Select Publications
Book Chapters
, 2018, 'Epigenetic Alterations in Primary Prostate Cancer', in Precision Molecular Pathology of Prostate Cancer, Springer Nature, pp. 193 - 211, http://dx.doi.org/10.1007/978-3-319-64096-9_13
, 2016, 'Single-Cell Genomics and Epigenomics', in Tseng FG; Santra TS (ed.), Essentials of Single-Cell Analysis Concepts, Applications and Future Prospects, SPRINGER-VERLAG BERLIN, pp. 257 - 301, http://dx.doi.org/10.1007/978-3-662-49118-8_10
Journal articles
, 2026, 'Endocrine therapy reprogramming of breast cancer facilitates metastatic escape via upregulation of P-Rex1/Rac1 signalling', Nature Communications, 17, http://dx.doi.org/10.1038/s41467-026-70683-x
, 2026, 'Modelling the metastatic immune microenvironment in triple-negative breast cancer', Breast Cancer Research, 28, http://dx.doi.org/10.1186/s13058-025-02186-4
, 2026, 'ID #448 Epigenomic erosion and enhancer dependence in H3.3K27M diffuse midline glioma', Neuro-Oncology Pediatrics, 2, pp. wuag026.154, http://dx.doi.org/10.1093/neuped/wuag026.154
, 2026, 'ID #674 Unmasking Epigenomic Vulnerabilities in Diffuse Midline Glioma to Guide Epigenetic Therapy', Neuro-Oncology Pediatrics, 2, http://dx.doi.org/10.1093/neuped/wuag026.273
, 2026, 'Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma', Science Translational Medicine, 18, http://dx.doi.org/10.1126/scitranslmed.adr1557
, 2025, 'The Bermuda Triangle of paediatric brain cancers: epigenetics, developmental timing window and cell of origin', Cancer and Metastasis Reviews, 44, http://dx.doi.org/10.1007/s10555-025-10284-0
, 2025, 'DMG-08. Single-Cell Analysis of ONC201 and Paxalisib Resistance Mechanisms in Diffuse Intrinsic Pontine Glioma', Neuro-Oncology Pediatrics, 1, http://dx.doi.org/10.1093/neuped/wuaf001.038
, 2025, 'Epigenetic Alterations in Age-Related Macular Degeneration: Mechanisms and Implications', International Journal of Molecular Sciences, 26, http://dx.doi.org/10.3390/ijms26157601
, 2025, 'MDB-27. PHASE IB CLINICAL TRIAL ASSESSING SAFETY, TOLERABILITY, AND PRELIMINARY EFFICACY OF ALOCELYVIR (ALLOGENEIC MESENCHYMAL CELLS + ONCOLYTIC ADENOVIRUS) IN PEDIATRIC PATIENTS WITH RECURRENT/PROGRESSIVE MEDULOBLASTOMA', Neuro-Oncology Pediatrics, 1, http://dx.doi.org/10.1093/neuped/wuaf001.226
, 2024, 'EZHIP's role in diffuse midline glioma: echoes of oncohistones?', Trends in Cancer, 10, pp. 1095 - 1105, http://dx.doi.org/10.1016/j.trecan.2024.09.002
, 2024, 'Performance comparison of high throughput single-cell RNA-Seq platforms in complex tissues', Heliyon, 10, http://dx.doi.org/10.1016/j.heliyon.2024.e37185
, 2024, 'PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma', Journal of Clinical Investigation, 134, pp. e170329, http://dx.doi.org/10.1172/JCI170329
, 2023, 'Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes', Scientific Reports, 13, pp. 3775, http://dx.doi.org/10.1038/s41598-023-30395-4
, 2023, 'EXTH-36. COMBINING ONC201 AND PAXALISIB FOR THE TREATMENT OF DIFFUSE MIDLINE GLIOMA (DMG); THE PRECLINICAL RESULTS UNDERPINNING THE INTERNATIONAL PHASE II CLINICAL TRIAL (NCT05009992)', Neuro-Oncology, 25, pp. v232 - v232, http://dx.doi.org/10.1093/neuonc/noad179.0889
, 2023, 'ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma', Cancer Research, 83, pp. 2421 - 2437, http://dx.doi.org/10.1158/0008-5472.CAN-23-0186
, 2023, 'ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma.', Cancer Res, 83, pp. 2421 - 2437, http://dx.doi.org/10.1158/0008-5472.CAN-23-0186
, 2023, 'Pleiotrophin drives a prometastatic immune niche in breast cancer', Journal of Experimental Medicine, 220, http://dx.doi.org/10.1084/jem.20220610
, 2023, 'Abstract B016: Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment', Cancer Research, 83, pp. b016 - b016, http://dx.doi.org/10.1158/1538-7445.metastasis22-b016
, 2023, 'Editorial: Epigenetic therapy against cancer: toward new molecular targets and technologies', Frontiers in Cell and Developmental Biology, 11, http://dx.doi.org/10.3389/fcell.2023.1218986
, 2022, 'Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-32255-7
, 2022, 'EXTH-12. PRECLINICAL AND CASE STUDY EXAMINATION OF THE COMBINATION OF THE CLPP AGONIST ONC201 WITH THE PI3K/AKT INHIBITOR PAXALISIB FOR THE TREATMENT OF DIFFUSE MIDLINE GLIOMA', Neuro-Oncology, 24, pp. vii211 - vii211, http://dx.doi.org/10.1093/neuonc/noac209.811
