By Scientia Professor Vlado Perkovic

Journal articles

Liyanage T; Ninomiya T; Wang A; Neal B; Jun M; Wong MG; Jardine M; Hillis GS; Perkovic V; Jun M; Wang Y, 2016, 'Effects of the mediterranean diet on cardiovascular outcomes-a systematic review and meta-analysis', PLoS ONE, 11, pp. e0159252, http://dx.doi.org/10.1371/journal.pone.0159252

Gabb GM; Mangoni A; Anderson CS; Cowley D; Dowden JS; Golledge J; Hankey GJ; Howes FS; Leckie L; Perkovic V; Schlaich M; Zwar NA; Medley TL; Arnolda L, 2016, 'Guideline for the diagnosis and management of hypertension in adults — 2016', Medical Journal of Australia, 205, pp. 85 - 89, http://dx.doi.org/10.5694/mja16.00526

Chan KE; Giugliano RP; Patel MR; Abramson S; Jardine M; Zhao S; Perkovic V; Maddux FW; Piccini JP, 2016, 'Nonvitamin K Anticoagulant Agents in Patients With Advanced Chronic Kidney Disease or on Dialysis With AF', Journal of the American College of Cardiology, 67, pp. 2888 - 2899, http://dx.doi.org/10.1016/j.jacc.2016.02.082

Rodgers A; Perkovic V, 2016, 'A randomized trial of intensive versus standard blood-pressure control [10]', New England Journal of Medicine, 374, pp. 2295, http://dx.doi.org/10.1056/NEJMc1602668

Roberts MA; Pilmore HL; Ierino FL; Badve SV; Cass A; Garg AX; Isbel NM; Krum H; Pascoe EM; Perkovic V; Scaria A; Tonkin AM; Vergara LA; Hawley CM; Levin A; Hare D; Martin A; Wheeler DC; Fulcher G; Brown H; Colquhoun D; Korczyk D; Mather A; Wong A; Bisscheroux P; Gillies A; Garvey L; Tan KS; Lennan E; Pitkin M; Ahearn K; Carroll RP; Scott E; Cooper B; Pearse J; Snelling P; Burman J; Hand S; Pedagogos E; Karschimkus C; Pilmore A; Walker R; Ellis G; Marshall MR; Paul C; Johnson D; Helyar J; Morrish A; Paul-Brent PA; Reidlinger D; Zhang L, 2016, 'The β-Blocker to Lower Cardiovascular Dialysis Events (BLOCADE) feasibility study: A randomized controlled trial', American Journal of Kidney Diseases, 67, pp. 902 - 911, http://dx.doi.org/10.1053/j.ajkd.2015.10.029

Nigwekar SU; Kang A; Zoungas S; Cass A; Gallagher MP; Kulshrestha S; Navaneethan SD; Perkovic V; Strippoli GFM; Jardine MJ, 2016, 'Interventions for lowering plasma homocysteine levels in dialysis patients', Cochrane Database of Systematic Reviews, 2016, http://dx.doi.org/10.1002/14651858.CD004683.pub4

Wu JHY; Foote C; Blomster J; Toyama T; Perkovic V; Sundström J; Neal B, 2016, 'Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: A systematic review and meta-analysis', The Lancet Diabetes and Endocrinology, 4, pp. 411 - 419, http://dx.doi.org/10.1016/S2213-8587(16)00052-8

Wong MG; Perkovic V; Chalmers J; Woodward M; Li Q; Cooper ME; Hamet P; Harrap S; Heller S; Macmahon S; Mancia G; Marre M; Matthews D; Neal B; Poulter N; Rodgers A; Williams B; Zoungas S, 2016, 'Long-term benefits of intensive glucose Control for preventing end-stage kidney disease: ADVANCE-ON', Diabetes Care, 39, pp. 694 - 700, http://dx.doi.org/10.2337/dc15-2322

Schievink B; De Zeeuw D; Smink PA; Andress D; Brennan JJ; Coll B; Correa-Rotter R; Hou FF; Kohan D; Kitzman DW; Makino H; Parving HH; Perkovic V; Remuzzi G; Tobe S; Toto R; Hoekman J; Lambers Heerspink HJ, 2016, 'Prediction of the effect of atrasentan on renal and heart failure outcomes based on short-term changes in multiple risk markers', European Journal of Preventive Cardiology, 23, pp. 758 - 768, http://dx.doi.org/10.1177/2047487315598709

