By Associate Professor Tanya Lynn Applegate

Journal articles

Applegate TL; Gaudieri S; Plauzolles A; Chopra A; Grebely J; Lucas M; Hellard M; Luciani F; Dore GJ; Matthews GV, 2015, 'Naturally occurring dominant drug resistance mutations occur infrequently in the setting of recently acquired hepatitis C', Antiviral Therapy, 20, pp. 199 - 208, http://dx.doi.org/10.3851/IMP2821

Hajarizadeh B; Grady B; Page K; Kim AY; McGovern BH; Cox AL; Rice TM; Sacks-Davis R; Bruneau J; Morris M; Amin J; Schinkel J; Applegate T; Maher L; Hellard M; Lloyd AR; Prins M; Geskus RB; Dore GJ; Grebely J; Lauer G; Shoukry NH; Hahn J; Shiboski S; Rice TM; Alavi M; Bouchard R; Aneja J; Teutsch S; White B; Wells B; Zang G; Matthews G; Marks P; Yeung B; Prince LE; Roy E; Bates A; Enriquez J; Chow S; McCredie L; Aitken C; Doyle J; Spelman T; Evans J, 2014, 'Interferon lambda 3 genotype predicts hepatitis C virus RNA levels in early acute infection among people who inject drugs: The InC³ Study', Journal of Clinical Virology, 61, pp. 430 - 434, http://dx.doi.org/10.1016/j.jcv.2014.08.027

Jacka B; Applegate T; Krajden M; Olmstead A; Harrigan PR; Marshall BDL; Debeck K; Milloy MJ; Lamoury F; Pybus OG; Lima VD; Magiorkinis G; Montoya V; Montaner J; Joy J; Woods C; Dobrer S; Dore GJ; Poon AFY; Grebely J, 2014, 'Phylogenetic clustering of hepatitis C virus among people who inject drugs in Vancouver, Canada', Hepatology, 60, pp. 1571 - 1580, http://dx.doi.org/10.1002/hep.27310

Hajarizadeh B; Grebely J; Applegate T; Matthews GV; Amin J; Petoumenos K; Hellard M; Rawlinson W; Lloyd A; Kaldor J; Dore GJ; Dolan K, 2014, 'Dynamics of HCV RNA Levels During Acute Hepatitis C Virus Infection', Journal of Medical Virology, 86, pp. 1722 - 1729, http://dx.doi.org/10.1002/jmv.24010

Bradshaw D; Lamoury F; Catlett B; Mcallister J; Applegate T; Dore G; Matthews G; Danta M, 2014, 'Seminal HCV RNA level may mirror dynamics of plasma HCV RNA in HIV-infected men with acute HCV', HIV MEDICINE, 15, pp. 8 - 8

Bradshaw D; Applegate T; Dore G; Hellard M; Sasadeusz J; Matthews G; Danta M, 2014, 'The majority of acute HCV infection in HIV-positive men who have sex with men (HIV plus MSM) is transmitted permucosally in the context of HIV serosorting in Australia', HIV MEDICINE, 15, pp. 137 - 137

Savkovic B; Nichols J; Birkett D; Applegate T; Ledger S; Symonds G; Murray JM, 2014, 'A Quantitative Comparison of Anti-HIV Gene Therapy Delivered to Hematopoietic Stem Cells versus CD4+ T Cells', PLoS Computational Biology, 10, http://dx.doi.org/10.1371/journal.pcbi.1003681

Feld JJ; Grebely J; Matthews GV; Applegate T; Hellard M; Sherker A; Cherepanov V; Petoumenos K; Yeung B; Kaldor JM; Lloyd AR; Dore GJ, 2013, 'Plasma interferon-gamma-inducible protein-10 levels are associated with early, but not sustained virological response during treatment of acute or early chronic HCV infection', PLoS ONE, 8, pp. e80003, http://dx.doi.org/10.1371/journal.pone.0080003

