By Conjoint Professor Steven krilis

Journal articles

Wong GW; Foster PS; Yasuda S; Qi JC; Mahalingam S; Mellor EA; Katsoulotos G; Li X; Boyce JA; Krilis SA; Stevens RL, 2002, 'Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase γ: TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor α/signal transducer and activator of transcription (STAT) 6-dependent pathway', Journal of Biological Chemistry, 277, pp. 41906 - 41915, http://dx.doi.org/10.1074/jbc.M205868200

Guerin J; Sheng Y; Reddel S; Michael Iverson G; Chapman MG; Krilis SA, 2002, 'Heparin inhibits the binding of β2-glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein. Elucidation of the consequences of the two biological events in patients with the anti-phospholipid syndrome', Journal of Biological Chemistry, 277, pp. 2644 - 2649, http://dx.doi.org/10.1074/jbc.M110176200

Wong GW; Foster PS; Yasuda S; Qi JC; Mahalingam S; Mellor EA; Li L; Katsoulotos GP; Boyce JA; Krilis S; Stevens RL, 2002, 'Biochemical and Functional Characterisation of Human Transmembrane Tryptase (TMT)/Tryptase y', The Journal of Biological Chemistry, 277, pp. 41906 - 41915

Arvieux J; Renaudineau Y; Mane I; Perraul R; Krilis S; Youinou P, 2002, 'Distinguishing Features of Anti-2-glycoprotein 1 Antibodies between Patients with Leprasy and the Antiphospholipid Syndrome', Thrombosis and Haemostasis, 87, pp. 599 - 605

Guerin J; Sheng YH; Reddel SW; Iverson GM; Chapman MG; Krilis S, 2002, 'Heparin Inhabits the Binding of .2-glycoprotein 1 to Phospholipids and Promotes the Plasmin-mediated Inactivation of this Blood Protein', The Journal of Biological Chemistry, 277, pp. 2644 - 2649

Qi JC; Stevens RL; Wadley RB; Collins AM; Cooley MA; Naif H; Nasr N; Cunningham AL; Katsoulotos GP; Wanigasek Y; Roufogalis B; Krilis S, 2002, 'IL-16 Regulation of Human Mast Cells/Basophils and Their Susceptibility to HIV-1', Journal of Immunology, 168, pp. 4127 - 4134

Yang Y; Li L; Wong GW; Krilis S; Madhusudhan MS; Sali A; Stevens RL, 2002, 'RasGRP4, a New Mast Cell - Restricted Ras Guanine Nucleotide-releasing Protein with Calcium- and Diacylglycerol-binding Motifs', The Journal of Biological Chemistry, 277, pp. 25756 - 25774

Iverson GM; Reddel SW; Victoria EJ; Cockerill KA; Wang YX; Marti-Renom MA; Sali A; Marquis DM; Krilis S; Linnik MD, 2002, 'Use of Single Point Mutations in Domain I of B2-Glycoprotein I to Determine Fine Antigenic Specifity of Antiphospholipid Autoantibodies', Journal of Immunology, pp. 7097 - 7103

Sheng Y; Hanly JG; Reddel SW; Kouts S; Guerin J; Koike T; Ichikawa K; Sturgess A; Krilis SA, 2001, 'Detection of 'antiphospholipid' antibodies: A single chromogenic assay of thrombin generation sensitively detects lupus anticoagulants, anticardiolipin antibodies, plus antibodies binding β 2-glycoprotein I and prothrombin', Clinical and Experimental Immunology, 124, pp. 502 - 508, http://dx.doi.org/10.1046/j.1365-2249.2001.01555.x

Sheng Y; Reddel SW; Herzog H; Wang YX; Brighton T; France MP; Krilis SA, 2001, 'Impaired In vitro thrombin generation in beta 2-glycoprotein I null mice', ARTHRITIS RESEARCH & THERAPY, 3, http://dx.doi.org/10.1186/ar248

