Researcher

Dr Sophia Gu

Biography

My Expertise
Drug delivery

Bio-imaging nanoprobe for early and accurate diagnosis of diseases

Theranostic nanomedicine 

Bio-nano interface

Nanozyme

Nanoparticles for cancer therapy, cardiovascular disease

Nanoparticle synthesis and modification

Two-dimensional nanomaterials

Biography
Dr Zi (Sophia) Gu is a Group Leader, Senior Lecturer and Principle Investigator at the School of Chemical Engineering of UNSW, a member of Australian Centre for...view more

My Expertise
Drug delivery

Bio-imaging nanoprobe for early and accurate diagnosis of diseases

Theranostic nanomedicine 

Bio-nano interface

Nanozyme

Nanoparticles for cancer therapy, cardiovascular disease

Nanoparticle synthesis and modification

Two-dimensional nanomaterials

Biography
Dr Zi (Sophia) Gu is a Group Leader, Senior Lecturer and Principle Investigator at the School of Chemical Engineering of UNSW, a member of Australian Centre for NanoMedicine, a member of Australian Nanotechnology Network, and a member of Translational Cancer Research Network. She obtained PhD from The University of Queensland (UQ) in 2011, and secured a NHMRC EC Fellowship in 2013 when she started to conduct independent research at UQ prior to joining UNSW in 2016.

Her group has been working on multidisciplinary research projects that combine the knowledge and skills across material chemistry, biomedical engineering and nanotechnology, and developed several nanoparticle platforms for disease diagnosis and treatment. She has published over 40 research papers and a provisional patent. Most of these publications are in top tier journals in the fields of Material Science (Advanced Materials, Advanced Functional Materials, Materials Horizons), Nanotechnology (Advanced Science, Small Methods), Chemistry (Chemistry of Materials), Biomaterials (Biomaterials), and Pharmaceutical Science (Journal of Controlled Release, Pharmaceutics). She has been awarded several grants, fellowships and awards, and has been taking several leadership roles such as an Associate Editor for Journal of Nanobiotechnology (Springer Nature).

Research Appointments
Senior Lecturer, University of New South Wales, 2019-present
Lecturer (Tenure), University of New South Wales, 2018
Lecturer (Tenure Track), University of New South Wales, 2016-2018
NHMR EC Fellow, University of New South Wales, 2016-2019
NHMRC EC Fellow, University of Queensland, 2014-2016
Postdoctoral Researcher, University of Queensland, 2011-2013
Research Fellow, Cornell University, US, 2010
Course Teaching
CEIC6712 Pharmaceutical Design and Engineering
GSOE9111 Energy Storage
CEIC4001 Process Design Project
CEIC2007 Chemical Engineering Laboratory
CHEN6703 Advanced Particle Systems
CEIC Thesis A, B, C (project supervision)
Current PhD Students
Xichu Wang (2020 - present, Joint)
Yike Xie (2019 - present, Primary)
Qianyi Zhang (2019 - present, Primary)
Hari Kumar Peguda (2018 - present, Co-supervision)
Pham Thi Thu Phuong (2018 - present, Co-supervision)
He Zhang (2018 - present, Primary)
Ruizhe Liu (2018 - present, Co-supervision)
Fiona Zhang (2017 - present, Joint)
Zhenbang Cao (2016 - present, Primary)
Current Master by Research Students
Hao Zhang (2019 - present, Primary)
Former PhD Students
Dr Bei Li - University of Queensland (2015 - 2019, Co-supervision)
Dr Huali Zuo - University of Queensland (2014-2017, Co-supervision)
Awards and Honours
2018, Research Excellence Award, Australian Association of Chinese Biomedical Scientists
2018, Rising Star Award, Australian Association of Chinese Biomedical Scientists
2017, Monash Engineering Women's Leadership Award
2014-2018, NHMRC Early Career Fellowship
2014, Ian Potter Foundation Travel Award
2013, Deputy Vice-Chancellor (Academic) Award, The University of Queensland
2010, Graduate School International Travel Award, The University of Queensland
2008-2010, Endeavour International Postgraduate Research Scholarship
2008, Chinese Government Award for Outstanding Student Abroad, China Scholarship Council
2007, Best Student Poster Award at 4th ARC Centre of Excellence for Functional Nanomaterials Annual Conference
Research Collaborations
Dr Gu collaborates with a number of active researchers from UNSW, The University of Queensland, Royal Brisbane and Women's Hospital, Tsinghua University, Chinese Academy of Sciences, and Cornell University, in multidisciplinary research.