Jacka B; Lamoury F; Simmonds P; Dore GJ; Grebely J; Applegate T, 2013, 'Sequencing of the Hepatitis C Virus: A Systematic Review', PLoS ONE, 8, pp. e67073, http://dx.doi.org/10.1371/journal.pone.0067073

Grebely J; Feld JJ; Applegate T; Matthews GV; Hellard M; Sherker A; Petoumenos K; Zang G; Shaw I; Yeung B; George J; Teutsch S; Kaldor JM; Cherepanov V; Bruneau J; Shoukry NH; Lloyd AR; Dore GJ, 2013, 'Plasma interferon-gamma-inducible protein-10 (IP-10) levels during acute hepatitis C virus infection', Hepatology, 57, pp. 2124 - 2134, http://dx.doi.org/10.1002/hep.26263

Grebely J; Hellard M; Applegate TL; Petoumenos K; Yeung B; Feld J; Rawlinson WD; Lloyd AR; George J; Kaldor JM; Dore GJ; Matthews G; Dolan K, 2012, 'Virological responses during treatment for recent hepatitis C virus: Potential benefit for ribavirin use in HCV/HIV co-infection', AIDS, 26, pp. 1653 - 1661, http://dx.doi.org/10.1097/QAD.0b013e3283553719

Mcintyre GJ; Groneman JL; Yu YH; Tran A; Applegate TL, 2011, 'Multiple shRNA combinations for near-complete coverage of all HIV-1 strains', AIDS Research and Therapy, 8, pp. 1, http://www.aidsrestherapy.com/content/8/1/1

Applegate TL; Birkett DJ; Mcintyre GJ; Jaramillo AB; Symonds G; Murray JM, 2010, 'In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy', Retrovirology, 7:83, pp. 1 - 14, http://www.retrovirology.com/content/7/1/83

Grebely J; Petoumenos K; Hellard M; Matthews G; Suppiah V; Applegate TL; Yeung B; Marks P; Rawlinson WD; Lloyd AROLA; Booth D; Kaldor JM; George J; Dore GJ; Amin J; Cameron B; Acraman B; Dolan K; Bloch M; Van Beek I; Li H; Madden A, 2010, 'Potential Role for Interleukin-28B Genotype in Treatment Decision-Making in Recent Hepatitis C Virus Infection', Hepatology, 52, pp. 1216 - 1224, http://dx.doi.org/10.1002/hep.23850

Mcintyre GJ; Groneman JL; Yu YH; Jaramillo A; Shen S; Applegate TL, 2009, '96 shRNAs designed for maximal coverage of HIV-1 variants', Retrovirology, 6, http://dx.doi.org/10.1186/1742-4690-6-55

Mcintyre GJ; Yu Y; Tran A; Jaramillo AB; Arndt AJ; Millington ML; Boyd MP; Elliott FA; Shen SW; Murray JM; Applegate TL, 2009, 'Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success', Virology Journal, 6, pp. 184, http://www.virologyj.com/content/6/1/184

Millington ML; Arndt A; Boyd MP; Applegate TL; Shen SW, 2009, 'Towards a clinically relevant lentiviral transduction protocol for primary human CD34 hematopoietic stem/progenitor cells', PLoS One, 4, pp. e6461

Mcintyre GJ; Groneman JL; Tran A; Applegate TL, 2008, 'An infinitely expandable cloning strategy plus repeat-proof PCR for working with multiple shRNA', PLoS ONE, 3, http://dx.doi.org/10.1371/journal.pone.0003827

Mokany E; Todd AV; Fuery CJ; Applegate TL, 2006, 'Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR.', Methods in molecular medicine, 125, pp. 127 - 147

Haber PS; Apte MV; Moran C; Applegate TL; Pirola RC; Korsten MA; Mccaughan GW; Wilson JS, 2004, 'Non-oxidative metabolism of ethanol by rat pancreatic acini', Pancreatology, 4, pp. 82 - 89, http://dx.doi.org/10.1159/000077608

