By Dr Hassan Choucair

Journal articles

Tam S; Umashankar B; Rahman MK; Choucair H; Rawling T; Murray M, 2024, 'The Novel Anticancer Aryl-Ureido Fatty Acid CTU Increases Reactive Oxygen Species Production That Impairs Mitochondrial Fusion Mechanisms and Promotes MDA-MB-231 Cell Death', International Journal of Molecular Sciences, 25, http://dx.doi.org/10.3390/ijms251910577

Rahman MK; Umashankar B; Choucair H; Bourget K; Rawling T; Murray M, 2024, 'The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU', International Journal of Biochemistry and Cell Biology, 171, http://dx.doi.org/10.1016/j.biocel.2024.106571

Rahman MK; Umashankar B; Choucair H; Pazderka C; Bourget K; Chen Y; Dunstan CR; Rawling T; Murray M, 2023, 'Inclusion of the in-chain sulfur in 3-thiaCTU increases the efficiency of mitochondrial targeting and cell killing by anticancer aryl-urea fatty acids', European Journal of Pharmacology, 939, http://dx.doi.org/10.1016/j.ejphar.2022.175470

Choucair H; Rahman MK; Umashankar B; Al-Zubaidi Y; Bourget K; Chen Y; Dunstan C; Rawling T; Murray M, 2022, 'The aryl-ureido fatty acid CTU activates endoplasmic reticulum stress and PERK/NOXA-mediated apoptosis in tumor cells by a dual mitochondrial-targeting mechanism', Cancer Letters, 526, pp. 131 - 141, http://dx.doi.org/10.1016/j.canlet.2021.11.022

al-Zubaidi Y; Chen Y; Khalilur Rahman M; Umashankar B; Choucair H; Bourget K; Chung L; Qi Y; Witting PK; Anderson RL; O'Neill GM; Dunstan CR; Rawling T; Murray M, 2021, 'PTU, a novel ureido-fatty acid, inhibits MDA-MB-231 cell invasion and dissemination by modulating Wnt5a secretion and cytoskeletal signaling', Biochemical Pharmacology, 192, http://dx.doi.org/10.1016/j.bcp.2021.114726

Al-Zubaidi Y; Pazderka C; Koolaji N; Rahman MK; Choucair H; Umashankar B; Bourget K; Chen Y; Rawling T; Murray M, 2019, 'Aryl-urea fatty acids that activate the p38 MAP kinase and down-regulate multiple cyclins decrease the viability of MDA-MB-231 breast cancer cells', European Journal of Pharmaceutical Sciences, 129, pp. 87 - 98, http://dx.doi.org/10.1016/j.ejps.2018.12.015

Rawling T; Choucair H; Koolaji N; Bourget K; Allison SE; Chen YJ; Dunstan CR; Murray M, 2017, 'A Novel Arylurea Fatty Acid That Targets the Mitochondrion and Depletes Cardiolipin to Promote Killing of Breast Cancer Cells', Journal of Medicinal Chemistry, 60, pp. 8661 - 8666, http://dx.doi.org/10.1021/acs.jmedchem.7b00701

Conference Papers

Rahman MK; Rawling T; Al-Zubaidi Y; Choucair H; Umashankar B; Chen Y; Bourget K; Tam S; Smith C; Murray M, 2019, 'Inhibition of IRE1-mediated pro-tumorigenic responses enhances the sensitivity of MDA-MB-231 cells to the novel arylurea-fatty acid CTU', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1535-7163.TARG-19-A119

Murray M; Choucair H; Allison S; Bourget K; Chen Y; Dunstan C; Rawling T, 2017, 'A novel synthetic omega-3 fatty acid epoxide analogue activates breast cancer cell killing in vitro and in vivo', in BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, SCOTLAND, Aberdeen, pp. 117 - 117, presented at Joint Conference of the 5th International Conference on the Mechanism of Action of Nutraceuticals (ICMAN) / Meeting of the Natural-Products-Section of the International-Union-of-Basic-and-Clinical-Pharmacology (IUPHAR), SCOTLAND, Aberdeen, 27 September 2017 - 29 September 2017, http://dx.doi.org/10.1016/j.bcp.2017.06.090

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