By Dr Charles Cox

Journal articles

Wang HJ; Wang Y; Mirjavadi SS; Andersen T; Moldovan L; Vatankhah P; Russell B; Jin J; Zhou Z; Li Q; Cox CD; Su QP; Ju LA, 2024, 'Microscale geometrical modulation of PIEZO1 mediated mechanosensing through cytoskeletal redistribution', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-49833-6

Guo Y; Cheng D; Yu ZY; Schiatti T; Chan AY; Hill AP; Peyronnet R; Feneley MP; Cox CD; Martinac B, 2024, 'Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL-1 atrial myocytes', Journal of Physiology, 602, pp. 4363 - 4386, http://dx.doi.org/10.1113/JP284474

Cox CD; Poole K; Martinac B, 2024, 'Re-evaluating TRP channel mechanosensitivity', Trends in Biochemical Sciences, 49, pp. 693 - 702, http://dx.doi.org/10.1016/j.tibs.2024.05.004

Janbandhu V; Tallapragada V; Li JV; Shewale B; Ghazanfar S; Patrick R; Cox CD; Harvey RP, 2024, 'Novel Mouse Model for Selective Tagging, Purification, and Manipulation of Cardiac Myofibroblasts', Circulation, 149, pp. 1931 - 1934, http://dx.doi.org/10.1161/CIRCULATIONAHA.123.067754

Han Y; Zhou Z; Jin R; Dai F; Ge Y; Ju X; Ma X; He S; Yuan L; Wang Y; Yang W; Yue X; Chen Z; Sun Y; Corry B; Cox CD; Zhang Y, 2024, 'Mechanical activation opens a lipid-lined pore in OSCA ion channels', Nature, 628, pp. 910 - 918, http://dx.doi.org/10.1038/s41586-024-07256-9

Cheng D; Zhou Z; Li J; Yao M; Cox CD, 2024, 'PIEZO1 channels as regulators of integrin-mediated focal adhesions in cardiac fibroblasts', Biophysical Journal, 123, pp. 68a - 68a, http://dx.doi.org/10.1016/j.bpj.2023.11.485

Zhang M; Shan Y; Cox CD; Pei D, 2023, 'A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-39688-8

Yang S; Miao X; Arnold S; Li B; Ly AT; Wang H; Wang M; Guo X; Pathak MM; Zhao W; Cox CD; Shi Z, 2023, 'Author Correction: Membrane curvature governs the distribution of Piezo1 in live cells (Nature Communications, (2022), 13, 1, (7467), 10.1038/s41467-022-35034-6)', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-36108-9

Bavi N; Cox CD; Nikolaev YA; Martinac B, 2023, 'Molecular insights into the force-from-lipids gating of mechanosensitive channels', Current Opinion in Physiology, 36, http://dx.doi.org/10.1016/j.cophys.2023.100706

Zhang Y; Jiang F; Zhao YC; Cho AN; Fang G; Cox CD; Zreiqat H; Lu ZF; Lu H; Ju LA, 2023, '3D spheroid-microvasculature-on-a-chip for tumor-endothelium mechanobiology interplay', Biomedical Materials (Bristol), 18, http://dx.doi.org/10.1088/1748-605X/ace7a4

Zhou Z; Ma X; Lin Y; Cheng D; Bavi N; Secker GA; Li JV; Janbandhu V; Sutton DL; Scott HS; Yao M; Harvey RP; Harvey NL; Corry B; Zhang Y; Cox CD, 2023, 'MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels', Science, 381, pp. 799 - 804, http://dx.doi.org/10.1126/science.adh8190

Cheng D; Wang J; Yao M; Cox CD, 2023, 'Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions', Biochemical Society Transactions, http://dx.doi.org/10.1042/BST20230042

Yang S; Miao X; Arnold S; Li B; Ly A; Wang H; Wang M; Guo X; Pathak MM; Zhao W; Cox CD; Shi Z, 2023, 'Membrane curvature governs the distribution of Piezo1 in live cells', Biophysical Journal, 122, pp. 58a - 58a, http://dx.doi.org/10.1016/j.bpj.2022.11.525