Xie X; Liu Y; Perkovic V; Li X; Ninomiya T; Hou W; Zhao N; Liu L; Lv J; Zhang H; Wang H, 2016, 'Renin-Angiotensin System Inhibitors and Kidney and Cardiovascular Outcomes in Patients with CKD: A Bayesian Network Meta-analysis of Randomized Clinical Trials', American Journal of Kidney Diseases, 67, pp. 728 - 741, http://dx.doi.org/10.1053/j.ajkd.2015.10.011

Wang Y; Ivany JN; Perkovic V; Gallagher MP; Woodward M; Jardine MJ, 2016, 'Anticoagulants and antiplatelet agents for preventing central venous haemodialysis catheter malfunction in patients with end-stage kidney disease', Cochrane Database of Systematic Reviews, 2016, http://dx.doi.org/10.1002/14651858.CD009631.pub2

Gallagher M; Wong MG; Perkovic V, 2016, 'ALTITUDE: Defining a ceiling for blockade of the renin-angiotensin system?', The Lancet Diabetes and Endocrinology, 4, pp. 289 - 290, http://dx.doi.org/10.1016/S2213-8587(15)00518-5

Knight J; Perkovic V, 2016, 'The Affordable Dialysis Prize steams ahead', The Lancet, 387, pp. 1040, http://dx.doi.org/10.1016/S0140-6736(16)00657-7

Dal-Ré R; Jha V; Lv J; Chaudhury RR; Wang Y; Perkovic V, 2016, 'International trials in middle-income countries: different local scenarios require different ethical approaches', Journal of the Royal Society of Medicine, 109, pp. 47 - 51, http://dx.doi.org/10.1177/0141076815608854

Xie X; Atkins E; Lv J; Bennett A; Neal B; Ninomiya T; Woodward M; MacMahon S; Turnbull F; Hillis GS; Chalmers J; Mant J; Salam A; Rahimi K; Perkovic V; Rodgers A, 2016, 'Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: Updated systematic review and meta-analysis', The Lancet, 387, pp. 435 - 443, http://dx.doi.org/10.1016/S0140-6736(15)00805-3

Zhang L; Coombes J; Pascoe EM; Badve SV; Dalziel K; Cass A; Clarke P; Ferrari P; McDonald SP; Morrish AT; Pedagogos E; Perkovic V; Reidlinger D; Scaria A; Walker R; Vergara LA; Hawley CM; Johnson DW, 2016, 'The effect of pentoxifylline on oxidative stress in chronic kidney disease patients with erythropoiesis-stimulating agent hyporesponsiveness: Sub-study of the HERO trial', Redox Report, 21, pp. 14 - 23, http://dx.doi.org/10.1179/1351000215Y.0000000022

Sukkar L; Hong D; Wong MG; Badve SV; Rogers K; Perkovic V; Walsh M; Yu X; Hillis GS; Gallagher M; Jardine M, 2016, 'Effects of ischaemic conditioning on major clinical outcomes in people undergoing invasive procedures: Systematic review and meta-analysis', BMJ (Online), 355, http://dx.doi.org/10.1136/bmj.i5599

Fulcher G; Matthews DR; Perkovic V; de Zeeuw D; Mahaffey KW; Mathieu C; Woo V; Wysham C; Capuano G; Desai M; Shaw W; Vercruysse F; Meininger G; Neal B; Home P; Anderson J; Campbell I; Lachin J; Scharfstein D; Solomon S; Uzzo R; Amerena J; Chow C; Figtree G; French G; Hillis J; Jenkins B; Lindley R; McGrath B; Street A; Watson J, 2016, 'Efficacy and safety of canagliflozin when used in conjunction with incretin-mimetic therapy in patients with type 2 diabetes', Diabetes, Obesity and Metabolism, 18, pp. 82 - 91, http://dx.doi.org/10.1111/dom.12589

