By Associate Professor Renee M Whan

Book Chapters

Pandzic E; Whan R; Macmillan A, 2022, 'Rapid FLIM Measurement of Membrane Tension Probe Flipper-TR', in Membrane Lipids: Methods and Protocols, pp. 257 - 283, http://dx.doi.org/10.1007/978-1-0716-1843-1_20

Pandzic E; Whan R; Macmillan A, 2021, 'Rapid FLIM Measurement of Membrane Tension Probe Flipper-TR', in Cranfield CG (ed.), Membrane Lipids. Methods in Molecular Biology, Springer Protocols, Humana, New York, NY, pp. 1 - 300, http://dx.doi.org/10.1007/978-1-0716-1843-1_20

Carnell M; Macmillan A; Whan R, 2015, 'Fluorescence recovery after photobleaching (FRAP): Acquisition, analysis, and applications', in , pp. 255 - 271, http://dx.doi.org/10.1007/978-1-4939-1752-5_18

Journal articles

Hamm JN; Liao Y; von Kügelgen A; Dombrowski N; Landers E; Brownlee C; Johansson EMV; Whan RM; Baker MAB; Baum B; Bharat TAM; Duggin IG; Spang A; Cavicchioli R, 2024, 'The parasitic lifestyle of an archaeal symbiont', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-49962-y

Tillu VA; Redpath GMI; Rae J; Ruan J; Yao Y; Cagigas ML; Whan R; Hardeman EC; Gunning PW; Ananthanarayanan V; Parton RG; Ariotti N, 2024, 'Precision in situ cryogenic correlative light and electron microscopy of optogenetically positioned organelles', Journal of Cell Science, 137, http://dx.doi.org/10.1242/jcs.262163

Manandhar B; Pandzic E; Deshpande N; Chen SY; Wasinger VC; Kockx M; Glaros EN; Ong KL; Thomas SR; Wilkins MR; Whan RM; Cochran BJ; Rye KA, 2024, 'ApoA-I Protects Pancreatic β-Cells from Cholesterol-Induced Mitochondrial Damage and Restores Their Ability to Secrete Insulin', Arteriosclerosis, Thrombosis, and Vascular Biology, 44, pp. E20 - E38, http://dx.doi.org/10.1161/ATVBAHA.123.319378

Li YE; Norris DM; Xiao FN; Pandzic E; Whan RM; Fok S; Zhou M; Du G; Liu Y; Du X; Yang H, 2024, 'Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains', Journal of Cell Biology, 223, http://dx.doi.org/10.1083/jcb.202307041

Johnson L; Bartlett-Tomasetig F; Fok S; Whan R; Berliner J; Hemley SJ; Stoodley MA; Bilston LE, 2023, 'A novel method to quantify perivascular space enlargement near the syrinx in a rodent model of post-traumatic syringomyelia', Scientific Reports, 13, http://dx.doi.org/10.1038/s41598-023-42275-y

Poursani EM; Mercatelli D; Raninga P; Bell JL; Saletta F; Kohane FV; Neumann DP; Zheng Y; Rouaen JRC; Jue TR; Michniewicz FT; Schadel P; Kasiou E; Tsoli M; Cirillo G; Waters S; Shai-Hee T; Cazzoli R; Brettle M; Slapetova I; Kasherman M; Whan R; Souza-Fonseca-Guimaraes F; Vahdat L; Ziegler D; Lock JG; Giorgi FM; Khanna KK; Vittorio O, 2023, 'Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer', Cell and Bioscience, 13, http://dx.doi.org/10.1186/s13578-023-01083-7

Lukmantara I; Chen F; Mak HY; Zadoorian A; Du X; Xiao FN; MacMurray Norris D; Pandzic E; Whan R; Zhong Q; Yang H, 2022, 'PI(3)P and DFCP1 regulate the biogenesis of lipid droplets', Molecular Biology of the Cell, 33, http://dx.doi.org/10.1091/mbc.E22-07-0279

Wong SL; Pandzic E; Kardia E; Allan KM; Whan RM; Waters SA, 2022, 'Quantifying Intracellular Viral Pathogen: Specimen Preparation, Visualization and Quantification of Multiple Immunofluorescent Signals in Fixed Human Airway Epithelium Cultured at Air-Liquid Interface', Journal of Personalized Medicine, 12, http://dx.doi.org/10.3390/jpm12101668

