Select Publications
Journal articles
2016, 'Early antiretroviral therapy at high CD4 counts does not improve arterial elasticity: A substudy of the strategic timing of antiretroviral treatment (START) trial', Open Forum Infectious Diseases, 3, pp. ofw213, http://dx.doi.org/10.1093/ofid/ofw213
,2015, 'Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study', PLoS ONE, 10, pp. e0139981, http://dx.doi.org/10.1371/journal.pone.0139981
,2015, 'Erratum: Raltegravir Non-Inferior to Nucleoside Based Regimens in SECOND-LINE Therapy with Lopinavir/Ritonavir over 96 Weeks: A Randomised Open Label Study for the Treatment Of HIV-1 Infection (PLoS ONE (2015)10:2 (e0118228) Doi: 10.1371/journal.pone.0118228 ))', PLoS ONE, 10, pp. e0140623, http://dx.doi.org/10.1371/journal.pone.0140623
,2015, 'Pharmacokinetic and Pharmacodynamic Comparison of Once-Daily Efavirenz (400 mg vs. 600 mg) in Treatment-Naive HIV-Infected Patients: Results of the ENCORE1 Study', Clinical Pharmacology and Therapeutics, 98, pp. 406 - 416, http://dx.doi.org/10.1002/cpt.156
,2015, 'Initiation of antiretroviral therapy in early asymptomatic HIV infection', New England Journal of Medicine, 373, pp. 795 - 807, http://dx.doi.org/10.1056/NEJMoa1506816
,2015, 'Factors Associated with Plasma IL-6 Levels during HIV Infection', Journal of Infectious Diseases, 212, pp. 585 - 595, http://dx.doi.org/10.1093/infdis/jiv123
,2015, 'Efficacy and safety of efavirenz 400 mg daily versus 600 mg daily: 96-week data from the randomised, double-blind, placebo-controlled, non-inferiority ENCORE1 study', The Lancet Infectious Diseases, 15, pp. 793 - 802, http://dx.doi.org/10.1016/S1473-3099(15)70060-5
,2015, 'Early antiretroviral therapy with raltegravir generates sustained reductions in HIV reservoirs but not lower T-cell activation levels.', AIDS, 29, pp. 911 - 919, http://dx.doi.org/10.1097/QAD.0000000000000625
,2015, 'The impact of registration of clinical trials units: The UK experience', Clinical Trials, 12, pp. 166 - 173, http://dx.doi.org/10.1177/1740774514561242
,2015, 'Assessing site performance in the Altair study, a multinational clinical trial', Trials, 16, http://dx.doi.org/10.1186/s13063-015-0653-x
,2015, 'Baseline cardiovascular risk in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial', HIV Medicine, 16, pp. 46 - 54, http://dx.doi.org/10.1111/hiv.12233
,2015, 'Cerebrospinal fluid exposure of efavirenz and its major metabolites when dosed at 400 mg and 600 mg once daily: A randomized controlled trial', Clinical Infectious Diseases, 60, pp. 1026 - 1032, http://dx.doi.org/10.1093/cid/ciu976
,2015, 'Demographic and HIV-specific characteristics of participants enrolled in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial', HIV Medicine, 16, pp. 30 - 36, http://dx.doi.org/10.1111/hiv.12231
,2015, 'Why START? Reflections that led to the conduct of this large long-term strategic HIV trial', HIV Medicine, 16, pp. 1 - 9, http://dx.doi.org/10.1111/hiv.12227
,2015, 'Differences in the direction of change of cerebral function parameters are evident over three years in HIV-infected individuals electively commencing initial cART', PLoS ONE, 10, pp. e0118608, http://dx.doi.org/10.1371/journal.pone.0118608
,2015, 'Raltegravir non-inferior to nucleoside based regimens in second-line therapy with lopinavir/ritonavir over 96 weeks: A randomised open label study for the treatment of HIV-1 infection', PLoS ONE, 10, pp. e0118228, http://dx.doi.org/10.1371/journal.pone.0118228
,2015, 'Baseline HIV-1 resistance, virological outcomes, and emergent resistance in the SECOND-LINE trial: An exploratory analysis', The Lancet HIV, 2, pp. e42 - e51, http://dx.doi.org/10.1016/S2352-3018(14)00061-7
