By Dr Daniel Fernandez Ruiz

Journal articles

Ashayeripanah M; Vega-Ramos J; Fernandez-Ruiz D; Valikhani S; Lun ATL; White JT; Young LJ; Yaftiyan A; Zhan Y; Wakim L; Caminschi I; Lahoud MH; Lew AM; Shortman K; Smyth GK; Heath WR; Mintern JD; Roquilly A; Villadangos JA, 2024, 'Systemic inflammatory response syndrome triggered by blood-borne pathogens induces prolonged dendritic cell paralysis and immunosuppression', Cell Reports, 43, http://dx.doi.org/10.1016/j.celrep.2024.113754

Carrera Montoya J; Collett S; Fernandez Ruiz D; Earnest L; Edeling MA; Yap AHY; Wong CY; Cooney JP; Davidson KC; Roberts J; Rockman S; Tran BM; McAuley JL; Deliyannis G; Grimley SL; Purcell DFJ; Waters SA; Godfrey DI; Hans D; Pellegrini M; Mackenzie JM; Vincan E; Heath WR; Torresi J, 2024, 'Human Nasal Epithelium Organoids for Assessing Neutralizing Antibodies to a Protective SARS-CoV-2 Virus-like Particle Vaccine', Organoids, 3, pp. 18 - 31, http://dx.doi.org/10.3390/organoids3010002

Ganley M; Holz LE; Minnell JJ; de Menezes MN; Burn OK; Poa KCY; Draper SL; English K; Chan STS; Anderson RJ; Compton BJ; Marshall AJ; Cozijnsen A; Chua YC; Ge Z; Farrand KJ; Mamum JC; Xu C; Cockburn IA; Yui K; Bertolino P; Gras S; Le Nours J; Rossjohn J; Fernandez-Ruiz D; McFadden GI; Ackerley DF; Painter GF; Hermans IF; Heath WR, 2023, 'mRNA vaccine against malaria tailored for liver-resident memory T cells', Nature Immunology, 24, pp. 1487 - 1498, http://dx.doi.org/10.1038/s41590-023-01562-6

Chora Â; Marques S; Gonçalves JL; Lima P; Gomes da Costa D; Fernandez-Ruiz D; Marreiros MI; Ruivo P; Carvalho T; Ribeiro RM; Serre K; Heath WR; Silva-Santos B; Tate AT; Mota MM; Fernandez Ruiz D, 2023, 'Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis', Immunity, 56, pp. 592 - 605.e8, http://dx.doi.org/10.1016/j.immuni.2023.01.031

Valencia-Hernandez AM; Zillinger T; Ge Z; Tan PS; Cozijnsen A; I. McFadden G; Lahoud MH; Caminschi I; Barchet W; Heath WR; Fernandez-Ruiz D, 2023, 'Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells', Vaccine, 41, pp. 1094 - 1107, http://dx.doi.org/10.1016/j.vaccine.2022.12.047

Heath WR; Holz LE; Fernandez-Ruiz D, 2022, 'The Batman and Robin of liver-stage immunity to malaria', Trends in Parasitology, 38, pp. 7 - 8, http://dx.doi.org/10.1016/j.pt.2021.11.002

Ntita M; Inoue SI; Jian JY; Bayarsaikhan G; Kimura K; Kimura D; Miyakoda M; Nozaki E; Sakurai T; Fernandez-Ruiz D; Heath WR; Yui K, 2022, 'Type I interferon production elicits differential CD4⁺T-cell responses in mice infected with Plasmodium berghei ANKA and P. chabaudi', International Immunology, 34, pp. 21 - 33, http://dx.doi.org/10.1093/intimm/dxab090

Li J; Panetta F; O'Keeffe M; Rojas IML; Radford KJ; Zhang JG; Fernandez-Ruiz D; Davey GM; Gully BS; Tullett KM; Rossjohn J; Berry R; Lee CN; Lahoud MH; Heath WR; Caminschi I, 2021, 'Elucidating the motif for cpg oligonucleotide binding to the dendritic cell receptor dec-205 leads to improved adjuvants for liver-resident memory', Journal of Immunology, 207, pp. 1836 - 1847, http://dx.doi.org/10.4049/jimmunol.2001153