Bavi O; Zhou Z; Bavi N; Mehdi Vaez Allaei S; Cox CD; Martinac B, 2022, 'Asymmetric effects of amphipathic molecules on mechanosensitive channels', Scientific Reports, 12, http://dx.doi.org/10.1038/s41598-022-14446-w

Yang S; Miao X; Arnold S; Li B; Ly AT; Wang H; Wang M; Guo X; Pathak MM; Zhao W; Cox CD; Shi Z, 2022, 'Membrane curvature governs the distribution of Piezo1 in live cells', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-35034-6

Yao M; Tijore A; Cheng D; Li JV; Hariharan A; Martinac B; Van Nhieu GT; Cox CD; Sheetz M, 2022, 'Force- and cell state–dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry', Science Advances, 8, http://dx.doi.org/10.1126/sciadv.abo1461

Lai A; Thurgood P; Cox CD; Chheang C; Peter K; Jaworowski A; Khoshmanesh K; Baratchi S, 2022, 'Piezo1 Response to Shear Stress Is Controlled by the Components of the Extracellular Matrix', ACS Applied Materials and Interfaces, 14, pp. 40559 - 40568, http://dx.doi.org/10.1021/acsami.2c09169

Yu ZY; Gong H; Kesteven S; Guo Y; Wu J; Li JV; Cheng D; Zhou Z; Iismaa SE; Kaidonis X; Graham RM; Cox CD; Feneley MP; Martinac B, 2022, 'Piezo1 is the cardiac mechanosensor that initiates the cardiomyocyte hypertrophic response to pressure overload in adult mice', Nature Cardiovascular Research, 1, pp. 577 - 591, http://dx.doi.org/10.1038/s44161-022-00082-0

Fatkin D; Cox CD; Martinac B, 2022, 'Fishing for Links between Omega-3 Fatty Acids and Atrial Fibrillation', Circulation, 145, pp. 1037 - 1039, http://dx.doi.org/10.1161/CIRCULATIONAHA.121.058596

Lai A; Cox CD; Chandra Sekar N; Thurgood P; Jaworowski A; Peter K; Baratchi S, 2022, 'Mechanosensing by Piezo1 and its implications for physiology and various pathologies', Biological Reviews, 97, pp. 604 - 614, http://dx.doi.org/10.1111/brv.12814

Wang H; Obeidy P; Wang Z; Zhao Y; Wang Y; Su QP; Cox CD; Ju LA, 2022, 'Fluorescence-coupled micropipette aspiration assay to examine calcium mobilization caused by red blood cell mechanosensing', European Biophysics Journal, 51, pp. 135 - 146, http://dx.doi.org/10.1007/s00249-022-01595-z

dos Remedios C; Cranfield C; Whelan D; Cox C; Shearwin K; Ho J; Allen T; Shibuya R; Hibino E; Hayashi K; Li A, 2022, 'A special issue of the Australian society for Biophysics', Biophysical Reviews, 14, http://dx.doi.org/10.1007/s12551-022-00936-8

Chow PH; Cox CD; Pei JV; Anabaraonye N; Nourmohammadi S; Henderson SW; Martinac B; Abdulmalik O; Yool AJ, 2022, 'Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling', Frontiers in Pharmacology, 12, http://dx.doi.org/10.3389/fphar.2021.794791

Kuchel PW; Romanenko K; Shishmarev D; Galvosas P; Cox CD, 2021, 'Enhanced Ca²⁺ influx in mechanically distorted erythrocytes measured with ¹⁹F nuclear magnetic resonance spectroscopy', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-83044-z

Li JV; Ng CA; Cheng D; Zhou Z; Yao M; Guo Y; Yu ZY; Ramaswamy Y; Ju LA; Kuchel PW; Feneley MP; Fatkin D; Cox CD, 2021, 'Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations', Communications Biology, 4, http://dx.doi.org/10.1038/s42003-021-02528-w