Sukkar L; Hong D; Wong MG; Badve SV; Perkovic V; Yu X; Hillis GS; Gallagher M; Jardine M, 2016, 'MP221EFFECTS OF ISCHAEMIC CONDITIONING ON MAJOR CLINICAL OUTCOMES IN PEOPLE UNDERGOING INVASIVE PROCEDURES: A SYSTEMATIC REVIEW AND METAANALYSIS', Nephrology Dialysis Transplantation, 31, pp. i413 - i413, http://dx.doi.org/10.1093/ndt/gfw187.27

Anderson C; Arnolda L; Cowley D; Dowden J; Gabb G; Golledge J; Hankey G; Howes F; Leckie L; Mangoni A; Perkovic V; Schlaich M; Zwar N; Medley T; Wilson J; Branagan M, 2016, 'National Heart Foundation Hypertension Guideline - 2016', Heart, Lung and Circulation, 25, pp. S18 - S18, http://dx.doi.org/10.1016/j.hlc.2016.06.039

Perkovic V; Rodgers A, 2015, 'Redefining blood-pressure targets - SPRINT starts the marathon', New England Journal of Medicine, 373, pp. 2175 - 2178, http://dx.doi.org/10.1056/NEJMe1513301

Groop PH; Cooper ME; Perkovic V; Sharma K; Schernthaner G; Haneda M; Hocher B; Gordat M; Cescutti J; Woerle HJ; Von Eynatten M, 2015, 'Dipeptidyl peptidase-4 inhibition with linagliptin and effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: Rationale and design of the MARLINA-T2D^™ trial', Diabetes and Vascular Disease Research, 12, pp. 455 - 462, http://dx.doi.org/10.1177/1479164115579002

Palmer SC; Navaneethan SD; Craig JC; Johnson DW; Perkovic V; Hegbrant J; Strippoli GFM, 2015, 'HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis', Sao Paulo Medical Journal, 133, pp. 541, http://dx.doi.org/10.1590/1516-3180.20151336T2

Perkovic V; Jardine M; Vijapurkar U; Meininger G, 2015, 'Renal effects of canagliflozin in type 2 diabetes mellitus', Current Medical Research and Opinion, 31, pp. 2219 - 2231, http://dx.doi.org/10.1185/03007995.2015.1092128

Thomas MC; Woodward M; Neal B; Li Q; Pickering R; Marre M; Williams B; Perkovic V; Cooper ME; Zoungas S; Chalmers J; Hillis GS, 2015, 'Relationship between levels of advanced glycation end products and their soluble receptor and adverse outcomes in adults with type 2 diabetes', Diabetes Care, 38, pp. 1891 - 1897, http://dx.doi.org/10.2337/dc15-0925

Fulcher G; Matthews DR; Perkovic V; de Zeeuw D; Mahaffey KW; Weiss R; Rosenstock J; Capuano G; Desai M; Shaw W; Vercruysse F; Meininger G; Neal B, 2015, 'Efficacy and Safety of Canagliflozin Used in Conjunction with Sulfonylurea in Patients with Type 2 Diabetes Mellitus: A Randomized, Controlled Trial', Diabetes Therapy, 6, pp. 289 - 302, http://dx.doi.org/10.1007/s13300-015-0117-z

Toyama T; Furuichi K; Shimizu M; Hara A; Iwata Y; Sakai N; Perkovic V; Kobayashi M; Mano T; Kaneko S; Wada T, 2015, 'Relationship between serum uric acid levels and chronic kidney disease in a Japanese cohort with normal or mildly reduced kidney function', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0137449

Kohan DE; Heerspink HJL; Coll B; Andress D; Brennan JJ; Kitzman DW; Correa-Rotter R; Makino H; Perkovic V; Hou FF; Remuzzi G; Tobe SW; Toto R; Parving HH; De Zeeuw D, 2015, 'Predictors of atrasentan-associated fluid retention and change in albuminuria in patients with diabetic nephropathy', Clinical Journal of the American Society of Nephrology, 10, pp. 1568 - 1574, http://dx.doi.org/10.2215/CJN.00570115

