By Dr Hansen Kosasih

Journal articles

Beck D; Cao H; Tian F; Huang Y; Jiang M; Zhao H; Tai X; Xu W; Kosasih HJ; Kealy DJ; Zhao W; Taylor SJ; Couttas TA; Song G; Chacon-Fajardo D; Walia Y; Wang M; Dowle AA; Holding AN; Bridge KS; Zhang C; Wang J; Mi JQ; Lock RB; de Bock CE; Jing D, 2024, 'PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia', Nature Communications, 15, pp. 9697, http://dx.doi.org/10.1038/s41467-024-54096-2

Toscan CE; McCalmont H; Ashoorzadeh A; Lin X; Fu Z; Doculara L; Kosasih HJ; Cadiz R; Zhou A; Williams S; Evans K; Khalili F; Cai R; Yeats KL; Gifford AJ; Pickford R; Mayoh C; Xie J; Henderson MJ; Trahair TN; Patterson AV; Smaill JB; de Bock CE; Lock RB, 2024, 'The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia', Blood Cancer Journal, 14, pp. 192, http://dx.doi.org/10.1038/s41408-024-01180-x

Kosasih HJ; de Bock CE, 2024, 'Less is more: Depleting myeloid-biased HSCs to restore immune function', HemaSphere, 8, pp. e125, http://dx.doi.org/10.1002/hem3.125

Randall J; Evans K; Watts B; Kosasih HJ; Smith CM; Earley EJ; Erickson SW; Jocoy EL; Bult CJ; Teicher BA; de Bock CE; Smith MA; Lock RB, 2024, 'In vivo activity of the second-generation proteasome inhibitor ixazomib against pediatric T-cell acute lymphoblastic leukemia xenografts', Experimental Hematology, 132, pp. 104176, http://dx.doi.org/10.1016/j.exphem.2024.104176

Kosasih HJ; Healey G; Brennan MS; Bjelosevic S; Sadras T; Jalud FB; Ibnat T; Ng AP; Mayoh C; Mao J; Tax G; Ludlow LEA; Johnstone RW; Herold MJ; Khaw SL; de Bock CE; Ekert PG, 2024, 'A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax', HemaSphere, 8, pp. e1, http://dx.doi.org/10.1002/hem3.1

Gu A; Schmidt B; Lonsdale A; Jalaldeen R; Kosasih HJ; Brown LM; Sadras T; Ekert PG; Oshlack A, 2023, 'TALLSorts: a T-cell acute lymphoblastic leukemia subtype classifier using RNA-seq expression data', Blood Advances, 7, pp. 7402 - 7406, http://dx.doi.org/10.1182/bloodadvances.2023010385

De Coninck S; De Smedt R; Lintermans B; Reunes L; Kosasih HJ; Reekmans A; Brown LM; Van Roy N; Palhais B; Roels J; Van der Linden M; Van Dorpe J; Ntziachristos P; Van Delft FW; Mansour MR; Pieters T; Lammens T; De Moerloose B; De Bock CE; Goossens S; Van Vlierberghe P, 2023, 'Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma.', Haematologica, 109, http://dx.doi.org/10.3324/haematol.2023.283981

Sadras T; Jalud FB; Kosasih HJ; Horne CR; Brown LM; El-Kamand S; de Bock CE; McAloney L; Ng AP; Davidson NM; Ludlow LEA; Oshlack A; Cowley MJ; Khaw SL; Murphy JM; Ekert PG, 2023, 'Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL', Leukemia, 37, pp. 1 - 5, http://dx.doi.org/10.1038/s41375-023-01843-x

Ryland GL; Umeda M; Holmfeldt L; Lehmann S; Herlin MK; Ma J; Khanlari M; Rubnitz JE; Ries RE; Kosasih HJ; Ekert PG; Goh HN; Tiong IS; Grimmond SM; Haferlach C; Day RB; Ley TJ; Meshinchi S; Ma X; Blombery P; Klco JM, 2023, 'Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions', Blood, 141, pp. 800 - 805, http://dx.doi.org/10.1182/blood.2022017874

Lonsdale A; Halman A; Brown L; Kosasih H; Ekert P; Oshlack A, 2023, 'Toblerone: detecting exon deletion events in cancer using RNA-seq', F1000Research, 12, http://dx.doi.org/10.12688/f1000research.129490.1

