Dr. Luque research is focused on the structural characterisation of viral macromolecular complexes by three-dimensional electron microscopy techniques, specifically cryoEM and image processing. He have made significant contributions to the structural characterisation of a number of viral systems including i) dsRNA viruses such as Rotavirus, Birnavirus and several fungal viruses; ii) ssRNA viruses such as rabbit haemorrhagic disease virus, human rhinovirus, respiratory syncytial virus, human metapneumovirus, and cowpea chlorotic mottle virus; iii) ssDNA viruses such as beak and feather disease virus and bat circovirus and iv) dsDNA bacteriophages such as T5, T7 and P22.

The most recent focus of his research is investigating how different viruses interact with the complex membranous system that surround and reside within the cell. In collaboration with other groups he is studding this phenomenon in three main research lines: i) development of nanotransporters/nanocages based on viral capsids, ii) membrane fusion proteins from different viruses including human respiratory syncytial virus (hRSV), human metapneumovirus (hMPV) and coronavirus (SARS-CoV-2 & MERS) and iii) rotavirus entry and tropism.