By Professor Stuart Graham Tangye

Journal articles

Seddiki N; Santner-Nanan B; Tangye SG; Alexander SI; Solomon M; Lee S; Nanan R; Fazekas De Saint Groth B, 2006, 'Persistence of naive CD45RA⁺ regulatory T cells in adult life', Blood, 107, pp. 2830 - 2838, http://dx.doi.org/10.1182/blood-2005-06-2403

Cuss AK; Avery DT; Cannons JL; Yu LJ; Nichols KE; Shaw PJ; Tangye SG, 2006, 'Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity', Journal of Immunology, 176, pp. 1506 - 1516, http://dx.doi.org/10.4049/jimmunol.176.3.1506

Ma CS; Pittaluga S; Avery DT; Hare NJ; Maric I; Klion AD; Nichols KE; Tangye SG, 2006, 'Selective generation of functional somatically mutated IgM ⁺CD27⁺, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease', Journal of Clinical Investigation, 116, pp. 322 - 333, http://dx.doi.org/10.1007/0-387-34403-9_44

Tangye S; Mackay F, 2006, 'B Cells and Autoimmunity', , pp. 139 - 156, http://dx.doi.org/10.1016/B978-012595961-2/50014-7

Tangye SG; Bryant V; Cuss A; Good K, 2006, 'BAFF, APRIL and human B cell disorders', Seminars in Immunology, 18, pp. 305 - 317

Liu SM; Xavier R; Good K; Newton R; Sisavanh M; Zimmer S; Deng C; Silva D; Frost M; Tangye SG; Rolph MS; Mackay C; Chtanova T, 2006, 'Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes', Journal of Allergy and Clinical Immunology, 118, pp. 496 - 503

Good K; Bryant V; Tangye SG, 2006, 'Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21', Journal of Immunology, 177, pp. 5236 - 5247

Gu C; Tangye SG; Sun XF; Luo Y; Lin Z; Wu J, 2006, 'The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 14447 - 14452

Dupré L; Andolfi G; Tangye SG; Clementi R; Locatelli F; Aricò M; Aiuti A; Roncarolo MG, 2005, 'SAP controls the cytolytic activity of CD8⁺ T cells against EBV-infected cells', Blood, 105, pp. 4383 - 4389, http://dx.doi.org/10.1182/blood-2004-08-3269

Avery DT; Ellyard JI; Mackay F; Corcoran LM; Hodgkin PD; Tangye SG, 2005, 'Erratum: Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage (Journal of Immunology (2005) 174 (4034-4042))', Journal of Immunology, 174, pp. 5885, http://dx.doi.org/10.4049/jimmunol.174.9.5885

Avery DT; Ellyard JI; Mackay F; Corcoran LM; Hodgkin PD; Tangye SG, 2005, 'Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage (vol 174, pg 4034, 2005)', JOURNAL OF IMMUNOLOGY, 174, pp. 5885 - 5885, http://dx.doi.org/10.4049/jimmunol.174.9.5885

Ma CS; Hare NJ; Nichols KE; Dupré L; Andolfi G; Roncarolo M-G; Adelstein S; Hodgkin PD; Tangye SG, 2005, 'Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells', Journal of Clinical Investigation, 115, pp. 1049 - 1059, http://dx.doi.org/10.1172/jci23139

Ma CS; Hare NJ; Nichols KE; Dupré L; Andolfi G; Roncarolo MG; Adelstein S; Hodgkin PD; Tangye SG, 2005, 'Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4⁺ T cells', Journal of Clinical Investigation, 115, pp. 1049 - 1059, http://dx.doi.org/10.1172/JCI200523139

Nichols KE; Hom J; Gong SY; Ganguly A; Ma CS; Cannons JL; Tangye SG; Schwartzberg PL; Koretzky GA; Stein PL, 2005, 'Regulation of NKT cell development by SAP, the protein defective in XLP', Nature Medicine, 11, pp. 340 - 345, http://dx.doi.org/10.1038/nm1189

Nichols KE; Ma CS; Cannons JL; Schwartzberg PL; Tangye SG, 2005, 'Molecular and cellular pathogenesis of X-linked lymphoproliferative disease', Immunological Reviews, 203, pp. 180 - 199, http://dx.doi.org/10.1111/j.0105-2896.2005.00230.x