Qi JC; Li L; Krilis S, 2001, 'Cells with features of mast cells and basophils', Allergy and Clinical Immunology International, 13, pp. 197 - 202

Wong GW; Yasuda S; Madhusudhan MS; Yang Y; Krilis S; Li L; Sali A; Stevens RL, 2001, 'Human Tryptas essilon (PRSS26), a new member of the Chromosome 16p13.3 family of human serine proteases expressed in airway epithelian cells', The Journal of Biological Chemistry, pp. 49169 - 49182

Sheng YH; Reddel SW; Herzog H; Brighton TA; France MP; Robertson SL; Krilis S; Wang YX, 2001, 'Impaired thrombin generation in Beta 2-gylcoprotein I null mice', The Journal of Biological Chemistry, pp. 13817 - 13821

Li Y; Li L; Wadley RB; Reddel SW; Qi JC; Archis CA; Collins AM; Clarke E; Cooley MA; Kouts S; Naif H; Alali M; Cunningham AL; Wong GW; Stevens RL; Krilis S, 2001, 'Mast cell/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5 and CXCR4', Blood, pp. 3484 - 3490

Wong GW; Li L; Madhusudhan MS; Krilis S; Gurish MF; Rothenberg ME; Sali A; Stevens RL, 2001, 'Tryptase 4, a new member of the chromosome 17 family of mouse serine proteases', The Journal of Biological Chemistry, pp. 20648 - 20658

Li Y; Li L; Wadley R; Reddel S; Qi J; Archis C; Collins A; Clark E; Cooley M; Kouts S; Hassan N; Mohammed A; Cunningham A; Wong G; Stevens R; Krilis S, 2000, 'Identification of a novel population of mast cells/basophils in human periphal blood of allergic patients which is HIV-1 susceptible due to its surface expression of CD4, CCR5, and CXCR4', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 105, pp. S86 - S87, http://dx.doi.org/10.1016/S0091-6749(00)90690-0

Wong G; Krilis S; Stevens R, 2000, 'Identification, cloning, and expression of a new human and mouse tryptase', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 105, pp. S89 - S89, http://dx.doi.org/10.1016/S0091-6749(00)90697-3

Reddel SW; Wang Y; Sheng YH; Krilis S, 2000, 'Epitope studies with anti-beta 2-glycoprotein I antibodies from autoantibody and immunized sources', Journal of Autoimmunity, 15, pp. 91 - 96

Li L; Li Y; Krilis SA, 1999, 'Monoclonal antibodies recognizing antigens expressed in human mast cells and their progenitors', FASEB JOURNAL, 13, pp. A337 - A337, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033301949&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Li L; Li Y; Reddel SW; Cherrian M; Friend DS; Stevens RL; Krilis SA, 1999, 'Cells that have features of both mast cells and basophils in the peripheral blood of allergy, asthma, and drug reactive', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 103, pp. S43 - S43, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000078509000169&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Li L; Krilis SA, 1999, 'Mast-cell growth and differentiation', Allergy European Journal of Allergy and Clinical Immunology, 54, pp. 306 - 313, http://dx.doi.org/10.1034/j.1398-9995.1999.00086.x

Li L; Li Y; Krilis SA, 1999, 'Monoclonal antibodies recognizing antigens expressed in human mast cells and their progenitors.', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 103, pp. S43 - S43, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000078509000170&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Reddel SW; Krilis SA, 1999, 'Testing for and clinical significance of anticardiolipin antibodies', Clinical and Diagnostic Laboratory Immunology, 6, pp. 775 - 782, http://dx.doi.org/10.1128/cdli.6.6.775-782.1999

Huang C; Li L; Krilis S; Chanasyk K; Tang Y; Li Z; Hunt JE; Stevens RL, 1999, 'Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft', The Journal of Biological Chemistry, pp. 19670 - 19676

Wong GW; Tang Y; E F; Sali A; Li L; Li YW; Huang C; Friend DS; Krilis S; Stevens RL, 1999, 'Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension', The Journal of Biological Chemistry, pp. 30784 - 30793

