By Emeritus Professor Rodney Phillips

Journal articles

Pillay T; Zhang HT; Drijfhout JW; Robinson N; Brown H; Khan M; Moodley J; Adhikari M; Pfafferott K; Feeney ME; St. John A; Holmes EC; Coovadia HM; Klenerman P; Goulder PJR; Phillips RE, 2005, 'Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection', Journal of Virology, 79, pp. 12100 - 12105, http://dx.doi.org/10.1128/JVI.79.18.12100-12105.2005

Harcourt GC; Donfield S; Gomperts E; Daar ES; Goulder PJR; Phillips RE; Klenerman P, 2005, 'Longitudinal analysis of CD8 T-cell responses to HIV and hepatitis C virus in a cohort of co-infected haemophiliacs', AIDS, 19, pp. 1135 - 1143, http://dx.doi.org/10.1097/01.aids.0000176213.10367.05

Edwards CTT; Pfafferott KJ; Goulder PJR; Phillips RE; Holmes EC, 2005, 'Intrapatient escape in the A*0201-restricted epitope SLYNTVATL drives evolution of human immunodeficiency virus type 1 at the population level', Journal of Virology, 79, pp. 9363 - 9366, http://dx.doi.org/10.1128/JVI.79.14.9363-9366.2005

Joos B; Trkola A; Fischer M; Kuster H; Rusert P; Leemann C; Böni J; Oxenius A; Price DA; Phillips RE; Wong JK; Hirschel B; Weber R; Günthard HF, 2005, 'Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions', Journal of Virology, 79, pp. 9026 - 9037, http://dx.doi.org/10.1128/JVI.79.14.9026-9037.2005

Leslie A; Kavanagh D; Honeyborne I; Pfafferott K; Edwards C; Pillay T; Hilton L; Thobakgale C; Ramduth D; Draenert R; Le Gall S; Luzzi G; Edwards A; Brander C; Sewell AK; Moore S; Mullins J; Moore C; Mallal S; Bhardwaj N; Yusim K; Phillips R; Klenerman P; Korber B; Kiepiela P; Walker B; Goulder P, 2005, 'Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA', Journal of Experimental Medicine, 201, pp. 891 - 902, http://dx.doi.org/10.1084/jem.20041455

Pillay T; Phillips RE, 2005, 'Adaptive evolution in perinatal HIV-I', Best Practice and Research: Clinical Obstetrics and Gynaecology, 19, pp. 211 - 229, http://dx.doi.org/10.1016/j.bpobgyn.2004.10.004

Scriba TJ; Zhang HT; Brown HL; Oxenius A; Tamm N; Fidler S; Fox J; Weber JN; Klenerman P; Day CL; Lucas M; Phillips RE, 2005, 'HIV-1-specific CD4⁺ T lymphocyte turnover and activation increase upon viral rebound', Journal of Clinical Investigation, 115, pp. 443 - 450, http://dx.doi.org/10.1172/JCI200523084

Scherer A; Frater J; Oxenius A; Agudelo J; Price DA; Günthard HF; Barnardo M; Perrin L; Hirschel B; Phillips RE; McLean AR; Aebi C; Battegay M; Bernasconi E; Biedermann K; Bischoff L; Boni J; Bosbach S; Brenner I; Büchel I; Bucher H; Bürgisser P; Cattacin S; Chapalay S; Cheseaux JJ; Cuvit AL; Drack G; Dubs R; Egger M; Elzi L; Erb P; Fantelli K; Fischer M; Flepp M; Fontana A; Francioli P; Francioli-Volz MC; Furrer H; Gorgievski M; Gremlich E; Günthards H; Gyr T; Hirsch HH; Hirschel B; Hösli I; Irion O; Jirasko-Emmenegger N; Joller-Jemelka HI; Kaiser L; Kaufmann G; Keiser O; Kind C; Klimkait T; Knecht C; Lauper U; Ledergerbers B; Leuenberger L; Merks B; Müller S; Nadal D; Oliveira J; Opravil M; Pin BO; Paccaud F; Pantaleo G; Piffaretti JC; Reber M; Reiss P; Remy B; Reymond B; Rickenbach M; Rudin C; Russotti M; Schiffer V; Schmid P; Schreyer A; Schüpbach J; Speck R; Taffe P; Tarr P; Telenti A; Trkola A; Vallet Y; Vanhems P; Vernazza P; Weber R; Wechsler A; Wunder D; Wyler-Lazarevitch CA; Yeni P; Yerly S; Yilmaz A; Ziekau I, 2004, 'Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS', Proceedings of the National Academy of Sciences of the United States of America, 101, pp. 12266 - 12270, http://dx.doi.org/10.1073/pnas.0404091101

