By Dr Brenna Osborne

Book Chapters

Osborne B; Brandon AE; Smith GC; Turner N, 2019, 'Impact of lifestyle and clinical interventions on mitochondrial function in obesity and type 2 diabetes', in Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases, pp. 367 - 397, http://dx.doi.org/10.1016/B978-0-12-811752-1.00016-X

Osborne B; Brandon A; Smith GC; Turner N, 2019, 'Impact of Lifestyle and Clinical Interventions on Mitochondrial Function in Obesity and Type 2 Diabetes', in Morio B; Pénicaud L; Rigoulet M (ed.), Mitochondria in Obesity and Type 2 Diabetes, Elsevier, pp. 367 - 397, http://dx.doi.org/10.1016/C2016-0-01694-7

Osborne B; Keane FM; Chowdhury S; Yao TW; Nadvi NA; Gall MG; Chen Y; Ribeiro AJV; Church WB; McCaughan GW; Gorrell MD; Yu DMT, 2011, 'Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy', in Dunn B (ed.), Proteinases as Drug Targets, Royal Society of Chemistry, Cambridge, UK, pp. 118 - 144, http://dx.doi.org/10.1039/9781849733151

Journal articles

Petr MA; Matiyevskaya F; Osborne B; Berglind M; Reves S; Zhang B; Ezra MB; Carmona-Marin LM; Syadzha MF; Mediavilla MC; Keijzers G; Bakula D; Mkrtchyan GV; Scheibye-Knudsen M, 2024, 'Pharmacological interventions in human aging', Ageing Research Reviews, 95, http://dx.doi.org/10.1016/j.arr.2024.102213

Osborne B; Wright LE; Brandon AE; Stuart E; Small L; Hoeks J; Schrauwen P; Sinclair DA; Montgomery MK; Cooney GJ; Turner N, 2023, 'SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance', The Journal of endocrinology, 258, pp. e220101, http://dx.doi.org/10.1530/JOE-22-0101

Heckenbach I; Mkrtchyan GV; Ezra MB; Bakula D; Madsen JS; Nielsen MH; Oró D; Osborne B; Covarrubias AJ; Idda ML; Gorospe M; Mortensen L; Verdin E; Westendorp R; Scheibye-Knudsen M, 2022, 'Nuclear morphology is a deep learning biomarker of cellular senescence', Nature Aging, 2, pp. 742 - 755, http://dx.doi.org/10.1038/s43587-022-00263-3

Osborne B; Reznick J; Wright LE; Sinclair DA; Cooney GJ; Turner N, 2022, 'Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice', Biochemical and Biophysical Research Communications, 607, pp. 131 - 137, http://dx.doi.org/10.1016/j.bbrc.2022.03.088

Mkrtchyan GV; Abdelmohsen K; Andreux P; Bagdonaite I; Barzilai N; Brunak S; Cabreiro F; Cabo RD; Campisi J; Cuervo AM; Demaria M; Ewald CY; Fang EF; Faragher R; Ferrucci L; Freund A; Silva-García CG; Georgievskaya A; Gladyshev VN; Glass DJ; Gorbunova V; Grey AD; He WW; Hoeijmakers J; Hoffmann E; Horvath S; Houtkooper RH; Jensen MK; Jensen MB; Kane A; Kassem M; Keizer PD; Kennedy B; Karsenty G; Lamming DW; Lee KF; MacAulay N; Mamoshina P; Mellon J; Molenaars M; Moskalev A; Mund A; Niedernhofer L; Osborne B; Pak HH; Parkhitko A; Raimundo N; Rando TA; Rasmussen LJ; Reis C; Riedel CG; Franco-Romero A; Schumacher B; Sinclair DA; Suh Y; Taub PR; Toiber D; Treebak JT; Valenzano DR; Verdin E; Vijg J; Young S; Zhang L; Bakula D; Zhavoronkov A; Scheibye-Knudsen M, 2020, 'ARDD 2020: from aging mechanisms to interventions', Aging, 12, pp. 24486 - 24503, http://dx.doi.org/10.18632/aging.202454