Applegate TL; Iland HJ; Mokany E; Todd AV, 2002, 'Molecular monitoring of acute promyelocytic leukemia by DzyNA reverse transcription-PCR', CLINICAL CHEMISTRY, 48, pp. 1858 - 1860, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000178238100041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Applegate TL; Iland HJ; Mokany E; Todd AV, 2002, 'Diagnosis and molecular monitoring of acute promyelocytic leukemia using DzyNA reverse transcription-PCR to quantify PML/RARα fusion transcripts', Clinical Chemistry, 48, pp. 1338 - 1343, http://dx.doi.org/10.1093/clinchem/48.8.1338

End DW; Smets G; Todd AV; Applegate TL; Fuery CJ; Angibaud P; Venet M; Sanz G; Poignet H; Skrzat S; Devine A; Wouters W; Bowden C, 2001, 'Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro', Cancer Research, 61, pp. 131 - 137

Impey HL; Applegate TL; Haughton MA; Fuery CJ; King JE; Todd AV, 2000, 'Factors that influence deoxyribozyme cleavage during polymerase chain reaction', Analytical Biochemistry, 286, pp. 300 - 303, http://dx.doi.org/10.1006/abio.2000.4818

Todd AV; Fuery CJ; Impey HL; Applegate TL; Haughton MA, 2000, 'DzyNA-PCR: Use of DNAzymes to detect and quantify nucleic acid sequences in a real-time fluorescent format', Clinical Chemistry, 46, pp. 625 - 630, http://dx.doi.org/10.1093/clinchem/46.5.625

Fuery CJ; Impey H; Roberts NK; Applegate TL; Ward RL; Hawkins NJ; Sheehan C; O Grady R; Todd AV, 2000, 'Detection of rare mutant alleles by restriction endonuclease-mediated selective-PCR: assay design and optimization', Clinical Chemistry, 46, pp. 620 - 624

Ward RL; Sheehan C; Norrie M; Applegate TL; Fuery CJ; Impey H; Hawkins NJ; Todd AV, 2000, 'Factors influencing the detection of mutant K-ras in the serum of patients with colorectal cancer', Annals of the New York Academy of Sciences, 906, pp. 17 - 18, http://dx.doi.org/10.1111/j.1749-6632.2000.tb06583.x

Roberts NJ; Impey H; Applegate TL; Furey C; Ward RL; Todd AV, 1999, 'Rapid and sensitive detection of mutant alleles in codon 12 of K-ras by restriction endonuclease-mediated selective polymerase chain reaction (REMS-PCR)', BioTechniques, 27, pp. 418 - 422

Haber PS; Apte MV; Applegate TL; Norton ID; Korsten MA; Pirola RC; Wilson JS, 1998, 'Metabolism of ethanol by rat pancreatic acinar cells', Journal of Laboratory and Clinical Medicine, 132, pp. 294 - 302, http://dx.doi.org/10.1016/S0022-2143(98)90042-7

Haber PS; Apte MV; Applegate TL; Norton ID; Korsten MA; Pirola R; Wilson JS, 1998, 'Metabolism of ethanol by rat pancreatic acinar cells', Journal of Laboratory and Clinical Medicine, 132, pp. 203 - 294, http://linkinghub.elsevier.com/retrieve/pii/S0022-2143(98)90042-7

Apte MV; Haber PS; Applegate TL; Norton ID; Mccaughan GW; Korsten MA; Pirola RC; Wilson JS, 1998, 'Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture', Gut, pp. 128 - 133, http://dx.doi.org/10.1136/gut.43.1.128

Apte MV; Norton ID; Haber PS; Applegate TL; Mccaughan GW; Korsten MA; Pirola RC; Wilson JS, 1998, 'The effect of ethanol on pancreatic enzymes - a dietary artefact?', Biochimica et Biophysica ACTA, 1379, pp. 314 - 324, http://dx.doi.org/10.1016/S0304-4165(97)00109-8

Applegate TL; Karjalainen A; Bygrave FL, 1997, 'Rapid Ca²⁺ influx induced by the action of dibutylhydroquinone and glucagon in the perfused rat liver', Biochemical Journal, 323, pp. 463 - 467, http://dx.doi.org/10.1042/bj3230463

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