Nichols KE; Hom J; Ganguly A; Ma CS; Tangye SG; Cannons JL; Schwartzberg PL; Koretzky GA; Stein PL, 2004, 'Regulation of NKT Cell Development by Sap, the Adaptor Mutated in X-Linked Lymphoproliferative Disease.', Blood, 104, pp. 317 - 317, http://dx.doi.org/10.1182/blood.v104.11.317.317

Tangye SG; Hodgkin PD, 2004, 'Divide and conquer: The importance of cell division in regulating B-cell responses', Immunology, 112, pp. 509 - 520, http://dx.doi.org/10.1111/j.1365-2567.2004.01950.x

Ellyard JI; Avery DT; Phan TG; Hare NJ; Hodgkin PD; Tangye SG, 2004, 'Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow', Blood, 103, pp. 3805 - 3812, http://dx.doi.org/10.1182/blood-2003-09-3109

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; Mackay F; Hodgkin PD; Tangye SG, 2004, 'BAFF selectively enhances the survival of plasmablasts generated from human memory B cells', Journal of Clinical Investigation, 113, pp. 1069 - 1069, http://dx.doi.org/10.1172/jci18025e1

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; Mackay F; Hodgkin PD; Tangye SG, 2004, 'Erratum: BAFF selectively enhances the survival of plasmablasts generated from human memory B cells (Journal of Clinical Investigation (2003) 112 (286-297) doi:10.1172/JCI200318025)', Journal of Clinical Investigation, 113, pp. 1069, http://dx.doi.org/10.1172/JCI200318025C

Ma CS; Hodgkin PD; Tangye SG, 2004, 'Automatic generation of lymphocyte heterogeneity: Division-dependent changes in the expression of CD27, CCR7 and CD45 by activated human naive CD4⁺ T cells are independently regulated', Immunology and Cell Biology, 82, pp. 67 - 74, http://dx.doi.org/10.1046/j.0818-9641.2003.01206.x

Hasbold J; Corcoran LM; Tarlinton DM; Tangye SG; Hodgkin PD, 2004, 'Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation', Nature Immunology, 5, pp. 55 - 63, http://dx.doi.org/10.1038/ni1016

Tangye SG; Nichols KE; Hare NJ; Van de Weerdt BCM, 2003, 'Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation', Journal of Immunology, 171, pp. 2485 - 2495, http://dx.doi.org/10.4049/jimmunol.171.5.2485

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; Mackay F; Hodgkin PD; Tangye SG, 2003, 'BAFF selectively enhances the survival of plasmablasts generated from human memory B cells', Journal of Clinical Investigation, 112, pp. 286 - 297, http://dx.doi.org/10.1172/jci200318025

Tangye SG; Avery DT; Deenick EK; Hodgkin PD, 2003, 'Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses', Journal of Immunology, 170, pp. 686 - 694, http://dx.doi.org/10.4049/jimmunol.170.2.686

Tangye SG; Avery DT; Hodgkin PD, 2003, 'A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells', Journal of Immunology, 170, pp. 261 - 269, http://dx.doi.org/10.4049/jimmunol.170.1.261

Avery DT; Kalled SL; Ellyard JI; Ambrose C; Bixler SA; Thien M; Brink R; MacKay F; Hodgkin PD; Tangye SG, 2003, 'BAFF selectively enhances the survival of plasmablasts generated from human memory B cells', Journal of Clinical Investigation, 112, pp. 286 - 297, http://dx.doi.org/10.1172/JCI18025

Tangye SG; Ferguson A; Avery DT; Ma CS; Hodgkin PD, 2002, 'Isotype switching by human B cells is division-associated and regulated by cytokines', Journal of Immunology, 169, pp. 4298 - 4306, http://dx.doi.org/10.4049/jimmunol.169.8.4298

Tangye SG; Van De Weerdt BCM; Avery DT; Hodgkin PD, 2002, 'CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2', European Journal of Immunology, 32, pp. 1640 - 1649, http://dx.doi.org/10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S

Weston KM; Tangye SG; Dunn RD; Smith A; Morris MB; Raison RL, 2001, 'IgM expressed by leukemic CD5⁺ B cells binds mouse immunoglobulin light chain', Journal of Molecular Recognition, 14, pp. 245 - 253, http://dx.doi.org/10.1002/jmr.539

