By Associate Professor Erin Howden

Journal articles

Hieda M; Sarma S; Hearon CM; Dias KA; Martinez J; Samels M; Everding B; Palmer D; Livingston S; Morris M; Howden E; Levine BD, 2020, 'Increased Myocardial Stiffness in Patients with High-Risk Left Ventricular Hypertrophy: The Hallmark of Stage-B Heart Failure with Preserved Ejection Fraction', Circulation, 141, pp. 115 - 123, http://dx.doi.org/10.1161/CIRCULATIONAHA.119.040332

Dillon H; Dausin C; Claessen G; Lindqvist A; Mitchell A; Wright L; Howden E; La Gerche A, 2020, '008 Differential Oxygen Consumption and Cardiac Response to Cardiopulmonary Exercise Testing in Upright, Semi-Supine and Supine Cycling Positions', Heart Lung and Circulation, 29, pp. s40 - s41, http://dx.doi.org/10.1016/j.hlc.2020.09.015

Foulkes S; Wright L; Paratz E; Antill Y; Loi S; Daly R; Fraser S; Howden E; La Gerche A, 2020, '286 Anthracycline Chemotherapy is not associated with Reductions in Right-Ventricular or Left Atrial Strain in Early-Stage Breast Cancer Patients', Heart Lung and Circulation, 29, pp. s162, http://dx.doi.org/10.1016/j.hlc.2020.09.293

Wright L; Kawakami H; Howden E; Marwick T, 2020, '305 Comparison of a Novel “length of Line” Speckle Tracking Approach for Left Atrial Strain Measurement', Heart Lung and Circulation, 29, pp. s170, http://dx.doi.org/10.1016/j.hlc.2020.09.312

Foulkes S; Howden E; Antill Y; Loi S; Haykowsky M; Daly R; Fraser S; La Gerche A, 2020, '399 Reduced End Systolic Volume is associated With Attenuated Cardiac Reserve and Lower Exercise Capacity in Women Recently Diagnosed With Breast Cancer', Heart Lung and Circulation, 29, pp. s217 - s218, http://dx.doi.org/10.1016/j.hlc.2020.09.406

Costello BT; Roberts TJ; Howden EJ; Bigaran A; Foulkes SJ; Beaudry RI; Janssens K; Haykowsky MJ; Antill Y; Nightingale S; Loi S; La Gerche A, 2019, 'Exercise Attenuates Cardiotoxicity of Anthracycline Chemotherapy Measured by Global Longitudinal Strain', Jacc Cardiooncology, 1, pp. 298 - 301, http://dx.doi.org/10.1016/j.jaccao.2019.09.002

Beetham KS; Howden EJ; Fassett RG; Petersen A; Trewin AJ; Isbel NM; Coombes JS, 2019, 'High-intensity interval training in chronic kidney disease: A randomized pilot study', Scandinavian Journal of Medicine and Science in Sports, 29, pp. 1197 - 1204, http://dx.doi.org/10.1111/sms.13436

Foulkes SJ; Howden EJ; Bigaran A; Janssens K; Antill Y; Loi S; Claus P; Haykowsky MJ; Daly RM; Fraser SF; La Gerche A, 2019, 'Persistent Impairment in Cardiopulmonary Fitness after Breast Cancer Chemotherapy', Medicine and Science in Sports and Exercise, 51, pp. 1573 - 1581, http://dx.doi.org/10.1249/MSS.0000000000001970

Taylor CE; Boulton D; Howden EJ; Siebenmann C; Macefield VG, 2019, 'Central command increases muscle sympathetic nerve activity more to contracting than noncontracting muscle during rhythmic isotonic leg exercise', Journal of Neurophysiology, 121, pp. 1704 - 1710, http://dx.doi.org/10.1152/jn.00075.2019

Howden EJ; Bigaran A; Beaudry R; Fraser S; Selig S; Foulkes S; Antill Y; Nightingale S; Loi S; Haykowsky MJ; La Gerche A, 2019, 'Exercise as a diagnostic and therapeutic tool for the prevention of cardiovascular dysfunction in breast cancer patients', European Journal of Preventive Cardiology, 26, pp. 305 - 315, http://dx.doi.org/10.1177/2047487318811181

Hieda M; Howden EJ; Sarma S; Cornwell W; Lawley JS; Tarumi T; Palmer D; Samels M; Everding B; Livingston S; Fu Q; Zhang R; Levine BD, 2019, 'The impact of 2 years of high-intensity exercise training on a model of integrated cardiovascular regulation', Journal of Physiology, 597, pp. 419 - 429, http://dx.doi.org/10.1113/JP276676