Wong SL; Awatade NT; Astore MA; Allan KM; Carnell MJ; Slapetova I; Chen PC; Setiadi J; Pandzic E; Fawcett LK; Widger JR; Whan RM; Griffith R; Ooi CY; Kuyucak S; Jaffe A; Waters SA, 2022, 'Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect', American Journal of Respiratory Cell and Molecular Biology, 67, pp. 99 - 111, http://dx.doi.org/10.1165/rcmb.2021-0337OC

Ahmed-Cox A; Macmillan AM; Pandzic E; Whan RM; Kavallaris M, 2022, 'Application of Rapid Fluorescence Lifetime Imaging Microscopy (RapidFLIM) to Examine Dynamics of Nanoparticle Uptake in Live Cells', Cells, 11, http://dx.doi.org/10.3390/cells11040642

Wong SL; Awatade NT; Astore MA; Allan KM; Carnell MJ; Slapetova I; Chen PC; Capraro A; Fawcett LK; Whan RM; Griffith R; Ooi CY; Kuyucak S; Jaffe A; Waters SA, 2022, 'Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity', iScience, 25, pp. 103710, http://dx.doi.org/10.1016/j.isci.2021.103710

Ahmed-Cox A; Pandzic E; Johnston ST; Heu C; McGhee J; Mansfeld FM; Crampin EJ; Davis TP; Whan RM; Kavallaris M, 2022, 'Spatio-temporal analysis of nanoparticles in live tumor spheroids impacted by cell origin and density', Journal of Controlled Release, 341, pp. 661 - 675, http://dx.doi.org/10.1016/j.jconrel.2021.12.014

Wang J; Browne L; Slapetova I; Shang F; Lee K; Lynch J; Beretov J; Whan R; Graham PH; Millar EKA, 2021, 'Multiplexed immunofluorescence identifies high stromal CD68⁺PD-L1⁺ macrophages as a predictor of improved survival in triple negative breast cancer', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-01116-6

Manandhar B; Pandzic E; Deshpande N; Chen S-Y; Wasinger VC; Kockx M; Glaros E; Ong KL; Thomas S; Wilkins M; Whan R; Cochran BJ; Rye KA, 2021, 'The Anti-Oxidant Function Of Apolipoprotein A-I Rescues Pancreatic beta-Cells From Cholesterol-Induced Mitochondrial Dysfunction', ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 41, http://dx.doi.org/10.1161/atvb.41.suppl_1.122

Tikoo S; Jain R; Tomasetig F; On K; Martinez B; Heu C; Stehle D; Obeidy P; Guo D; Vincent JN; Cook AJL; Roediger B; Feil R; Whan RM; Weninger W, 2021, 'Amelanotic B16-F10 Melanoma Compatible with Advanced Three-Dimensional Imaging Modalities', Journal of Investigative Dermatology, 141, pp. 2090 - 2094.e6, http://dx.doi.org/10.1016/j.jid.2021.01.025

Li YE; Wang Y; Du X; Zhang T; Mak H; Hancock SE; McEwen H; Pandzic E; Whan RM; Aw YC; Lukmantara IE; Yuan Y; Dong X; Don A; Turner N; Qi S; Yang H, 2021, 'TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/jcb.202103105

Awatade N; Wong S; Capraro A; Pandzic E; Slapetova I; Zhong L; Fawcett L; Whan R; Jaffe A; Waters S, 2021, 'Significant functional differences in differentiated Conditionally Reprogrammed (CRC)- and Feeder-free Dual SMAD inhibited-expanded human nasal epithelial cells', Journal of Cystic Fibrosis, 20, pp. 364 - 371, http://dx.doi.org/10.1016/j.jcf.2020.12.019

Pandzic E; Whan RM, 2021, 'A Practical Guide to Fluorescence Temporal and Spatial Correlation Spectroscopy', The Biophysicist, 2, pp. 40 - 69, http://dx.doi.org/10.35459/tbp.2019.000143

Capraro A; Wong S; Adhikari A; Allan K; Patel H; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan R; Turville S; Vittorio O; Bull R; Kaakoush N; Rawlinson W; Tedla N; Vafaee F; Waters S, 2021, 'Ageing impairs the airway epithelium defence response to SARS-CoV-2', , http://dx.doi.org/10.1101/2021.04.05.437453

Capraro A; Whan R; Thomas S; Jaffe A; Bridge W; Waters S; Hart-Smith G; Zhong L; Pandzic E; Fernando BSM; Awatade N; Wong S, 2020, 'Novel Antioxidant Therapy with the Immediate Precursor to Glutathione, -Glutamylcysteine (GGC), Ameliorates LPS-Induced Cellular Stress in In Vitro 3D-Differentiated Airway Model from Primary Cystic Fibrosis Human Bronchial Cells', Antioxidants, 9, pp. 1 - 19, http://dx.doi.org/10.3390/antiox9121204