Jun M; Turin TC; Woodward M; Perkovic V; Lambers Heerspink HJ; Manns BJ; Tonelli M; Hemmelgarn BR, 2015, 'Assessing the validity of surrogate outcomes for ESRD: A meta-analysis', Journal of the American Society of Nephrology, 26, pp. 2289 - 2302, http://dx.doi.org/10.1681/ASN.2014040396

Jardine M; Perkovic V, 2015, 'First Light after the Long Night: A Follow-up Report of the Randomized FHN Nocturnal Trial', American Journal of Kidney Diseases, 66, pp. 379 - 382, http://dx.doi.org/10.1053/j.ajkd.2015.06.007

Cooper ME; Perkovic V; McGill JB; Groop PH; Wanner C; Rosenstock J; Hehnke U; Woerle HJ; Von Eynatten M, 2015, 'Kidney Disease End Points in a Pooled Analysis of Individual Patient-Level Data from a Large Clinical Trials Program of the Dipeptidyl Peptidase 4 Inhibitor Linagliptin in Type 2 Diabetes', American Journal of Kidney Diseases, 66, pp. 441 - 449, http://dx.doi.org/10.1053/j.ajkd.2015.03.024

Badve SV; Zhang L; Coombes JS; Pascoe EM; Cass A; Clarke P; Ferrari P; McDonald SP; Morrish AT; Pedagogos E; Perkovic V; Reidlinger D; Scaria A; Walker R; Vergara LA; Hawley CM; Johnson DW; D'Almeida E; Fassett R; Kirkpatrick C; Phoon R, 2015, 'Association between serum alkaline phosphatase and primary resistance to erythropoiesis stimulating agents in chronic kidney disease: A secondary analysis of the HERO trial', Canadian Journal of Kidney Health and Disease, 2, http://dx.doi.org/10.1186/s40697-015-0066-5

Tong A; Crowe S; Chando S; Cass A; Chadban SJ; Chapman JR; Gallagher M; Hawley CM; Hill S; Howard K; Johnson DW; Kerr PG; McKenzie A; Parker D; Perkovic V; Polkinghorne KR; Pollock C; Strippoli GFM; Tugwell P; Walker RG; Webster AC; Wong G; Craig JC, 2015, 'Research Priorities in CKD: Report of a National Workshop Conducted in Australia', American Journal of Kidney Diseases, 66, pp. 212 - 222, http://dx.doi.org/10.1053/j.ajkd.2015.02.341

Hillis GS; Welsh P; Chalmers J; Perkovic V; Chow CK; Li Q; Jun M; Neal B; Zoungas S; Poulter N; Mancia G; Williams B; Sattar N; Woodward M, 2015, 'Erratum. The relative and combined ability of high-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide to predict cardiovascular events and death in patients With type 2 diabetes. Diabetes Care 2014;37:295-303', Diabetes Care, 38, pp. 1393, http://dx.doi.org/10.2337/dc15-er07

Liyanage T; Ninomiya T; Jha V; Neal B; Patrice HM; Okpechi I; Zhao MH; Lv J; Garg AX; Knight J; Rodgers A; Gallagher M; Kotwal S; Cass A; Perkovic V, 2015, 'Worldwide access to treatment for end-stage kidney disease: A systematic review', The Lancet, 385, pp. 1975 - 1982, http://dx.doi.org/10.1016/S0140-6736(14)61601-9

Kang A; Nigwekar SU; Perkovic V; Kulshrestha S; Zoungas S; Navaneethan SD; Cass A; Gallagher MP; Ninomiya T; Strippoli GFM; Jardine MJ, 2015, 'Interventions for lowering plasma homocysteine levels in kidney transplant recipients', Cochrane Database of Systematic Reviews, 2015, pp. cd007910, http://dx.doi.org/10.1002/14651858.CD007910.pub2

Zhu B; Zhu CF; Lin Y; Perkovic V; Li XF; Yang R; Tang XL; Zhu XL; Cheng XX; Li Q; Chen HY; Sun Y; Chen QW; Wang YJ, 2015, 'Clinical characteristics of IgA nephropathy associated with low complement 4 levels', Renal Failure, 37, pp. 424 - 432, http://dx.doi.org/10.3109/0886022X.2014.994408