Kuchel PW; Cox CD; Daners D; Shishmarev D; Galvosas P, 2021, 'Surface model of the human red blood cell simulating changes in membrane curvature under strain', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-92699-7

Zhou Z; Li JV; Martinac B; Cox CD, 2021, 'Loss-of-Function Piezo1 Mutations Display Altered Stability Driven by Ubiquitination and Proteasomal Degradation', Frontiers in Pharmacology, 12, http://dx.doi.org/10.3389/fphar.2021.766416

Cox CD; Zhang Y; Zhou Z; Walz T; Martinac B, 2021, 'Cyclodextrins increase membrane tension and are universal activators of mechanosensitive channels', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2104820118

Cranfield C; Whelan D; Cox C; Shearwin K; Ho J; Allen T; Shibuya R; Hibino E; Hayashi K; dos Remedios C; Li A, 2021, 'Announcing the call for the Special Issue on “The Australian Society for Biophysics (ASB) – 2021 Meeting”', Biophysical Reviews, 13, pp. 485 - 486, http://dx.doi.org/10.1007/s12551-021-00813-w

Guo Y; Yu ZY; Wu J; Gong H; Kesteven S; Iismaa SE; Chan AY; Holman S; Pinto S; Pironet A; Cox CD; Graham RM; Vennekens R; Feneley MP; Martinac B, 2021, 'The ca²⁺-activated cation channel trpm4 is a positive regulator of pressure overload-induced cardiac hypertrophy', eLife, 10, http://dx.doi.org/10.7554/eLife.66582

Lai A; Chen YC; Cox CD; Jaworowski A; Peter K; Baratchi S, 2021, 'Analyzing the shear-induced sensitization of mechanosensitive ion channel Piezo-1 in human aortic endothelial cells', Journal of Cellular Physiology, 236, pp. 2976 - 2987, http://dx.doi.org/10.1002/jcp.30056

Pineda S; Nikolova-Krstevski V; Leimena C; Atkinson AJ; Altekoester AK; Cox CD; Jacoby A; Huttner IG; Ju YK; Soka M; Ohanian M; Trivedi G; Kalvakuri S; Birker K; Johnson R; Molenaar P; Kuchar D; Allen DG; Van Helden DF; Harvey RP; Hill AP; Bodmer R; Vogler G; Dobrzynski H; Ocorr K; Fatkin D, 2021, 'Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk', Circulation: Genomic and Precision Medicine, 14, pp. E003144, http://dx.doi.org/10.1161/CIRCGEN.120.003144

Zhang Y; Daday C; Gu RX; Cox CD; Martinac B; de Groot BL; Walz T, 2021, 'Visualization of the mechanosensitive ion channel MscS under membrane tension', Nature, 590, pp. 509 - 514, http://dx.doi.org/10.1038/s41586-021-03196-w

Silvani G; Romanov V; Cox CD; Martinac B, 2021, 'Biomechanical Characterization of Endothelial Cells Exposed to Shear Stress Using Acoustic Force Spectroscopy', Frontiers in Bioengineering and Biotechnology, 9, http://dx.doi.org/10.3389/fbioe.2021.612151

Romanov V; Silvani G; Zhu H; Cox CD; Martinac B, 2021, 'An Acoustic Platform for Single-Cell, High-Throughput Measurements of the Viscoelastic Properties of Cells', Small, 17, http://dx.doi.org/10.1002/smll.202005759

Zhang Y; Angiulli G; Martinac B; Cox CD; Walz T, 2021, 'Cyclodextrins for structural and functional studies of mechanosensitive channels', Journal of Structural Biology: X, 5, http://dx.doi.org/10.1016/j.yjsbx.2021.100053

Vero Li J; D Cox C; Martinac B, 2021, 'The anchor domain is critical for Piezo1 channel mechanosensitivity', Channels, 15, pp. 438 - 446, http://dx.doi.org/10.1080/19336950.2021.1923199

