By Associate Professor Kelly Joanne Clemens

Book Chapters

Khoo S; McNally G; Clemens K, 2019, 'The orexin system and nicotine addiction: Preclinical insights', in Preedy VR (ed.), Neuroscience of Nicotine: Mechanisms and treatment, Academic Press, pp. 509 - 517, http://dx.doi.org/10.1016/B978-0-12-813035-3.00061-7

Khoo SY-S; McNally GP; Clemens KJ, 2019, 'Chapter 61 The Orexin System and Nicotine Addiction: Preclinical Insights', in Neuroscience of Nicotine, Elsevier, pp. 509 - 517, http://dx.doi.org/10.1016/b978-0-12-813035-3.00061-7

McKetin R; Clemens KJ; Kaye SS, 2013, ', Methamphetamine addiction', in Miller PM (ed.), Principles of Addiction, Academic Press

McKetin R; Kaye SS; Clemens KJ; Hermens D, 2013, 'Chapter 70 Methamphetamine Addiction', in Principles of Addiction, Elsevier, pp. 689 - 698, http://dx.doi.org/10.1016/b978-0-12-398336-7.00070-x

McKetin R; Kaye SS; Clemens KJ; Hermens D, 2013, 'Methamphetamine addiction', in Miller PM (ed.), Principles of addiction: comprehensive addictive behaviors and disorders, Academic Press, San Diego, CA, pp. 689 - 698

Caille S; Clemens K; Stinus L; Cador M, 2012, 'Modeling nicotine addiction in rats', in , pp. 243 - 256, http://dx.doi.org/10.1007/978-1-61779-458-2_15

Journal articles

Su F; Pfundstein G; Sah S; Zhang S; Keable R; Hagan DW; Sharpe LJ; Clemens KJ; Begg D; Phelps EA; Brown AJ; Leshchyns'ka I; Sytnyk V, 2025, 'Neuronal growth regulator 1 (NEGR1) promotes the synaptic targeting of glutamic acid decarboxylase 65 (GAD65)', Journal of Neurochemistry, 169, http://dx.doi.org/10.1111/jnc.16279

Williams IAR; Clemens KJ, 2024, 'Emerging evidence of a link between inflammation and the neuropathology of prenatal opioid exposure', Current Opinion in Neurobiology, 89, http://dx.doi.org/10.1016/j.conb.2024.102924

Muenstermann C; Clemens KJ, 2024, 'Epigenetic mechanisms of nicotine dependence', Neuroscience and Biobehavioral Reviews, 156, http://dx.doi.org/10.1016/j.neubiorev.2023.105505

Sah S; Keable R; Pfundstein G; Clemens KJ; Begg D; Schachner M; Leshchyns’ka I; Sytnyk V, 2023, 'Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits', Cerebral Cortex, 33, pp. 10047 - 10065, http://dx.doi.org/10.1093/cercor/bhad264

Clemens KJ; Oei JL; Jantzie LL, 2023, 'Editorial: The neurology and neurobiology of neonatal abstinence syndrome', Frontiers in Pediatrics, 11, http://dx.doi.org/10.3389/fped.2023.1201352

Holmes NM; Fam JP; Clemens KJ; Laurent V; Westbrook RF, 2022, 'The neural substrates of higher-order conditioning: A review', Neuroscience and Biobehavioral Reviews, 138, http://dx.doi.org/10.1016/j.neubiorev.2022.104687

Youngson NA; Castino MR; Stuart A; Kershaw KA; Holmes NM; Heffernan EC; Waters PD; Morris KV; Clemens KJ, 2022, 'A role for a novel natural antisense-BDNF in the maintenance of nicotine-seeking', Addiction Neuroscience, 2, http://dx.doi.org/10.1016/j.addicn.2022.100010