Millar E; Browne L; Slapetova I; Shang F; Ren Y; Bradshaw R; Brauer HA; O’toole S; Beretov J; Whan R; Graham PH, 2020, 'Tils immunophenotype in breast cancer predicts local failure and overall survival: Analysis in a large radiotherapy trial with long-term follow-up', Cancers, 12, pp. 1 - 15, http://dx.doi.org/10.3390/cancers12092365

Pandzic E; Morkel CA; Li A; Cooke R; Whan RM; dos Remedios CG, 2020, 'Nanomolar ATP binding to single myosin cross-bridges in rigor: a molecular approach to studying myosin ATP kinetics using single human cardiomyocytes', Biophysical Reviews, 12, pp. 1031 - 1040, http://dx.doi.org/10.1007/s12551-020-00716-2

Tjandra KC; McCarthy N; Yang L; Laos AJ; Sharbeen G; Phillips PA; Forgham H; Sagnella SM; Whan RM; Kavallaris M; Thordarson P; McCarroll JA, 2020, 'Identification of Novel Medulloblastoma Cell-Targeting Peptides for Use in Selective Chemotherapy Drug Delivery', Journal of Medicinal Chemistry, 63, pp. 2181 - 2193, http://dx.doi.org/10.1021/acs.jmedchem.9b00851

Putra VDL; Song MJ; McBride-Gagyi S; Chang H; Poole K; Whan R; Dean D; Sansalone V; Knothe Tate ML, 2020, 'Mechanomics Approaches to Understand Cell Behavior in Context of Tissue Neogenesis, During Prenatal Development and Postnatal Healing', Frontiers in Cell and Developmental Biology, 7, pp. 354, http://dx.doi.org/10.3389/fcell.2019.00354

Syed SM; Kumar M; Ghosh A; Tomasetig F; Ali A; Whan RM; Alterman D; Tanwar PS, 2020, 'Endometrial Axin2⁺ Cells Drive Epithelial Homeostasis, Regeneration, and Cancer following Oncogenic Transformation', Cell Stem Cell, 26, pp. 64 - 80.e13, http://dx.doi.org/10.1016/j.stem.2019.11.012

Awatade N; Wong S; Pandzic E; Slapetova I; Capraro A; Zhong L; Turgutoglu N; Fawcett L; Whan R; Jaffe A; Waters S, 2020, 'Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD inhibited expanded human nasal epithelial cells', , http://dx.doi.org/10.1101/2020.05.29.120006

Putra VDL; Jalilian I; Campbell M; Poole K; Whan R; Tomasetig F; Knothe Tate ML, 2019, 'Mapping the Mechanome–A Protocol for Simultaneous Live Imaging and Quantitative Analysis of Cell Mechanoadaptation and Ingression', Bio-protocol, 9, http://dx.doi.org/10.21769/BioProtoc.3439

Sitiwin E; Madigan MC; Gratton E; Cherepanoff S; Conway RM; Whan R; Macmillan A, 2019, 'Shedding light on melanins within in situ human eye melanocytes using 2-photon microscopy profiling techniques', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-54871-y

Meiring JCM; Bryce NS; Cagigas ML; Benda A; Whan RM; Ariotti N; Parton RG; Stear JH; Hardeman EC; Gunning PW; Lastra Cagigas M, 2019, 'Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres', Journal of Cell Science, 132, pp. jcs228916, http://dx.doi.org/10.1242/jcs.228916

Kopecky C; Pandzic E; Parmar A; Szajer J; Lee V; Dupuy A; Arthur A; Fok S; Whan R; Ryder WJ; Rye KA; Cochran BJ, 2019, 'Translocator protein localises to CD11b ⁺ macrophages in atherosclerosis', Atherosclerosis, 284, pp. 153 - 159, http://dx.doi.org/10.1016/j.atherosclerosis.2019.03.011

Park M; Richardson A; Pandzic E; Lobo EP; Whan R; Watson SL; Lyons JG; Wakefield D; Di Girolamo N, 2019, 'Visualizing the Contribution of Keratin-14⁺ Limbal Epithelial Precursors in Corneal Wound Healing', Stem Cell Reports, 12, pp. 14 - 28, http://dx.doi.org/10.1016/j.stemcr.2018.11.014

Sagnella SM; Trieu J; Brahmbhatt H; MacDiarmid JA; MacMillan A; Whan RM; Fife CM; McCarroll JA; Gifford AJ; Ziegler DS; Kavallaris M, 2018, 'Targeted doxorubicin-loaded bacterially derived nano-cells for the treatment of neuroblastoma', Molecular Cancer Therapeutics, 17, pp. 1012 - 1023, http://dx.doi.org/10.1158/1535-7163.MCT-17-0738