Ghazanfari N; Gregory JL; Devi S; Fernandez-Ruiz D; Beattie L; Mueller SN; Heath WR, 2021, 'CD8⁺ and CD4⁺ T cells infiltrate into the brain during plasmodium berghei ANKA infection and form long-term resident memory', Journal of Immunology, 207, pp. 1578 - 1590, http://dx.doi.org/10.4049/jimmunol.2000773

Pack AD; Schwartzhoff PV; Zacharias ZR; Fernandez-Ruiz D; Heath WR; Gurung P; Legge KL; Janse CJ; Butler NS; Fernandez Ruiz D, 2021, 'Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity', Cell Reports, 36, http://dx.doi.org/10.1016/j.celrep.2021.109586

Jian JY; Inoue SI; Bayarsaikhan G; Miyakoda M; Kimura D; Kimura K; Nozaki E; Sakurai T; Fernandez-Ruiz D; Heath WR; Yui K, 2021, 'CD49d marks Th1 and Tfh-like antigen-specific CD4⁺T cells during Plasmodium chabaudi infection', International Immunology, 33, pp. 409 - 422, http://dx.doi.org/10.1093/intimm/dxab020

Ghilas S; Enders MH; May R; Holz LE; Fernandez-Ruiz D; Cozijnsen A; Mollard V; Cockburn IA; McFadden GI; Heath WR; Beattie L, 2021, 'Development of Plasmodium-specific liver-resident memory CD8⁺ T cells after heat-killed sporozoite immunization in mice', European Journal of Immunology, 51, pp. 1153 - 1165, http://dx.doi.org/10.1002/eji.202048757

Surette FA; Guthmiller JJ; Li L; Sturtz AJ; Vijay R; Pope RL; McClellan BL; Pack AD; Zander RA; Shao P; Lan LYL; Fernandez-Ruiz D; Heath WR; Wilson PC; Butler NS; Fernandez Ruiz D, 2021, 'Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity', PLoS Pathogens, 17, http://dx.doi.org/10.1371/JOURNAL.PPAT.1009288

Fernandez-Ruiz D; de Menezes MN; Holz LE; Ghilas S; Heath WR; Beattie L, 2021, 'Harnessing liver-resident memory T cells for protection against malaria', Expert Review of Vaccines, 20, pp. 127 - 141, http://dx.doi.org/10.1080/14760584.2021.1881485

Enders MH; Bayarsaikhan G; Ghilas S; Chua YC; May R; de Menezes MN; Ge Z; Tan PS; Cozijnsen A; Mollard V; Yui K; McFadden GI; Lahoud MH; Caminschi I; Purcell AW; Schittenhelm RB; Beattie L; Heath WR; Fernandez-Ruiz D; Fernandez Ruiz D, 2021, 'Plasmodium berghei Hsp90 contains a natural immunogenic I-A^b-restricted antigen common to rodent and human Plasmodium species', Current Research in Immunology, 2, pp. 79 - 92, http://dx.doi.org/10.1016/j.crimmu.2021.06.002

Ghilas S; Valencia-Hernandez AM; Enders MH; Heath WR; Fernandez-Ruiz D; Fernandez Ruiz D, 2020, 'Resident memory t cells and their role within the liver', International Journal of Molecular Sciences, 21, http://dx.doi.org/10.3390/ijms21228565

Kato Y; Steiner TM; Park HY; Hitchcock RO; Zaid A; Hor JL; Devi S; Davey GM; Vremec D; Tullett KM; Tan PS; Ahmet F; Mueller SN; Alonso S; Tarlinton DM; Ploegh HL; Kaisho T; Beattie L; Manton JH; Fernandez-Ruiz D; Shortman K; Lahoud MH; Heath WR; Caminschi I; Fernandez Ruiz D, 2020, 'Display of native antigen on cDC1 that have spatial access to both T and B cells underlies efficient humoral vaccination', Journal of Immunology, 205, pp. 1842 - 1856, http://dx.doi.org/10.4049/jimmunol.2000549

