By Dr Dominik Froehlich

Journal articles

Kalotay E; Klugmann M; Housley GD; Fröhlich D, 2023, 'Dominant aminoacyl-tRNA synthetase disorders: lessons learned from in vivo disease models', Frontiers in Neuroscience, 17, http://dx.doi.org/10.3389/fnins.2023.1182845

Kalotay E; Klugmann M; Housley GD; Fröhlich D, 2023, 'Recessive aminoacyl-tRNA synthetase disorders: lessons learned from in vivo disease models', Frontiers in Neuroscience, 17, http://dx.doi.org/10.3389/fnins.2023.1182874

Klugmann M; Suchowerska AK; Housley GD; Fröhlich D, 2023, 'Histological and biochemical methods to assess aminoacyl-tRNA synthetase expression in human post-mortem brain tissue', Rare Disease and Orphan Drugs Journal, 2, pp. 8 - 8, http://dx.doi.org/10.20517/rdodj.2023.05

Fröhlich D; Kalotay E; von Jonquieres G; Bongers A; Lee B; Suchowerska AK; Housley GD; Klugmann M, 2022, 'Dual-function AAV gene therapy reverses late-stage Canavan disease pathology in mice', Frontiers in Molecular Neuroscience, 15, http://dx.doi.org/10.3389/fnmol.2022.1061257

Klugmann M; Kalotay E; Delerue F; Ittner LM; Bongers A; Yu J; Morris MJ; Housley GD; Fröhlich D, 2022, 'Correction to: Developmental delay and late onset HBSL pathology in hypomorphic Dars1 ^M256L mice (Neurochemical Research, (2022), 47, 7, (1972-1984), 10.1007/s11064-022-03582-4)', Neurochemical Research, 47, pp. 1985 - 1990, http://dx.doi.org/10.1007/s11064-022-03602-3

Klugmann M; Kalotay E; Delerue F; Ittner LM; Bongers A; Yu J; Morris MJ; Housley GD; Fröhlich D, 2022, 'Developmental delay and late onset HBSL pathology in hypomorphic Dars1 ^M256L mice', Neurochemical Research, 47, pp. 1972 - 1984, http://dx.doi.org/10.1007/s11064-022-03582-4

Fröhlich D; Gessler DJ; Klugmann M, 2022, 'Editorial: Myelin Repair: At the Crossing-Lines of Myelin Biology and Gene Therapy', Frontiers in Cellular Neuroscience, 16, http://dx.doi.org/10.3389/fncel.2022.853742

Muthiah A; Housley GD; Klugmann M; Fröhlich D, 2021, 'The Leukodystrophies HBSL and LBSL—Correlates and Distinctions', Frontiers in Cellular Neuroscience, 14, http://dx.doi.org/10.3389/fncel.2020.626610

Fröhlich D; Mendes MI; Kueh AJ; Bongers A; Herold MJ; Salomons GS; Housley GD; Klugmann M, 2021, 'A Hypomorphic Dars1^D367Y Model Recapitulates Key Aspects of the Leukodystrophy HBSL', Frontiers in Cellular Neuroscience, 14, http://dx.doi.org/10.3389/fncel.2020.625879

Frühbeis C; Kuo-Elsner WP; Müller C; Barth K; Peris L; Tenzer S; Möbius W; Werner HB; Nave KA; Fröhlich D; Krämer-Albers EM, 2020, 'Oligodendrocytes support axonal transport and maintenance via exosome secretion', PLoS Biology, 18, http://dx.doi.org/10.1371/journal.pbio.3000621

Das A; Fröhlich D; Achanta LB; Rowlands BD; Housley GD; Klugmann M; Rae CD, 2020, 'Correction to: L-Aspartate, L-Ornithine and L-Ornithine-L-Aspartate (LOLA) and Their Impact on Brain Energy Metabolism (Neurochemical Research, (2020), 45, 6, (1438-1450), 10.1007/s11064-020-03044-9)', Neurochemical Research, 45, pp. 2527, http://dx.doi.org/10.1007/s11064-020-03087-y

Das A; Fröhlich D; Achanta LB; Rowlands BD; Housley GD; Klugmann M; Rae CD; Froehlich D, 2020, 'L-Aspartate, L-Ornithine and L-Ornithine-L-Aspartate (LOLA) and Their Impact on Brain Energy Metabolism', Neurochemical Research, 45, pp. 1438 - 1450, http://dx.doi.org/10.1007/s11064-020-03044-9