Xi CR; Di Fazio A; Nadvi NA; Patel K; Xiang MSW; Zhang HE; Deshpande C; Low JKK; Wang XT; Chen Y; McMillan CLD; Isaacs A; Osborne B; de Ribeiro AJV; McCaughan GW; Mackay JP; Church WB; Gorrell MD, 2020, 'A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2', Molecules, 25, http://dx.doi.org/10.3390/MOLECULES25225392

Osborne B; Bakula D; Ben Ezra M; Dresen C; Hartmann E; Kristensen SM; Mkrtchyan GV; Nielsen MH; Petr MA; Scheibye-Knudsen M, 2020, 'New methodologies in ageing research', Ageing Research Reviews, 62, http://dx.doi.org/10.1016/j.arr.2020.101094

, 2020, 'Next generation diabetes scientists shape global research culture: A reflective proposal from postdoctoral researchers in diabetes research', Acta Physiologica, 229, http://dx.doi.org/10.1111/apha.13455

Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, 219, http://dx.doi.org/10.1083/jcb.201905162

Montgomery MK; Osborne B; Brandon AE; O'Reilly L; Fiveash CE; Brown SHJ; Wilkins BP; Samsudeen A; Yu J; Devanapalli B; Hertzog A; Tolun AA; Kavanagh T; Cooper AA; Mitchell TW; Biden TJ; Smith NJ; Cooney GJ; Turner N, 2019, 'Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84', FASEB Journal, 33, pp. 12264 - 12276, http://dx.doi.org/10.1096/fj.201900234R

Liu M; Hancock SE; Sultani G; Wilkins BP; Ding E; Osborne B; Quek LE; Turner N, 2019, 'Snail-overexpression induces epithelialmesenchymal transition and metabolic reprogramming in human pancreatic ductal adenocarcinoma and non-tumorigenic ductal cells', Journal of Clinical Medicine, 8, http://dx.doi.org/10.3390/jcm8060822

Somers K; Wen VW; Middlemiss SMC; Osborne B; Forgham H; Jung MS; Karsa M; Clifton M; Bongers A; Gao J; Mayoh C; Raoufi-Rad N; Kusnadi EP; Hannan KM; Scott DA; Kwek A; Liu B; Flemming C; Chudakova DA; Pandher R; Failes TW; Lim J; Angeli A; Osterman AL; Imamura T; Kees UR; Supuran CT; Pearson RB; Hannan RD; Davis TP; McCarroll J; Kavallaris M; Turner N; Gudkov AV; Haber M; Norris MD; Henderson MJ, 2019, 'A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction', Oncogene, 38, pp. 3824 - 3842, http://dx.doi.org/10.1038/s41388-018-0666-5

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2019, 'Erratum: Impairment of an Endothelial NAD⁺-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))', Cell, 176, pp. 944 - 945, http://dx.doi.org/10.1016/j.cell.2019.01.026

Keijzers G; Bakula D; Petr MA; Madsen NGK; Teklu A; Mkrtchyan G; Osborne B; Scheibye-Knudsen M, 2019, 'Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20010074

Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS; Brandon A, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, 9, pp. 3165, http://dx.doi.org/10.1038/s41467-018-05613-7

Bentley NL; Fiveash CE; Osborne B; Quek LE; Ogura M; Inagaki N; Cooney GJ; Polly P; Montgomery MK; Turner N, 2018, 'Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice', Biochemical and Biophysical Research Communications, 503, pp. 1349 - 1355, http://dx.doi.org/10.1016/j.bbrc.2018.07.047

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD⁺-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, 173, pp. 74 - 89.e20, http://dx.doi.org/10.1016/j.cell.2018.02.008

