Researcher

Dr Sophia Gu

Biography

My Expertise

  • Drug delivery

  • Bio-imaging contrast agent

  • Early and accurate disease diagnosis

  • Theranostic nanomedicine 

  • Nanoparticles for cancer therapy

  • Nanoparticles for cardiovascular disease

  • Nanoparticle synthesis and modification

  • Two-dimensional nanomaterials

Biography

Dr Zi (Sophia) Gu is Senior Lecturer, NHMRC Early Career Fellow and a member of Australian Centre for NanoMedicine (ACN). Sophia leads a nanomedicine...view more

My Expertise

  • Drug delivery

  • Bio-imaging contrast agent

  • Early and accurate disease diagnosis

  • Theranostic nanomedicine 

  • Nanoparticles for cancer therapy

  • Nanoparticles for cardiovascular disease

  • Nanoparticle synthesis and modification

  • Two-dimensional nanomaterials

Biography

Dr Zi (Sophia) Gu is Senior Lecturer, NHMRC Early Career Fellow and a member of Australian Centre for NanoMedicine (ACN). Sophia leads a nanomedicine research group at School of Chemical Engineering, UNSW.

Sophia has extensive experience in the formulation of medically applied nanomaterials, drug delivery, bio-imaging, and in vitro and in vivo assays. She has developed several new technologies to diagnose and treat diseases including development of a targeted drug delivery system to prevent restenosis and an ultrasensitive MRI contrast agent. These technologies promise to be commercialized, and are currently advertised to attract private funding by commercialisation entity (UNSW Knowledge Exchange).

Sophia has published >30 papers in top-ranked journals in the filed of nanobiotechnology including Adv. Mater., Mater. Today, Adv. Sci., Mater. Horizons, Biomaterials, Chem. Mater., Adv. Healthc. Mater., J. Control. Release, etc. Sophia has delivered >20 invited conference talks from 2016.

Sophia has won >10 competitive awards, fellowships and grants, including NHMRC Early Career Fellowship (Peter Doherty Biomedical Early Career Fellowship, 2014-2018), Rising Star Award (2018), Monash Engineering Women Leader Award (2017), etc. The total amount of funding that I have attracted amounts to $700,000.

Sophia is the Chair of Academic Engagement Committee of UNSW Chem Eng, and serves as committee member in Undergraduate and Postgraduate Recruitment Committees. Sophia is a guest editor for the journal Crystal, and a member of several professional societies, e.g. Australian Nanotechnology Network, Women in Technology Society, Australian Society for Medical Research. 

Research Appointments

  • Senior Lecturer, University of New South Wales, 2019-present
  • Lecturer (Tenure), University of New South Wales, 2018
  • Lecturer (Tenure Track), University of New South Wales, 2016-2018
  • NHMR EC Fellow, University of New South Wales, 2016-2019
  • NHMRC EC Fellow, University of Queensland, 2014-2016
  • Postdoctoral Researcher, University of Queensland, 2011-2013
  • Research Fellow, Cornell University, US, 2010

Course Teaching

  • GSOE9111 Energy Storage
  • CEIC4001 Process Design Project
  • CEIC2007 Chemical Engineering Laboratory
  • CHEN6703 Advanced Particle Systems
  • CEIC Thesis A, B, C (project supervision)

Current PhD Students

  • Qianyi Zhang - UNSW (2019 - present)
  • Hari Kumar Peguda - UNSW (2018 - present)
  • Pham Thi Thu Phuong - UNSW (2018 - present)
  • He Zhang - UNSW (2018 - present)
  • Ruizhe Liu - UNSW (2018 - present)
  • Fiona Zhang - UNSW (2017 - present)
  • Zhenbang Cao - UNSW (2016 - present)
  • Bei Li - UQ (2015 - present)

Current Master by Research Students

  • Hao Zhang - UNSW (2019 - present)

Former PhD Students

  • Dr Huali Zuo - University of Queensland (2014-2017)