Fam J; Clemens KJ; Westbrook RF; Morris MJ; Kendig MD, 2022, 'Chronic exposure to cafeteria-style diet in rats alters sweet taste preference and reduces motivation for, but not ‘liking’ of sucrose', Appetite, 168, http://dx.doi.org/10.1016/j.appet.2021.105742

Mastrogiovanni NA; Wheeler AK; Clemens KJ, 2021, 'Social isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing', Scientific Reports, 11, pp. 2422, http://dx.doi.org/10.1038/s41598-021-81966-2

Finney CA; Proschogo NW; Snepvangers A; Holmes NM; Westbrook RF; Clemens KJ, 2020, 'The effect of standard laboratory diets on estrogen signaling and spatial memory in male and female rats', Physiology and Behavior, 215, pp. 112787, http://dx.doi.org/10.1016/j.physbeh.2019.112787

Kyme AZ; Angelis GI; Eisenhuth J; Fulton RR; Zhou V; Hart G; Popovic K; Akhtar M; Ryder WJ; Clemens KJ; Balleine BW; Parmar A; Pascali G; Perkins G; Meikle SR, 2019, 'Open-field PET: Simultaneous brain functional imaging and behavioural response measurements in freely moving small animals', NeuroImage, 188, pp. 92 - 101, http://dx.doi.org/10.1016/j.neuroimage.2018.11.051

Clemens KJ; Stuart A; Ferguson SG, 2019, 'Pre-quit nicotine decreases nicotine self-administration and attenuates cue- and drug-induced reinstatement', Journal of Psychopharmacology, 33, pp. 364 - 371, http://dx.doi.org/10.1177/0269881118822074

Holmes NM; Pan J; Davis A; Panayi MC; Clemens KJ, 2019, 'Rats choose high doses of nicotine in order to compensate for changes in its price and availability', Addiction Biology, 24, pp. 849 - 859, http://dx.doi.org/10.1111/adb.12637

Clemens KJ; Holmes NM, 2018, 'An extended history of drug self-administration results in multiple sources of control over drug seeking behavior', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 87, pp. 48 - 55, http://dx.doi.org/10.1016/j.pnpbp.2017.11.011

Khoo SYS; Clemens KJ; McNally GP, 2018, 'Palatable food self-administration and reinstatement are not affected by dual orexin receptor antagonism', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 87, pp. 147 - 157, http://dx.doi.org/10.1016/j.pnpbp.2017.06.028

Castino MR; Baker-Andresen D; Ratnu VS; Shevchenko G; Morris KV; Bredy TW; Youngson NA; Clemens KJ, 2018, 'Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats', Genes, Brain and Behavior, 17, pp. 98 - 106, http://dx.doi.org/10.1111/gbb.12421

Khoo SY; McNally GP; Clemens KJ, 2017, 'The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking', PLoS One, 12, pp. e0173967 - e0173967, http://dx.doi.org/10.1371/journal.pone.0173967

Clemens KJ; Lay BPP; Holmes NM, 2017, 'Extended nicotine self-administration increases sensitivity to nicotine, motivation to seek nicotine and the reinforcing properties of nicotine-paired cues.', Addiction Biology, 22, pp. 400 - 410, http://dx.doi.org/10.1111/adb.12336

Huynh C; Fam J; Ahmed SH; Clemens KJ, 2017, 'Rats quit nicotine for a sweet reward following an extensive history of nicotine use', Addiction Biology, 22, pp. 142 - 151, http://dx.doi.org/10.1111/adb.12306

Macnamara CL; Holmes NM; Westbrook RF; Clemens KJ, 2016, 'Varenicline impairs extinction and enhances reinstatement across repeated cycles of nicotine self-administration in rats', Neuropharmacology, 105, pp. 463 - 470, http://dx.doi.org/10.1016/j.neuropharm.2016.02.023

Sharpe MJ; Clemens KJ; Morris MJ; Westbrook RF, 2016, 'Daily Exposure to Sucrose Impairs Subsequent Learning About Food Cues: A Role for Alterations in Ghrelin Signaling and Dopamine D2 Receptors', Neuropsychopharmacology, 41, pp. 1357 - 1365, http://dx.doi.org/10.1038/npp.2015.287