Sultani G; Samsudeen AF; Osborne B; Turner N, 2017, 'NAD⁺: A key metabolic regulator with great therapeutic potential', Journal of Neuroendocrinology, 29, http://dx.doi.org/10.1111/jne.12508

Montgomery MK; Brown SHJ; Lim XY; Fiveash CE; Osborne B; Bentley NL; Braude JP; Mitchell TW; Coster ACF; Don AS; Cooney GJ; Schmitz-Peiffer C; Turner N, 2016, 'Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861, pp. 1828 - 1839, http://dx.doi.org/10.1016/j.bbalip.2016.08.016

Osborne B; Bentley NL; Montgomery MK; Turner N, 2016, 'The role of mitochondrial sirtuins in health and disease', Free Radical Biology and Medicine, 100, pp. 164 - 174, http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.197

Turner N; Zeng XY; Osborne B; Rogers S; Ye JM, 2016, 'Repurposing Drugs to Target the Diabetes Epidemic', Trends in Pharmacological Sciences, 37, pp. 379 - 389, http://dx.doi.org/10.1016/j.tips.2016.01.007

Hayward B; Molero JC; Windmill K; Sanigorski A; Weir J; McRae NL; Aston-Mourney K; Osborne B; Liao B; Walder KR; Meikle PJ; Konstantopoulos N; Schmitz-Peiffer C, 2016, 'Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate', Experimental and Clinical Endocrinology and Diabetes, 124, pp. 602 - 612, http://dx.doi.org/10.1055/s-0042-111516

Montgomery MK; Fiveash CE; Braude JP; Osborne B; Brown SHJ; Mitchell TW; Turner N, 2015, 'Disparate metabolic response to fructose feeding between different mouse strains', Scientific Reports, 5, http://dx.doi.org/10.1038/srep18474

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602

Liu M; Montgomery MK; Fiveash CE; Osborne B; Cooney GJ; Bell-Anderson K; Turner N, 2014, 'PPARα -independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis', Scientific Reports, 4, http://dx.doi.org/10.1038/srep05538

Osborne B; Yao TW; Wang XM; Chen Y; Kotan LD; Nadvi NA; Herdem M; McCaughan GW; Allen JD; Yu DMT; Topaloglu AK; Gorrell MD, 2014, 'A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation', Biochimica et Biophysica Acta - Proteins and Proteomics, 1844, pp. 1248 - 1259, http://dx.doi.org/10.1016/j.bbapap.2014.03.015

Osborne B; Cooney GJ; Turner N, 2014, 'Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?', Biochimica et Biophysica Acta - General Subjects, 1840, pp. 1295 - 1302, http://dx.doi.org/10.1016/j.bbagen.2013.08.016

Montgomery MK; Osborne B; Brown SHJ; Small L; Mitchell TW; Cooney GJ; Turner N, 2013, 'Contrasting metabolic effects of medium-versus long-chain fatty acids in skeletal muscle', Journal of Lipid Research, 54, pp. 3322 - 3333, http://dx.doi.org/10.1194/jlr.M040451

Keane FM; Yao TW; Seelk S; Gall MG; Chowdhury S; Poplawski SE; Lai JH; Li Y; Wu W; Farrell P; Vieira de Ribeiro AJ; Osborne B; Yu DM; Seth D; Rahman K; Haber P; Topaloglu AK; Wang C; Thomson S; Hennessy A; Prins J; Twigg SM; McLennan SV; McCaughan GW; Bachovchin WW; Gorrell MD, 2013, 'Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs.', FEBS Open Bio, 4, pp. 43 - 54, http://dx.doi.org/10.1016/j.fob.2013.12.001

Osborne B; Montgomery M; Reznick J; Cooney GJ; Turner N, 2012, 'Effect of acute hepatic overexpression of SIRT3 on metabolic parameters in short-term high fat fed mice', DIABETOLOGIA, 55, pp. S263 - S263, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208826501385&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Yu DMT; Yao TW; Chowdhury S; Nadvi NA; Osborne B; Church WB; McCaughan GW; Gorrell MD, 2010, 'The dipeptidyl peptidase IV family in cancer and cell biology', FEBS Journal, 277, pp. 1126 - 1144, http://dx.doi.org/10.1111/j.1742-4658.2009.07526.x