Jardine MJ; Zuo L; Gray NA; De Zoysa J; Chan CT; Gallagher MP; Howard K; Hertier S; Cass A; Perkovic V, 2015, 'Design and participant baseline characteristics of 'A Clinical Trial of IntensiVE Dialysis': The ACTIVE Dialysis Study', Nephrology, 20, pp. 257 - 265, http://dx.doi.org/10.1111/nep.12385

Agodoa L; Estacio R; Schrier R; Lubsen J; Chalmers J; Cutler J; Davis B; Wing L; Poulter NR; Sever P; Remuzzi G; Ruggenenti P; Nissen S; Lindholm LH; Fukui T; Ogihara T; Saruta T; Black H; Sleight P; Lievre M; Suzuki H; Fox K; Lisheng L; Ohkubo T; Imai Y; Yusuf S; Bulpitt CJ; Lewis E; Brown M; Palmer C; Wang J; Pepine C; Ishii M; Yui Y; Kuramoto K; Pfeff Er M; Asselbergs FW; Van Gilst WH; Byington B; Pitt B; Brenner B; Remme WJ; De Zeeuw D; Rahman M; Viberti G; Teo K; Zanchetti A; Malacco E; Mancia G; Staessen J; Fagard R; Holman R; Hansson L; Kostis J; Kanno Y; Lueders S; Matsuzaki M; Poole-Wilson P; Schrader J; Rahimi K; Anderson C; Chapman N; Collins R; MacMahon S; Neal B; Rodgers A; Whelton P; Woodward M, 2015, 'Effects of blood pressure lowering on cardiovascular risk according to baseline body-mass index: A meta-analysis of randomised trials', The Lancet, 385, pp. 867 - 874, http://dx.doi.org/10.1016/S0140-6736(14)61171-5

Neal B; Perkovic V; De Zeeuw D; Mahaffey KW; Fulcher G; Ways K; Desai M; Shaw W; Capuano G; Alba M; Jiang J; Vercruysse F; Meininger G; Matthews D, 2015, 'Efficacy and safety of canaglif lozin, an inhibitor of sodium-glucose cotransporter 2, when used in conjunction with insulin therapy in patients with type 2 diabetes', Diabetes Care, 38, pp. 403 - 411, http://dx.doi.org/10.2337/dc14-1237

Roberts MA; Pilmore HL; Ierino FL; Badve SV; Cass A; Garg AX; Hawley CM; Isbel NM; Krum H; Pascoe EM; Tonkin AM; Vergara LA; Perkovic V, 2015, 'The rationale and design of the Beta-blocker to LOwer CArdiovascular Dialysis Events (BLOCADE) Feasibility Study', Nephrology, 20, pp. 140 - 147, http://dx.doi.org/10.1111/nep.12362

Emdin CA; Rahimi K; Neal B; Callender T; Perkovic V; Patel A, 2015, 'Blood pressure lowering in type 2 diabetes : A systematic review and meta-analysis', JAMA - Journal of the American Medical Association, 313, pp. 603 - 615, http://dx.doi.org/10.1001/jama.2014.18574

Jun M; James MT; Manns BJ; Quinn RR; Ravani P; Tonelli M; Perkovic V; Winkelmayer WC; Ma Z; Hemmelgarn BR, 2015, 'The association between kidney function and major bleeding in older adults with atrial fibrillation starting warfarin treatment: Population based observational study', The BMJ, 350, http://dx.doi.org/10.1136/bmj.h246

Johnson DW; Pascoe EM; Badve SV; Dalziel K; Cass A; Clarke P; Ferrari P; McDonald SP; Morrish AT; Pedagogos E; Perkovic V; Reidlinger D; Scaria A; Walker R; Vergara LA; Hawley CM; D'Almeida E; Fassett R; Kirkpatrick C; Phoon R; Tonkin A; Forbes A; Levin A; Wheeler DC; Jardine M; Burman J; Hand S; Garvey L; Suranyi M; Gilbert M; Endre Z; McNamara K; Snelling P; Mahadevan K; Pollock A; Leary D; Ratanjee S; Kirby J; Juneja R; Hill K; Cook N; Bisscheroux P; McMahon L; Kent A; Raspudic M; Steinwandel U; Dogra S; Pellicano S; Paul-Brent PA, 2015, 'A randomized, placebo-controlled trial of pentoxifylline on erythropoiesis-stimulating agent hyporesponsiveness in anemic patients with CKD: The handling erythropoietin resistance with oxpentifylline (HERO) trial', American Journal of Kidney Diseases, 65, pp. 49 - 57, http://dx.doi.org/10.1053/j.ajkd.2014.06.020