Castino MR; Cornish JL; Clemens KJ, 2015, 'Inhibition of histone deacetylases facilitates extinction and attenuates reinstatement of nicotine self-administration in rats', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0124796

Clemens KJ; Castino MR; Cornish JL; Goodchild AK; Holmes NM, 2014, 'Behavioral and Neural Substrates of Habit Formation in Rats Intravenously Self-Administering Nicotine', Neuropsychopharmacology, 39, pp. 2584 - 2593, http://dx.doi.org/10.1038/npp.2014.111

Clemens KJ; Castino MR; Cornish JL; Goodchild AK; Holmes NM, 2014, 'Behavioral and Neural Substrates of Habit Formation in Rats Intravenously Self-Administering Nicotine', Neuropsychopharmacology, http://dx.doi.org/10.1038/npp.2014.111

Castino M; Cornish J; Goodchild A; Clemens K, 2013, 'THE ROLE OF HISTONE ACETYLATION IN THE ACQUISITION, EXTINCTION AND REINSTATEMENT OF NICOTINE SELF-ADMINISTRATION IN RATS', BEHAVIOURAL PHARMACOLOGY, 24, pp. E50 - E50, http://dx.doi.org/10.1097/01.fbp.0000434849.25290.97

Motbey CP; Clemens KJ; Apetz N; Winstock AR; Ramsey J; Li KM; Wyatt N; Callaghan PD; Bowen MT; Cornish JL; McGregor IS, 2013, 'High levels of intravenous mephedrone (4-methylmethcathinone) self-administration in rats: Neural consequences and comparison with methamphetamine', Journal of Psychopharmacology, 27, pp. 823 - 836, http://dx.doi.org/10.1177/0269881113490325

Pardey MC; Kumar NN; Goodchild AK; Clemens KJ; Homewood J; Cornish JL, 2012, 'Long-term effects of chronic oral ritalin administration on cognitive and neural development in adolescent Wistar Kyoto rats', Brain Sciences, 2, pp. 375 - 404, http://dx.doi.org/10.3390/brainsci2030375

Holmes N; Clemens KJ, 2011, 'Multiple interpretations of cocaine-seeking behaviour after prolonged self-administration training.', Journal of Neuroscience, 31, pp. 3935 - 3936, http://dx.doi.org/10.1523/JNEUROSCI.6354-10.2011

Vendruscolo LF; Gueye AB; Vendruscolo JCM; Clemens KJ; Mormède P; Darnaudéry M; Cador M, 2010, 'Reduced alcohol drinking in adult rats exposed to sucrose during adolescence', Neuropharmacology, 59, pp. 388 - 394, http://dx.doi.org/10.1016/j.neuropharm.2010.05.015

Clemens KJ; Caillé S; Cador M, 2010, 'The effects of response operandum and prior food training on intravenous Nicotine self-administration in rats', Psychopharmacology, 211, pp. 43 - 54, http://dx.doi.org/10.1007/s00213-010-1866-z

Clemens KJ; Caillé S; Stinus L; Cador M, 2009, 'The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats', International Journal of Neuropsychopharmacology, 12, pp. 1355 - 1366, http://dx.doi.org/10.1017/S1461145709000273

Hamlin AS; Mcnally GP; Choi EA; Clemens KJ, 2009, 'Paraventricular thalamus mediates context-induced reinstatement (renewal) of extinguished reward seeking', European Journal of Neuroscience, 29, pp. 802 - 812

Clemens KJ; Vendruscolo LF, 2008, 'Anxious to drink: Gabapentin normalizes GABAergic transmission in the central amygdala and reduces symptoms of ethanol dependence', Journal of Neuroscience, 28, pp. 9087 - 9089, http://dx.doi.org/10.1523/JNEUROSCI.2928-08.2008