Holz LE; Chua YC; de Menezes MN; Anderson RJ; Draper SL; Compton BJ; Chan STS; Mathew J; Li J; Kedzierski L; Wang Z; Beattie L; Enders MH; Ghilas S; May R; Steiner TM; Lange J; Fernandez-Ruiz D; Valencia-Hernandez AM; Osmond TL; Farrand KJ; Seneviratna R; Almeida CF; Tullett KM; Bertolino P; Bowen DG; Cozijnsen A; Mollard V; McFadden GI; Caminschi I; Lahoud MH; Kedzierska K; Turner SJ; Godfrey DI; Hermans IF; Painter GF; Heath WR, 2020, 'Glycolipid-peptide vaccination induces liver-resident memory CD8⁺ T cells that protect against rodent malaria', Science Immunology, 5, http://dx.doi.org/10.1126/SCIIMMUNOL.AAZ8035

Valencia-Hernandez AM; Ng WY; Ghazanfari N; Ghilas S; de Menezes MN; Holz LE; Huang C; English K; Naung M; Tan PS; Tullett KM; Steiner TM; Enders MH; Beattie L; Chua YC; Jones CM; Cozijnsen A; Mollard V; Cai Y; Bowen DG; Purcell AW; La Gruta NL; Villadangos JA; de Koning-Ward T; Barry AE; Barchet W; Cockburn IA; McFadden GI; Gras S; Lahoud MH; Bertolino P; Schittenhelm RB; Caminschi I; Heath WR; Fernandez-Ruiz D, 2020, 'A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice', Cell Host and Microbe, 27, pp. 950 - 962.e7, http://dx.doi.org/10.1016/j.chom.2020.04.010

Fernandez-Ruiz D; Ng WY; Holz LE; Ma JZ; Zaid A; Wong YC; Lau LS; Mollard V; Cozijnsen A; Collins N; Li J; Davey GM; Kato Y; Devi S; Skandari R; Pauley M; Manton JH; Godfrey DI; Braun A; Tay SS; Tan PS; Bowen DG; Koch-Nolte F; Rissiek B; Carbone FR; Crabb BS; Lahoud M; Cockburn IA; Mueller SN; Bertolino P; McFadden GI; Caminschi I; Heath WR, 2019, 'Erratum: Liver-Resident Memory CD8⁺ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection (Immunity (2016) 45(4) (889–902), (S1074761316303351), (10.1016/j.immuni.2016.08.011))', Immunity, 51, pp. 780, http://dx.doi.org/10.1016/j.immuni.2019.09.019

Bachem A; Makhlouf C; Binger KJ; de Souza DP; Tull D; Hochheiser K; Whitney PG; Fernandez-Ruiz D; Dähling S; Kastenmüller W; Jönsson J; Gressier E; Lew AM; Perdomo C; Kupz A; Figgett W; Mackay F; Oleshansky M; Russ BE; Parish IA; Kallies A; McConville MJ; Turner SJ; Gebhardt T; Bedoui S, 2019, 'Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8⁺ T Cells', Immunity, 51, pp. 285 - 297.e5, http://dx.doi.org/10.1016/j.immuni.2019.06.002

Benoun JM; Peres NG; Wang N; Pham OH; Rudisill VL; Fogassy ZN; Whitney PG; Fernandez-Ruiz D; Gebhardt T; Pham QM; Puddington L; Bedoui S; Strugnell RA; McSorley SJ, 2018, 'Optimal protection against Salmonella infection requires noncirculating memory', Proceedings of the National Academy of Sciences of the United States of America, 115, pp. 10416 - 10421, http://dx.doi.org/10.1073/pnas.1808339115

