By Associate Professor Lindsay Edward Wu

Journal articles

Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair DA; Homer H, 2015, 'Erratum: Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes (PLoS ONE (2015) 10:5 (e0126194) DOI:10.1371/journal.pone.0126194)', Plos One, 10, pp. e0126194, http://dx.doi.org/10.1371/journal.pone.0126194

Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair D; Homer H, 2015, 'Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes', Plos One, 10, pp. e0130058, http://dx.doi.org/10.1371/journal.pone.0130058

Wu LE; Sinclair DA, 2014, 'SIRT2 controls the pentose phosphate switch', EMBO Journal, 33, pp. 1287 - 1288, http://dx.doi.org/10.15252/embj.201488713

Wu LE; Samocha-Bonet D; Whitworth PT; Fazakerley DJ; Turner N; Biden TJ; James DE; Cantley J, 2014, 'Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity', Molecular Metabolism, 3, pp. 465 - 473, http://dx.doi.org/10.1016/j.molmet.2014.02.005

Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, 19, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009

Wu LE; Solon S; McMahon AC; Ballard JWO; Ruohonen K; Cogger VC; Warren A; Pichaud N; Melvin RG; Gokarn R; Khalil M; Huang X; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'Disparate consequences of macronutrients on appetite, longevity and cardiometabolic health reconciled by nutritional geometry', Cell Metabolism

Wu LE; Gomes AP; Sinclair DA, 2014, 'Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis', Cancer Cell, 25, pp. 12 - 19, http://dx.doi.org/10.1016/j.ccr.2013.12.005

Ma X; Yang P; Kaplan WH; Lee BH; Wu LE; Yang JYH; Yasunaga M; Sato K; Chisholm DJ; James DE, 2014, 'ISL1 regulates peroxisome proliferator-activated receptor γ activation and early adipogenesis via bone morphogenetic protein 4-dependent and -independent mechanisms', Molecular and Cellular Biology, 34, pp. 3607 - 3617, http://dx.doi.org/10.1128/MCB.00583-14

North BJ; Rosenberg MA; Jeganathan KB; Hafner AV; Michan S; Dai J; Baker DJ; Cen Y; Wu LE; Sauve AA; Van Deursen JM; Rosenzweig A; Sinclair DA, 2014, 'SIRT2 induces the checkpoint kinase BubR1 to increase lifespan', EMBO Journal, 33, pp. 1438 - 1453, http://dx.doi.org/10.15252/embj.201386907

Wu LE; Meoli CC; Mangiafico SP; Fazakerley DJ; Cogger VC; Mohamad M; Pant H; Kang MJ; Powter E; Burchfield JG; Xirouchaki CE; Mikolaizak AS; Stöckli J; Kolumam G; Van Bruggen N; Gamble JR; Le Couteur DG; Cooney GJ; Andrikopoulos S; James DE, 2014, 'Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction', Diabetes, 63, pp. 2656 - 2667, http://dx.doi.org/10.2337/db13-1665

Poorten DVD; Samer CF; Ramezani-Moghadam M; Coulter S; Kacevska M; Schrijnders D; Wu LE; McLeod D; Bugianesi E; Komuta M; Roskams T; Hebbard L; George J, 2013, 'Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?†', Hepatology, http://dx.doi.org/10.1002/hep.26072

Hocking SL; Wu LE; Guilhaus M; Chisholm DJ; James DE, 2010, 'Intrinsic depot-specific differences in the secretome of adipose tissue, preadipocytes, and adipose tissue-derived microvascular endothelial cells', Diabetes, 59, pp. 3008 - 3016, http://dx.doi.org/10.2337/db10-0483

Wu LE; Hocking SL; James DE, 2010, 'Macrophage infiltration and cytokine release in adipose tissue: angiogenesis or inflammation?', Diabetology International, 1, pp. 26 - 34, http://dx.doi.org/10.1007/s13340-010-0003-x

Wu LE; Carter EA; Rayner BS; McLeod AI; Marshall CP; Levina A; Aitken JB; Witting PK; Lai B; Cai Z; Vogt S; Lee YC; Tobin MJ; Harris HH; Lay PA, 2010, 'Silicon Nitride as a Versatile Growth Substrate for Microspectroscopic Imaging and Mapping of Individual Cells.', Molecular Biosystems, 6, pp. 1316 - 1322

Zhang SH; Chen XY; Wong KS; Leung T; Wu LE; Fan XJ, 2009, 'FP08-MO-02 Compliance of patients with guideline in secondary prevention of stroke: a multicentre study in China', Journal of the Neurological Sciences, 285, pp. s69, http://dx.doi.org/10.1016/s0022-510x(09)70303-x

Crowe SM; Wu LE; Economou C; Turpin S; Matzaris M; Hoehn KL; Hevener A; James DE; Duh E; Watt M, 2009, 'Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity', Cell Metabolism, 10, pp. 40 - 47

Hoehn K; Hohnen-Behrens C; Cederberg A; Wu LE; Turner N; Yuasa T; Ebina Y; James DE, 2008, 'IRS1-independent defects define major nodes of insulin resistance', Cell Metabolism, 7, pp. 421 - 433, http://dx.doi.org/10.1016/j.cmet.2008.04.005