Cornish JL; Clemens KJ; Thompson MR; Callaghan PD; Dawson B; McGregor IS, 2008, 'High ambient temperature increases intravenous methamphetamine self-administration on fixed and progressive ratio schedules in rats', Journal of Psychopharmacology, 22, pp. 100 - 110, http://dx.doi.org/10.1177/0269881107082286

Hamlin AS; Clemens KJ; Mcnally GP, 2008, 'Renewal of extinguished cocaine-seeking', Neuroscience, 151, pp. 659 - 670, http://dx.doi.org/10.1016/j.neuroscience.2007.11.018

Clemens KJ; Cornish JL; Hunt GE; McGregor IS, 2007, 'Repeated weekly exposure to MDMA, methamphetamine or their combination: Long-term behavioural and neurochemical effects in rats', Drug and Alcohol Dependence, 86, pp. 183 - 190, http://dx.doi.org/10.1016/j.drugalcdep.2006.06.004

Clemens KJ; McGregor IS; Hunt GE; Cornish JL, 2007, 'MDMA, methamphetamine and their combination: Possible lessons for party drug users from recent preclinical research', Drug and Alcohol Review, 26, pp. 9 - 15, http://dx.doi.org/10.1080/09595230601036945

Clemens KJ; Cornish JL; Hunt GE; McGregor IS, 2006, 'Intravenous methamphetamine self-administration in rats: Effects of intravenous or intraperitoneal MDMA co-administration', Pharmacology Biochemistry and Behavior, 85, pp. 454 - 463, http://dx.doi.org/10.1016/j.pbb.2006.09.015

McGregor I; Clemens K; Cornish J; Thompson M; Li K; Hunt G, 2005, 'MDMA, methamphetamine and their combination: Comparison of long-term behavioural and neural effects in rats', BEHAVIOURAL PHARMACOLOGY, 16, pp. S11 - S11, http://dx.doi.org/10.1097/00008877-200509001-00033

Clemens KJ; Cornish JL; Li KM; Hunt GE; McGregor IS, 2005, 'MDMA ('Ecstasy') and methamphetamine combined: Order of administration influences hyperthermic and long-term adverse effects in female rats', Neuropharmacology, 49, pp. 195 - 207, http://dx.doi.org/10.1016/j.neuropharm.2005.03.002

Cornish JL; Lontos JM; Clemens KJ; McGregor IS, 2005, 'Cocaine and heroin ('speedball') self-administration: The involvement of nucleus accumbens dopamine and μ-opiate, but not δ-opiate receptors', Psychopharmacology, 180, pp. 21 - 32, http://dx.doi.org/10.1007/s00213-004-2135-9

Clemens KJ; Van Nieuwenhuyzen PS; Li KM; Cornish JL; Hunt GE; McGregor IS, 2004, 'MDMA ("ecstacy"), methamphetamine and their combination: Long-term changes in social interaction and neurochemistry in the rat', Psychopharmacology, 173, pp. 318 - 325, http://dx.doi.org/10.1007/s00213-004-1786-x

Thompson MR; Li KN; Clemens KJ; Gurtman CG; Hunt GE; Cornish JL; McGregor IS, 2004, 'Chronic fluoxetine treatment partly attenuates the long-term anxiety and depressive symptoms induced by MDMA ('Ecstasy') in rats', Neuropsychopharmacology, 29, pp. 694 - 704, http://dx.doi.org/10.1038/sj.npp.1300347

McGregor IS; Clemens KJ; Van Der Plasse G; Li KM; Hunt GE; Chen F; Lawrence AJ, 2003, 'Increased anxiety 3 months after brief exposure to MDMA ('Ecstasy') in rats: Association with altered 5-HT transporter and receptor density', Neuropsychopharmacology, 28, pp. 1472 - 1484, http://dx.doi.org/10.1038/sj.npp.1300185

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