Baker JE; Majeti R; Tangye SG; Weiss A, 2001, 'Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cγ1 phosphorylation', Molecular and Cellular Biology, 21, pp. 2393 - 2403, http://dx.doi.org/10.1128/MCB.21.7.2393-2403.2001

Tangye SG; Cherwinski H; Lanier LL; Phillips JH, 2000, '2B4-mediated activation of human natural killer cells', Molecular Immunology, 37, pp. 493 - 501, http://dx.doi.org/10.1016/S0161-5890(00)00076-6

Tangye SG; Phillips JH; Lanier LL; Nichols KE, 2000, 'Cutting edge: Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome', Journal of Immunology, 165, pp. 2932 - 2936, http://dx.doi.org/10.4049/jimmunol.165.6.2932

Tangye SG; Phillips JH; Lanier LL, 2000, 'The CD2-subset of the Ig superfamily of cell surface molecules: Receptor-ligand pairs expressed by NK cells and other immune cells', Seminars in Immunology, 12, pp. 149 - 157, http://dx.doi.org/10.1006/smim.2000.0217

Castro AG; Hauser TM; Cocks BG; Abrams J; Zurawski S; Churakova T; Zonin F; Robinson D; Tangye SG; Aversa G; Nichols KE; De Vries JE; Lanier LL; O'Garra A, 1999, 'Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): Differential expression and responsiveness in Th1 and Th2 cells', Journal of Immunology, 163, pp. 5860 - 5870

Tangye SG; Lazetic S; Woollatt E; Sutherland GR; Lanier LL; Phillips JH, 1999, 'Cutting edge: Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP', Journal of Immunology, 162, pp. 6981 - 6985

Tangye SG; Liu YJ; Aversa G; Phillips JH; De Vries JE, 1998, 'Identification of functional human splenic memory B cells by expression of CD148 and CD27', Journal of Experimental Medicine, 188, pp. 1691 - 1703, http://dx.doi.org/10.1084/jem.188.9.1691

Tangye SG; Wu J; Aversa G; De Vries JE; Lanier LL; Phillips JH, 1998, 'Cutting edge: Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148', Journal of Immunology, 161, pp. 3803 - 3807

Tangye SG; Phillips JH; Lanier LL; De Vries JE; Aversa G, 1998, 'CD148: A receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation', Journal of Immunology, 161, pp. 3249 - 3255

Tangye SG; Aversa G; Lanier LL; De Vries JE; Phillips JH, 1998, 'CD148: A cell-surface phosphatase involved in T cell activation', FASEB Journal, 12

Tangye SG; Weston KM; Raison RL, 1998, 'Interleukin-10 inhibits the in vitro proliferation of human activated leukemic CD5⁺ B-Cells', Leukemia and Lymphoma, 31, pp. 121 - 130, http://dx.doi.org/10.3109/10428199809057592

Tangye SG; Weston KM; Raison RL, 1997, 'Cytokines and cross-linking of sIgM augment PMA-induced activation of human leukaemic CD5⁺ B cells', Immunology and Cell Biology, 75, pp. 561 - 567, http://dx.doi.org/10.1038/icb.1997.87

Tangye SG; Raison RL, 1997, 'Human cytokines suppress apoptosis of leukaemic CD5⁺ B cells and preserve expression of bcl-2', Immunology and Cell Biology, 75, pp. 127 - 135, http://dx.doi.org/10.1038/icb.1997.17

Tangye SG; Aversa G; Phillips JH; de Vries JE, 1997, 'Characterization of a cell surface molecule involved in T-cell activation', Immunology Letters, 56, pp. 1 - 1, http://dx.doi.org/10.1016/s0165-2478(97)85004-3

Tangye SG; Raison RL, 1996, 'Leukaemic CD5⁺ B-cell apoptosis: Co-incidence of cell death and DNA fragmentation with reduced bcl-2 expression', British Journal of Haematology, 92, pp. 950 - 953, http://dx.doi.org/10.1046/j.1365-2141.1996.427965.x

TANGYE SG; WESTON KM; RAISON RL, 1995, 'Phorbol ester activates CD5⁺ leukaemic B cells via a T cell‐independent mechanism', Immunology and Cell Biology, 73, pp. 44 - 51, http://dx.doi.org/10.1111/j.1440-1711.1995.tb03832.x

Back to profile page