UNSW Cellular Genomics Futures Institute

UNSW Cellular Genomics Futures Institute

 

"Inventing technologies to decode individual cell DNA, chromatin, RNA, and protein outputs that will be used for precise diagnosis and precision treatment of human disease"

 

Single cell genomics is the next great revolution in medicine. The field leverages the massively parallel technologies that enabled large-scale human genome sequencing and makes it possible to see the entire genome in action at the quantum of individual cells.

The UNSW Cellular Genomics Futures Institute will leverage growing UNSW Sydney and Garvan Institute of Medical Research scientific leadership in this field. It will tackle major challenges in single cell data acquisition and data analytics. This will allow it to decode the state of DNA, chromatin, and its entire output as RNA and protein in thousands of single cells, to uncover diagnostic cell origins, molecular targets, and treatments for human disease with unparalleled precision. This will have a major impact on the precision health management of patients, through early detection and personalised treatment of disease, and will reduce the costs of healthcare.

 

OUR AIMS
Develop the first NATA-accredited diagnostic test in Australia for lung disease based on single-cell genomic analysis
Undertake clinical trials in partnership with pharmaceutical companies for applications in cancer, autoimmune disorders, and infectious disease
Develop diagnostic tests that predict the development of blood cancers and other disorders
Develop machine learning and statistical methods for analysis of cellular genomics data to predict and monitor the cell types that cause disease
Lead a flagship program in the international Human Cell Atlas project by generating and analysing population-level healthy and diseased cohorts of cell types in blood and bone marrow, providing a reference dataset that will be used by researchers globally
AN INVESTMENT IN THE FUTURE
Technology has rocketed ahead to where we can now analyse the genetic output of even a single cell. By investing in this area, we can substantially boost health outcomes, developing early detection and precision therapies to help millions of people. The UNSW Cellular Genomics Futures Institute will capitalise on the combined research firepower of the Garvan Institute of Medical Research and UNSW Sydney.
Cellular Genomics is the next great revolution in medicine. The UNSW Cellular Genomics Futures Institute will invent technologies to decode individual cell DNA, chromatin, RNA, and protein outputs that will be used for precise diagnosis and precision treatment of human disease.
UNSW Cellular Genomics Futures Institute – Why We’re Investing
UNSW Cellular Genomics Futures Institute – Our Vision
RESEARCH THEMES
Single cell meeting population genetics – blood cells and the Human Cell Atlas

We will establish world-leading capabilities in decoding connections between genome output as RNA and inherited genome polymorphisms, focussing on blood cell disorders.

Decoding DNA and chromatin variants with RNA and protein output

We will track rare rogue immune cells that drive autoimmune disease, to provide precise cellular and molecular diagnoses, clarify autoimmune disease heterogeneity, and provide precise cellular targets and endpoints for clinical trials.

Decoding and recoding cells for therapy

We will build upon single cell multi-omics capabilities to tackle the challenge of single cell gene editing and the engineering of cells as therapeutics.

Decoding cell changes for diagnosis with liquid biopsies

We will develop a world-first liquid biopsy for diagnosis of lung disease, with the aim of dramatically reducing current diagnosis costs, increasing accuracy, and removing the need for surgical lung biopsies.

Decoding cells for developing therapies for virus-induced cancer

We will solve key challenges in decoding individual cell DNA, RNA, and protein outputs when the cells are in a biopsy from a solid organ, as opposed to a cell suspension from blood or other body fluids.

COLLABORATIONS

The Institute will bring together researchers from different disciplines at UNSW to collaborate with scientists from the Garvan Institute of Medical Research.

UNSW's collaborating faculties:

 

Medicine        Science        Engineering

CONTACT US
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