Field of Research (FoR)
Qualifications: MBBS, DipPaed, PhD, FRACP
Dr (Keith) Chee Y. Ooi (MBBS Dip Paeds FRACP PhD) is a Clinical Academic – Senior Lecturer at the Discipline of Paediatrics, School of Women’s and Children’s Health, University of New South Wales (UNSW) and Consultant Paediatric Gastroenterologist at Sydney Children’s Hospital Randwick. He is a translational clinician investigator, who is an internationally recognised expert in cystic fibrosis...view more
Qualifications: MBBS, DipPaed, PhD, FRACP
Dr (Keith) Chee Y. Ooi (MBBS Dip Paeds FRACP PhD) is a Clinical Academic – Senior Lecturer at the Discipline of Paediatrics, School of Women’s and Children’s Health, University of New South Wales (UNSW) and Consultant Paediatric Gastroenterologist at Sydney Children’s Hospital Randwick. He is a translational clinician investigator, who is an internationally recognised expert in cystic fibrosis (CF) and pancreatic diseases in childhood, and is regularly invited to speak at prestigious international and national conferences. He has won numerous awards and receives research funding nationally and internationally. He received the UNSW Medicine Dean’s Rising Star Award in 2015.
Clinically, he sees children with all aspects of gastrointestinal, pancreatic, nutritional and liver conditions. His research is translational and specifically aimed at improving child health outcomes.
Dr Ooi graduated from the University of Melbourne in 2000, with the Clara Myers Prize. He commenced training in paediatric gastroenterology at Sydney Children’s Hospital Randwick, supported by the Sydney Children’s Hospital Foundation Subspecialty Fellowship Award (2006, 2007). He accepted the offer of a 3-year clinical research fellowship (2007-2010) at the prestigious Hospital for Sick Children and University of Toronto, Toronto, Canada, to pursue a research path. This was supported by the Sydney Children’s Hospital Travelling Fellowship Award (2007), Canadian Cystic Fibrosis Foundation Fellowship Award (2008-2010) and Career Enhancement Award, Canadian Child Health Clinician Scientist Program (2009-2010). He was awarded both the Dick Hamilton and Clinical Research awards in 2010 by the Hospital for Sick Children and University of Toronto respectively, for his research excellence. He returned to Sydney in mid-2010 as a clinical academic in pursuit of research and academia, while having opportunities for clinical interface within a tertiary hospital setting. He completed his PhD on genotype-phenotype correlations in cystic fibrosis at UNSW
Dr Ooi supervises medical students (e.g. Independent Learning Projects and Honours) and higher degree research (PhD or Masters) students. He has an impressive track record of outputs and success in research supervision.
His interests and expertise are in gastroenterological conditions in cystic fibrosis (CF), diagnostic dilemmas and non-classic manifestations of CF (from infancy to adulthood), and childhood pancreatic diseases.
His CF-related works include the first study to unravel the complex relationship between severity of CFTR mutations and risk of pancreatitis (Ooi et al. Gastroenterology 2011). He also developed and validated a novel surrogate measure of CF mutation and genotype severity, known as the “Pancreatic Insufficiency Prevalence (PIP)” score. His recent works also extend into understanding the disease processes affecting the gastrointestinal tract in CF, using faecal biomarkers and bacterial analyses (Pang et al. J Gastroenterol Hepatol 2015, Dhaliwal et al. J Pediatr Gastroenterol Nutr 2015, Ooi et al. Dig Dis Sci 2015). He also contributes to CF liver disease subsection of the North American Consortium for CF Genetic Studies.
CF diagnostic issues and non-classic manifestations
Dr Ooi is passionate about diagnostic issues related to children and adults with single-organ manifestations of CF (Ooi et al. Thorax 2012, Ooi et al. Thorax 2014) and newborn screen positive infants with an indeterminate diagnosis of CF (Ooi et al. Pediatrics 2015). He has experience in electrophysiological diagnostic tests, including the nasal potential difference test and intestinal ion channel measurement. He developed a novel diagnostic test for CF known as the “combined ion channel measurement” (Ooi et al. Ann Am Thorac Soc 2014).
Pancreatitis and pancreatic diseases in childhood
Dr Ooi is an international expert in childhood pancreatitis. He has developed clinical tools for predicting severe and biliary causes of acute pancreatitis in children. He is the only Australasian investigator for the largest research consortium studying children with acute recurrent and chronic pancreatitis.
Dr Ooi has published widely in journals, textbooks and conference proceedings. He has published as either first or last author in the top journals in the fields of gastroenterology (Ooi et al. Gastroenterology 2010, Ooi et al. Gastroenterology 2011), CF (Ooi et al. Thorax 2012, Ooi et al. Thorax 2014) and paediatrics (Ooi et al. Pediatrics 2015).
Dr Ooi has received funding nationally and internationally.
- 2015- 2020: National Institute of Health, USA (U01 DK108334-01) (over $2 million). International Study Group of Pediatric Pancreatitis: In search for a cure (INSPIRRE) to Study Pediatric Chronic Pancreatitis. Chief (Principal) Investigator.
- 2015-2016: UNSW Learning and Teaching Innovation Grant. A Novel Computer-based Approach to Educating Medical Students through an Online Experiential Role-playing Game. Chief Investigator (CIA).
- 2015-2016: Sydney Children’s Hospital Foundation Seed Funding. Early Feeding in Acute Pancreatitis in Children – A Randomised Controlled Trial. Chief Investigator (CIA).
- 2014-2015: National Institute of Health, USA (DK096327-02S1). International Study Group of Pediatric Pancreatitis: In search for a cure (INSPIRRE). Co-Investigator.
- 2012-2015: National Institute of Health, USA (DK096327). International Study Group of Pediatric Pancreatitis: In search for a cure (INSPIRRE). Co-Investigator.
- 2012-2015 (extended): Cystic Fibrosis Australia Research Trust. The “gut-lung axis”. Chief Investigator (CIA).
- 2012: Servier Staff Research Fellowship, Royal Australasian College of Physicians Research and Education Foundation Award. Molecular characterization and understanding the effects of altered gut microbiota in cystic fibrosis. Chief Investigator (CIA).
- 2012: UNSW Goldstar-NHMRC (APP1027693). Investigation of the role of the intestinal microflora in the aetiology of Crohn's Disease. Associate Investigator.
Learning and Teaching:
Dr Ooi is interested in improving quality of teaching, and is currently developing and evaluating novel innovative approaches to medical education. He received the Learning and Teaching Innovation Grant in 2015. He was the Convenor for Paediatrics (Phase 3 of the undergraduate medical program) for the Faculty of Medicine, UNSW between 2010-2013.