Vogt S; Lai B; Finney L; Palmer B; Wu LE; Harris H; Paunesku T; de Jonge M; Legnini D; Maser J; Glesne D; Lay P; Woloschak G, 2007, 'Imaging trace elements in cells with x-ray fluorescence microscopy', MICROSCOPY AND MICROANALYSIS, 13, pp. 40 - 41, http://dx.doi.org/10.1017/S1431927607076283

Conference Papers

Weekley CM; Wong ASA; Parker MW; Wu LE, 2023, 'Structural biology of glucose-6-phosphate dehydrogenase and small molecule activators', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. C839 - C839

Mahbub SB; Campbell J; Tan TCY; Habibalahi A; Bertoldo MJ; Goss DM; Walter K; Wu LE; Dunning KR; Goldys E, 2021, 'Label-free multispectral identification of native fluorophores to assess embryo and oocyte quality', in Leary JF; Tarnok A; Georgakoudi I (eds.), Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX, SPIE, pp. 7 - 7, presented at Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX, 06 March 2021 - 12 March 2021, http://dx.doi.org/10.1117/12.2579141

Riepsamen A; Listijono D; Kalani S; Cooke S; Ledger W; Wu L; Sinclair D, 2019, 'Sirtuins are required for forming fertilization-ready eggs', BJOG: An International Journal of Obstetrics & Gynaecology, Brisbane, Australia, presented at Royal College of Obstetricians and Gynaecologists World Congress, Brisbane, Australia, 10 April 2019, http://dx.doi.org/10.1111/1471-0528.13368

Homer H; Riepsamen A; Wu LE; Sinclair D, 2015, 'Sirt2-mediated BubR1 regulation promotes oocyte maturation', in HUMAN REPRODUCTION, OXFORD UNIV PRESS, PORTUGAL, Lisbon, pp. 11 - 11, presented at 31st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), PORTUGAL, Lisbon, 14 June 2015 - 17 June 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359740300024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

, 2015, 'Abstract book of the 31st ESHRE Annual Meeting, Lisbon, Portugal, 14–17 June 2015', in Human Reproduction, Oxford University Press (OUP), pp. i1 - i501, http://dx.doi.org/10.1093/humrep/30.supplement_1.1

Cogger V; Mohamad M; Wu L; De Cabo R; Le Couteur DG, 2014, 'DEFENESTRATION OF THE LIVER SINUSOIDAL ENDOTHELIAL CELL IMPAIRS INSULIN AND GLUCOSE UPTAKE', in GERONTOLOGIST, OXFORD UNIV PRESS INC, pp. 164 - 164, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346337501490&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wu LE; James DE; Cantley J, 2010, 'Secreted adipocyte fatty acid binding protein (FABP4) forms the molecular basis of the adipo-insular axis', in DIABETOLOGIA, SPRINGER, SWEDEN, Stockholm, pp. S58 - S58, presented at 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), SWEDEN, Stockholm, 20 September 2010 - 24 September 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000280689700124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wu LE; Larance M; Ramm G; Raftery M; Guilhaus M; James DE, 2009, 'Proteomic Analysis of Adipokine Secretion in Insulin Resistance', in DIABETES, AMER DIABETES ASSOC, LA, New Orleans, pp. A333 - A334, presented at 69th Annual Meeting of the American-Diabetes-Association, LA, New Orleans, 05 June 2009 - 09 June 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000266352602014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wu LE; Guo X; Yan CH; He JL; Liu D; Chen J; Wu L; Jia L, 2009, 'Evaluation of Quality of Life and Factors in Patients after Stroke', in CEREBROVASCULAR DISEASES, KARGER, pp. 215 - 215

Conference Abstracts

Wu X; Wu LE; Crawford R; Mao X; Prasadam I, 2023, 'IMPLICATIONS OF NICOTINAMIDE ADENINE DINUCLEOTIDE METABOLISM IN CARTILAGE DEGENERATION AND OSTEOARTHRITIS', in AGING CLINICAL AND EXPERIMENTAL RESEARCH, SPRINGER, Vol. 35, pp. S307 - S307

Murphy T; Wu L; Sandow S; Das A; Naim H, 2020, 'Effect of Dietary Nicotinamide Mononucleotide (NMN) on Function and Mechanics of Skeletal Muscle Arteries from Aged Mice', in FASEB JOURNAL, WILEY, CA, San Diego, Vol. 34, presented at Annual Meeting on Experimental Biology, CA, San Diego, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.04752

Sultani G; Bentley N; Osborne B; Joshi S; Araki T; Montgomery M; Polly P; Byrne F; Wu L; Turner N, 2018, 'PO-011 Impact of compartment-specific changes in NAD biosynthesis on diethylnitrosamine-induced liver cancer', in ESMO Open, Elsevier, Vol. 3, pp. a25, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.56

Chowdhury MKH; Morris M; Turner N; Wu L; Shepherd P; Smith G, 2017, 'Niclosamide blocks glucagon phosphorylation of serine 552 on β‐catenin leading to decrease target genes expression and improve glucose metabolism via PKA signalling pathway', in The FASEB Journal, Wiley, Vol. 31, http://dx.doi.org/10.1096/fasebj.31.1_supplement.780.4