Sheng Y; Kandiah DA; Krilis SA, 1998, 'Anti-β2-glycoprotein I autoantibodies from patients with the 'antiphospholipid' syndrome bind to β2-glycoprotein I with low affinity: Dimerization of β2-glycoprotein I induces a significant increase in anti- β2-glycoprotein I antibody affinity', Journal of Immunology, 161, pp. 2038 - 2043, http://dx.doi.org/10.4049/jimmunol.161.4.2038

Kandiah DA; Krilis SA, 1998, 'Anti-β2-glycoprotein I and anti-prothrombin antibodies in patients with the 'antiphospholipid' syndrome: Immunological specificity and clotting profiles', Lupus, 7, pp. 323 - 332, http://dx.doi.org/10.1191/096120398678920253

Tsutsumi A; Ichikawa K; Atsumi T; Matsuura E; Koike T; Krilis SA, 1998, 'Use of various methods for anticardiolipin detection in the updated American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus: Comment on the letter by Hochberg [1]', Arthritis and Rheumatism, 41, pp. 1326 - 1327, http://dx.doi.org/10.1002/1529-0131(199807)41:7<1326::AID-ART29>3.0.CO;2-4

Del Papa N; Sheng YH; Raschi E; Kandiah DA; Tincani A; Khamashta MA; Atsumi T; Hughes GRV; Ichikawa K; Koike T; Balestrieri G; Krilis SA; Meroni PL, 1998, 'Human β2-glycoprotein I binds to endothelial cells through a cluster of lysine residues that are critical for anionic phospholipid binding and offers epitopes for anti-β2-glycoprotein I antibodies', Journal of Immunology, 160, pp. 5572 - 5578, http://dx.doi.org/10.4049/jimmunol.160.11.5572

Vlachoyiannopoulos PG; Petrovas C; Tektonidou M; Krilis S; Moutsopoulos HM, 1998, 'Antibodies to β2-glycoprotein-I: Urea resistance, binding specificity, and association with thrombosis', Journal of Clinical Immunology, 18, pp. 380 - 391, http://dx.doi.org/10.1023/A:1023274505128

Sheng Y; Kandiah DA; Krilis SA, 1998, 'β2-Glycoprotein I : Target antigen for 'antiphospholipid' antibodies. Immunological and molecular aspects', Lupus, 7, pp. S5 - S9, http://dx.doi.org/10.1177/096120339800700202

Sheng YH; Kandiah DA; Krilis S, 1998, 'Anti-B2_Glycoprotein I Autoantibodies from Patients with the `Antiphospholipid` Syndrome Bind to B2_Glycoprotein I with Low Affinity: Demerization of B2-Glycoprotein I Induces a Significant Increase in Anti-B2_Glycoprotein I Anti', Journal of Immunology, 161, pp. 2038 - 2043

Kandiah DA; Krilis S, 1998, 'Anti-B2-glycoprotein I and anti-prothrombin antibodies in patients with the `antiphospholipid` syndrome: Immunological specificity and clotting profiles.', Lupus, pp. 323 - 332

Skopouli F; Li L; Boumba D; Stefanaki S; Hanel K; Moutsopoulos HM; Krilis S, 1998, 'Association of mast cells with fibrosis and fatty infiltration in the minor salivary glands of patients with Sjogren`s syndrome', Clinical and Experimental Rheumatology, 16, pp. 63 - 65

Skopouli F; Li L; Boumba D; Stefanaki S; Hanel K; Moutsopoulos HM; Krilis S, 1998, 'Association of mast cells with fibrosis and fatty infiltration in the minor salivary glands of patients with Sjogren`s syndrome', Clinical and Experimental Rheumatology, 16, pp. 63 - 65