Oxenius A; Price DA; Trkola A; Edwards C; Gostick E; Zhang HT; Easterbrook PJ; Tun T; Johnson A; Waters A; Holmes EC; Phillips RE, 2004, 'Loss of viral control in early HIV-1 infection is temporally associated with sequential escape from CD8 ⁺ T cell responses and decrease in HIV-1-specific CD4 ⁺ and CD8 ⁺ T cell frequencies', Journal of Infectious Diseases, 190, pp. 713 - 721, http://dx.doi.org/10.1086/422760

Harcourt GC; Lucas M; Sheridan I; Barnes E; Phillips R; Klenerman P, 2004, 'Longitudinal mapping of protective CD4⁺ T cell responses against HCV: Analysis of fluctuating dominant and subdominant HLA-DR11 restricted epitopes', Journal of Viral Hepatitis, 11, pp. 324 - 331, http://dx.doi.org/10.1111/j.1365-2893.2004.00516.x

Plana M; Garcia F; Oxenius A; Ortiz GM; Lopez A; Cruceta A; Mestre G; Fumero E; Fagard C; Sambeat MA; Segura F; Miró JM; Arnedo M; Lopalcos L; Pumarola T; Hirschel B; Phillips RE; Nixon DF; Gallart T; Gatell JM, 2004, 'Relevance of HIV-1-specific CD4⁺ helper T-cell responses during structured treatment interruptions in patients with CD4⁺ T-cell nadir above 400/mm³', Journal of Acquired Immune Deficiency Syndromes, 36, pp. 791 - 799, http://dx.doi.org/10.1097/00126334-200407010-00005

Oxenius A; Price DA; Hersberger M; Schlaepfer E; Weber R; Weber M; Kundig TM; Böni J; Joller H; Phillips RE; Flepp M; Opravil M; Speck RF, 2004, 'HIV-specific cellular immune response is inversely correlated with disease progression as defined by decline of CD4⁺ T cells in relation to HIV RNA load', Journal of Infectious Diseases, 189, pp. 1199 - 1208, http://dx.doi.org/10.1086/382028

Karrer U; Wagner M; Sierro S; Oxenius A; Hengel H; Dumrese T; Freigang S; Koszinowski UH; Phillips RE; Klenerman P, 2004, 'Expansion of Protective CD8⁺ T-Cell Responses Driven by Recombinant Cytomegaloviruses', Journal of Virology, 78, pp. 2255 - 2264, http://dx.doi.org/10.1128/JVI.78.5.2255-2264.2004

Lucas M; Vargas-Cuero AL; Lauer GM; Barnes E; Willberg CB; Semmo N; Walker BD; Phillips R; Klenerman P, 2004, 'Pervasive Influence of Hepatitis C Virus on the Phenotype of Antiviral CD8⁺ T Cells', Journal of Immunology, 172, pp. 1744 - 1753, http://dx.doi.org/10.4049/jimmunol.172.3.1744

Fagard C; Oxenius A; Günthard H; Garcia F; Le Braz M; Mestre G; Battegay M; Furrer H; Vernazza P; Bernasconi E; Telenti A; Weber R; Leduc D; Yerly S; Price D; Dawson SJ; Klimkait T; Perneger TV; McLean A; Clotet B; Gatell JM; Perrin L; Plana M; Phillips R; Hirschel B, 2003, 'A prospective trial of structured treatment interruptions in human immunodeficiency virus infection', Archives of Internal Medicine, 163, pp. 1220 - 1226, http://dx.doi.org/10.1001/archinte.163.10.1220

Price DA; Scullard G; Oxenius A; Braganza R; Beddows SA; Kazmi S; Clarke JR; Johnson GE; Weber JN; Phillips RE, 2003, 'Discordant outcomes following failure of antiretroviral therapy are associated with substantial differences in human immunodeficiency virus-specific cellular immunity', Journal of Virology, 77, pp. 6041 - 6049, http://dx.doi.org/10.1128/JVI.77.10.6041-6049.2003

