By Associate Professor Mandy Ballinger

Journal articles

Peng G; Bojadzieva J; Ballinger ML; Li J; Blackford AL; Mai PL; Savage SA; Thomas DM; Strong LC; Wang W, 2017, 'Estimating TP53 mutation carrier probability in families with li-fraumeni syndrome using LFSPRO', Cancer Epidemiology Biomarkers and Prevention, 26, pp. 837 - 844, http://dx.doi.org/10.1158/1055-9965.EPI-16-0695

Leroy B; Ballinger ML; Baran-Marszak F; Bond GL; Braithwaite A; Concin N; Donehower LA; El-Deiry WS; Fenaux P; Gaidano G; Langerød A; Hellstrom-Lindberg E; Iggo R; Lehmann-Che J; Mai PL; Malkin D; Moll UM; Myers JN; Nichols KE; Pospisilova S; Ashton-Prolla P; Rossi D; Savage SA; Strong LC; Tonin PN; Zeillinger R; Zenz T; Fraumeni JF; Taschner PEM; Hainaut P; Soussi T, 2017, 'Recommended guidelines for validation, quality control, and reporting of TP53 variants in clinical practice', Cancer Research, 77, pp. 1250 - 1260, http://dx.doi.org/10.1158/0008-5472.CAN-16-2179

Ballinger ML; Thomas DM, 2016, 'Sarcoma and germ-line DICER1 mutations – Authors’ reply', Lancet Oncology, 17, pp. e471, http://dx.doi.org/10.1016/S1470-2045(16)30527-7

Ballinger ML; Goode DL; Ray-Coquard I; James PA; Mitchell G; Niedermayr E; Puri A; Schiffman JD; Dite GS; Cipponi A; Maki RG; Brohl AS; Myklebost O; Stratford EW; Lorenz S; Ahn SM; Ahn JH; Kim JE; Shanley S; Beshay V; Randall RL; Judson I; Seddon B; Campbell IG; Young MA; Sarin R; Blay JY; O'Donoghue SI; Thomas DM, 2016, 'Monogenic and polygenic determinants of sarcoma risk: an international genetic study', Lancet Oncology, 17, pp. 1261 - 1271, http://dx.doi.org/10.1016/S1470-2045(16)30147-4

Thomas DM; Ballinger ML, 2016, 'Diagnosis and management of hereditary sarcoma', Recent Results in Cancer Research, 205, pp. 169 - 189, http://dx.doi.org/10.1007/978-3-319-29998-3_10

McBride KA; Hallowell N; Tattersall MHN; Kirk J; Ballinger ML; Thomas DM; Mitchell G; Young MA, 2016, 'Timing and context: important considerations in the return of genetic results to research participants', Journal of Community Genetics, 7, pp. 11 - 20, http://dx.doi.org/10.1007/s12687-015-0231-7

Thomas D, 2016, 'International survey of awareness of genetic risk in the clinical sarcoma community', Asia Pac J Clin Oncol, 12, pp. 133 - 142, http://dx.doi.org/10.1111/ajco.12457

Mirabello L; Koster R; Moriarity BS; Spector LG; Meltzer PS; Gary J; Machiela MJ; Pankratz N; Panagiotou OA; Largaespada D; Wang Z; Gastier-Foster JM; Gorlick R; Khanna C; de Toledo SRC; Petrilli AS; Patiño-Garcia A; Sierrasesúmaga L; Lecanda F; Andrulis IL; Wunder JS; Gokgoz N; Serra M; Hattinger C; Picci P; Scotlandi K; Flanagan AM; Tirabosco R; Amary MF; Halai D; Ballinger ML; Thomas DM; Davis S; Barkauskas DA; Marina N; Helman L; Otto GM; Becklin KL; Wolf NK; Weg MT; Tucker M; Wacholder S; Fraumeni JF; Caporaso NE; Boland JF; Hicks BD; Vogt A; Burdett L; Yeager M; Hoover RN; Chanock SJ; Savage SA, 2015, 'A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma', Cancer Discovery, 5, pp. 920 - 931, http://dx.doi.org/10.1158/2159-8290.CD-15-0125

Ballinger ML; Mitchell G; Thomas DM, 2015, 'Surveillance recommendations for patients with germline TP53 mutations', Current Opinion in Oncology, 27, pp. 332 - 337, http://dx.doi.org/10.1097/CCO.0000000000000200

Thomas DM; James PA; Ballinger ML, 2015, 'Clinical implications of genomics for cancer risk genetics', Lancet Oncology, 16, pp. e303 - e308, http://dx.doi.org/10.1016/S1470-2045(15)70026-4

