517, http://dx.doi.org/10.1039/c9md00580c

Martin AD; Wojciechowski JP; Du EY; Rawal A; Stefen H; Au CG; Hou L; Cranfield CG; Fath T; Ittner LM; Thordarson P, 2020, 'Decoupling the effects of hydrophilic and hydrophobic moieties at the neuron-nanofibre interface', Chemical Science, vol. 11, pp. 1375 - 1382, http://dx.doi.org/10.1039/c9sc05686f

Lei M; Teo JD; Song H; McEwen HP; Yup Lee J; Couttas TA; Duncan T; Chesworth R; Bertz J; Przybyla M; Van Eersel J; Heng B; Guillemin GJ; Ittner LM; Fath T; Garner B; Ittner A; Karl T; Don AS, 2019, 'Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 39, pp. 9645 - 9659, http://dx.doi.org/10.1523/JNEUROSCI.0524-19.2019

Brettle M; Stefen H; Djordjevic A; Fok SYY; Chan JW; van Hummel A; van der Hoven J; Przybyla M; Volkerling A; Ke YD; Delerue F; Ittner LM; Fath T, 2019, 'Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice', Frontiers in Molecular Neuroscience, vol. 12, http://dx.doi.org/10.3389/fnmol.2019.00231

Ke YD; Chan G; Stefanoska K; Au C; Bi M; Müller J; Przybyla M; Feiten A; Prikas E; Halliday GM; Piguet O; Kiernan MC; Kassiou M; Hodges JR; Loy CT; Mattick JS; Ittner A; Kril JJ; Sutherland GT; Ittner LM, 2019, 'CNS cell type-specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation', Journal of Biological Chemistry, vol. 294, pp. 14149 - 14162, http://dx.doi.org/10.1074/jbc.RA118.005263

Cheng HWA; Sokias R; Werry EL; Ittner LM; Reekie TA; Du J; Gao Q; Hibbs DE; Kassiou M, 2019, 'First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold', Journal of Medicinal Chemistry, vol. 62, pp. 8235 - 8248, http://dx.doi.org/10.1021/acs.jmedchem.9b00980

Ittner LM; Klugmann M; Ke YD, 2019, 'Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues', British Journal of Pharmacology, vol. 176, pp. 3649 - 3665, http://dx.doi.org/10.1111/bph.14637

Bright F; Werry EL; Dobson-Stone C; Piguet O; Ittner LM; Halliday GM; Hodges JR; Kiernan MC; Loy CT; Kassiou M; Kril JJ, 2019, 'Neuroinflammation in frontotemporal dementia', Nature Reviews Neurology, vol. 15, pp. 540 - 555, http://dx.doi.org/10.1038/s41582-019-0231-z

Werry EL; Bright FM; Piguet O; Ittner LM; Halliday GM; Hodges JR; Kiernan MC; Loy CT; Kril JJ; Kassiou M, 2019, 'Recent developments in TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders', International Journal of Molecular Sciences, vol. 20, http://dx.doi.org/10.3390/ijms20133161

Stefanoska K; Bertz J; Volkerling AM; van der Hoven J; Ittner LM; Ittner A, 2018, 'Neuronal MAP kinase p38α inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-32592-y

Zhao Y; Keshiya S; Atashrazm F; Gao J; Ittner LM; Alessi DR; Halliday GM; Fu Y; Dzamko N, 2018, 'Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice', Neurobiology of Disease, vol. 120, pp. 76 - 87, http://dx.doi.org/10.1016/j.nbd.2018.09.003

Ke YD; Ittner LM, 2018, 'Epothilone D – correct drug, wrong disease', Neuropathology and Applied Neurobiology, vol. 44, pp. 548 - 549, http://dx.doi.org/10.1111/nan.12478

Martin AD; Chua SW; Au CG; Stefen H; Przybyla M; Lin Y; Bertz J; Thordarson P; Fath T; Ke YD; Ittner LM, 2018, 'Peptide Nanofiber Substrates for Long-Term Culturing of Primary Neurons', ACS Applied Materials and Interfaces, vol. 10, pp. 25127 - 25134, http://dx.doi.org/10.1021/acsami.8b07560