Williams CJ; Gurd BJ; Bonafiglia JT; Voisin S; Li Z; Harvey N; Croci I; Taylor JL; Gajanand T; Ramos JS; Fassett RG; Little JP; Francois ME; Hearon CM; Sarma S; Janssen SLJE; Van Craenenbroeck EM; Beckers P; Cornelissen VA; Pattyn N; Howden EJ; Keating SE; Bye A; Stensvold D; Wisloff U; Papadimitriou I; Yan X; Bishop DJ; Eynon N; Coombes JS, 2019, 'A multi-center comparison of VO2peak trainability between interval training and moderate intensity continuous training', Frontiers in Physiology, 10, http://dx.doi.org/10.3389/fphys.2019.00019

Beaudry RI; Howden EJ; Foulkes S; Bigaran A; Claus P; Haykowsky MJ; Gerche AL, 2019, 'Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy', Physiological Reports, 7, http://dx.doi.org/10.14814/phy2.13971

Dias KA; Lawley JS; Gatterer H; Howden EJ; Sarma S; Cornwell WK; Hearon CM; Samels M; Everding B; Liang ASW; Hendrix M; Piper T; Thevis M; Bruick RK; Levine BD, 2019, 'Effect of acute and chronic xenon inhalation on erythropoietin, hematological parameters, and athletic performance', Journal of Applied Physiology, 127, pp. 1503 - 1510, http://dx.doi.org/10.1152/japplphysiol.00289.2019

McNamara DA; Aiad N; Howden E; Hieda M; Link MS; Palmer D; Samels M; Everding B; Ng J; Adams-Huet B; Opondo M; Sarma S; Levine BD, 2019, 'Left atrial electromechanical remodeling following 2 years of high-intensity exercise training in sedentary middle-aged adults', Circulation, 139, pp. 1507 - 1516, http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037615

Petersen LG; Lawley JS; Lilja-Cyron A; Petersen JCG; Howden EJ; Sarma S; Cornwell WK; Zhang R; Whitworth LA; Williams MA; Juhler M; Levine BD, 2019, 'Lower body negative pressure to safely reduce intracranial pressure', Journal of Physiology, 597, pp. 237 - 248, http://dx.doi.org/10.1113/JP276557

Lawley JS; Gatterer H; Dias KA; Howden EJ; Sarma S; Cornwell WK; Hearon CM; Samels M; Everding B; Bruick RK; Hendrix M; Piper T; Thevis M; Levine BD, 2019, 'Safety, hemodynamic effects, and detection of acute xenon inhalation: Rationale for banning xenon from sport', Journal of Applied Physiology, 127, pp. 1511 - 1518, http://dx.doi.org/10.1152/japplphysiol.00290.2019

Foulkes S; Costello B; Howden E; Elliott D; Conyers R; La Gerche A, 2019, 'Exercise Cardiac MRI Unmasks Cardiac Dysfunction in Childhood and Adolescent Cancer Survivors with Reduced Cardiopulmonary Fitness', Heart Lung and Circulation, 28, pp. s135, http://dx.doi.org/10.1016/j.hlc.2019.06.010

Janssens K; Claessen G; Foulkes S; Sully F; Flannery D; Howden E; La Gerche A, 2019, 'High Peak Exercise Blood Pressure in Athletes is Proportional to Exercise Capacity; Need for a New Approach to Normal Reference Values', Heart, Lung and Circulation, 28, pp. S141 - S141, http://dx.doi.org/10.1016/j.hlc.2019.06.021

Howden E; Foulkes S; Wright L; Sully F; Janssens K; Dillon H; Costello B; La Gerche A, 2019, 'Traditional Markers of Myocardial Dysfunction Fail to Detect Marked Reductions in Physical Fitness Among Chemotherapy Patients', Heart Lung and Circulation, 28, pp. s136, http://dx.doi.org/10.1016/j.hlc.2019.06.011

Beetham KS; Howden EJ; Isbel NM; Coombes JS, 2018, 'Agreement between cystatin-C and creatinine based eGFR estimates after a 12-month exercise intervention in patients with chronic kidney disease', BMC Nephrology, 19, http://dx.doi.org/10.1186/s12882-018-1146-4

Howden EJ; Levine BD, 2018, 'Response by Howden and Levine to Letters Regarding Article, "Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications for Heart Failure Prevention"', Circulation, 138, pp. 1759 - 1760, http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036249

Howden EJ; La Gerche A; Arthur JF; McMullen JR; Jennings GL; Dunstan DW; Owen N; Avery S; Kingwell BA, 2018, 'Standing up to the cardiometabolic consequences of hematological cancers', Blood Reviews, 32, pp. 349 - 360, http://dx.doi.org/10.1016/j.blre.2018.02.005