Thomas DM; Ballinger ML, 2015, 'Etiologic, environmental and inherited risk factors in sarcomas', Journal of Surgical Oncology, 111, pp. 490 - 495, http://dx.doi.org/10.1002/jso.23809

McBride KA; Ballinger ML; Killick E; Kirk J; Tattersall MHN; Eeles RA; Thomas DM; Mitchell G, 2014, 'Li-Fraumeni syndrome: Cancer risk assessment and clinical management', Nature Reviews Clinical Oncology, 11, pp. 260 - 271, http://dx.doi.org/10.1038/nrclinonc.2014.41

Young M-A; Herlihy A; Mitchell G; Thomas DM; Ballinger M; Tucker K; Lewis CR; Neuhaus S; International Sarcoma Kindred Study ; Halliday J, 2013, 'The attitudes of people with sarcoma and their family towards genomics and incidental information arising from genetic research.', Clin Sarcoma Res, 3, pp. 11, http://dx.doi.org/10.1186/2045-3329-3-11

Mitchell G; Ballinger ML; Wong S; Hewitt C; James P; Young MA; Cipponi A; Pang T; Goode DL; Dobrovic A; Thomas DM; Porceddu S; Gattas M; Neuhaus S; Suthers G; Tattersall M; Tucker K; Lewis C; Carey-Smith R, 2013, 'High Frequency of Germline TP53 Mutations in a Prospective Adult-Onset Sarcoma Cohort', Plos One, 8, http://dx.doi.org/10.1371/journal.pone.0069026

Little PJ; Rostam MA; Piva TJ; Getachew R; Kamato D; Guidone D; Ballinger ML; Zheng W; Osman N, 2013, 'Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells', Journal of Pharmacy and Pharmacology, 65, pp. 1055 - 1063, http://dx.doi.org/10.1111/jphp.12064

Osman N; Grande-Allen KJ; Ballinger ML; Getachew R; Marasco S; O'Brien KD; Little PJ, 2013, 'Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans', Cardiovascular Pathology, 22, pp. 146 - 155, http://dx.doi.org/10.1016/j.carpath.2012.07.002

Downing ME; Dite GS; Ballinger ML; The International Sarcoma Kindred Study Consortium , 2012, 'An increased incidence of Hodgkin's lymphoma in patients with adult-onset sarcoma', Clinical Sarcoma Research, 2, pp. 1, http://dx.doi.org/10.1186/2045-3329-2-1

Little PJ; Getachew R; Rezaei HB; Sanchez-Guerrero E; Khachigian LM; Wang H; Liao S; Zheng W; Ballinger ML; Osman N, 2012, 'Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFâ receptor phosphorylation', Archives of Biochemistry and Biophysics, 525, pp. 25 - 31, http://dx.doi.org/10.1016/j.abb.2012.05.025

Thomas D; Ballinger M; International Sarcoma Kindred Study Consortium , 2012, 'Inherited and de novo germline TP53 mutations in adult-onset sarcoma', Hereditary Cancer in Clinical Practice, 10, pp. a3, http://dx.doi.org/10.1186/1897-4287-10-s2-a3

Thomas DM; Ballinger ML; International Sarcoma Kindred Study Consortium , 2012, 'Inherited and de novo germline TP53 mutations in adult-onset sarcoma', Hereditary Cancer in Clinical Practice, 10, pp. a26, http://dx.doi.org/10.1186/1897-4287-10-s2-a26

Mahendran K; Ballinger M; Kirk J; Thomas D; Tattersall M, 2012, 'Pathogenic germline TP53 mutations in adult sarcoma patients; implications for treatment and screening – description of an upcoming project', Hereditary Cancer in Clinical Practice, 10, pp. a61, http://dx.doi.org/10.1186/1897-4287-10-s2-a61

Burch ML; Ballinger ML; Yang SNY; Getachew R; Itman C; Loveland K; Osman N; Little PJ, 2010, 'Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor βtype I receptor', Journal of Biological Chemistry, 285, pp. 26798 - 26805, http://dx.doi.org/10.1074/jbc.M109.092767

Ballinger ML; Osman N; Hashimura K; Haan JBD; Jandeleit-Dahm K; Allen T; Tannock LR; Rutledge JC; Little PJ, 2010, 'Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo', Journal of Cellular and Molecular Medicine, 14, pp. 1408 - 1418, http://dx.doi.org/10.1111/j.1582-4934.2009.00902.x