Karrer U; Sierro S; Wagner M; Oxenius A; Hengel H; Koszinowski UH; Phillips RE; Klenerman P, 2003, 'Memory inflation: Continuous accumulation of antiviral CD8⁺ T cells over time', Journal of Immunology, 170, pp. 2022 - 2029, http://dx.doi.org/10.4049/jimmunol.170.4.2022

Harcourt GC; Lucas M; Godkin AJ; Kantzanou M; Phillips RE; Klenerman P, 2003, 'Evidence for lack of cross-genotype protection of CD4+ T cell responses during chronic hepatitis C virus infection', Clinical and Experimental Immunology, 131, pp. 122 - 129, http://dx.doi.org/10.1046/j.1365-2249.2003.02033.x

Oxenius A; Price DA; Dawson SJ; Günthard HF; Fischer M; Perrin L; Ramirez E; Fagard C; Hirschel B; Scullard G; Weber JN; McLean AR; Phillips RE, 2002, 'Residual HIV-specific CD4 and CD8 T cell frequencies after prolonged antiretroviral therapy reflect pretreatment plasma virus load', AIDS, 16, pp. 2317 - 2322, http://dx.doi.org/10.1097/00002030-200211220-00012

Oxenius A; Sewell AK; Dawson SJ; Günthard HF; Fischer M; Gillespie GM; Rowland-Jones SL; Fagard C; Hirschel B; Phillips RE; Price DA, 2002, 'Functional discrepancies in HIV-specific CD8⁺ T-lymphocyte populations are related to plasma virus load', Journal of Clinical Immunology, 22, pp. 363 - 374, http://dx.doi.org/10.1023/A:1020656300027

Phillips RE, 2002, 'Immunology taught by Darwin', Nature Immunology, 3, pp. 987 - 989, http://dx.doi.org/10.1038/ni1102-987

Fidler S; Oxenius A; Brady M; Clarke J; Cropley I; Babiker A; Zhang HT; Price D; Phillips R; Weber J, 2002, 'Virological and immunological effects of short-course antiretroviral therapy in primary HIV infection', AIDS, 16, pp. 2049 - 2054, http://dx.doi.org/10.1097/00002030-200210180-00010

Oxenius A; Price DA; Günthard HF; Dawson SJ; Fagard C; Perrin L; Fischer M; Weber R; Plana M; García F; Hirschel B; McLean A; Phillips RE, 2002, 'Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection', Proceedings of the National Academy of Sciences of the United States of America, 99, pp. 13747 - 13752, http://dx.doi.org/10.1073/pnas.202372199

Oxenius A; McLean AR; Fischer M; Price DA; Dawson SJ; Hafner R; Schneider C; Joller H; Hirschel B; Phillips RE; Weber R; Günthard HF, 2002, 'Human immunodeficiency virus-specific CD8⁺ T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy', Journal of Virology, 76, pp. 10169 - 10176, http://dx.doi.org/10.1128/JVI.76.20.10169-10176.2002

Mattes FM; Vargas AL; Hassan-Walker AF; Sweny P; Davenport A; Phillips RE; Griffiths PD; Emery VC, 2002, 'Cd8 Cytotoxic Lymphocyte Responses against Cytomegalovirus in Renal Transplant Patients and Healthy Individuals', Clinical Science, 103, pp. 28P - 29P, http://dx.doi.org/10.1042/cs103028pb

Brady M; Fidler S; Oxenius A; Phillips R; Weber J, 2002, 'Short Course Antiretroviral Therapy in Primary Hiv-1 Infection', Clinical Science, 103, pp. 25P - 26P, http://dx.doi.org/10.1042/cs103025pb

Oxenius A; Jakobsen BK; Easterbrook PJ; Boulter JM; Tun T; Waters A; Agudelo J; Barnardo M; Phillips RE; Price DA, 2002, 'Complete mapping of a novel HLA A*6801-restricted HIV-1 Tat epitope directly ex vivo with a rapid modified enzyme-linked immunospot assay', AIDS, 16, pp. 1285 - 1287, http://dx.doi.org/10.1097/00002030-200206140-00012

