Dr Pinese currently heads the Genomic Childhood Cancer Risk Team at the Children's Cancer Institute, where he researches the genomic basis of childhood cancer risk.

Previously, Dr Pinese completed his undergraduate studies at UNSW Australia on the biology of ageing, before moving to the Garvan Institute to pursue cancer research. 

At the Garvan Institute, Dr Pinese was a member of the world's largest sequencing effort in pancreatic cancer, and for his work received a PhD on the molecular determinants of survival of patients with pancreatic adenocarcinoma.  Dr Pinese then joined the Kinghorn Centre for Clinical Genomics, where he performed rapid-turnaround genomic analysis for cancer patients, and helped to develop Australia's first clinically-accredited whole genome sequencing test for rare disease. Dr Pinese then went on to lead the analysis of the Medical Genome Reference Bank, the largest genome sequencing cohort of well elderly individuals in the world.

Dr Pinese's work has been recognised by awards from professional societies (AGTA, ABACBS) and funding bodies (Cure Cancer Australia), and is currently supported by an NHMRC Emerging Leadership Fellowship.