Laba TL; Usherwood T; Leeder S; Yusuf F; Gillespie J; Perkovic V; Wilson A; Jan S; Essue B, 2015, 'Co-payments for health care: What is their real cost?', Australian Health Review, 39, pp. 33 - 36, http://dx.doi.org/10.1071/AH14087

Wong MG; Wanner C; Knight J; Perkovic V, 2015, 'Lowering cholesterol in chronic kidney disease: Is it safe and effective?', European Heart Journal, 36, pp. 2988 - 2995, http://dx.doi.org/10.1093/eurheartj/ehv393

Lo C; Toyama T; Hirakawa Y; Jun M; Cass A; Hawley C; Pilmore H; Badve S; Perkovic V; Zoungas S, 2015, 'Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease', Cochrane Database of Systematic Reviews

Zoungas S; Chalmers J; Neal B; Billot L; Li Q; Biostat M; Hirakawa Y; Arima H; Monaghan H; Joshi R; Colagiuri S; Cooper ME; Glasziou P; Grobbee D; Hamet P; Harrap S; Heller S; Lisheng L; Mancia G; Marre M; Matthews DR; Mogensen CE; Perkovic V; Poulter N; Rodgers A; Williams B; MacMahon S; Patel A; Woodward M, 2014, 'Follow-up of blood-pressure lowering and glucose control in type 2 diabetes', New England Journal of Medicine, 371, pp. 1392 - 1406, http://dx.doi.org/10.1056/NEJMoa1407963

Sundström J; Arima H; Woodward M; Jackson R; Karmali K; Lloyd-Jones D; Baigent C; Emberson J; Rahimi K; Macmahon S; Patel A; Perkovic V; Turnbull F; Neal B; Agodoa L; Estacio R; Schrier R; Lubsen J; Chalmers J; Cutler J; Davis B; Wing L; Poulter NR; Sever P; Remuzzi G; Ruggenenti P; Nissen S; Lindholm LH; Fukui T; Ogihara T; Saruta T; Black H; Sleight P; Lievre M; Suzuki H; Fox K; Lisheng L; Ohkubo T; Imai Y; Yusuf S; Bulpitt CJ; Lewis E; Brown M; Palmer C; Wang J; Pepine C; Ishii M; Yui Y; Kuramoto K; Pfeffer M; Asselbergs FW; van Gilst WH; Byington B; Pitt B; Brenner B; Remme WJ; de Zeeuw D; Rahman M; Viberti G; Teo K; Zanchetti A; Malacco E; Mancia G; Staessen J; Fagard R; Holman R; Hansson L; Kostis J; Kanno Y; Lueders S; Matsuzaki M; Poole-Wilson P; Schrader J; Anderson C; Chapman N; Collins R; Rodgers A; Whelton P, 2014, 'Blood pressure-lowering treatment based on cardiovascular risk: A meta-analysis of individual patient data', The Lancet, 384, pp. 591 - 598, http://dx.doi.org/10.1016/S0140-6736(14)61212-5

Johnson DW; Pascoe E; Badve SV; Dalziel K; Cass A; Clarke P; Ferrari P; Mcdonald SP; Morrish AT; Pedagogos E; Perkovic V; Scaria A; Walker R; Vergara LA; Hawley CM, 2014, 'A RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF PENTOXIFYLLINE ON ERYTHROPOIESIS STIMULATING AGENT RESISTANCE IN ANAEMIC PATIENTS WITH CHRONIC KIDNEY DISEASE - THE HERO TRIAL', NEPHROLOGY, 19, pp. 29 - 29, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339715700047&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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