Researcher

Dr Joanna Achinger-Kawecka

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Biography

Dr Joanna Achinger-Kawecka’s research focuses on investigating the role of the 3D epigenome in cancer, particularly in driving tumour progression and treatment resistance in breast and prostate cancer. Joanna completed her PhD at the University of Tuebingen, Germany, investigating microRNA signatures as predictive biomarkers for breast cancer treatment outcome. Following her PhD, Joanna joined the laboratory of Prof Susan Clark at the Garvan...view more

Dr Joanna Achinger-Kawecka’s research focuses on investigating the role of the 3D epigenome in cancer, particularly in driving tumour progression and treatment resistance in breast and prostate cancer. Joanna completed her PhD at the University of Tuebingen, Germany, investigating microRNA signatures as predictive biomarkers for breast cancer treatment outcome. Following her PhD, Joanna joined the laboratory of Prof Susan Clark at the Garvan Institute, where she established cutting-edge experimental and computational approaches to study the 3D genome organization during development and progression of cancer.


My Grants

 

Title of Project and Chief Investigators Role in Project Funding Organisation Start Date Duration Total Grant Amount

Targeting the Three-Dimensional Epigenome in Endocrine Resistant Breast Cancer

 

CIA Cancer Council NSW Project Grant 2020 3 years $434,000

Decoding 3D genome architecture in individual single-cells to establish molecular mechanisms of gene regulation in cancer (Achinger-Kawecka J, Clark S, Schmitt A, Rokny H)

 

PI UNSW Cellular Genomics Futures Institute Seed Grant 2020 1 year $99,000

Single-Cell Hi-C: A Novel Tool to Identify Key Epigenetic Drivers of Endocrine Resistant Breast Cancer

 

PI Estee Lauder Companies Breast Cancer Campaign 2019 1 year

$15,000

Genetic perturbations to the 3D genome architecture: Implications for endocrine resistance in breast cancer (Clark S, Achinger-Kawecka J)

Co-I National Breast Cancer Foundation 2017 1 year

$200,000

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


My Qualifications

PhD in Pharmacogenomics 2014 (University of Tuebingen, Germany)

Masters of Biotechnology 2011 (Warsaw University of Life Sciences, Poland)

Bachelor of Science 2009 (Warsaw University of Life Sciences, Poland)


My Awards

2019 - Best Selected Speaker Prize, 2019 Post-Doc Symposium, Garvan Institute

2018 - CASS Foundation Travel Grant

2017 - The Ian Potter Foundation Travel Grant

2016 - Best Postdoc Prize, 24th St Vincent’s Campus Research Symposium

2016 - Heliflite Young Explorer Award

2015 - Best Oral Presentation Prize, 23rd St Vincent’s Campus Research Symposium

2011 – EU FP7 Marie Curie Initial Training Network “Fighting Drug Failure” Fellowship

 


My Research Supervision


Supervision keywords


Areas of supervision

PhD, Masters, Honours and UROP positions available. 

Project: Uncovering the 3D Genome Architecture in Cancer

Discipline: Epigenetics

Project level: PhD/Honours

Supervisor: Prof Susan Clark & Dr Joanna Achinger-Kawecka

Project commencement: Variable

Summary: The three-dimensional (3D) genome organisation regulates gene expression by bringing distal regulatory elements, such as enhancers, to gene promoters in close spatial proximity. However, the link between 3D genome organization and the development and progression of cancer remains elusive.

Our group has shown that 3D genome structure is deregulated in cancer and occurs coincident with epigenetic remodelling, revealing an important link between altered DNA methylation, 3D chromatin interactions and deregulation of key genes in cancer.

This project will employ cutting-edge experimental and computational approaches to (1) create 3D genome architecture maps in single cells, (2) integrate 3D architecture maps with epigenome and gene expression maps (3) functionally validate identified mechanisms using genome-editing. Together, this research will systematically dissect the underlying mechanisms of 3D epigenome remodelling in cancer and provide vital mechanistic insights for novel treatment strategies in cancer.

We are currently recruiting enthusiastic students who are interested in using cutting-edge molecular techniques for epigenomics (Hi-C, RNA-seq, ChIP-seq) and single-cell technologies to establish the fundamental mechanisms of cancer progression, which will allow for the development of novel targeted treatment strategies for recurrent disease.

Contact: Dr Joanna Achinger-Kawecka (j.achinger@garvan.org.au)

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Location

Garvan Institute of Medical Research

Publications

by Dr Joanna Achinger-Kawecka