Fraser S; Howden E; Foulkes S; Bigaran A; Janssens K; Beaudry R; Selig S; Haykowsky MJ; Antill YC; Loi S; LaGerche A, 2018, 'Role of cardiac reserve as a tool to unmask cardiotoxicity following anthracycline therapy and whether exercise training can attenuate cardiotoxicity.', Journal of Clinical Oncology, 36, pp. 556 - 556, http://dx.doi.org/10.1200/jco.2018.36.15_suppl.556

Opondo MA; Aiad N; Cain MA; Sarma S; Howden E; Stoller DA; Ng J; van Rijckevorsel P; Hieda M; Tarumi T; Palmer MD; Levine BD, 2018, 'Does High-Intensity Endurance Training Increase the Risk of Atrial Fibrillation? A Longitudinal Study of Left Atrial Structure and Function', Circulation Arrhythmia and Electrophysiology, 11, pp. e005598, http://dx.doi.org/10.1161/CIRCEP.117.005598

Howden EJ; Sarma S; Lawley JS; Opondo M; Cornwell W; Stoller D; Urey MA; Adams-Huet B; Levine BD, 2018, 'Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications for Heart Failure Prevention', Circulation, 137, pp. 1549 - 1560, http://dx.doi.org/10.1161/CIRCULATIONAHA.117.030617

Howden EJ; Carrick-Ranson G; Sarma S; Hieda M; Fujimoto N; Levine BD, 2018, 'Effects of Sedentary Aging and Lifelong Exercise on Left Ventricular Systolic Function', Medicine and Science in Sports and Exercise, 50, pp. 494 - 501, http://dx.doi.org/10.1249/MSS.0000000000001464

Beetham KS; Howden EJ; Krishnasamy R; Isbel NM; Coombes JS, 2018, 'Feasibility of Higher intensity exercise in patients with chronic kidney disease', Journal of Sports Medicine and Physical Fitness, 58, pp. 127 - 134, http://dx.doi.org/10.23736/S0022-4707.16.06575-0

Hieda M; Howden E; Shibata S; Fujimoto N; Bhella PS; Hastings JL; Tarumi T; Sarma S; Fu Q; Zhang R; Levine BD, 2018, 'Impact of lifelong exercise training dose on ventricular-arterial coupling', Circulation, 138, pp. 2638 - 2647, http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035116

Hieda M; Howden E; Shibata S; Tarumi T; Lawley J; Hearon C; Palmer D; Fu Q; Zhang R; Sarma S; Levine BD, 2018, 'Preload-corrected dynamic starling mechanism in patients with heart failure with preserved ejection fraction', Journal of Applied Physiology, 124, pp. 76 - 82, http://dx.doi.org/10.1152/japplphysiol.00718.2017

Hieda M; Howden E; Sarma S; Cornwell W; Urey MA; Stoller D; Levine B, 2018, 'THE IMPACT OF 2-YEARS HIGH INTENSITY EXERCISE TRAINING ON INTEGRATED CARDIOVASCULAR REGULATION', Journal of the American College of Cardiology, 71, pp. a1796, http://dx.doi.org/10.1016/s0735-1097(18)32337-4

Fadaee SB; Beetham KS; Howden EJ; Stanton T; Isbel NM; Coombes JS, 2017, 'Oxidative stress is associated with decreased heart rate variability in patients with chronic kidney disease', Redox Report, 22, pp. 197 - 204, http://dx.doi.org/10.1080/13510002.2016.1173326

Flannery D; Howden EJ; La Gerche A, 2017, 'POINT: COUNTER POINT', Journal of Applied Physiology, 123, pp. 692, http://dx.doi.org/10.1152/JAPPLPHYSIOL.00546.2017

Howden EJ; East C; Lawley JS; Stickford ASL; Verhees M; Fu Q; Levine BD, 2017, 'Integrative blood pressure response to upright tilt post renal denervation', American Journal of Hypertension, 30, pp. 632 - 641, http://dx.doi.org/10.1093/ajh/hpx018

Small DM; Beetham KS; Howden EJ; Briskey DR; Johnson DW; Isbel NM; Gobe GC; Coombes JS, 2017, 'Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease', Redox Report, 22, pp. 127 - 136, http://dx.doi.org/10.1080/13510002.2016.1276314

Howden EJ; Lawley JS; Esler M; Levine BD, 2017, 'Potential role of endurance training in altering renal sympathetic nerve activity in CKD?', Autonomic Neuroscience Basic and Clinical, 204, pp. 74 - 80, http://dx.doi.org/10.1016/j.autneu.2016.11.002

Lawley JS; Petersen LG; Howden EJ; Sarma S; Cornwell WK; Zhang R; Whitworth LA; Williams MA; Levine BD, 2017, 'Effect of gravity and microgravity on intracranial pressure', Journal of Physiology, 595, pp. 2115 - 2127, http://dx.doi.org/10.1113/JP273557