Ten Most Significant Career Publications
1. Cao Z; Zhang L; Liang K; Cheong S; Boyer C; Gooding JJ; Chen Y;* Gu Z,* 2018, 'Biodegradable 2D Fe–Al Hydroxide for Nanocatalytic Tumor-Dynamic Therapy with Tumor Specificity', Advanced Science, vol. 5, http://dx.doi.org/10.1002/advs.201801155, (IF 15.804)

2. Li B; Gu Z;* Kurniawan N; Chen W; Xu ZP,* 2017, 'Manganese-Based Layered Double Hydroxide Nanoparticles as a T 1 -MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity', Advanced Materials, vol. 29, http://dx.doi.org/10.1002/adma.201700373, (IF 25.809)

3. Li B; Hao G; Sun B; Gu Z;* Xu ZP,* 2020, 'Engineering a Therapy-Induced “Immunogenic Cancer Cell Death” Amplifier to Boost Systemic Tumor Elimination', Advanced Functional Materials, http://dx.doi.org/10.1002/adfm.201909745 (IF 15.621)

4. Cao Z; Li B; Sun L; Li L; Xu ZP;* Gu Z,* 2020, '2D Layered Double Hydroxide Nanoparticles: Recent Progress toward Preclinical/Clinical Nanomedicine', Small Methods, vol. 4, http://dx.doi.org/10.1002/smtd.201900343

5. Li B; Tang J; Chen W; Hao G; Kurniawan N; Gu Z;* Xu ZP*, 2018, 'Novel theranostic nanoplatform for complete mice tumor elimination via MR imaging-guided acid-enhanced photothermo-/chemo-therapy', Biomaterials, vol. 177, pp. 40 - 51, http://dx.doi.org/10.1016/j.biomaterials.2018.05.055, (IF 10.273)

6. Guo Z; Wang T; Rawal A; Hou J; Cao Z; Zhang H; Xu J; Gu Z;* Chen V; Liang K,* 2019, 'Biocatalytic self-propelled submarine-like metal-organic framework microparticles with pH-triggered buoyancy control for directional vertical motion', Materials Today, vol. 28, pp. 10 - 16, http://dx.doi.org/10.1016/j.mattod.2019.04.022.(IF 24.372)

7. Ge J; Zhang Q; Zeng J;* Gu Z;* Gao M, 2020, 'Radiolabeling nanomaterials for multimodality imaging: New insights into nuclear medicine and cancer diagnosis', Biomaterials, vol. 228, http://dx.doi.org/10.1016/j.biomaterials.2019.119553 (IF 10.273)

8. Qian X; Gu Z;* Chen Y,* 2017, 'Two-dimensional black phosphorus nanosheets for theranostic nanomedicine', Materials Horizons, vol. 4, pp. 800 - 816, http://dx.doi.org/10.1039/c7mh00305f (IF 14.356)

9. Gu Z; Rolfe BE; Xu ZP; Thomas AC; Campbell JH; Lu GQM,* 2010, 'Enhanced effects of low molecular weight heparin intercalated with layered double hydroxide nanoparticles on rat vascular smooth muscle cells', Biomaterials, vol. 31, pp. 5455 - 5462, http://dx.doi.org/10.1016/j.biomaterials.2010.03.050 (IF: 10.273) (IF 10.273)

10. Gu Z; Thomas AC; Xu ZP; Campbell JH; Lu GQ,* 2008, 'In vitro sustained release of LMWH from MgAl-layered double hydroxide nanohybrids', Chemistry of Materials, vol. 20, pp. 3715 - 3722, http://dx.doi.org/10.1021/cm703602t (IF 10.159)

(*Corresponding author)

We are looking for highly motivated, intelligent and team-playing students to do their PhD or Honours degrees in our group. 
Postgraduate Scholarship Opportunities
Domestic Research Scholarship: https://research.unsw.edu.au/domestic-research-scholarships
International Research Scholarship: https://research.unsw.edu.au/international-research-scholarships
UNSW-China Scholarship Council (CSC) Joint Scholarship program. For more details, click here. To apply CSC, click here. Top-up scholarship (7k pa) will be provided to CSC awardees.
UNSW / HEC Pakistan Joint Scholarship: https://research.unsw.edu.au/unsw-home-country-joint-scholarships;
UNSW / CONICYT Chile Joint Scholarship: https://research.unsw.edu.au/unsw-home-country-joint-scholarships;
Research Assistant positions are available at specific time. 

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Contact

+61 2 93854964

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