Meroni PL; Del Papa N; Raschi E; Borghi MO; Tincani A; Balestrieri G; Khamashta M; Hughes GJ; Koike T; Krilis S; Panzery P, 1998, 'B2-Glycoprotein I as a `Cofactor` for anti-phospholipid reactivity with endothelial cells', Lupus, pp. 44 - 47

Sheng YH; Kandiah DA; Krilis S, 1998, 'B2-Glycoprotein I: Target antigen for `antiphospholipid` antibodies. Immunological and molecular aspects', Lupus, pp. 5 - 9

Kandiah DA; Sali A; Sheng YH; Victoria EJ; Marquis DM; Coutts SM; Krilis S, 1998, 'Current insights into the antiphospholip syndrome:clinical, immunological and molecular aspects.', Advances in Immunology, pp. 507 - 563

Kandiah DA; Krilis S, 1998, 'Heterogeneity of Lupus Anticoagulant (LA) Antibodies: LA Activity in Dilute Russell`s Viper Venom Time and Dilute Kaolin Clotting Time Detect Different Populations OF Antibodies with the `Antiphospholipid` Syndrome', Thrombosis and Haemostasis, pp. 250 - 257

Del Papa N; Sheng YH; Raschi E; Kandiah DA; Tincani A; Khamashta M; Atsumi T; Hughes GJ; Ichikawa K; Koike T; Balestrieri G; Krilis S; Meroni PL, 1998, 'Human B2-Glycoprotein I Binds to Endothelial Cells Through a Cluster of Lysine Residues That Are Critical for Anionic Phospholipid Binding and Offrs', Journal of Immunology, 160, pp. 5572 - 5578

Li L; Li Y; Reddel SW; Cherrian M; Friend DS; Stevens RL; Krilis S, 1998, 'Identification of Basophilic Cells that Express Mast Cell Granule Proteases in the Peripheral Blood of Asthma, Allergy, and Drug-Reactive Patients', Journal of Immunology, 161, pp. 5079 - 5086

Li L; Krilis SA, 1997, 'Conditioned media obtained from a human mastocytosis cell strain induce mast cells expressing chymase but not tryptase from human progenitors', International Archives of Allergy and Immunology, 113, pp. 289 - 290, http://dx.doi.org/10.1159/000237576

Sheng Y; Krilis SA; Sali A, 1997, 'Site-directed mutagenesis of recombinant human β2-glycoprotein I. Effect of phospholipid binding and anticardiolipin antibody activity', Annals of the New York Academy of Sciences, 815, pp. 331 - 333, http://dx.doi.org/10.1111/j.1749-6632.1997.tb52077.x

Sheng YH; Herzog H; Krilis S, 1997, 'Cloning and characterization of the gene encoding mouse B2-Glycoprotein 1', Genomics, pp. 128 - 130

Sheng YH; Sali A; Krilis S, 1997, 'Mutagenesis of recombinant human B2-glycoprotein 1:effect of phospholipid binding and anticardiolipin antibody activity', Journal of Immunology, pp. 331 - 333

Kandiah DA; Sheng YH; Krilis SA, 1996, 'β2-glycoprotein I: Target antigen for autoantibodies in the (antiphospholipid syndrome)', Lupus, 5, pp. 381 - 385, http://dx.doi.org/10.1177/096120339600500509

Kandiah DA; Sheng YH; Krilis S, 1996, 'b2-glycoprotein I: target antigen for autoantibodies in the Antiphospholipid Syndrome', Lupus, pp. 381 - 385

Kandiah DA; Krilis S, 1996, 'Immunology of `antiphospholipid` antibodies and their interaction with plasma proteins', Lupus, pp. 153 - 155

Kandiah DA; Krilis S, 1996, 'Laboratory detection of `antiphospholipid` antibodies', Lupus, pp. 160 - 162

Li L; Meng XW; Krilis S, 1996, 'Mast cells expressing chymase but not tryptase can be derived by culturing human progenitors in conditioned medium obtained from a human mastocytosis cell strain with c-kit ligand', Journal of Immunology, 156, pp. 4839 - 4844

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