Howden EJ; Lawley JS; Samels M; Palmer D; Everding B; Livingston S; Sarma S; Levine BD, 2017, 'Effect of Prolonged Endurance Training on Ambulatory Systolic Blood Pressure and Arterial Function', Medicine & Science in Sports & Exercise, 49, pp. 837, http://dx.doi.org/10.1249/01.mss.0000519250.58306.83

Palmer D; Livingston S; Howden E; Samels M; Everding B; Sarma T, 2017, 'Progressive, High Intensity Endurance Exercise Training Significantly Increases Maximal Cardiac Power Output In Middle Aged, Previously Sedentary Adults', Medicine & Science in Sports & Exercise, 49, pp. 278, http://dx.doi.org/10.1249/01.mss.0000517618.41025.10

Lawley JS; Hannes G; Howden EJ; Sarma S; Hieda M; Hearon C; Hendrix M; Piper T; Thevis M; Levine BD, 2017, 'Safety, Detection and Hemodynamic Effects of Acute Xenon Inhalation', Medicine & Science in Sports & Exercise, 49, pp. 838, http://dx.doi.org/10.1249/01.mss.0000519251.65930.4a

Samels M; Howden E; Sarma T; Lawley J; Palmer D; Everding B; Cornwell W; Hearon C; Livingston S; Levine BD, 2017, 'Two-Year High-Intensity Aerobic Training Program Prevents Age-Associated Health Risk Factor Development in Sedentary Middle-Aged Adults', Medicine & Science in Sports & Exercise, 49, pp. 345, http://dx.doi.org/10.1249/01.mss.0000517821.25334.d0

Stray-Gundersen J; Howden EJ; Parsons DB; Thompson JR, 2016, 'Neither hematocrit normalization nor exercise training restores oxygen consumption to normal levels in hemodialysis patients', Journal of the American Society of Nephrology, 27, pp. 3769 - 3779, http://dx.doi.org/10.1681/ASN.2015091034

Grace MS; Howden EJ, 2016, 'Preventive strategies to mitigate the deleterious effects of ischemic reperfusion injury. Focus on ‘acute hot water immersion is protective against impaired vascular function following forearm ischemia-reperfusion in young healthy humans’', American Journal of Physiology Regulatory Integrative and Comparative Physiology, 311, pp. R992 - R993, http://dx.doi.org/10.1152/ajpregu.00442.2016

George SA; Bivens TB; Howden EJ; Saleem Y; Galbreath MM; Hendrickson D; Fu Q; Levine BD, 2016, 'The international POTS registry: Evaluating the efficacy of an exercise training intervention in a community setting', Heart Rhythm, 13, pp. 943 - 950, http://dx.doi.org/10.1016/j.hrthm.2015.12.012

Krishnasamy R; Hawley CM; Stanton T; Howden EJ; Beetham KS; Strand H; Leano R; Haluska BA; Coombes JS; Isbel NM, 2016, 'Association between left ventricular global longitudinal strain, health-related quality of life and functional capacity in chronic kidney disease patients with preserved ejection fraction', Nephrology, 21, pp. 108 - 115, http://dx.doi.org/10.1111/nep.12557

Howden EJ; Sarma S; Lawley J; Samels M; Palmer D; Everding B; Livingston S; Levine B, 2016, 'Dose Matters', Medicine & Science in Sports & Exercise, 48, pp. 671, http://dx.doi.org/10.1249/01.mss.0000487015.30704.66

Afridi A; Howden E; Samels M; Everding B; Palmer D; Livingston S; Sarma T; Levine BD, 2016, 'Interval TRIMP Scores Predict Improvement in Maximal Oxygen Consumption in middle-aged, sedentary Individuals', Medicine & Science in Sports & Exercise, 48, pp. 436, http://dx.doi.org/10.1249/01.mss.0000486312.57614.d5

Palmer D; Lawley J; Howden E; Sarma T; Cornwell B; Samels M; Everding B; Livingston S; Morris M; Williams M; Whitworth L; Levine B, 2016, 'Valsalva Maneuver During Resistance Exercise Increases Intracranial Pressure and Imposes a Transient Stress On The Cerebral Circulation.', Medicine & Science in Sports & Exercise, 48, pp. 363, http://dx.doi.org/10.1249/01.mss.0000486099.76041.cb

Howden EJ; Coombes JS; Isbel NM, 2015, 'The role of exercise training in the management of chronic kidney disease', Current Opinion in Nephrology and Hypertension, 24, pp. 480 - 487, http://dx.doi.org/10.1097/MNH.0000000000000165

Howden EJ; Perhonen M; Peshock RM; Zhang R; Arbab-Zadeh A; Adams-Huet B; Levine BD, 2015, 'Females have a blunted cardiovascular response to one year of intensive supervised endurance training', Journal of Applied Physiology, 119, pp. 37 - 46, http://dx.doi.org/10.1152/japplphysiol.00092.2015

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