Auber M; Fröhlich D; Drechsel O; Karaulanov E; Krämer-Albers EM, 2019, 'Serum-free media supplements carry miRNAs that co-purify with extracellular vesicles', Journal of Extracellular Vesicles, 8, http://dx.doi.org/10.1080/20013078.2019.1656042

Fröhlich D; Suchowerska AK; Voss C; He R; Wolvetang E; Von Jonquieres G; Simons C; Fath T; Housley GD; Klugmann M; Froehlich D, 2018, 'Expression pattern of the aspartyl-tRNA synthetase DARS in the human brain', Frontiers in Molecular Neuroscience, 11, pp. 81, http://dx.doi.org/10.3389/fnmol.2018.00081

von Jonquieres G; Spencer ZHT; Rowlands BD; Klugmann CB; Bongers A; Harasta AE; Parley KE; Cederholm J; Teahan O; Pickford R; Delerue F; Ittner LM; Fröhlich D; McLean CA; Don AS; Schneider M; Housley GD; Rae CD; Klugmann M; Froehlich D, 2018, 'Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy', Acta Neuropathologica, 135, pp. 95 - 113, http://dx.doi.org/10.1007/s00401-017-1784-9

Fröhlich D; Suchowerska AK; Spencer ZHT; von Jonquieres G; Klugmann CB; Bongers A; Delerue F; Stefen H; Ittner LM; Fath T; Housley GD; Klugmann M, 2017, 'In vivo characterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL', Neurobiology of Disease, 97, pp. 24 - 35, http://dx.doi.org/10.1016/j.nbd.2016.10.008

von Jonquieres G; Fröhlich D; Klugmann CB; Wen X; Harasta AE; Ramkumar R; Spencer ZHT; Housley GD; Klugmann M, 2016, 'Recombinant human myelin-associated glycoprotein promoter drives selective AAV-mediated transgene expression in oligodendrocytes', Frontiers in Molecular Neuroscience, 9, http://dx.doi.org/10.3389/fnmol.2016.00013

Froehlich D; Fruehbeis C; Kuo WP; Moebius W; Goebbels S; Nave K-A; Schneider A; Simons M; Klugmann M; Trotter J; Kraemer-Albers E-M, 2014, 'Transfer of exosomes from oligodendrocytes to neurons', ACTA PHYSIOLOGICA, 210, pp. 134 - 134, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000332259900346&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Fröhlich D; Kuo WP; Frühbeis C; Sun JJ; Zehendner CM; Luhmann HJ; Pinto S; Toedling J; Trotter J; Krämer-Albers EM, 2014, 'Multifaceted effects of oligodendroglial exosomes on neurons: Impact on neuronal firing rate, signal transduction and gene regulation', Philosophical Transactions of the Royal Society B: Biological Sciences, 369, http://dx.doi.org/10.1098/rstb.2013.0510

Frühbeis C; Fröhlich D; Kuo WP; Krämer-Albers EM, 2013, 'Extracellular vesicles as mediators of neuron-glia communication', Frontiers in Cellular Neuroscience, http://dx.doi.org/10.3389/fncel.2013.00182

Frühbeis C; Fröhlich D; Kuo WP; Amphornrat J; Thilemann S; Saab AS; Kirchhoff F; Möbius W; Goebbels S; Nave KA; Schneider A; Simons M; Klugmann M; Trotter J; Krämer-Albers EM, 2013, 'Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte-Neuron Communication', PLoS Biology, 11, http://dx.doi.org/10.1371/journal.pbio.1001604

Von Jonquieres G; Mersmann N; Klugmann CB; Harasta AE; Lutz B; Teahan O; Housley GD; Frohlich D; Kramer-Albers EM; Klugmann M, 2013, 'Glial Promoter Selectivity following AAV-Delivery to the Immature Brain', PLoS ONE, 8, pp. Article number e65646, http://dx.doi.org/10.1371/journal.pone.0065646

Frühbeis C; Fröhlich D; Krämer-Albers EM, 2012, 'Emerging roles of exosomes in neuron-glia communication', Frontiers in Physiology, 3 APR, http://dx.doi.org/10.3389/fphys.2012.00119

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