Xin MW; Yao TW; Nadvi NA; Osborne B; McCaughan GW; Gorrell MD, 2008, 'Fibroblast activation protein and chronic liver disease', Frontiers in Bioscience, 13, pp. 3168 - 3180, http://dx.doi.org/10.2741/2918

Conference Abstracts

Sultani G; Bentley N; Osborne B; Joshi S; Araki T; Montgomery M; Polly P; Byrne F; Wu L; Turner N, 2018, 'PO-011 Impact of compartment-specific changes in NAD biosynthesis on diethylnitrosamine-induced liver cancer', in ESMO Open, Elsevier BV, Vol. 3, pp. A25 - A25, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.56

Montgomery MK; Brandon AE; O'Reilly L; Osborne B; Fiveash CE; Brown SH; Smith NJ; Mitchell TW; Biden TJ; Cooney GJ; Turner N, 2016, 'The free fatty acid receptor GPR84: A new player in glucose tolerance and mitochondrial function?', in DIABETOLOGIA, SPRINGER, GERMANY, Munich, Vol. 59, pp. S322 - S322, presented at 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), GERMANY, Munich, 12 September 2016 - 16 September 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000398373702048&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hoeks J; Wright L; Jörgensen JA; Osborne B; Montgomery M; Cooney G; Schrauwen P; Turner N, 2012, 'PS - 46. SIRT3 overexpression in rat skeletal muscle does not alleviate high-fat diet-induced insulin resistance', in Nederlands Tijdschrift voor Diabetologie, Springer Science and Business Media LLC, Vol. 10, pp. 130 - 130, http://dx.doi.org/10.1007/s12467-012-0080-5

Theses / Dissertations

Osborne B, 2015, An investigation of the mitochondrial sirtuin enzyme SIRT3 and its influence on the response of skeletal muscle and liver to lipid oversupply

Preprints

Petr MA; Carmona-Marin L; Tulika T; Kristensen S; Reves S; Bakula D; Keijzers G; Osborne B; Mitchell S; Hamilton S; Kato J; Alfaras I; Teklu A; Heckenbach I; Madsen J; Ezra MB; Mkrtchyan G; Varner E; Fink B; Krusenstiern EV; Snyder N; Herranz H; Cabo RD; Scheibye-Knudsen M, 2022, Ketones facilitate transcriptional resolution of secondary DNA structures in premature aging, http://dx.doi.org/10.1101/2022.03.08.483430

Amanda Tan RP; Kozlova I; Su F; Sah S; Keable R; Hagan W; Bustamante S; Du X; Osborne B; Turner N; Clemens K; Begg D; Phelps E; Yang H; Leshchyns’ka I; Sytnyk V, 2022, Neuronal growth regulator 1 (NEGR1) promotes synaptic targeting of glutamic acid decarboxylase 65 (GAD65), http://dx.doi.org/10.1101/2022.02.08.479601

Xi C; Arianna Di Fazio A; Nadvi N; Patel K; Xiang M; Zhang HE; Deshpande C; Low J; Wang XT; Chen Y; McMillan C; Isaacs A; Osborne B; Vieira de Ribeiro AJ; McCaughan G; Mackay J; Church B; Gorrell M, 2020, A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2, http://dx.doi.org/10.20944/preprints202009.0390.v2

Xi C; Arianna Di Fazio A; Nadvi N; Patel K; Xiang M; Zhang HE; Deshpande C; Low J; Wang XT; Chen Y; Osborne B; Vieira de Ribeiro AJ; McCaughan G; Church B; Mackay J; Gorrell M, 2020, A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2, http://dx.doi.org/10.20944/preprints202009.0390.v1

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