Awards and Honours

  • 2018, Research Excellence Award, Australian Association of Chinese Biomedical Scientists
  • 2018, Rising Star Award, Australian Association of Chinese Biomedical Scientists
  • 2017, Monash Engineering Women's Leadership Award
  • 2014-2018, NHMRC Early Career Fellowship
  • 2014, Ian Potter Foundation Travel Award
  • 2013, Deputy Vice-Chancellor (Academic) Award, The University of Queensland
  • 2010, Graduate School International Travel Award, The University of Queensland
  • 2008-2010, Endeavour International Postgraduate Research Scholarship
  • 2008, Chinese Government Award for Outstanding Student Abroad, China Scholarship Council
  • 2007, Best Student Poster Award at 4th ARC Centre of Excellence for Functional Nanomaterials Annual Conference

Research Collaborations

Dr Gu collaborates with a number of active researchers from UNSW, The University of Queensland, Royal Brisbane and Women's Hospital, Tsinghua University, Chinese Academy of Sciences, Shanghai University, and Cornell University, in multidisciplinary research.

Ten Most Significant Career Publications

1. Z. Cao, L. Zhang, S. Cheong, C. Boyer, J.J. Gooding, Y. Chen,* Z. Gu,* Biodegradable 2D Fe–Al Hydroxide for Nanocatalytic Tumor-Dynamic Therapy with Tumor Specificity, Advanced Science, 2018, 5, 1801155. (IF: 15.804)

2. B. Li, Z. Gu,* N. Kurniawan, W. Chen, Z. P. Xu,* Manganese-Based Layered Double Hydroxide Nanoparticles as a T1-MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity, Advanced Materials, 2017, 29, 1700373-1700381. (IF: 25.809)

3. B. Li, J. Tang, W. Chen, G. Hao, N. Kurniawan, Z. Gu,* ZP Xu,* Novel theranostic nanoplatform for complete mice tumor elimination via MR imaging-guided acid-enhanced photothermo-/chemo-therapy', Biomaterials, 2018, 177, 40 - 51 (IF: 10.273)

4. Z. Guo, T. Wang, A. Rawal, J. Hou, Z. Cao, H. Zhang, J. Xu, Z. Gu,* V. Chen, K. Liang,* Biocatalytic self-propelled submarine-like metal-organic framework microparticles with pH-triggered buoyancy control for directional vertical motion, Materials Today,2019.(IF: 24.372)

5. X. Qian, Z. Gu,* Y. Chen,* Two-dimensional black phosphorus nanosheets for theranostic nanomedicine, Materials Horizons, 2017, DOI: 10.1039/C7MH00305F. (IF: 14.356)

6. Z. Gu, B.E. Rolfe, Z.P. Xu, A.C. Thomas, J.H. Campbell, and G.Q. Lu, Enhanced effect of low molecular weight heparin intercalated with layered double hydroxide nanoparticles on rat vascular smooth muscle cells, Biomaterials, 2010, 31, 5455-5462; (IF: 10.273)

7. Z. Gu, B.E. Rolfe, Z.P. Xu, A.C. Thomas, J.H. Campbell, and G.Q. Lu, Cellular trafficking of low molecular weight heparin incorporated in layered double hydroxide nanoparticles in rat vascular smooth muscle cells, Biomaterials, 2011, 32, 7234-7240; (IF: 10.273)

8. Z. Gu, A. C. Thomas, Z.P. Xu, J.H. Campbell, and G.Q. Lu, In vitro sustained release of LMWH from MgAl-layered double hydroxide nanohybrids, Chemistry of Materials, 2008, 20, 3715-3722; (IF: 10.159)

9. Z. Gu, B.E. Rolfe, Z.P. Xu, J.H. Campbell, G.Q. Lu, and A.C. Thomas, Antibody-targeted drug delivery to injured arteries using layered double hydroxide nanoparticles, Advanced Healthcare Materials, 2012, 1, 669-673; (IF: 6.27)

10. Z. Gu, J.J. Atherton, Z.P. Xu, Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications, Chemical Communications, 2015, 51, 3024-3036; (IF: 6.164)

(*Corresponding author)

 

We are looking for highly motivated, intelligent and team-playing students to do their PhD or Honours degrees in our group. 

Postgraduate Scholarship Opportunities

View less

Location

Room 507, Building F10

Contact

+61 2 93854964

Follow