,2015, 'Pre-therapy inflammation and coagulation activation and long-term CD4 count responses to the initiation of antiretroviral therapy', HIV Medicine, 16, pp. 449 - 454, http://dx.doi.org/10.1111/hiv.12258
,, 2015, '8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015).', J Int AIDS Soc, 18, pp. 20479, http://dx.doi.org/10.7448/IAS.18.5.20479
2014, 'The Opposites Attract Study of viral load, HIV treatment and HIV transmission in serodiscordant homosexual male couples: Design and methods', BMC Public Health, 14, pp. 917, http://dx.doi.org/10.1186/1471-2458-14-917
,2014, 'Markers of inflammation and activation of coagulation are associated with anaemia in antiretroviral-treated HIV disease', AIDS, 28, pp. 1791 - 1796, http://dx.doi.org/10.1097/QAD.0000000000000344
,2014, 'Outcomes of influenza A(H1N1)pdm09 virus infection: Results from two international cohort studies', PLoS ONE, 9, http://dx.doi.org/10.1371/journal.pone.0101785
,2014, 'Severity of Cardiovascular Disease Outcomes Among Patients With HIV Is Related to Markers of Inflammation and Coagulation', JOURNAL OF THE AMERICAN HEART ASSOCIATION, 3, http://dx.doi.org/10.1161/JAHA.114.000844
,2014, 'Short communication: CD4 T cell declines occurring during suppressive antiretroviral therapy reflect continued production of Casp8p41', AIDS Research and Human Retroviruses, 30, pp. 476 - 479, http://dx.doi.org/10.1089/aid.2013.0243
,2014, 'Adjudicated morbidity and mortality outcomes by age among individuals with HIV infection on suppressive antiretroviral therapy', PLoS ONE, 9, pp. e95061, http://dx.doi.org/10.1371/journal.pone.0095061
,2014, 'Hip structural parameters over 96 weeks in HIV-infected adults switching treatment to tenofovir-emtricitabine or abacavir-lamivudine', PLoS ONE, 9, pp. e94858, http://dx.doi.org/10.1371/journal.pone.0094858
,2014, 'An update to the HIV-TRePS system: the development of new computational models that do not require a genotype to predict HIV treatment outcomes', Journal of Antimicrobial Chemotherapy, 69, pp. 1104 - 1110, http://dx.doi.org/10.1093/jac/dkt447
,2014, 'HLA Alleles association with changes in bone mineral density in HIV-1-infected adults changing treatment to tenofovir-emtricitabine or abacavir-lamivudine', PLoS ONE, 9, pp. e93333, http://dx.doi.org/10.1371/journal.pone.0093333
,2014, 'Factors associated with D-dimer levels in HIV-infected individuals', PLoS ONE, 9, http://dx.doi.org/10.1371/journal.pone.0090978
,2014, 'Glomerular filtration rate estimated using creatinine, cystatin C or both markers and the risk of clinical events in HIV-infected individuals', HIV Medicine, 15, pp. 116 - 123, http://dx.doi.org/10.1111/hiv.12087
,2014, 'A comparison of computational models with and without genotyping for prediction of response to second-line HIV therapy', HIV Medicine, 15, pp. 442 - 448, http://dx.doi.org/10.1111/hiv.12156
,2014, 'Biomarkers of inflammation, coagulation and microbial translocation in HIV/HCV co-infected patients in the SMART study', Journal of Clinical Virology, 60, pp. 295 - 300, http://dx.doi.org/10.1016/j.jcv.2014.03.017
,2014, 'Bone mineral density over 96 weeks in adults failing first-line therapy randomized to raltegravir/lopinavir/ ritonavir compared with standard second-line therapy', Journal of Acquired Immune Deficiency Syndromes, 67, pp. 161 - 168, http://dx.doi.org/10.1097/QAI.0000000000000288
,2014, 'Comparison of central and local HIV-1 RNA quantification from two international clinical trials', AIDS, 28, pp. 2480 - 2483, http://dx.doi.org/10.1097/QAD.0000000000000461
,2014, 'Determinants of developing widened spatial QRS-T angle in HIV-infected individuals: Results from the Strategies for Management of Antiretroviral Therapy [SMART] Study', Journal of Electrocardiology, 47, pp. 264 - 271, http://dx.doi.org/10.1016/j.jelectrocard.2013.12.001