Pandžić E; Abu-Arish A; Whan RM; Hanrahan JW; Wiseman PW, 2018, 'Velocity landscape correlation resolves multiple flowing protein populations from fluorescence image time series', Methods, 140-141, pp. 126 - 139, http://dx.doi.org/10.1016/j.ymeth.2018.02.011

Chua SW; Cornejo A; Van Eersel J; Stevens CH; Vaca I; Cueto M; Kassiou M; Gladbach A; Macmillan A; Lewis L; Whan R; Ittner LM, 2017, 'The Polyphenol Altenusin Inhibits in Vitro Fibrillization of Tau and Reduces Induced Tau Pathology in Primary Neurons', ACS Chemical Neuroscience, 8, pp. 743 - 751, http://dx.doi.org/10.1021/acschemneuro.6b00433

Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504

Pandzic E; Gelissen IC; Whan R; Barter PJ; Sviridov D; Gaus K; Rye KA; Cochran BJ, 2017, 'The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments', Scientific Reports, 7, http://dx.doi.org/10.1038/srep42025

Ng JL; Knothe LE; Whan RM; Knothe U; Knothe Tate ML, 2017, 'Scale-up of nature's tissue weaving algorithms to engineer advanced functional materials', Nature Scientific Reports, 7, pp. 40396, http://dx.doi.org/10.1038/srep40396

Yu NYC; O'Brien CA; Slapetova I; Whan RM; Knothe Tate ML, 2017, 'Live Tissue Imaging to Elucidate Mechanical Modulation of Stem Cell Niche Quiescence.', Stem Cells Transl Med, 6, pp. 285 - 292, http://dx.doi.org/10.5966/sctm.2015-0306

Nicovich PR; Janco M; Sobey T; Gajwani M; Obeidy P; Whan R; Gaus K; Gunning PW; Coster ACF; Böcking T, 2016, 'Effect of surface chemistry on tropomyosin binding to actin filaments on surfaces', Cytoskeleton, 73, pp. 729 - 738, http://dx.doi.org/10.1002/cm.21342

Benda A; Aitken H; Davies DS; Whan R; Goldsbury C, 2016, 'STED imaging of tau filaments in Alzheimer's disease cortical grey matter', Journal of Structural Biology, 195, pp. 345 - 352, http://dx.doi.org/10.1016/j.jsb.2016.07.003

Yu NYC; O'Brien CA; Slapetova I; Whan R; Knothe Tate ML, 2016, 'Live cell imaging to elucidate mechanical modulation of stem cell niche quiescence', Stem cells translational medicine, http://dx.doi.org/10.5966/sctm.2015-0306

Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113

Moore SR; Heu C; Yu NYC; Knothe U; Milz S; Knothe Tate ML; Whan R, 2016, 'Translating Periosteum's Regenerative Power: Insights from Quantitative Analysis of Tissue Genesis with a Periosteum Substitute Implant', Stem Cells Translational Medicine, 5, pp. 1739 - 1749, http://dx.doi.org/10.5966/sctm.2016-0004

Constantine M; Liew CK; Lo V; MacMillan A; Cranfield CG; Sunde M; Whan R; Graham RM; Martinac B, 2016, 'Heterologously-expressed and Liposome-reconstituted Human Transient Receptor Potential Melastatin 4 Channel (TRPM4) is a Functional Tetramer', Scientific Reports, 6, http://dx.doi.org/10.1038/srep19352

Carmona-Mora P; Widagdo J; Tomasetig F; Canales CP; Cha Y; Lee W; Alshawaf A; Dottori M; Whan RM; Hardeman EC; Palmer SJ, 2015, 'The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation', Human Genetics, 134, pp. 1099 - 1115, http://dx.doi.org/10.1007/s00439-015-1591-0

Nicovich PR; Macartney EL; Whan RM; Crean AJ, 2015, 'Measuring Sperm Movement within the Female Reproductive Tract using Fourier Analysis', Microscopy and Microanalysis, 21, pp. 256 - 263, http://dx.doi.org/10.1017/S1431927614014627

Jalilian I; Heu C; Cheng H; Freittag H; Desouza M; Stehn JR; Bryce NS; Whan RM; Hardeman EC; Fath T; Schevzov G; Gunning PW, 2015, 'Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton', PLoS ONE, 10, pp. e0126214, http://dx.doi.org/10.1371/journal.pone.0126214

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