Holz LE; Prier JE; Freestone D; Steiner TM; English K; Johnson DN; Mollard V; Cozijnsen A; Davey GM; Godfrey DI; Yui K; Mackay LK; Lahoud MH; Caminschi I; McFadden GI; Bertolino P; Fernandez-Ruiz D; Heath WR; Fernandez Ruiz D, 2018, 'CD8⁺ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver', Cell Reports, 25, pp. 68 - 79.e4, http://dx.doi.org/10.1016/j.celrep.2018.08.094

James KR; Soon MSF; Sebina I; Fernandez-Ruiz D; Davey G; Liligeto UN; Nair AS; Fogg LG; Edwards CL; Best SE; Lansink LIM; Schroder K; Wilson JAC; Austin R; Suhrbier A; Lane SW; Hill GR; Engwerda CR; Heath WR; Haque A, 2018, 'IFN regulatory factor 3 balances Th1 and t follicular helper immunity during nonlethal blood-Stage plasmodium infection', Journal of Immunology, 200, pp. 1443 - 1456, http://dx.doi.org/10.4049/jimmunol.1700782

Fernandez-Ruiz D; Lau LS; Ghazanfari N; Jones CM; Ng WY; Davey GM; Berthold D; Holz L; Kato Y; Enders MH; Bayarsaikhan G; Hendriks SH; Lansink LIM; Engel JA; Soon MSF; James KR; Cozijnsen A; Mollard V; Uboldi AD; Tonkin CJ; De Koning-Ward TF; Gilson PR; Kaisho T; Haque A; Crabb BS; Carbone FR; McFadden GI; Heath WR, 2017, 'Development of a novel CD4⁺ TCR transgenic line that reveals a dominant role for CD8⁺ dendritic cells and CD40 signaling in the generation of helper and CTL responses to blood-stage malaria', Journal of Immunology, 199, pp. 4165 - 4179, http://dx.doi.org/10.4049/jimmunol.1700186

Lönnberg T; Svensson V; James KR; Fernandez-Ruiz D; Sebina I; Montandon R; Soon MSF; Fogg LG; Nair AS; Liligeto UN; Stubbington MJT; Ly LH; Bagger FO; Zwiessele M; Lawrence ND; Souza-Fonseca-Guimaraes F; Bunn PT; Engwerda CR; Heath WR; Billker O; Stegle O; Haque A; Teichmann SA, 2017, 'Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFH fate bifurcation in malaria', Science Immunology, 2, http://dx.doi.org/10.1126/sciimmunol.aal2192

Fernandez-Ruiz D; Ng WY; Holz LE; Ma JZ; Zaid A; Wong YC; Lau LS; Mollard V; Cozijnsen A; Collins N; Li J; Davey GM; Kato Y; Devi S; Skandari R; Pauley M; Manton JH; Godfrey DI; Braun A; Tay SS; Tan PS; Bowen DG; Koch-Nolte F; Rissiek B; Carbone FR; Crabb BS; Lahoud M; Cockburn IA; Mueller SN; Bertolino P; McFadden GI; Caminschi I; Heath WR, 2016, 'Liver-Resident Memory CD8⁺ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection', Immunity, 45, pp. 889 - 902, http://dx.doi.org/10.1016/j.immuni.2016.08.011

Proserpio V; Piccolo A; Haim-Vilmovsky L; Kar G; Lönnberg T; Svensson V; Pramanik J; Natarajan KN; Zhai W; Zhang X; Donati G; Kayikci M; Kotar J; McKenzie ANJ; Montandon R; James KR; Fernandez-Ruiz D; Heath WR; Haque A; Billker O; Woodhouse S; Cicuta P; Nicodemi M; Teichmann SA; Fernandez Ruiz D, 2016, 'Erratum to: Single cell analysis of CD4+ T cell differentiation reveals three major cell states and progressive acceleration of proliferation [Genome Biol. 17 (2016) 103]', Genome Biology, 17, http://dx.doi.org/10.1186/s13059-016-0998-9