,2014, 'Efficacy of 400 mg efavirenz versus standard 600 mg dose in HIV-infected, antiretroviral-naive adults (ENCORE1): A randomised, double-blind, placebo-controlled, non-inferiority trial', The Lancet, 383, pp. 1474 - 1482, http://dx.doi.org/10.1016/S0140-6736(13)62187-X
,2014, 'HIV DNA subspecies persist in both activated and resting memory CD4+ T cells during antiretroviral therapy', Journal of Virology, 88, pp. 3516 - 3526, http://dx.doi.org/10.1128/JVI.03331-13
,2014, 'Interleukin-6, high sensitivity C-reactive protein, and the development of type 2 diabetes among HIV-positive patients taking antiretroviral therapy', Journal of Acquired Immune Deficiency Syndromes, 67, pp. 538 - 546, http://dx.doi.org/10.1097/qai.0000000000000354
,2013, 'Short communication: HIV blips while on antiretroviral therapy can indicate consistently detectable viral levels due to assay underreporting', AIDS Research and Human Retroviruses, 29, pp. 1621 - 1625, http://dx.doi.org/10.1089/aid.2013.0132
,2013, 'Bone mineral density in HIV participants randomized to raltegravir and lopinavir/ritonavir compared with standard second line therapy', AIDS, 27, pp. 2403 - 2411, http://dx.doi.org/10.1097/01.aids.0000432534.47217.b4
,2013, 'Improved neurocognitive test performance in both arms of the SMART study: Impact of practice effect', Journal of NeuroVirology, 19, pp. 383 - 392, http://dx.doi.org/10.1007/s13365-013-0190-x
,2013, 'Contribution of genetic background, traditional risk factors, and HIV-related factors to coronary artery disease events in HIV-positive persons', Clinical Infectious Diseases, 57, pp. 112 - 121, http://dx.doi.org/10.1093/cid/cit196
,2013, 'Factors associated with adherence amongst 5295 people receiving antiretroviral therapy as part of an international trial', Journal of Infectious Diseases, 208, pp. 40 - 49, http://dx.doi.org/10.1093/infdis/jis731
,2013, 'Predictors of clinical progression in HIV-1-infected adults initiating combination antiretroviral therapy with advanced disease in the Asia-Pacific region: Results from the TREAT Asia HIV Observational Database', Journal of the International Association of Providers of AIDS Care, 12, pp. 270 - 277, http://dx.doi.org/10.1177/1545109712469684
,2013, 'The search for an HIV cure: Tackling latent infection', The Lancet Infectious Diseases, 13, pp. 614 - 621, http://dx.doi.org/10.1016/S1473-3099(13)70043-4
,2013, 'Predicting risk of cancer during HIV infection: The role of inflammatory and coagulation biomarkers', AIDS, 27, pp. 1433 - 1441, http://dx.doi.org/10.1097/QAD.0b013e32835f6b0c
,2013, 'Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses', Journal of Infectious Diseases, 207, pp. 1379 - 1388, http://dx.doi.org/10.1093/infdis/jit033
,2013, 'Biomarkers and electrocardiographic evidence of myocardial ischemia in patients with human immunodeficiency virus infection', American Journal of Cardiology, 111, pp. 760 - 764, http://dx.doi.org/10.1016/j.amjcard.2012.11.032
,2013, 'Electrocardiographic spatial QRS-T angle and incident cardiovascular disease in hiv-infected patients (from the Strategies for the Management of Antiretroviral Therapy [SMART] Study)', American Journal of Cardiology, 111, pp. 118 - 124, http://dx.doi.org/10.1016/j.amjcard.2012.08.054
,2013, 'HIV lipodystrophy in participants randomised to lopinavir/ritonavir (LPV/r) +2-3 nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTI) or LPV/r + raltegravir as second-line antiretroviral therapy.', PloS one, 8, http://dx.doi.org/10.1371/journal.pone.0077138
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