, 2022, 'Erratum: Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment (Journal Clinical Investigation (2022) 132:7 (e148667) 10.1172/JCI148667)', Journal of Clinical Investigation, 132, http://dx.doi.org/10.1172/JCI165107
, 2022, 'ALTEN: A High-Fidelity Primary Tissue-Engineering Platform to Assess Cellular Responses Ex Vivo', Advanced Science, 9, http://dx.doi.org/10.1002/advs.202103332
, 2022, 'Abstract 3144: Pleiotrophin drives a pro-metastatic immune niche within breast tumor microenvironment', Cancer Research, 82, pp. 3144 - 3144, http://dx.doi.org/10.1158/1538-7445.am2022-3144
, 2022, 'Disentangling single-cell omics representation with a power spectral density-based feature extraction', Nucleic Acids Research, 50, pp. 5482 - 5492, http://dx.doi.org/10.1093/nar/gkac436
, 2022, 'DIPG-07. Preclinical and case study results underpinning the phase II clinical trial testing the combination of ONC201 and paxalisib for the treatment of patients with diffuse midline glioma (NCT05009992)', Neuro-Oncology, 24, pp. i18 - i19, http://dx.doi.org/10.1093/neuonc/noac079.064
, 2022, 'Erratum: The H2A.Z-nucleosome code in mammals: emerging functions (Trends in Genetics (2022) 38(3) (273–289), (S0168952521002870), (10.1016/j.tig.2021.10.003)): (Trends in Genetics, 38:3 p:273–289, 2022)', Trends in Genetics, 38, pp. 516, http://dx.doi.org/10.1016/j.tig.2022.02.004
, 2022, 'Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment', Journal of Clinical Investigation, 132, http://dx.doi.org/10.1172/JCI148667
, 2022, 'The H2A.Z-nuclesome code in mammals: emerging functions', Trends in Genetics, 38, pp. 273 - 289, http://dx.doi.org/10.1016/j.tig.2021.10.003
, 2021, 'Tumor dissociation of highly viable cell suspensions for single-cell omic analyses in mouse models of breast cancer', STAR Protocols, 2, http://dx.doi.org/10.1016/j.xpro.2021.100841
, 2021, 'Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies', Frontiers in Oncology, 11, http://dx.doi.org/10.3389/fonc.2021.782766
, 2021, 'Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', Cell Reports, 35, http://dx.doi.org/10.1016/j.celrep.2021.108945
, 2021, 'Abstract LT010: Pleiotrophin drives pro-metastatic immune niche within breast tumor microenvironment', Cancer Research, 81, pp. lt010 - lt010, http://dx.doi.org/10.1158/1538-7445.tme21-lt010
, 2020, 'Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-019-13753-7
, 2020, 'Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer', Nature Communications, 11, pp. 320, http://dx.doi.org/10.1038/s41467-019-14098-x
, 2020, 'Genomic Cytometry and New Modalities for Deep Single-Cell Interrogation', Cytometry Part A, 97, pp. 1007 - 1016, http://dx.doi.org/10.1002/cyto.a.24209
, 2020, 'Transient exposure to miR-203 enhances the differentiation capacity of established pluripotent stem cells', EMBO Journal, 39, http://dx.doi.org/10.15252/embj.2019104324
, 2020, 'Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer', Cells, 9, http://dx.doi.org/10.3390/cells9030561
, 2019, 'A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation', Iscience, 21, pp. 773 - 788, http://dx.doi.org/10.1016/j.isci.2019.10.053
, 2019, 'Characterisation of developmental pathways that drive metastatic progression of breast cancer at single cell resolution', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p022
, 2019, 'Droplet-based single cell RNAseq tools: A practical guide', Lab on A Chip, 19, pp. 1706 - 1727, http://dx.doi.org/10.1039/c8lc01239c
, 2018, 'Single-cell transcriptomics in cancer immunobiology: The future of precision oncology', Frontiers in Immunology, 9, http://dx.doi.org/10.3389/fimmu.2018.02582
, 2017, 'Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer', Nature Communications, 8, pp. 1346, http://dx.doi.org/10.1038/s41467-017-01393-8
, 2017, 'Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer', Oncogene, 36, pp. 1328 - 1338, http://dx.doi.org/10.1038/onc.2016.297
, 2017, 'Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer', Oncotarget, 8, pp. 26755 - 26770, http://dx.doi.org/10.18632/oncotarget.15815
, 2016, 'H2A.Z acetylation and transcription: Ready, steady, go!', Epigenomics, 8, pp. 583 - 586, http://dx.doi.org/10.2217/epi-2016-0016
, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', Plos Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330
, 2015, 'Prostate cancer epigenetic biomarkers: Next-generation technologies', Oncogene, 34, pp. 1609 - 1618, http://dx.doi.org/10.1038/onc.2014.111