My Expertise
I have a passion for molecular and brain evolution. This has allowed me to develop expertise in Single-cell omics, Brain organoids, Splicing code, RNA biology, Autism spectrum disorder, and intellectual disability.
Keywords
Fields of Research (FoR)
Bioinformatics and computational biology, Neurogenetics, Genetics, Genomics and transcriptomicsBiography
About me
Juli Wang acquired her Honours degree and Master's in Science degree at the University of Toronto, Canada. Before her PhD, her research was conducted at Professor Benjamin Blencowe's lab and focused on the canonical splicing of RNA in the mammalian brain. After moving to Australia in 2019, Juli Wang acquired her PhD at UNSW by investigating the molecular evolution and epigenetic regulations in the mammalian brain. She is currently...view more
About me
Juli Wang acquired her Honours degree and Master's in Science degree at the University of Toronto, Canada. Before her PhD, her research was conducted at Professor Benjamin Blencowe's lab and focused on the canonical splicing of RNA in the mammalian brain. After moving to Australia in 2019, Juli Wang acquired her PhD at UNSW by investigating the molecular evolution and epigenetic regulations in the mammalian brain. She is currently working as a postdoctoral researcher under the supervision of Prof. Irina Voineagu.
Currently, Juli is employing Bioinformatics, Molecular Genetics, and Genomics to pursue two research aims. The first aim is to investigate the epigenetic regulation of brain development and neural developmental disorders, such as autism spectrum disorder (ASD) and intellectual disorder (ID). To this end, Juli combines single-cell omic analyses, brain organoids technology, and genetic editing to dissect the role of epigenetic regulators during corticogenesis in brain organoids derived from patients and healthy individuals.
Another aim of Juli's research is to characterize the crosstalk between canonical RNA splicing and circular RNA in the human brain. To this end, Juli employs multiple CRISPR-Cas systems to silence different RNA species and thereby dissect the role of circRNA, splicing regulators, and canonical splicing events in neuronal cell lines derived from the human brain.
Publications
- *Wang, J. & Voineagu, I. From synapse to sensation: the role of circTulp4. Trends in Neurosciences, doi:https://doi.org/10.1016/j.tins.2024.08.005 (2024).
- *Wang, J., Weatheritt, R. & Voineagu, I. Alu-minating the Mechanisms Underlying Primate Cortex Evolution. Biol Psychiatry 92, 760-771, doi:10.1016/j.biopsych.2022.04.021 (2022).
- Avgan, N., *Wang, J. I., Fernandez-Chamorro, J. & Weatheritt, R. J. Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control. Genome Biology 20, 141, doi:10.1186/s13059-019-1757-5 (2019).
- Han, H. Braunschweig, U. Gonatopoulos-Pournatzis, T. Weatheritt, R. J. Hirsch, C. L. Ha, K. C. H. Radovani, E. Nabeel-Shah, S. Sterne-Weiler, T. *Wang, J. et al. Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors. Mol Cell 65, 539-553.e537, doi:10.1016/j.molcel.2017.01.011 (2017).
My Grants
2024/09 - 2024/12 |Cellular Genomics Incubator Research Funding. Awarded by the University of the New South Wales, Australia| Research: Glioblastoma and lncRNAs.
2024/05 - 2024/12 |BABS Early Career Research Grant. Awarded by the University of the New South Wales, Australia| Research: Drug Screen, Congenital heart disorders
2022/03 - 2022/08 | Adrian Lee Travel Scholarship. Awarded by the University of the New South Wales, Australia | Research: Intellectual disability, Brain development
My Awards
2019/09 - 2023/09 | University International Postgraduate Award. Awarded by the University of New South Wales, Australia | Awarded AUD 97,970 to support research in the field of Neuroscience, Functional Genomics
2019/09 - 2021/03 | Rosemary Pryor Foundation Award. Awarded by the Garvan Institute of Medical Research, Australia | Awarded AUD 48,000 to support research in Alzheimer’s disease and Dementia, RNA biology.
2017/5 - 2018/05 | Natural Sciences and Engineering Research Council (NSERC) Awards. Awarded by the University of Toronto, Canada | Awarded CAD 17,500 to support research in Research: Molecular Genetics, RNA biology, Autism spectrum disorder
2017/5 - 2018/05 | Ontario Graduate Scholarship - Provincial Awards. Awarded by the University of Toronto, Canada | Offered CAD 17,500 to support research in Molecular Genetics, RNA biology, Autism spectrum disorder
2016/9 | Department of Molecular Genetics Merit Entrance Award. Awarded by the University of Toronto, Canada | Awarded CAD 2,000 to acknowledge research excellence in Molecular Genetics, RNA biology, Autism spectrum disorder
2016/5 | Honours of Bachelor of Science with High Distinction. University of Toronto, Canada | Certificate of Distinction
2016/5 - 2016/09 | Undergraduate Research Opportunity Award for Summer Term. University of Toronto, Canada | Awarded CAD 4,800 to support research in Chemical therapeutics, Autism spectrum disorder, Molecular Genetics
2015/08 | C.L. Burton Open Scholarship in Science and Math for Students with Academic Excellency. University of Toronto, Canada | Awarded CAD 400 to acknowledge academic excellence.
2015/5 - 2015/09 | Undergraduate Research Opportunity Award for Summer Term. University of Toronto, Canada | Awarded CAD 4,800 to support research in: RNA splicing, Autism spectrum disorder, Molecular Genetics
2014/08 | Dr. J. A. & C. P. D. Scholarship in Science and Math for Students with Academic Excellency. University of Toronto, Canada | Awarded CAD 200 to acknowledge academic excellence.
2013 - 2016 | Dean’s List Scholar in the Faculty of Arts and Science University of Toronto, Canada | Annually Certificated Distinction for four years in row.