Proserpio V; Piccolo A; Haim-Vilmovsky L; Kar G; Lönnberg T; Svensson V; Pramanik J; Natarajan KN; Zhai W; Zhang X; Donati G; Kayikci M; Kotar J; McKenzie ANJ; Montandon R; Billker O; Woodhouse S; Cicuta P; Nicodemi M; Teichmann SA; Fernandez Ruiz D, 2016, 'Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation', Genome Biology, 17, pp. 103, http://dx.doi.org/10.1186/s13059-016-0957-5

Holz LE; Fernandez-Ruiz D; Heath WR; Fernandez Ruiz D, 2016, 'Protective immunity to liver-stage malaria', Clinical and Translational Immunology, 5, pp. e105, http://dx.doi.org/10.1038/CTI.2016.60

Lau LS; Fernandez-Ruiz D; Mollard V; Sturm A; Neller MA; Cozijnsen A; Gregory JL; Davey GM; Jones CM; Lin YH; Haque A; Engwerda CR; Nie CQ; Hansen DS; Murphy KM; Papenfuss AT; Miles JJ; Burrows SR; de Koning-Ward T; McFadden GI; Carbone FR; Crabb BS; Heath WR; Fernandez Ruiz D, 2014, 'CD8+ T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria', PLoS Pathogens, 10, pp. e1004135, http://dx.doi.org/10.1371/journal.ppat.1004135

Kupz A; Guarda G; Gebhardt T; Sander LE; Short KR; Diavatopoulos DA; Wijburg OLC; Cao H; Waithman JC; Chen W; Fernandez-Ruiz D; Whitney PG; Heath WR; Curtiss R; Tschopp J; Strugnell RA; Bedoui S, 2012, 'NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8 ⁺ T cells', Nature Immunology, 13, pp. 162 - 169, http://dx.doi.org/10.1038/ni.2195

Lau LS; Fernandez Ruiz D; Davey GM; De Koning-Ward TF; Papenfuss AT; Carbone FR; Brooks AG; Crabb BS; Heath WR, 2011, 'Blood-stage plasmodium berghei infection generates a potent, specific CD8⁺ T-cell response despite residence largely in cells lacking MHC i processing machinery', Journal of Infectious Diseases, 204, pp. 1989 - 1996, http://dx.doi.org/10.1093/infdis/jir656

Hoves S; Sutton VR; Haynes NM; Hawkins ED; Ruiz DF; Baschuk N; Sedelies KA; Schnurr M; Stagg J; Andrews DM; Villadangos JA; Trapani JA, 2011, 'A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells', Journal of Immunology, 187, pp. 1166 - 1175, http://dx.doi.org/10.4049/jimmunol.1001670

Specht S; Ruiz DF; Dubben B; Deininger S; Hoerauf A, 2010, 'Filaria-induced IL-10 suppresses murine cerebral malaria', Microbes and Infection, 12, pp. 635 - 642, http://dx.doi.org/10.1016/j.micinf.2010.04.006

Fernández Ruiz D; Dubben B; Saeftel M; Endl E; Deininger S; Hoerauf A; Specht S, 2009, 'Filarial infection induces protection against P. berghei liver stages in mice', Microbes and Infection, 11, pp. 172 - 180, http://dx.doi.org/10.1016/j.micinf.2008.11.003

Preprints

Fernandez-Ruiz D; Lau LS; Ghazanfari N; Jones C; Ng WY; Davey G; Berthold D; Holz L; Kato Y; Bayarsaikhan G; Hendriks S; James K; Cozijnsen A; Mollard V; de Koning-Ward T; Gilson P; Kaisho T; Haque A; Crabb B; Carbone F; McFadden G; Heath W, 2017, Development of a Novel CD4⁺TCR Transgenic Line that Reveals a Dominant Role for CD8⁺DC and CD40-Signaling in the Generation of Helper and CTL Responses to Blood Stage Malaria, http://dx.doi.org/10.1101/113837

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