Sewell AK; Booth BL; Cerundolo V; Phillips RE; Price DA, 2002, 'Differential processing of HLA A2-restricted HIV type 1 cytotoxic T lymphocyte epitopes', Viral Immunology, 15, pp. 193 - 196, http://dx.doi.org/10.1089/088282402317340332

Klenerman P; Wu Y; Phillips R, 2002, 'HIV: Current opinion in escapology', Current Opinion in Microbiology, 5, pp. 408 - 413, http://dx.doi.org/10.1016/S1369-5274(02)00339-9

Barnes E; Harcourt G; Brown D; Lucas M; Phillips R; Dusheiko G; Klenerman P, 2002, 'The dynamics of T-lymphocyte responses during combination therapy for chronic hepatitis C virus infection', Hepatology, 36, pp. 743 - 754, http://dx.doi.org/10.1053/jhep.2002.35344

Vargas AL; Lechner F; Kantzanou M; Phillips RE; Klenerman P, 2001, 'Ex vivo analysis of phenotype and TCR usage in relation to CD45 isoform expression on cytomegalovirus-specific CD8⁺ T lymphocytes', Clinical and Experimental Immunology, 125, pp. 432 - 439, http://dx.doi.org/10.1046/j.1365-2249.2001.01614.x

Karrer U; Oxenius A; Phillips R; Klenerman P, 2001, 'Memory T cells: Total recall or just a sense of déjà vu?', Nature Immunology, 2, pp. 991 - 993, http://dx.doi.org/10.1038/ni1101-991

Goulder PJR; Pasquier C; Holmes EC; Liang B; Tang Y; Izopet J; Saune K; Rosenberg ES; Burchett SK; McIntosh K; Barnardo M; Bunce M; Walker BD; Brander C; Phillips RE, 2001, 'Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation', Immunology Letters, 79, pp. 109 - 116, http://dx.doi.org/10.1016/S0165-2478(01)00272-3

Kelleher AD; Booth JL; Sewell AK; Oxenius A; Cerundolo V; McMichael AJ; Phillips RE; Price DA, 2001, 'Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes', AIDS Research and Human Retroviruses, 17, pp. 1063 - 1066, http://dx.doi.org/10.1089/088922201300343744

Oxenius A; Yerly S; Ramirez E; Phillips RE; Price DA; Perrin L, 2001, 'Distribution of functional HIV-specific CD8 T lymphocytes between blood and secondary lymphoid organs after 8-18 months of antiretroviral therapy in acutely infected patients', AIDS, 15, pp. 1653 - 1656, http://dx.doi.org/10.1097/00002030-200109070-00007

Purbhoo MA; Boulter JM; Price DA; Vuidepot AL; Hourigan CS; Rod Dunbar P; Olson K; Dawson SJ; Phillips RE; Jakobsen BK; Bell JI; Sewell AK, 2001, 'The Human CD8 Coreceptor Effects Cytotoxic T Cell Activation and Antigen Sensitivity Primarily by Mediating Complete Phosphorylation of the T Cell Receptor η Chain', Journal of Biological Chemistry, 276, pp. 32786 - 32792, http://dx.doi.org/10.1074/jbc.M102498200

Phillips RE; Harcourt GC; Price DA, 2001, 'CD4⁺ T cells: The great escape', Nature Medicine, 7, pp. 777 - 778, http://dx.doi.org/10.1038/89892

Gruener NH; Lechner F; Jung MC; Diepolder H; Gerlach T; Lauer G; Walker B; Sullivan J; Phillips R; Pape GR; Klenerman P, 2001, 'Sustained dysfunction of antiviral CD8⁺ T lymphocytes after infection with hepatitis C virus', Journal of Virology, 75, pp. 5550 - 5558, http://dx.doi.org/10.1128/JVI.75.12.5550-5558.2001

Oxenius A; McLean AR; Fischer M; Price DA; Dawson SJ; Hafner R; Schneider C; Joller H; Hirschel B; Phillips RE; Weber R; Günthard HF; Battegay M; Bucher H; Bernasconi E; Piffaretti JC; Bürgisser P; Francioli P; Pantaleo G; Rickenbach M; Telenti A; Egger M; Erb P; Klimkait T; Fierz W; Vernazza P; Wagels T; Flepp M; Günthard H; Grob P; Ledergerber B; Lauper U; Opravil M; Speck R; Trkola A; Weber R; Furrer HJ; Gorgievski M; Kaiser L; Perrin L; Yerly S; Kind C; Paccaud F; Rudin C; Schüpbach J, 2001, 'Human immunodeficiency virus-specific T lymphocyte cell', Virologie, 5, pp. 23 - 34