Ittner A; Ittner LM, 2018, 'Dendritic Tau in Alzheimer's Disease', Neuron, vol. 99, pp. 13 - 27, http://dx.doi.org/10.1016/j.neuron.2018.06.003

van Hummel A; Chan G; van der Hoven J; Morsch M; Ippati S; Suh L; Bi M; Asih PR; Lee WS; Butler TA; Przybyla M; Halliday GM; Piguet O; Kiernan MC; Chung RS; Ittner LM; Ke YD, 2018, 'Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice', American Journal of Pathology, vol. 188, pp. 1447 - 1456, http://dx.doi.org/10.1016/j.ajpath.2018.03.002

Ahmed RM; Ke YD; Vucic S; Ittner LM; Seeley W; Hodges JR; Piguet O; Halliday G; Kiernan MC, 2018, 'Physiological changes in neurodegeneration-mechanistic insights and clinical utility', Nature Reviews Neurology, vol. 14, pp. 259 - 271, http://dx.doi.org/10.1038/nrneurol.2018.23

Forrest SL; Kril JJ; Stevens CH; Kwok JB; Hallupp M; Kim WS; Huang Y; McGinley CV; Werka H; Kiernan MC; Gotz J; Spillantini MG; Hodges JR; Ittner LM; Halliday GM, 2018, 'Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies (vol 141, pg 521, 2018)', BRAIN, vol. 141, http://dx.doi.org/10.1093/brain/awy012

Stefanoska K; Volkerling A; Bertz J; Poljak A; Ke YD; Ittner LM; Ittner A, 2018, 'An N-terminal motif unique to primate tau enables differential protein–protein interactions', Journal of Biological Chemistry, vol. 293, pp. 3710 - 3719, http://dx.doi.org/10.1074/jbc.RA118.001784

Bodea L-G; Evans HT; Van der Jeugd A; Ittner LM; Delerue F; Kril J; Halliday G; Hodges J; Kiernan MC; Gotz J, 2018, 'Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model (vol 16, 377, 2017)', AGING CELL, vol. 17, http://dx.doi.org/10.1111/acel.12712

Forrest SL; Kril JJ; Stevens CH; Kwok JB; Hallupp M; Kim WS; Huang Y; McGinley CV; Werka H; Kiernan MC; Götz J; Spillantini MG; Hodges JR; Ittner LM; Halliday GM, 2018, 'Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies', Brain, vol. 141, pp. 521 - 534, http://dx.doi.org/10.1093/brain/awx328

Hafezi F; Gatzioufas Z; Angunawela R; Ittner LM, 2018, 'Absence of IL-6 prevents corneal wound healing after deep excimer laser ablation in vivo', Eye (Basingstoke), vol. 32, pp. 156 - 157, http://dx.doi.org/10.1038/eye.2017.238

Tan DCS; Yao S; Ittner A; Bertz J; Ke YD; Ittner LM; Delerue F, 2018, 'Generation of a New Tau Knockout (tau Δex1) Line Using CRISPR/Cas9 Genome Editing in Mice', Journal of Alzheimer's Disease, vol. 62, pp. 571 - 578, http://dx.doi.org/10.3233/JAD-171058

Aldilla VR; Martin AD; Nizalapur S; Marjo CE; Rich AM; Ho KKK; Ittner LM; Black DSC; Thordarson P; Kumar N, 2018, 'Glyoxylamide-based self-assembly hydrogels for sustained ciprofloxacin delivery', Journal of Materials Chemistry B, vol. 6, pp. 6089 - 6098, http://dx.doi.org/10.1039/C8TB01290C

von Jonquieres G; Spencer ZHT; Rowlands BD; Klugmann CB; Bongers A; Harasta AE; Parley KE; Cederholm J; Teahan O; Pickford R; Delerue F; Ittner LM; Fröhlich D; McLean CA; Don AS; Schneider M; Housley GD; Rae CD; Klugmann M, 2018, 'Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy', Acta Neuropathologica, vol. 135, pp. 95 - 113, http://dx.doi.org/10.1007/s00401-017-1784-9

Bi M; Gladbach A; Van Eersel J; Ittner A; Przybyla M; Van Hummel A; Chua SW; Hoven JVD; Lee WS; Müller J; Parmar J; Jonquieres GV; Stefen H; Guccione E; Fath T; Housley GD; Klugmann M; Ke YD; Ittner LM, 2017, 'Tau exacerbates excitotoxic brain damage in an animal model of stroke', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00618-0

Delerue F; Ittner LM, 2017, 'Generation of genetically modified mice through the microinjection of oocytes', Journal of Visualized Experiments, vol. 2017, http://dx.doi.org/10.3791/55765