Omari SA; Kosasih HJ; Chung T; de Bock CE, 2023, 'In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia', Heliyon, 9, http://dx.doi.org/10.1016/j.heliyon.2023.e22085

Schmidt B; Brown LM; Ryland GL; Lonsdale A; Kosasih HJ; Ludlow LE; Majewski IJ; Blombery P; Ekert PG; Davidson NM; Oshlack A, 2022, 'ALLSorts: an RNA-Seq subtype classifier for B-cell acute lymphoblastic leukemia', Blood Advances, 6, pp. 4093 - 4097, http://dx.doi.org/10.1182/bloodadvances.2021005894

Brown LM; Hediyeh-Zadeh S; Sadras T; Huckstep H; Sandow JJ; Bartolo RC; Kosasih HJ; Davidson NM; Schmidt B; Bjelosevic S; Johnstone R; Webb AI; Khaw SL; Oshlack A; Davis MJ; Ekert PG, 2022, 'SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia', Blood Advances, 6, pp. 2373 - 2387, http://dx.doi.org/10.1182/bloodadvances.2021006076

Schmidt B; Brown L; Ryland G; Lonsdale A; Kosasih H; Ludlow L; Majewski I; Blombery P; Ekert P; Davidson N; Oshlack A, 2021, 'ALLSorts: a RNA-Seq classifier for B-Cell Acute Lymphoblastic Leukemia', , http://dx.doi.org/10.1101/2021.08.01.454393

Kosasih HJ; Davidson NM; Bjelosevic S; Morrish E; Brennan MS; Oshlack A; Johnstone RW; Brumatti G; Khaw SL; Ekert PG, 2020, 'MLL-TFE3: A novel and aggressive KMT2A fusion identified in infant leukemia', Blood Advances, 4, pp. 4918 - 4923, http://dx.doi.org/10.1182/BLOODADVANCES.2020002708

Meyer C; Lopes BA; Caye-Eude A; Cavé H; Arfeuille C; Cuccuini W; Sutton R; Venn NC; Oh SH; Tsaur G; Escherich G; Feuchtinger T; Kosasih HJ; Khaw SL; Ekert PG; Pombo-de-Oliveira MS; Bidet A; Djahanschiri B; Ebersberger I; Zaliova M; Zuna J; Zermanova Z; Juvonen V; Grümayer RP; Fazio G; Cazzaniga G; Larghero P; Emerenciano M; Marschalek R, 2019, 'Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL–USP2 fusions', Leukemia, 33, pp. 2306 - 2340, http://dx.doi.org/10.1038/s41375-019-0451-7

Narayan N; Morenos L; Phipson B; Willis SN; Brumatti G; Eggers S; Lalaoui N; Brown LM; Kosasih HJ; Bartolo RC; Zhou L; Catchpoole D; Saffery R; Oshlack A; Goodall GJ; Ekert PG, 2017, 'Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia', Leukemia, 31, pp. 808 - 820, http://dx.doi.org/10.1038/leu.2016.279

Kosasih HJ; Last K; Rogerson FM; Golub SB; Gauci SJ; Russo VC; Stanton H; Wilson R; Lamande SR; Holden P; Fosang AJ, 2016, 'A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) forms catalytically active oligomers', Journal of Biological Chemistry, 291, pp. 3197 - 3208, http://dx.doi.org/10.1074/jbc.M115.704817

Conference Abstracts

Lock RB; Toscan CE; McCalmont H; Evans K; Doculara L; Kosasih HJ; Gifford AJ; Ashoorzadeh A; Lin X; Trahair TN; De Bock CE; Patterson AV; Smaill JB, 2023, 'The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, Vol. 142, pp. 4251 - 4251, http://dx.doi.org/10.1182/blood-2023-181298

Preprints

Jing D; Beck D; Cao H; Tian F; Huang Y; Zhao H; Tai X; XU WENQIAN; Kosasih H; Kealy D; Bridge K; Zhao W; Holding A; Dowle A; Taylor S; Song G; Fajardo D; Walia Y; Wang M; Zhang C; Wang J; Mi J-Q; Lock R; de Bock C, 2024, PU.1 Eviction at Lymphocyte-Specific Chromatin Domains Mediates Glucocorticoid Response in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.21203/rs.3.rs-3872306/v1

Lonsdale A; Halman A; Brown L; Kosasih H; Ekert P; Oshlack A, 2022, Toblerone: detecting exon deletion events in cancer using RNA-seq, http://dx.doi.org/10.1101/2022.10.27.514132

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