Burch ML; Yang SNY; Ballinger ML; Getachew R; Osman N; Little PJ, 2010, 'TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2', Cellular and Molecular Life Sciences, 67, pp. 2077 - 2090, http://dx.doi.org/10.1007/s00018-010-0315-9

Cardoso LEM; Little PJ; Ballinger ML; Chan CK; Braun KR; Potter-Perigo S; Bornfeldt KE; Kinsella MG; Wight TN, 2010, 'Platelet-derived growth factor differentially regulates the expression and post-translational modification of versican by arterial smooth muscle cells through distinct protein kinase C and extracellular signal-regulated kinase pathways', Journal of Biological Chemistry, 285, pp. 6987 - 6995, http://dx.doi.org/10.1074/jbc.M109.088674

Getachew R; Ballinger ML; Burch ML; Little PJ; Osman N, 2010, 'Characterisation of Ki11502 as a potent inhibitor of PDGF β receptor-mediated proteoglycan synthesis in vascular smooth muscle cells', European Journal of Pharmacology, 626, pp. 186 - 192, http://dx.doi.org/10.1016/j.ejphar.2009.09.066

Getachew R; Ballinger M; Burch M; Reid J; Khachigian LM, 2010, 'PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminologycan elongationon biglycan and increases binding to LDL.', Endocrinology, 151, pp. 4356 - 4367

Ballinger ML; Ivey ME; Osman N; Thomas WG; Little PJ, 2009, 'Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL', Atherosclerosis, 205, pp. 451 - 457, http://dx.doi.org/10.1016/j.atherosclerosis.2009.01.024

Yang SNY; Burch ML; Getachew R; Ballinger ML; Osman N; Little PJ, 2009, 'Growth factor-mediated hyper-elongation of glycosaminoglycan chains on biglycan requires transcription and translation', Archives of Physiology and Biochemistry, 115, pp. 147 - 154, http://dx.doi.org/10.1080/13813450903110754

Osman N; Ballinger ML; Dadlani HM; Getachew R; Burch ML; Little PJ, 2008, 'p38 MAP kinase mediated proteoglycan synthesis as a target for the prevention of atherosclerosis', Cardiovascular and Hematological Disorders Drug Targets, 8, pp. 287 - 292, http://dx.doi.org/10.2174/187152908786786205

Ballinger ML; Osman N; Wilks AF; Su S; Burns CJ; Bu X; Little PJ, 2008, 'Pyrido-pyrimidine derivative CYC10424 inhibits glycosaminoglycan changes on vascular smooth muscle-derived proteoglycans and reduces lipoprotein binding', Journal of Cardiovascular Pharmacology, 52, pp. 403 - 412, http://dx.doi.org/10.1097/FJC.0b013e31818a8907

Dadlani H; Osman N; Ballinger ML; Marasco S; Little PJ, 2008, 'Calcific aortic valve disease and hypertension', Current Hypertension Reviews, 4, pp. 107 - 113, http://dx.doi.org/10.2174/157340208784245884

Dadlani H; Ballinger ML; Osman N; Getachew R; Little PJ, 2008, 'Smad and p38 MAP kinase-mediated signaling of proteoglycan synthesis in vascular smooth muscle', Journal of Biological Chemistry, 283, pp. 7844 - 7852, http://dx.doi.org/10.1074/jbc.M703125200

Little PJ; Ballinger ML; Survase S; Osman N; Ogru E; Geytenbeek S; Bruemmer D; Nigro J, 2008, 'Phosphorylated troglitazone activates PPARγ and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis', Journal of Cardiovascular Pharmacology, 51, pp. 274 - 279, http://dx.doi.org/10.1097/FJC.0b013e3181626ce7

Little PJ; Ballinger ML; Burch ML; Osman N, 2008, 'Biosynthesis of Natural and Hyperelongated Chondroitin Sulfate Glycosaminoglycans: New Insights into an Elusive Process', The Open Biochemistry Journal, 2, pp. 135 - 142, http://dx.doi.org/10.2174/1874091x00802010135

Little PJ; Osman N; de Dios ST; Cemerlang N; Ballinger M; Nigro J, 2007, 'Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: Thiazolidinediones (glitazones) have enhanced activity under high glucose conditions', Cardiovascular Diabetology, 6, http://dx.doi.org/10.1186/1475-2840-6-33

Grande-Allen KJ; Osman N; Ballinger ML; Dadlani H; Marasco S; Little PJ, 2007, 'Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease', Cardiovascular Research, 76, pp. 19 - 28, http://dx.doi.org/10.1016/j.cardiores.2007.05.014

