By Dr Jamie Fletcher

Journal articles

Henderson M; Haber M; Porro A; Munoz M; Xue C; Murray JE; Flemming C; Smith J; Fletcher JI; Gherardi S; Kwek C; Russell AJ; Valli E; London WB; Buxton AB; Ashton LJ; Sartorelli AC; Cohn SL; Schwab M; Marshall GM; Perini G; Norris MD; Kwek C-K, 2011, 'ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux', Journal of the National Cancer Institute, 103, pp. 1236 - 1251, http://dx.doi.org/10.1093/jnci/djr256

Kvansakul M; Wei AH; Fletcher JI; Willis SN; Chen L; Roberts AW; Huang DCS; Colman PM, 2010, 'Structural basis for apoptosis inhibition by Epstein-Barr virus bhrf1', PLoS Pathogens, 6, http://dx.doi.org/10.1371/journal.ppat.1001236

Fletcher JI; Haber M; Henderson M; Norris MD, 2010, 'ABC transporters in cancer: more than just drug efflux pumps', Nature Reviews Cancer, 10, pp. 147 - 156, http://dx.doi.org/10.1038/nrc2789

Branson KM; Mertens HDT; Swarbrick JD; Fletcher JI; Kedzierski L; Gayler KR; Gooley PR; Smith BJ, 2009, 'Discovery of Inhibitors of Lupin Diadenosine 5 ',5 '''-P-1,P-4-Tetraphosphate Hydrolase by Virtual Screening', BIOCHEMISTRY, 48, pp. 7614 - 7620, http://dx.doi.org/10.1021/bi900813x

Fletcher JI; Meusburger S; Hawkins CJ; Riglar DT; Lee EF; Fairlie WD; Huang DCS; Adams JM, 2008, 'Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax', Proceedings of the National Academy of Sciences of the United States of America, 105, pp. 18081 - 18087, http://dx.doi.org/10.1073/pnas.0808691105

Fletcher JI; Huang DCS, 2008, 'Controlling the cell death mediators Bax and Bak - Puzzles and conundrums', CELL CYCLE, 7, pp. 39 - 44, http://dx.doi.org/10.4161/cc.7.1.5178

Mason KD; Carpinelli MR; Fletcher JI; Collinge JE; Hilton AA; Ellis S; Kelly PN; Ekert PG; Metcalf D; Roberts AW; Huang DCS; Kile BT, 2007, 'Programmed Anuclear Cell Death Delimits Platelet Life Span', Cell, 128, pp. 1173 - 1186, http://dx.doi.org/10.1016/j.cell.2007.01.037

Willis SN; Fletcher JI; Kaufmann T; van Delft MF; Chen L; Czabotar PE; Ierino H; Lee EF; Fairlie WD; Bouillet P; Strasser A; Kluck RM; Adams JM; Huang DCS, 2007, 'Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak', SCIENCE, 315, pp. 856 - 859, http://dx.doi.org/10.1126/science.1133289

Mason KD; Carpinelli MR; Collinge JE; Hilton AA; Fletcher JI; Roberts AW; Metcalf D; Huang DCS; Kile BT, 2006, 'The Bcl-2 Protein Family Is Essential for Platelet Survival In Vivo.', Blood, 108, pp. 697 - 697, http://dx.doi.org/10.1182/blood.v108.11.697.697

Fletcher JI; Huang DCS, 2006, 'BH3-only proteins: orchestrating cell death', CELL DEATH AND DIFFERENTIATION, 13, pp. 1268 - 1271, http://dx.doi.org/10.1038/sj.cdd.4401995

Willis SN; Chen L; Dewson G; Wei A; Naik E; Fletcher JI; Adams JM; Huang DCS, 2005, 'Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x(L), but not Bcl-2, until displaced by BH3-only proteins', GENES & DEVELOPMENT, 19, pp. 1294 - 1305, http://dx.doi.org/10.1101/gad.1304105

Voskoboinik I; Thia MC; Fletcher J; Ciccone A; Browne K; Smyth MJ; Trapani JA, 2005, 'Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain', JOURNAL OF BIOLOGICAL CHEMISTRY, 280, pp. 8426 - 8434, http://dx.doi.org/10.1074/jbc.M413303200