Moujalled D; Grubman A; Acevedo K; Yang S; Ke YD; Moujalled DM; Duncan C; Caragounis A; Perera ND; Turner BJ; Prudencio M; Petrucelli L; Blair I; Ittner LM; Crouch PJ; Liddell JR; White AR, 2017, 'TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway', Human Molecular Genetics, vol. 26, pp. 1732 - 1746, http://dx.doi.org/10.1093/hmg/ddx093

Chua SW; Cornejo A; Van Eersel J; Stevens CH; Vaca I; Cueto M; Kassiou M; Gladbach A; Macmillan A; Lewis L; Whan R; Ittner LM, 2017, 'The Polyphenol Altenusin Inhibits in Vitro Fibrillization of Tau and Reduces Induced Tau Pathology in Primary Neurons', ACS Chemical Neuroscience, vol. 8, pp. 743 - 751, http://dx.doi.org/10.1021/acschemneuro.6b00433

Bodea LG; Evans HT; Van der Jeugd A; Ittner LM; Delerue F; Kril J; Halliday G; Hodges J; Kiernan MC; Götz J, 2017, 'Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model', Aging Cell, vol. 16, pp. 377 - 386, http://dx.doi.org/10.1111/acel.12565

Ahmed RM; Irish M; van Eersel J; Ittner A; Ke YD; Volkerling A; van der Hoven J; Tanaka K; Karl T; Kassiou M; Kril JJ; Piguet O; Götz J; Kiernan MC; Halliday GM; Hodges JR; Ittner LM, 2017, 'Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology', Neuroscience and Biobehavioral Reviews, vol. 74, pp. 126 - 138, http://dx.doi.org/10.1016/j.neubiorev.2017.01.004

Pleines I; Woods J; Chappaz S; Kew V; Foad N; Ballester-Beltrán J; Aurbach K; Lincetto C; Lane RM; Schevzov G; Alexander WS; Hilton DJ; Astle WJ; Downes K; Nurden P; Westbury SK; Mumford AD; Obaji SG; Collins PW; BioResource N; Delerue F; Ittner LM; Bryce NS; Holliday M; Lucas CA; Hardeman EC; Ouwehand WH; Gunning PW; Turro E; Tijssen MR; Kile BT, 2017, 'Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia', Journal of Clinical Investigation, vol. 127, pp. 814 - 829, http://dx.doi.org/10.1172/JCI86154

Ittner A; Chua SW; Bertz J; Volkerling A; van der Hoven J; Gladbach A; Przybyla M; Bi M; van Hummel A; Stevens CH; Ippati S; Suh LS; Macmillan A; Sutherland G; Kril JJ; Silva APG; Mackay JP; Poljak A; Delerue F; Ke YD; Ittner LM, 2017, 'Site-specific phosphorylation of tau inhibits amyloid-beta toxicity in Alzheimer's mice (vol 354, 904, 2016)', SCIENCE, vol. 355, http://dx.doi.org/10.1126/science.aam9523

Tan RH; Ke YD; Ittner LM; Halliday GM, 2017, 'ALS/FTLD: experimental models and reality', Acta Neuropathologica, vol. 133, pp. 177 - 196, http://dx.doi.org/10.1007/s00401-016-1666-6

Harasta AE; Ittner LM, 2017, 'Alzheimer’s disease: Insights from genetic mouse models and current advances in human IPSC-derived neurons', Advances in Neurobiology, vol. 15, pp. 3 - 29, http://dx.doi.org/10.1007/978-3-319-57193-5_1

Tan RH; Kril JJ; Yang Y; Tom N; Hodges JR; Villemagne VL; Rowe CC; Leyton CE; Kwok JBJ; Ittner LM; Halliday GM, 2017, 'Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 9, pp. 10 - 20, http://dx.doi.org/10.1016/j.dadm.2017.05.005

Sokias R; Werry EL; Chua SW; Reekie TA; Munoz L; Wong ECN; Ittner LM; Kassiou M, 2017, 'Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination', MedChemComm, vol. 8, pp. 202 - 210, http://dx.doi.org/10.1039/c6md00523c

Fröhlich D; Suchowerska AK; Spencer ZHT; von Jonquieres G; Klugmann CB; Bongers A; Delerue F; Stefen H; Ittner LM; Fath T; Housley GD; Klugmann M, 2017, 'In vivo characterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL', Neurobiology of Disease, vol. 97, pp. 24 - 35, http://dx.doi.org/10.1016/j.nbd.2016.10.008


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