Little PJ; Ballinger ML; Osman N, 2007, 'Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis', Vascular Health and Risk Management, 3, pp. 117 - 124

de Dios ST; Frontanilla KV; Nigro J; Ballinger ML; Ivey ME; Cawson EA; Little PJ, 2007, 'Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents', Journal of Diabetes and Its Complications, 21, pp. 108 - 117, http://dx.doi.org/10.1016/j.jdiacomp.2006.03.003

Nigro J; Ballinger M; Osman N; Dart A; Little P, 2005, 'Anti-Atherogenic Role of Peroxisome Proliferator-Activated Receptor Ligands', Current Cardiology Reviews, 1, pp. 89 - 102, http://dx.doi.org/10.2174/1573403054021654

Ballinger ML; Thomas MC; Nigro J; Ivey ME; Dilley RJ; Little PJ, 2005, 'Glycated and carboxy-methylated proteins do not directly activate human vascular smooth muscle cells', Kidney International, 68, pp. 2756 - 2765, http://dx.doi.org/10.1111/j.1523-1755.2005.00746.x

Nigro J; Ballinger ML; Survase S; Osman N; Little PJ, 2005, 'New approaches to regulating the chondroitin/dermatan sulfate glycosaminoglycan component of the vascular extracellular matrix.', Thescientificworldjournal, 5, pp. 515 - 520, http://dx.doi.org/10.1100/tsw.2005.69

Nigro J; Ballinger ML; Dilley RJ; Jennings GLR; Wight TN; Little PJ, 2004, 'Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding', Diabetologia, 47, pp. 2105 - 2113, http://dx.doi.org/10.1007/s00125-004-1588-z

Ballinger ML; Nigro J; Frontanilla KV; Dart AM; Little PJ, 2004, 'Regulation of glycosaminoglycan structure and atherogenesis', Cellular and Molecular Life Sciences, 61, pp. 1296 - 1306, http://dx.doi.org/10.1007/s00018-004-3389-4

Conference Papers

Maddula M; Cohen JE; Kumarasinghe D; Ballinger ML; Tearle JLE; James KR; Nagrial A; Barnet M; Thavaneswaran S, 2026, 'Risk Factors in Sporadic Early-Onset Colorectal Cancer, Current Evidence and Emerging Insights: A Systematic Review', in Cancers, http://dx.doi.org/10.3390/cancers18101515

Pavlakis N; Lee CK; Ballinger ML; Brown CSB; Grady JP; Lin F; Thavaneswaran S; Mersiades AJ; Zhou DD-X; Lee J; John T; Napier CE; Cummins MM; Collignon E; Sebastian L; Turnbull OMH; Simes J; Thomas DM; Solomon BJ, 2025, 'ASPiRATION. Australian Nationwide Cohort Study to Assess Impact of Comprehensive Genomic Profiling in Metastatic Lung Cancer', in JOURNAL OF THORACIC ONCOLOGY, ELSEVIER SCIENCE INC

Harris S; Gaughran G; Napier C; Yap M; Grady J; Caillet V; Ballinger M; Kee D; Thavaneswaran S; Davies A; Southi N; Thomas D, 2025, 'KRAS Mutations in Australian Gastrointestinal Cancer Patients: An Analysis of the Molecular Screening and Therapeutics (MoST) Program', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY

Hersch J; Butow P; Latin A; O’Hara L; Ballinger ML; Laidsaar-Powell R; Bartley N; Cockburn C; Mccaffery K; Juraskova I, 2024, '103 Coproducing a novel online intervention to support shared decision making about cancer genomic testing', BMJ, pp. a46.2 - a4a46, presented at ISDM Conference – AMH Randomised Trial Abstract, http://dx.doi.org/10.1136/bmjebm-2024-sdc.102

Zaheed M; Napier CE; Cops EJ; Ferris N; Moodie K; Milner B; Moses D; Poplawski N; Dow EG; Harris M; Tucker K; Trainer A; James P; Thomas DM; Ballinger ML, 2023, 'Long-term clinical and psychosocial outcomes of surveillance in Li Fraumeni syndrome.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2023 - 06 June 2023

Bartley N; Best MC; Biesecker BB; Fisher A; Goldstein D; Meiser B; Thomas DM; Ballinger ML; Butow P, 2021, 'Effectively communicating comprehensive tumour genomic profiling results: Mitigating uncertainty for advanced cancer patients', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 180 - 180, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000717281500295&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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