Buyan A; Cox CD; Barnoud J; Li J; Chan HSM; Martinac B; Marrink SJ; Corry B, 2020, 'Piezo1 Forms Specific, Functionally Important Interactions with Phosphoinositides and Cholesterol', Biophysical Journal, 119, pp. 1683 - 1697, http://dx.doi.org/10.1016/j.bpj.2020.07.043

Ridone P; Pandzic E; Vassalli M; Cox CD; Macmillan A; Gottlieb PA; Martinac B, 2020, 'Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters', Journal of General Physiology, 152, http://dx.doi.org/10.1085/jgp.201912515

Xue F; Cox CD; Bavi N; Rohde PR; Nakayama Y; Martinac B, 2020, 'Membrane stiffness is one of the key determinants of E. coli MscS channel mechanosensitivity', Biochimica et Biophysica Acta - Biomembranes, 1862, http://dx.doi.org/10.1016/j.bbamem.2020.183203

Baratchi S; Khoshmanesh K; Cox CD; Gomez GA, 2020, 'Editorial: Mechanobiology: Emerging Tools and Methods', Frontiers in Bioengineering and Biotechnology, 8, http://dx.doi.org/10.3389/fbioe.2020.00289

Patkunarajah A; Stear JH; Moroni M; Schroeter L; Blaszkiewicz J; Tearle JLE; Cox CD; Fuerst C; Sánchez-Carranza O; Fernández M; Fleischer R; Eravci M; Weise C; Martinac B; Biro M; Lewin GR; Poole K, 2020, 'TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration.', eLife, 9, pp. e53308, http://dx.doi.org/10.7554/eLife.53308

Romanov V; Silvani G; Zhu H; Cox C; Martinac B, 2020, 'An acoustic platform for single-cell, high-throughput measurements of the viscoelastic properties of cells', , http://dx.doi.org/10.1101/2020.09.07.286898

Cox CD; Gottlieb PA, 2019, 'Amphipathic molecules modulate PIEZO1 activity', Biochemical Society Transactions, 47, pp. 1833 - 1842, http://dx.doi.org/10.1042/BST20190372

Cox CD; Bavi N; Martinac B, 2019, 'Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction', Cell Reports, 29, pp. 1 - 12, http://dx.doi.org/10.1016/j.celrep.2019.08.075

Nikolaev YA; Cox CD; Ridone P; Rohde PR; Cordero-Morales JF; Vásquez V; Laver DR; Martinac B, 2019, 'Mammalian TRP ion channels are insensitive to membrane stretch', Journal of Cell Science, 132, http://dx.doi.org/10.1242/jcs.238360

Buyan A; Cox C; Rae J; Barnoud J; Li J; Cvetovska J; Bastiani M; Chan HSM; Hodson M; Martinac B; Parton R; Marrink S; Corry B, 2019, 'Piezo1 Induces Local Curvature in a Mammalian Membrane and Forms Specific Protein-Lipid Interactions', , http://dx.doi.org/10.1101/787531

Fatkin D; Cox CD; Huttner IG; Martinac B, 2018, 'Is There a Role for Genes in Exercise-Induced Atrial Cardiomyopathy?', Heart Lung and Circulation, 27, pp. 1093 - 1098, http://dx.doi.org/10.1016/j.hlc.2018.03.028

Cox CD; Bavi N; Martinac B, 2018, 'Bacterial Mechanosensors', Annual Review of Physiology, 80, pp. 71 - 93, http://dx.doi.org/10.1146/annurev-physiol-021317-121351

Nikolova-Krstevski V; Wagner S; Yu ZY; Cox CD; Cvetkovska J; Hill AP; Huttner IG; Benson V; Werdich AA; MacRae C; Feneley MP; Friedrich O; Martinac B; Fatkin D, 2017, 'Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk', JACC: Basic to Translational Science, 2, pp. 575 - 590, http://dx.doi.org/10.1016/j.jacbts.2017.05.006

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