Chen L; Willis SN; Wei A; Smith BJ; Fletcher JI; Hinds MG; Colman PM; Day CL; Adams JM; Huang DCS, 2005, 'Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function', MOLECULAR CELL, 17, pp. 393 - 403, http://dx.doi.org/10.1016/j.molcel.2004.12.030

Swarbrick JD; Buyya S; Gunawardana D; Fletcher JI; Branson K; Smith B; Pepe S; McLennan A; Gayler KR; Gooley PR, 2005, 'Letter to the Editor: H-1, C-13, and N-15 resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP', JOURNAL OF BIOMOLECULAR NMR, 31, pp. 181 - 182, http://dx.doi.org/10.1007/s10858-004-7440-4

Adams JM; Huang DCS; Strasser A; Willis S; Chen L; Wei A; Van Delft M; Fletcher JI; Puthalakath H; Kuroda J; Michalak EM; Kelly PN; Bouillet P; Villunger A; O'Reilly L; Bath ML; Smith DP; Egle A; Harris AW; Hinds M; Colman P; Cory S, 2005, 'Subversion of the Bcl-2 life/death switch in cancer development and therapy', Molecular Approaches to Controlling Cancer, 70, pp. 469 - 477, http://dx.doi.org/10.1101/sqb.2005.70.009

de Planque MRR; Rijkers DTS; Fletcher JI; Liskamp RMJ; Separovic F, 2004, 'The alpha-M1 segment of the nicotinic acetylcholine receptor exhibits conformational flexibility in a membrane environment', BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1665, pp. 40 - 47, http://dx.doi.org/10.1016/j.bbamem.2004.06.021

Fletcher JI; Swarbrick JD; Maksel D; Gayler KR; Gooley PR, 2002, 'The structure of Ap(4)A hydrolase complexed with ATP-MgFx reveals the basis of substrate binding', STRUCTURE, 10, pp. 205 - 213, http://dx.doi.org/10.1016/S0969-2126(02)00696-2

Tedford HW; Fletcher JI; King GF, 2001, 'Functional Significance of the β-Hairpin in the Insecticidal Neurotoxin ω-Atracotoxin-Hv1a', Journal of Biological Chemistry, 276, pp. 26568 - 26576, http://dx.doi.org/10.1074/jbc.M102199200

Fletcher JI; Dingley AJ; Smith R; Connor M; Christie MJ; King GF, 1999, 'High-resolution solution structure of gurmarin, a sweet-taste- suppressing plant polypeptide', European Journal of Biochemistry, 264, pp. 525 - 533, http://dx.doi.org/10.1046/j.1432-1327.1999.00659.x

Wang XH; Smith R; Fletcher JI; Wilson H; Wood CJ; Howden MEH; King GF, 1999, 'Structure-function studies of ω-atracotoxin, a potent antagonist of insect voltage-gated calcium channels', European Journal of Biochemistry, 264, pp. 488 - 494, http://dx.doi.org/10.1046/j.1432-1327.1999.00646.x

Torres AM; Wang X; Fletcher JI; Alewood D; Alewood PF; Smith R; Simpson RJ; Nicholson GM; Sutherland SK; Gallagher CH; King GF; Kuchel PW, 1999, 'Solution structure of a defensin-like peptide from platypus venom', Biochemical Journal, 341, pp. 785 - 794, http://dx.doi.org/10.1042/0264-6021:3410785

Fletcher JI; Wang X; Connor M; Christie MJ; King GF; Nicholson GM, 1999, 'Spider toxins: A new group of potassium channel modulators', Perspectives in Drug Discovery and Design, 15-16, pp. 61 - 69, http://dx.doi.org/10.1023/A:1017039418046

Fletcher JI; Chapman BE; Mackay JP; Howden MEH; King GF, 1997, 'The structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel', Structure, 5, pp. 1525 - 1535, http://dx.doi.org/10.1016/S0969-2126(97)00301-8

Fletcher JI; Smith R; O Donoghue SI; Nilges M; Connor M; Howden MEH; Christie MJ; King GF, 1997, 'The structure of a novel insecticidal neurotoxin, atracotoxin-HVI, from the venom of an Australian funnel web spider', Nature Structural Biology, 4, pp. 559 - 566

Back to profile page