Hassan-Walker AF; Vargas Cuero AL; Mattes FM; Klenerman P; Lechner F; Burroughs AK; Griffiths PD; Phillips RE; Emery VC, 2001, 'CD8⁺ cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: Correlation with time from transplant to receipt of tacrolimus', Journal of Infectious Diseases, 183, pp. 835 - 843, http://dx.doi.org/10.1086/319260

Kelleher AD; Long C; Holmes EC; Allen RL; Wilson J; Conlon C; Workman C; Shaunak S; Olson K; Goulder P; Brander C; Ogg G; Sullivan JS; Dyer W; Jones I; McMichael AJ; Rowland-Jones S; Phillips RE, 2001, 'Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses', Journal of Experimental Medicine, 193, pp. 375 - 385, http://dx.doi.org/10.1084/jem.193.3.375

Oxenius A; Price DA; Dawson SJ; Tun T; Easterbrook PJ; Phillips RE; Sewell AK, 2001, 'Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens [1]', AIDS, 15, pp. 121 - 122, http://dx.doi.org/10.1097/00002030-200101050-00018

Oxenius A; Günthard HF; Hirschel B; Fidler S; Weber JN; Easterbrook PJ; Bell JI; Phillips RE; Price DA, 2001, 'Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8⁺ T lymphocyte activation in response to therapeutic manipulation of virus load', European Journal of Immunology, 31, pp. 1115 - 11121, http://dx.doi.org/10.1002/1521-4141(200104)31:4<1115::AID-IMMU1115>3.0.CO;2-9

Harcourt G; Hellier S; Bunce M; Satsangi J; Collier J; Chapman R; Phillips R; Klenerman P, 2001, 'Effect of HLA class II genotype on T helper lymphocyte responses and viral control in hepatitis C virus infection', Journal of Viral Hepatitis, 8, pp. 174 - 179, http://dx.doi.org/10.1046/j.1365-2893.2001.00289.x

Oxenius A; Fidler S; Brady M; Dawson SJ; Ruth K; Easterbrook PJ; Weber JN; Phillips RE; Price DA, 2001, 'Variable fate of virus-specific CD4⁺ T cells during primary HIV-1 infection', European Journal of Immunology, 31, pp. 3782 - 3788, http://dx.doi.org/10.1002/1521-4141(200112)31:12<3782::aid-immu3782>3.0.co;2-%23

Lechner F; Gruener NH; Urbani S; Uggeri J; Santantonio T; Kammer AR; Cerny A; Phillips R; Ferrari C; Pape GR; Klenerman P, 2000, 'CD8⁺ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained', European Journal of Immunology, 30, pp. 2479 - 2487, http://dx.doi.org/10.1002/1521-4141(200009)30:9<2479::AID-IMMU2479>3.0.CO;2-B

Lin CL; Sewell AK; Gao GF; Whelan KT; Phillips RE; Austyn JM, 2000, 'Macrophage-tropic HIV induces and exploits dendritic cell chemotaxis', Journal of Experimental Medicine, 192, pp. 587 - 593, http://dx.doi.org/10.1084/jem.192.4.587

Lechner F; Wong DKH; Dunbar PR; Chapman R; Chung RT; Dohrenwend P; Robbins G; Phillips R; Klenerman P; Walker BD, 2000, 'Analysis of successful immune responses in persons infected with hepatitis C virus', Journal of Experimental Medicine, 191, pp. 1499 - 1512, http://dx.doi.org/10.1084/jem.191.9.1499

Phillips RE; Oxenius A; Price DA; Bangham CRM, 2000, 'AIDS: The evolving story', Trends in Microbiology, 8, pp. 147 - 148, http://dx.doi.org/10.1016/S0966-842X(00)01706-6

Oxenius A; Price DA; Easterbrook PJ; O'Callaghan CA; Kelleher AD; Whelan JA; Sontag G; Sewell AK; Phillips RE, 2000, 'Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8⁺ and CD4⁺ T lymphocytes', Proceedings of the National Academy of Sciences of the United States of America, 97, pp. 3382 - 3387, http://dx.doi.org/10.1073/pnas.97.7.3382

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