Patents

Wu L; Sinclair D; Das A, 2023, Methods for enhancing vascular density, Australia, Patent No. 2017383100

Wu L; Sinclair D, 2022, Targeting NAD+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity, Patent No. Belgium, Denmark, Europe, France, Germany, Ireland, Italy, Netherlands, Poland, Portugal, Spain, Sweden, Switzerland, United Kingdom - 3288637; Japan - 7193232; United States - 11389469

Wu L; Sinclair D, 2020, Targeting NAD+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity, Patent No. United Stated Patent no. 10603334

Sinclair D; Gomes A; Wu L, 2018, NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation, Patent No. 9877981, https://pdfpiw.uspto.gov/.piw?Docid=09877981&homeurl=http:%2F%2Fpatft.uspto.gov%2Fnetacgi%2Fnph-Parser%3FSect1%3DPTO1%2526Sect2%3DHITOFF%2526d%3DPALL%2526p%3D1%2526u%3D%25252Fnetahtml%25252FPTO%25252Fsrchnum.htm%2526r%3D1%2526f%3DG%2526l%3D50%2526s1%3D9877981.PN.%2526OS%3DPN%2F9877981%2526RS%3DPN%2F9877981&PageNum=&Rtype=&SectionNum=&idkey=NONE&Input=View+first+page

Working Papers

Bertoldo MJ; Listijono DR; Ho W-HJ; Riepsamen AH; Jin XL; Selesniemi K; Goss DM; Mahbub S; Campbell JM; Habibalahi A; Loh W-GN; Youngson NA; Maniam J; Wong ASA; Richani D; Li C; Zhao Y; Marinova M; Kim L-J; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O’Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2019, NAD+ repletion rescues female fertility during reproductive ageing, Cold Spring Harbor Laboratory, http://dx.doi.org10.1101/721985

Capraro A; Wong SL; Adhikari A; Allan KM; Patel HR; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan RM; Turville S; Vittorio O; Bull RA; Kaakoush N; Rawlinson WD; Tedla N; Vafaee F; Waters SA, Ageing impairs the airway epithelium defence response to SARS-CoV-2, Cold Spring Harbor Laboratory, http://dx.doi.org10.1101/2021.04.05.437453

Preprints

Yu J; Laybutt DR; Kim L-J; Quek L-E; Wu LE; Morris MJ; Youngson NA, 2020, EXERCISE-INDUCED BENEFITS ON GLUCOSE HANDLING IN A MODEL OF DIET-INDUCED OBESITY ARE REDUCED BY CONCURRENT NICOTINAMIDE MONONUCLEOTIDE, http://dx.doi.org/10.1101/2020.06.22.164459

Frost ER; Richani D; Poljak A; Vuyyuru A; Liao X; Georgiou E; Gunasekara JMB; Mihalas BP; Sucquart IE; Kadam K; Wu LE; Gilchrist RB, A proteomic signature of oocyte quality from models of varying oocyte developmental competence, http://dx.doi.org/10.64898/2026.01.20.700687

Mihalas BP; Lin D; Bustamante S; Pickford R; Frost ER; Vuyyuru A; Wong DY; Bertoldo MJ; Wu LE; Gilchrist RB, Aging disrupts cumulus–oocyte NAD⁺ homeostasis, http://dx.doi.org/10.64898/2026.07.22.739977

Madawala R; Banks JL; Hancock SE; Quek L-E; Turner N; Wu LE, CD38 mediates nicotinamide mononucleotide (NMN) base exchange to yield nicotinic acid mononucleotide (NaMN), http://dx.doi.org/10.1101/2024.08.08.607247

Marinova MB; Madawala R; Ho W-HJ; Lovric V; Bertoldo MJ; Oliver RA; Maniam J; Morris MJ; Sinclair DA; Homer HA; Walters KA; Erlich JH; Walsh WR; Gilchrist RB; Wu LE, Chemotherapy accelerated bone ageing is reversed by NMN, http://dx.doi.org/10.1101/2025.10.13.679926

Kim L-J; Chalmers T; Smith G; Li C; Das A; Poon WKE; Wang J; Tucker S; Sinclair D; Quek L-E; Wu L, Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome, http://dx.doi.org/10.21203/rs.3.rs-87047/v1

Kim L-J; Chalmers TJ; Madawala R; Smith GC; Li C; Das A; Poon EWK; Wang J; Tucker SP; Sinclair DA; Quek L-E; Wu LE, Nicotinamide mononucleotide (NMN) deamidation by host-microbiome interactions, http://dx.doi.org/10.1101/2020.09.10.289561

Habibalahi A; Bertoldo MJ; Mahbub SB; Campbell JM; Goss DM; Ledger WL; Gilchrist RB; Wu LE; Goldys EM, NMN treatment reverses unique deep radiomic signature morphology of oocytes from aged mice, http://dx.doi.org/10.21203/rs.3.rs-951364/v1

Back to profile page